Detailed information for compound 282013

Basic information

Technical information
  • TDR Targets ID: 282013
  • Name: 7-chloro-2-oxo-3-phenyl-1H-quinoline-4-carbox ylic acid
  • MW: 299.709 | Formula: C16H10ClNO3
  • H donors: 2 H acceptors: 4 LogP: 3.95 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)nc(c(c2C(=O)O)c1ccccc1)O
  • InChi: 1S/C16H10ClNO3/c17-10-6-7-11-12(8-10)18-15(19)13(14(11)16(20)21)9-4-2-1-3-5-9/h1-8H,(H,18,19)(H,20,21)
  • InChiKey: DRGYXCZRNMIMFN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-chloro-2-keto-3-phenyl-1H-quinoline-4-carboxylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum expressed protein Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis glutamate (NMDA) receptor subunit Glutamate (NMDA) receptor subunit zeta 1   938 aa 822 aa 23.2 %
Drosophila melanogaster NMDA receptor 2 Glutamate (NMDA) receptor subunit zeta 1   938 aa 878 aa 27.4 %
Drosophila melanogaster Glutamate receptor IA Glutamate (NMDA) receptor subunit zeta 1   938 aa 979 aa 23.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0181 0.904 1
Loa Loa (eye worm) hypothetical protein 0.0198 1 1
Trypanosoma brucei multidrug resistance protein E 0.0114 0.5215 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0095 0.4143 0.4272
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0095 0.4143 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0095 0.4143 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0095 0.4143 0.4272
Trypanosoma brucei p-glycoprotein 0.0114 0.5215 1
Trichomonas vaginalis abcb9, putative 0.0095 0.4143 1
Trichomonas vaginalis ABC transporter, putative 0.0095 0.4143 1
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0114 0.5215 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0095 0.4143 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0044 0.1222 0.0294
Loa Loa (eye worm) TAR-binding protein 0.0074 0.2926 0.2587
Loa Loa (eye worm) ABC transporter 0.0044 0.1222 0.0801
Trichomonas vaginalis ABC transporter, putative 0.0095 0.4143 1
Loa Loa (eye worm) hypothetical protein 0.0181 0.904 0.8994
Entamoeba histolytica P-glycoprotein-5 0.0095 0.4143 0.7372
Echinococcus granulosus multidrug resistance associated protein 4 0.007 0.2678 0.2559
Trypanosoma cruzi hypothetical protein 0.007 0.2678 0.3646
Giardia lamblia Multidrug resistance-associated protein 1 0.0114 0.5215 0.5163
Brugia malayi Cytochrome P450 family protein 0.0035 0.0673 0.0251
Entamoeba histolytica ABC transporter, putative 0.0114 0.5215 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0044 0.1222 1
Schistosoma mansoni multidrug resistance protein 0.0095 0.4143 0.4272
Trichomonas vaginalis taga, putative 0.0095 0.4143 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0095 0.4143 0.4272
Echinococcus multilocularis ATP binding cassette sub family B 0.0044 0.1222 0.0856
Echinococcus multilocularis ATP binding cassette sub family B 0.0044 0.1222 0.0856
Echinococcus granulosus multidrug resistance protein 1 0.0095 0.4143 0.4272
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0095 0.4143 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2926 0.2849
Brugia malayi RNA binding protein 0.0074 0.2926 0.3341
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0095 0.4143 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0095 0.4143 1
Loa Loa (eye worm) multidrug resistance-associated protein 0.0071 0.2766 0.242
Echinococcus multilocularis glutamate receptor NMDA 0.0095 0.4135 0.4263
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0095 0.4143 1
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0043 0.1133 0.0752
Entamoeba histolytica ATP-binding cassette protein, putative 0.0114 0.5215 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0114 0.5215 1
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0044 0.1222 0.2949
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2926 0.2849
Entamoeba histolytica P-glycoprotein-2 0.0095 0.4143 0.7372
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0114 0.5215 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0095 0.4143 0.3862
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0095 0.4143 1
Echinococcus multilocularis multidrug resistance associated protein 1 0.0114 0.5215 0.5526
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0198 1 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0113 0.5127 0.5051
Loa Loa (eye worm) hypothetical protein 0.0032 0.049 0.0035
Trichomonas vaginalis abcb9, putative 0.0095 0.4143 1
Brugia malayi ABC transporter transmembrane region family protein 0.0114 0.5215 0.6482
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0032 0.0513 0.0027
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.2926 0.3341
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0044 0.1222 1
Trypanosoma cruzi multidrug resistance protein E, putative 0.0114 0.5215 1
Brugia malayi multidrug resistance related protein 1 0.0114 0.5215 0.6482
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0181 0.904 0.8907
Echinococcus granulosus nmda type glutamate receptor 0.0127 0.5964 0.6403
Brugia malayi ABC transporter 0.0044 0.1222 0.1004
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0095 0.4143 1
Onchocerca volvulus 0.0095 0.4143 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0114 0.5215 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0095 0.4143 1
Echinococcus multilocularis tar DNA binding protein 0.0074 0.2926 0.2849
