Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.1044 | 1 | 1 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.1044 | 1 | 0.5 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1044 | 1 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.1044 | 1 | 0.5 |
Treponema pallidum | methionine aminopeptidase (map) | 0.0872 | 0.7292 | 0.5 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0872 | 0.7292 | 1 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.1044 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.041 | 0 | 0.5 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.1044 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.041 | 0 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.1044 | 1 | 0.5 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0872 | 0.7292 | 0.7292 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0872 | 0.7292 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0872 | 0.7292 | 0.5 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.1044 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.041 | 0 | 0.5 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.1044 | 1 | 1 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.0872 | 0.7292 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.041 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.041 | 0 | 0.5 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.0872 | 0.7292 | 0.5 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0872 | 0.7292 | 1 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.0872 | 0.7292 | 0.5 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.1044 | 1 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.0872 | 0.7292 | 0.5 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1044 | 1 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase | 0.1044 | 1 | 1 |
Onchocerca volvulus | 0.041 | 0 | 0.5 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.041 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.0872 | 0.7292 | 0.5 |
Onchocerca volvulus | 0.041 | 0 | 0.5 | |
Onchocerca volvulus | 0.041 | 0 | 0.5 | |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.0872 | 0.7292 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 1 mg kg-1 | Dose required for 50% inhibition of rat passive cutaneous anaphylaxis model; Inactive orally at 1 mg/kg | ChEMBL. | 6808133 |
I50 (binding) | = 0.22 mM | 50% inhibition of human placental alkaline phosphatase in the presence of 10 mM p-nitrophenyl phosphate as substrate | ChEMBL. | 6808133 |
IC50 (binding) | = 0.22 mM | 50% inhibition of human placental alkaline phosphatase in the presence of 10 mM p-nitrophenyl phosphate as substrate | ChEMBL. | 6808133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.