Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor RXR | 0.001 | 0.0011 | 0.0011 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0237 | 0.0284 |
Brugia malayi | cytochrome P450 | 0.0011 | 0.0024 | 0.0024 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.0308 | 0.2537 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.0266 | 0.029 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.002 | 0.0123 | 0.0123 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0307 | 0.0307 |
Brugia malayi | PAS domain containing protein | 0.0016 | 0.008 | 0.008 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.007 | 0.0649 | 0.0776 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.008 | 0.008 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0307 | 0.0307 |
Echinococcus multilocularis | 0.0011 | 0.0024 | 0.0024 | |
Onchocerca volvulus | Dipeptidase C homolog | 0.0101 | 0.0978 | 1 |
Trypanosoma brucei | Metallopeptidase family M24, putative | 0.0101 | 0.0978 | 0.0956 |
Brugia malayi | steroid hormone receptor | 0.0018 | 0.0101 | 0.0101 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0018 | 0.0101 | 0.0101 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0101 | 0.0978 | 1 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0101 | 0.0978 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0018 | 0.0101 | 0.0101 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.0101 | 0.0978 | 0.0956 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24, putative | 0.0101 | 0.0978 | 0.0956 |
Treponema pallidum | methionine aminopeptidase (map) | 0.0798 | 0.8363 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.0101 | 0.0101 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0014 | 0.006 | 0.006 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0101 | 0.0978 | 1 |
Echinococcus multilocularis | Aryl hydrocarbon receptor nuclear | 0.0016 | 0.0083 | 0.0083 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0018 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.022 | 0.022 |
Brugia malayi | hypothetical protein | 0.001 | 0.0011 | 0.0011 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.0101 | 0.0101 |
Echinococcus granulosus | Xaa Pro aminopeptidase 3 | 0.0101 | 0.0978 | 0.0978 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0018 | 0.0101 | 0.012 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0123 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0712 | 0.0712 |
Brugia malayi | Cytochrome P450 family protein | 0.005 | 0.0436 | 0.0436 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0014 | 0.006 | 0.006 |
Schistosoma mansoni | amine oxidase | 0.0014 | 0.006 | 0.0072 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0024 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0123 | 0.0123 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0952 | 1 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0952 | 1 | 1 |
Onchocerca volvulus | Protein cycle homolog | 0.0038 | 0.031 | 0.3167 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0101 | 0.0978 | 0.0956 |
Trypanosoma cruzi | Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative | 0.0101 | 0.0978 | 0.0956 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0011 | 0.0011 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0018 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.006 | 0.006 |
Schistosoma mansoni | peptidase | 0.0101 | 0.0978 | 0.1169 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0101 | 0.0101 |
Entamoeba histolytica | Xaa-Pro dipeptidase, putative | 0.0101 | 0.0978 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.001 | 0.0011 | 0.0011 |
Brugia malayi | hypothetical protein | 0.0038 | 0.031 | 0.031 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.0566 | 0.0677 |
Loa Loa (eye worm) | doublecortin family protein | 0.002 | 0.0123 | 0.0123 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0018 | 0.0101 | 0.103 |
Echinococcus granulosus | RUN | 0.002 | 0.0123 | 0.0123 |
Mycobacterium ulcerans | dipeptidase PepE | 0.0101 | 0.0978 | 0.1143 |
Echinococcus multilocularis | FACT complex subunit SPT16 | 0.0101 | 0.0978 | 0.0978 |
Echinococcus granulosus | xaa Pro dipeptidase | 0.0101 | 0.0978 | 0.0978 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0101 | 0.0978 | 0.0978 |
Toxoplasma gondii | methionine aminopeptidase | 0.0798 | 0.8363 | 0.8359 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0054 | 0.048 | 0.048 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0014 | 0.006 | 0.0036 |
Onchocerca volvulus | 0.002 | 0.0123 | 0.1253 | |
Mycobacterium ulcerans | cytoplasmic peptidase PepQ | 0.0101 | 0.0978 | 0.1143 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.0308 | 0.0308 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0101 | 0.0978 | 0.1169 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0101 | 0.0978 | 0.1169 |
Brugia malayi | Inositol-1 | 0.0038 | 0.0308 | 0.0308 |
Plasmodium vivax | proliferation-associated protein 2g4, putative | 0.0101 | 0.0978 | 0.0923 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.0798 | 0.8363 | 0.8359 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0155 | 0.1547 | 0.1527 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0101 | 0.0978 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24, putative | 0.0101 | 0.0978 | 0.0956 |
Trypanosoma brucei | Xaa-Pro aminopeptidase, putative | 0.0101 | 0.0978 | 0.0956 |
Mycobacterium tuberculosis | Dipeptidase PepE | 0.0101 | 0.0978 | 0.1143 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0101 | 0.0978 | 0.0956 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0101 | 0.0101 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.002 | 0.0123 | 0.0123 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0101 | 0.0978 | 1 |
Onchocerca volvulus | 0.0076 | 0.0712 | 0.728 | |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0016 | 0.0079 | 0.0055 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0011 | 0.0011 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0101 | 0.0978 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0101 | 0.0101 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0018 | 0.0101 | 0.0101 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0155 | 0.1547 | 0.1527 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0018 | 0.0101 | 0.012 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.0101 | 0.0101 |