Echinococcus granulosus ATP binding cassette sub family B 0.0044 0.1222 0.0856
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2926 0.2849
Loa Loa (eye worm) intermediate filament protein 0.0032 0.049 0.0035
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0159 0.778 0.8526
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0095 0.4143 1
Schistosoma mansoni multidrug resistance protein 0.0044 0.1222 0.0856
Echinococcus multilocularis ATP binding cassette sub family B 0.0094 0.4054 0.4168
Echinococcus multilocularis multidrug resistance associated protein 4 0.007 0.2678 0.2559
Giardia lamblia ABC transporter, putative 0.0114 0.5215 0.5163
Schistosoma mansoni smdr2 0.0095 0.4143 0.4272
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0114 0.5215 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0023 0 0.5
Brugia malayi ABC transporter family protein 0.0044 0.1222 0.1004
Schistosoma mansoni multidrug resistance protein 0.0114 0.5215 0.5526
Schistosoma mansoni multidrug resistance protein 0.0114 0.5215 0.5526
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0114 0.5215 1
Schistosoma mansoni glutamate receptor NMDA 0.0109 0.4912 0.5171
Entamoeba histolytica P-glyco protein 6, putative 0.0095 0.4143 0.7372
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0044 0.1222 0.0856
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0095 0.4143 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0181 0.904 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0114 0.5215 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0095 0.4143 0.4272
Brugia malayi multidrug resistance protein 3 0.0095 0.4143 0.5011
Echinococcus multilocularis multidrug resistance protein 1 0.0095 0.4143 0.4272
Brugia malayi ABC transporter 0.0043 0.1133 0.0882
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0159 0.778 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.4054 0.3769
Echinococcus granulosus multidrug resistance protein 1 0.0053 0.1694 0.1408
Schistosoma mansoni multidrug resistance protein 0.0095 0.4143 0.4272
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0114 0.5215 0.4986
Echinococcus multilocularis 0.0044 0.1222 0.0856
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0095 0.4143 1
Echinococcus multilocularis multidrug resistance protein 1 0.0095 0.4143 0.4272
Trichomonas vaginalis ABC transporter, putative 0.0095 0.4143 1
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0044 0.1222 0.5
Schistosoma mansoni smdr1 0.0044 0.1222 0.0856
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0114 0.5215 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0094 0.4054 0.4168
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0095 0.4143 1
Echinococcus granulosus glutamate receptor NMDA 0.0095 0.4135 0.4263
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0023 0 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0095 0.4143 1
Echinococcus granulosus nmda type glutamate receptor 0.01 0.4398 0.4571
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0095 0.4143 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0095 0.4143 0.4272
Echinococcus granulosus ATP binding cassette sub family B 0.0043 0.1133 0.0752
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0044 0.1222 0.1004
Leishmania major p-glycoprotein 0.0095 0.4143 0.7314
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2926 0.2849
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0095 0.4143 0.3327
Brugia malayi ABC transporter family protein 0.0095 0.4143 0.5011
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0095 0.4143 0.4272
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0114 0.5215 0.4549
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0053 0.1694 0.1862
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0114 0.5215 1
Loa Loa (eye worm) ABC transporter 0.0044 0.1222 0.0801
Entamoeba histolytica ATP-binding cassette protein, putative 0.0114 0.5215 1
Brugia malayi hypothetical protein 0.0044 0.1222 0.1004
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0673 0.0226
Echinococcus granulosus multidrug resistance protein 1 0.0095 0.4143 0.4272
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0095 0.4143 0.7314
Toxoplasma gondii hypothetical protein 0.0198 1 1
Echinococcus granulosus multidrug resistance associated protein 1 0.0114 0.5215 0.5526
Echinococcus multilocularis multidrug resistance associated protein 7 0.0114 0.5215 0.5526
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0114 0.5215 1
Entamoeba histolytica P-glycoprotein-1 0.0095 0.4143 0.7372
Echinococcus granulosus ATP binding cassette sub family B 0.0044 0.1222 0.0856
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0095 0.4143 0.4272
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0095 0.4143 0.3327
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.2926 0.2587
Plasmodium vivax multidrug resistance protein 1, putative 0.0095 0.4143 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0159 0.778 0.8526
Brugia malayi TAR-binding protein 0.0074 0.2926 0.3341
Brugia malayi P-glycoprotein-like protein 0.0044 0.1222 0.1004
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0181 0.904 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0095 0.4143 0.4272
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0095 0.4143 1
Brugia malayi ABC transporter family protein 0.0044 0.1222 0.1004
Echinococcus granulosus tar DNA binding protein 0.0074 0.2926 0.2849
