Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease (functional) | = 2 % | In vivo evaluation for the percentage decrease in blood pressure at 135 micromol/kg administered through oral route in spontaneously hypertensive rats and observed for 6-12 h. | ChEMBL. | 1542102 |
Decrease (functional) | = 4 % | In vivo evaluation for the percentage decrease in blood pressure at 135 micromol/kg administered through oral route in spontaneously hypertensive rats and observed for 12-18 h. | ChEMBL. | 1542102 |
Decrease (functional) | = 7 % | In vivo evaluation for the percentage decrease in blood pressure at 135 micromol/kg administered through oral route in spontaneously hypertensive rats and observed for 0-6 h. | ChEMBL. | 1542102 |
IC50 (functional) | = 7.7 uM | In vitro evaluation of the compound for the vasorelaxant effects in circumferential strips of potassium-depolarized rabbit aorta. (IC50 in rabbit aorta strips contracted with KCl | ChEMBL. | 1542102 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.