Echinococcus granulosus | methionine aminopeptidase type I | 0.0101 | 0.0978 | 0.0978 |
Schistosoma mansoni | loxhd1 | 0.002 | 0.0123 | 0.0147 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0016 | 0.008 | 0.0024 |
Brugia malayi | nuclear receptor NHR-88 | 0.0018 | 0.0101 | 0.0101 |
Plasmodium falciparum | proliferation-associated protein 2g4, putative | 0.0101 | 0.0978 | 0.0923 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.005 | 0.0436 | 0.0436 |
Echinococcus multilocularis | Xaa Pro aminopeptidase 3 | 0.0101 | 0.0978 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0978 | 0.0978 |
Plasmodium falciparum | LCCL domain-containing protein | 0.002 | 0.0123 | 0.0063 |
Plasmodium falciparum | HP12 protein homolog, putative | 0.0155 | 0.1547 | 0.1496 |
Trypanosoma cruzi | Metallopeptidase family M24, putative | 0.0101 | 0.0978 | 0.0956 |
Loa Loa (eye worm) | metallopeptidase family M24 containing protein | 0.0101 | 0.0978 | 0.0978 |
Schistosoma mansoni | lipoxygenase | 0.012 | 0.1181 | 0.1412 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.0101 | 0.0101 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.0952 | 1 | 1 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.0101 | 0.0978 | 0.0978 |
Echinococcus multilocularis | Proliferation associated protein 2G4 | 0.0101 | 0.0978 | 0.0978 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.0308 | 0.0308 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0308 | 0.0284 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0101 | 0.0978 | 0.0978 |
Plasmodium falciparum | aminopeptidase P | 0.0101 | 0.0978 | 0.0923 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0011 | 0.0011 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0101 | 0.0978 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0018 | 0.0101 | 0.012 |
Leishmania major | methionine aminopeptidase 2, putative | 0.0101 | 0.0978 | 0.0956 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0018 | 0.0101 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0307 | 0.0307 |
Brugia malayi | ecdysteroid receptor | 0.0018 | 0.0101 | 0.0101 |
Brugia malayi | Doublecortin family protein | 0.002 | 0.0123 | 0.0123 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.0101 | 0.012 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0016 | 0.008 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0101 | 0.0101 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0155 | 0.1547 | 0.1527 |
Echinococcus granulosus | FACT complex subunit SPT16 | 0.0101 | 0.0978 | 0.0978 |
Leishmania major | aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 | 0.0101 | 0.0978 | 0.0956 |
Echinococcus multilocularis | 0.0014 | 0.006 | 0.006 | |
Brugia malayi | hypothetical protein | 0.002 | 0.0123 | 0.0123 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.007 | 0.0649 | 0.0649 |
Plasmodium falciparum | FACT complex subunit SPT16, putative | 0.0101 | 0.0978 | 0.0923 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0477 | 0.0477 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0308 | 0.2537 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.0266 | 0.029 |
Brugia malayi | aryl hydrocarbon receptor nuclear translocator protein, putative | 0.0038 | 0.031 | 0.031 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0018 | 0.0101 | 0.0101 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.0798 | 0.8363 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0101 | 0.0101 |
Mycobacterium ulcerans | dipeptidase | 0.0101 | 0.0978 | 0.1143 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.001 | 0.0011 | 0.0011 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.0101 | 0.0101 |
Mycobacterium ulcerans | monoamine oxidase | 0.0014 | 0.006 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0011 | 0.0011 |
Brugia malayi | hypothetical protein | 0.002 | 0.0123 | 0.0123 |
Leishmania major | hypothetical protein, conserved | 0.0155 | 0.1547 | 0.1527 |
Mycobacterium ulcerans | aminopeptidase | 0.0101 | 0.0978 | 0.1143 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.002 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0123 | 0.0123 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0018 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0011 | 0.0011 |
Entamoeba histolytica | peptidase, putative | 0.0101 | 0.0978 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.0496 | 0.0473 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0101 | 0.0978 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0006 | 0.0006 |
Brugia malayi | DNA-binding protein, 42 kDa containing protein | 0.0101 | 0.0978 | 0.0978 |
Plasmodium falciparum | methionine aminopeptidase 1c, putative | 0.0101 | 0.0978 | 0.0923 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0308 | 0.0368 |
Onchocerca volvulus | FACT complex subunit SPT16 homolog | 0.0101 | 0.0978 | 1 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0101 | 0.0978 | 0.0956 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0018 | 0.0101 | 0.0101 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0237 | 0.0284 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0018 | 0.0101 | 0.012 |
Loa Loa (eye worm) | cytochrome P450 | 0.0011 | 0.0024 | 0.0024 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0308 | 0.0284 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0798 | 0.8363 | 0.8363 |
Onchocerca volvulus | 0.0101 | 0.0978 | 1 | |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0798 | 0.8363 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0307 | 0.0307 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.002 | 0.0123 | 0.0063 |
Entamoeba histolytica | aminopeptidase, putative | 0.0101 | 0.0978 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0014 | 0.006 | 0.0072 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0101 | 0.0978 | 1 |
Brugia malayi | hypothetical protein | 0.001 | 0.0011 | 0.0011 |
Leishmania major | aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 | 0.0101 | 0.0978 | 0.0956 |