Entamoeba histolytica hypothetical protein 0.0114 0.5215 1
Giardia lamblia MRP-like ABC transporter 0.0114 0.5215 0.5163
Brugia malayi ABC transporter transmembrane region family protein 0.0043 0.1133 0.0882
Entamoeba histolytica multidrug resistance protein, putative 0.0114 0.5215 1
Echinococcus granulosus multidrug resistance protein 1 0.0053 0.1694 0.1408
Schistosoma mansoni multidrug resistance protein 0.0043 0.1133 0.0752
Loa Loa (eye worm) hypothetical protein 0.0114 0.5215 0.4986
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0044 0.1222 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0095 0.4143 1
Trichomonas vaginalis ABC transporter, putative 0.0095 0.4143 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.1222 0.0801
Schistosoma mansoni multidrug resistance protein 0.0114 0.5215 0.5526
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0181 0.904 1
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0044 0.1222 1
Loa Loa (eye worm) RNA binding protein 0.0074 0.2926 0.2587
Loa Loa (eye worm) ABC transporter 0.0044 0.1222 0.0801
Brugia malayi ABC transporter family protein 0.0044 0.1222 0.1004
Echinococcus granulosus multidrug resistance associated protein 7 0.0114 0.5215 0.5526
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0095 0.4143 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0095 0.4143 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0095 0.4143 0.4272
Echinococcus multilocularis ATP binding cassette sub family B 0.0044 0.1222 0.0856
Entamoeba histolytica P-glycoprotein-2, putative 0.0095 0.4143 0.7372
Loa Loa (eye worm) hypothetical protein 0.0113 0.5127 0.4894
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0095 0.4143 0.3862
Echinococcus multilocularis nmda type glutamate receptor 0.01 0.4398 0.4571
Loa Loa (eye worm) hypothetical protein 0.0095 0.4143 0.3862
Schistosoma mansoni multidrug resistance protein 0.0114 0.5215 0.5526
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0095 0.4143 1
Schistosoma mansoni multidrug resistance protein 0.0095 0.4143 0.4272
Schistosoma mansoni tar DNA-binding protein 0.0074 0.2926 0.2849
Entamoeba histolytica P-glycoprotein-2 0.0095 0.4143 0.7372
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0181 0.904 1
Leishmania major pentamidine resistance protein 1 0.0114 0.5215 1
Echinococcus multilocularis nmda type glutamate receptor 0.0127 0.5964 0.6403
Entamoeba histolytica P-glycoprotein 5, putative 0.0095 0.4143 0.7372
Loa Loa (eye worm) hypothetical protein 0.0043 0.1133 0.0709
Leishmania major ABC-thiol transporter 0.0114 0.5215 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0044 0.1222 0.0856
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0181 0.904 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0114 0.5215 0.5163
Echinococcus granulosus multidrug resistance protein 1 0.0095 0.4143 0.4272
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.049 0.0035
Loa Loa (eye worm) hypothetical protein 0.0095 0.4143 0.3862
Trichomonas vaginalis abcb9, putative 0.0095 0.4143 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0095 0.4143 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.5215 0.4986
Echinococcus multilocularis multidrug resistance protein 1 0.0053 0.1694 0.1408
Brugia malayi ABC transporter transmembrane region family protein 0.0044 0.1222 0.1004
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0095 0.4143 1
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0044 0.1222 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0095 0.4143 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0044 0.1222 1
Plasmodium falciparum multidrug resistance protein 1 0.0095 0.4143 1
Loa Loa (eye worm) hypothetical protein 0.0198 1 1
Entamoeba histolytica P-glycoprotein 6, putative 0.0044 0.1222 0.0217
Leishmania major p-glycoprotein e 0.0114 0.5215 1
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0044 0.1222 0.5
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0044 0.1222 0.2949
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0159 0.778 0.7674
Entamoeba histolytica P-glycoprotein 6, putative 0.0044 0.1222 0.0217
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0044 0.1222 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.9 uM In vitro ability to displace [3H]L-689,560 binding to glycine site on the N-methyl-D-aspartate (NMDA) glutamate receptor 1 from rat cortical membranes ChEMBL. 9057862
IC50 (binding) = 0.9 uM In vitro ability to displace [3H]L-689,560 binding to glycine site on the N-methyl-D-aspartate (NMDA) glutamate receptor 1 from rat cortical membranes ChEMBL. 9057862
Kb (functional) = 1.3 uM Evaluated to antagonize NMDA responses in a rat cortical slice preparations ChEMBL. 9057862
Kb (functional) = 1.3 uM Evaluated to antagonize NMDA responses in a rat cortical slice preparations ChEMBL. 9057862
No. of mice protected (functional) = 1 Compound was evaluated in vivo for their ability to protect against audiogenic seizure in DBA/2 mice when administered 20 mg/kg ip 30 min prior to noise stimulation out of 8 mice tested ChEMBL. 9057862
No. of mice protected (functional) = 1 Compound was evaluated in vivo for their ability to protect against audiogenic seizure in DBA/2 mice when administered 20 mg/kg ip 30 min prior to noise stimulation out of 8 mice tested ChEMBL. 9057862

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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