Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC30 (functional) | = 3 ug ml-1 | Tested in vitro for antiarrhythmic activity in isolated rabbit atria | ChEMBL. | 3572966 |
ED50 (functional) | = 0.75 mg kg-1 | Antiarrhythmic activity ( protection against CaCl2 induced ventricular fibrillation ) in anesthetized rat administered intravenously | ChEMBL. | 3572966 |
LD50 (ADMET) | = 11.2 mg kg-1 | The compound was tested for acute toxicity when given intravenously in rat | ChEMBL. | 3572966 |
LD50 (ADMET) | = 63 mg kg-1 | The compound was tested for acute toxicity when given intraperitoneally in mouse | ChEMBL. | 3572966 |
LD50 (ADMET) | = 63 mg kg-1 | The compound was tested for acute toxicity when given intraperitoneally in mouse | ChEMBL. | 3572966 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.