Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | udp-glc 4-epimerase, putative | 0.0103 | 0.3326 | 1 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0099 | 0.3179 | 0.2432 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.004 | 0.1029 | 0.1749 |
Brugia malayi | N-terminal motif family protein | 0.0177 | 0.5979 | 0.6211 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0988 | 0.1038 |
Schistosoma mansoni | lipoxygenase | 0.0103 | 0.3305 | 0.3473 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0988 | 0.0868 |
Trichomonas vaginalis | UDP-glucose 4-epimerase, putative | 0.0099 | 0.3179 | 0.2432 |
Loa Loa (eye worm) | glutaminase | 0.0275 | 0.9518 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0988 | 0.0546 |
Onchocerca volvulus | 0.004 | 0.1029 | 0.0082 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0988 | 0.0546 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0988 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1029 | 0.0592 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0988 | 0.1038 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.5979 | 0.6078 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0141 | 0.4679 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1029 | 0.1081 |
Schistosoma mansoni | loxhd1 | 0.004 | 0.1029 | 0.1081 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.004 | 0.1029 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0988 | 0.0546 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0141 | 0.4679 | 0.4928 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.4643 | 0.4878 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0988 | 0.0546 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0174 | 0.5881 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.1029 | 0.0912 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0988 | 0.0546 |
Echinococcus multilocularis | UDP glucose 4 epimerase | 0.0099 | 0.3179 | 0.5406 |
Echinococcus granulosus | UDP glucose 4 epimerase | 0.0099 | 0.3179 | 0.5406 |
Trichomonas vaginalis | glutaminase, putative | 0.0275 | 0.9518 | 0.9466 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.4643 | 0.4878 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.4643 | 0.7894 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0141 | 0.4679 | 0.4327 |
Schistosoma mansoni | glutaminase | 0.0275 | 0.9518 | 1 |
Brugia malayi | Doublecortin family protein | 0.004 | 0.1029 | 0.0912 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0177 | 0.5979 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.004 | 0.1029 | 0.0592 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0988 | 0.1741 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0988 | 0.0868 |
Trypanosoma cruzi | UDP-galactose 4-epimerase, putative | 0.0099 | 0.3179 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0288 | 1 | 1 |
Brugia malayi | UDP galactose 4'-epimerase | 0.0099 | 0.3179 | 0.3214 |
Mycobacterium ulcerans | glutaminase | 0.0275 | 0.9518 | 1 |
Echinococcus granulosus | RUN | 0.004 | 0.1029 | 0.1749 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.004 | 0.1029 | 0.1749 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.4643 | 0.7894 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0988 | 0.0546 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.004 | 0.1029 | 0.1749 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.014 | 0.4643 | 0.4781 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.004 | 0.1029 | 0.1749 |
Onchocerca volvulus | 0.004 | 0.1029 | 0.0082 | |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.004 | 0.1029 | 1 |
Trypanosoma cruzi | UDP-galactose 4-epimerase | 0.0099 | 0.3179 | 1 |
Schistosoma mansoni | rab6-interacting | 0.004 | 0.1029 | 0.1081 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0988 | 0.1679 |
Trypanosoma brucei | UDP-galactose 4-epimerase | 0.0103 | 0.3326 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0174 | 0.5881 | 0.6179 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0988 | 0.0868 |
Schistosoma mansoni | rab6-interacting | 0.004 | 0.1029 | 0.1081 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.4643 | 0.7894 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0988 | 0.1836 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0988 | 0.1836 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0988 | 0.1741 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.004 | 0.1029 | 0.1749 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0246 | 0.8478 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0288 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0495 | 0.034 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.4643 | 0.7894 |
