Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | ~ 50 uM | In vitro ability to displace [3H]L-689,560 binding to glycine site on the N-methyl-D-aspartate (NMDA) glutamate receptor 1 from rat cortical membranes | ChEMBL. | 9057862 |
IC50 (binding) | ~ 50 uM | In vitro ability to displace [3H]L-689,560 binding to glycine site on the N-methyl-D-aspartate (NMDA) glutamate receptor 1 from rat cortical membranes | ChEMBL. | 9057862 |
No. of mice protected (functional) | = 0 | Compound was evaluated in vivo for their ability to protect against audiogenic seizure in DBA/2 mice when administered 20 mg/kg ip 30 min prior to noise stimulation out of 8 mice tested | ChEMBL. | 9057862 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.