Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | 0.113928 | 1 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0861968 | 0.703479 | 0.703479 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.113928 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0314493 | 0.118075 | 0.118075 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.106624 | 0.921903 | 0.913142 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.106624 | 0.921903 | 0.921886 |
Echinococcus multilocularis | carbonic anhydrase | 0.0388948 | 0.197689 | 0.197689 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.106624 | 0.921903 | 0.921886 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0388948 | 0.197689 | 0.107682 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0388948 | 0.197689 | 0.107682 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.113928 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0388948 | 0.197689 | 0.107682 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.037923 | 0.187298 | 0.096125 |
Schistosoma mansoni | carbonic anhydrase | 0.0388948 | 0.197689 | 0.107682 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.113928 | 1 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.106624 | 0.921903 | 0.921903 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.106624 | 0.921903 | 0.921903 |
Schistosoma mansoni | hypothetical protein | 0.0388948 | 0.197689 | 0.107682 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0388948 | 0.197689 | 0.107682 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0314493 | 0.118075 | 0.118075 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0861968 | 0.703479 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase | 0.106624 | 0.921903 | 1 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.106624 | 0.921903 | 0.921886 |
Echinococcus granulosus | glutamate receptor 2 | 0.0314493 | 0.118075 | 0.118075 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0861968 | 0.703479 | 0.670214 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0861968 | 0.703479 | 0.670214 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0473401 | 0.287993 | 0.287993 |
Leishmania major | carbonic anhydrase-like protein | 0.113928 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.113928 | 1 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.0861968 | 0.703479 | 0.5 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.106624 | 0.921903 | 1 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.0861968 | 0.703479 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0388948 | 0.197689 | 0.107682 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0314493 | 0.118075 | 0.118075 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0314493 | 0.118075 | 0.118075 |
Echinococcus granulosus | carbonic anhydrase | 0.0388948 | 0.197689 | 0.197689 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0388948 | 0.197689 | 0.107682 |
Loa Loa (eye worm) | hypothetical protein | 0.0388948 | 0.197689 | 0.107682 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.106624 | 0.921903 | 0.921886 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.106624 | 0.921903 | 0.921886 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.0861968 | 0.703479 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0314493 | 0.118075 | 0.118075 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.106624 | 0.921903 | 0.921886 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.113928 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.113928 | 1 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.037923 | 0.187298 | 0.096125 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0314493 | 0.118075 | 0.118075 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.037923 | 0.187298 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0388948 | 0.197689 | 0.214249 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.037923 | 0.187298 | 0.187298 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0388948 | 0.197689 | 0.107682 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.0861968 | 0.703479 | 0.5 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.0861968 | 0.703479 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0388948 | 0.197689 | 0.197689 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0473401 | 0.287993 | 0.208116 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0383197 | 0.19154 | 0.100843 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0473401 | 0.287993 | 0.287993 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.037923 | 0.187298 | 0.096125 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0314493 | 0.118075 | 0.118075 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0298401 | 0.100869 | 0.100869 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0861968 | 0.703479 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0388948 | 0.197689 | 0.197689 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.113928 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.113928 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0388948 | 0.197689 | 0.107682 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.0861968 | 0.703479 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.113928 | 1 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.037923 | 0.187298 | 0.187298 |
Echinococcus granulosus | carbonic anhydrase | 0.0388948 | 0.197689 | 0.197689 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0388948 | 0.197689 | 0.107682 |
Brugia malayi | Methionine aminopeptidase protein type I | 0.106624 | 0.921903 | 0.913142 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0314493 | 0.118075 | 0.118075 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.0861968 | 0.703479 | 0.763016 |
Treponema pallidum | methionine aminopeptidase (map) | 0.0861968 | 0.703479 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0388948 | 0.197689 | 0.214249 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.0861968 | 0.703479 | 0.763016 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0314493 | 0.118075 | 0.118075 |
Echinococcus multilocularis | carbonic anhydrase | 0.0388948 | 0.197689 | 0.197689 |
Toxoplasma gondii | methionine aminopeptidase | 0.0861968 | 0.703479 | 0.763016 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.0861968 | 0.703479 | 0.763016 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0388948 | 0.197689 | 0.107682 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0388948 | 0.197689 | 0.107682 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.106624 | 0.921903 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.113928 | 1 | 1 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 12467620 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.