Brugia malayi | glutaminase DH11.1 | 0.0275 | 0.9518 | 1 |
Toxoplasma gondii | UDP-glucose 4-epimerase | 0.0099 | 0.3179 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0988 | 0.1679 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.014 | 0.4643 | 0.4597 |
Echinococcus multilocularis | RUN | 0.004 | 0.1029 | 0.1749 |
Loa Loa (eye worm) | glutaminase 2 | 0.0275 | 0.9518 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0174 | 0.5881 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0988 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1029 | 0.0592 |
Schistosoma mansoni | polycystin 1-related | 0.004 | 0.1029 | 0.1081 |
Loa Loa (eye worm) | UDP galactose 4'-epimerase | 0.0099 | 0.3179 | 0.2975 |
Brugia malayi | hypothetical protein | 0.004 | 0.1029 | 0.0912 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0288 | 1 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0988 | 0.1836 |
Schistosoma mansoni | UDP-glucose 4-epimerase | 0.0099 | 0.3179 | 0.334 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0099 | 0.3179 | 0.2432 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.4643 | 0.4878 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0988 | 0.0868 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.004 | 0.1029 | 0.1749 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0988 | 0.923 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
C20 APD95 (functional) | = 0.4 uM | Concentration required for 20% increase in action potential duration of canine Purkinje fiber (intracellular electrophysiology) in vitro measured at 95% repolarization was reported. Range is between 0.2-0.5 | ChEMBL. | 3572962 |
C20 APD95 (functional) | = 1.9 uM | Concentration required for 20% increase in action potential duration of canine Purkinje fiber (intracellular electrophysiology) in vitro measured at 95% repolarization was reported. Range is between 1.8-2.0 | ChEMBL. | 3572962 |
C20 APD95 (functional) | = 3 uM | Concentration required for 20% increase in action potential duration of canine Purkinje fiber (intracellular electrophysiology) in vitro measured at 95% repolarization was reported. Range is between 1.6-44 | ChEMBL. | 3572962 |
C20 FRP (functional) | = 0.3 uM | Concentration required for 20% increase in the functional refractory period of canine ventricular muscle (extracellular electrophysiology) in vitro was reported. Range is between 0.03-2.1 | ChEMBL. | 3572962 |
C20 FRP (functional) | = 3 uM | Concentration required for 20% increase in the functional refractory period of canine ventricular muscle (extracellular electrophysiology) in vitro was reported. Range is between 1.2-150 | ChEMBL. | 3572962 |
C20 FRP (functional) | = 40 uM | Concentration required for 20% increase in the functional refractory period of canine ventricular muscle (extracellular electrophysiology) in vitro was reported | ChEMBL. | 3572962 |
Efficacy (functional) | = 3 | Efficacy in blocking sustained ventricular tachycardia (rate>250 bpm) elicited by programmed electrical stimulation in anesthetized dogs after iv administration of 1.4 mg/kg; no. of successful exp / total no. of exp = 3/6 | ChEMBL. | 3572962 |
Efficacy (functional) | = 3 | Efficacy in blocking sustained ventricular tachycardia (rate>250 bpm) elicited by programmed electrical stimulation in anesthetized dogs after iv administration of dose 1.0 mg/kg; no. of successful exp / total no. of exp = 3/4 | ChEMBL. | 3572962 |
Efficacy (functional) | = 4 | Efficacy in blocking sustained ventricular tachycardia (rate>250 bpm) elicited by programmed electrical stimulation in conscious dogs after iv administration of dose 0.5 mg/kg; no. of successful exp / total no. of exp = 4/4 | ChEMBL. | 3572962 |
Efficacy (functional) | = 4 | Efficacy in blocking sustained ventricular tachycardia (rate>250 bpm) elicited by programmed electrical stimulation in anesthetized dogs after iv administration of 0.5 mg/kg; no. of successful exp / total no. of exp = 4/4 | ChEMBL. | 3572962 |
Efficacy (functional) | = 5 | Efficacy in blocking sustained ventricular tachycardia (rate>250 bpm) elicited by programmed electrical stimulation in conscious dogs after iv administration of 1.9 mg/kg; no. of successful exp / total no. of exp = 5/6 | ChEMBL. | 3572962 |
Efficacy (functional) | = 5 | Efficacy in blocking sustained ventricular tachycardia (rate>250 bpm) elicited by programmed electrical stimulation in conscious dogs after iv administration of 0.8 mg/kg; no. of successful exp / total no. of exp = 5/5 | ChEMBL. | 3572962 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.