Echinococcus multilocularis | muscleblind protein | 0.0152 | 0.152 | 0.152 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0101 | 0.0101 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.0798 | 0.8363 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0978 | 0.0978 |
Mycobacterium leprae | Possible regulatory protein | 0.0016 | 0.008 | 0.0067 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0018 | 0.0101 | 0.0101 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.0101 | 0.0101 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0014 | 0.006 | 0.0043 |
Onchocerca volvulus | 0.002 | 0.0123 | 0.1253 | |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0101 | 0.0978 | 1 |
Trypanosoma cruzi | Metallopeptidase family M24, putative | 0.0101 | 0.0978 | 0.0956 |
Mycobacterium tuberculosis | Probable cytoplasmic peptidase PepQ | 0.0101 | 0.0978 | 0.1143 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0308 | 0.0284 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0123 | 0.0147 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0237 | 0.0237 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 0.0101 | 0.0101 |
Echinococcus granulosus | Aryl hydrocarbon receptor nuclear | 0.0016 | 0.0083 | 0.0083 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0016 | 0.008 | 0.0056 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0011 | 0.0024 | 0.0024 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.0308 | 0.034 |
Wolbachia endosymbiont of Brugia malayi | Xaa-Pro aminopeptidase | 0.0101 | 0.0978 | 0.0832 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0101 | 0.0978 | 0.0956 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0018 | 0.0101 | 0.0101 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0037 | 0.0307 | 0.0307 |
Plasmodium vivax | peptidase, putative | 0.0101 | 0.0978 | 0.0923 |
Loa Loa (eye worm) | DNA-binding protein | 0.0101 | 0.0978 | 0.0978 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0798 | 0.8363 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0649 | 0.0649 |
Schistosoma mansoni | hypothetical protein | 0.0416 | 0.4317 | 0.5163 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0101 | 0.0978 | 0.5 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0123 | 0.0147 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0014 | 0.006 | 0.0043 |
Leishmania major | protein kinase, putative | 0.0016 | 0.008 | 0.0056 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0011 | 0.0011 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0018 | 0.0101 | 0.0101 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.0798 | 0.8363 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0152 | 0.152 | 0.152 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0018 | 0.0101 | 0.0101 |
Schistosoma mansoni | cytochrome P450 | 0.0011 | 0.0024 | 0.0029 |
Brugia malayi | Cytochrome P450 family protein | 0.0011 | 0.0024 | 0.0024 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0038 | 0.031 | 0.031 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0018 | 0.0101 | 0.103 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0101 | 0.0101 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0101 | 0.0978 | 0.0956 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.0952 | 1 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0005 | 0.0005 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0018 | 0.0101 | 0.0101 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0006 | 0.0006 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0101 | 0.0978 | 0.0923 |
Leishmania major | hypothetical protein, conserved | 0.0101 | 0.0978 | 0.0956 |
Plasmodium vivax | methionine aminopeptidase 1c, putative | 0.0101 | 0.0978 | 0.0923 |
Toxoplasma gondii | peptidase D, putative | 0.0101 | 0.0978 | 0.0956 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0018 | 0.0101 | 0.0101 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0014 | 0.006 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0307 | 0.0307 |
Schistosoma mansoni | aryl hydrocarbon receptor nuclear translocator homolog (darnt) | 0.0038 | 0.031 | 0.037 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0952 | 1 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0014 | 0.006 | 0.0036 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.0101 | 0.0101 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.0952 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0014 | 0.006 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0978 | 0.0978 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.0308 | 0.0308 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.0798 | 0.8363 | 0.8353 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0101 | 0.0978 | 0.0956 |
Echinococcus multilocularis | RUN | 0.002 | 0.0123 | 0.0123 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0101 | 0.0978 | 0.1169 |
Onchocerca volvulus | 0.0029 | 0.022 | 0.2245 | |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0018 | 0.0101 | 0.012 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0016 | 0.008 | 0.0056 |
Brugia malayi | hypothetical protein | 0.0014 | 0.006 | 0.006 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0018 | 0.0101 | 0.0101 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.001 | 0.0011 | 0.0013 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.0798 | 0.8363 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0018 | 0.0101 | 0.0101 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0237 | 0.0237 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.152 | 0.152 |
Schistosoma mansoni | lipoxygenase | 0.0084 | 0.0799 | 0.0955 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0649 | 0.0649 |
Schistosoma mansoni | Xaa-Pro dipeptidase (M24 family) | 0.0101 | 0.0978 | 0.1169 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.152 | 0.152 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0016 | 0.0083 | 0.01 |
Schistosoma mansoni | polycystin 1-related | 0.002 | 0.0123 | 0.0147 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0018 | 0.0101 | 0.0101 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0308 | 0.0368 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0101 | 0.0978 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0018 | 0.0101 | 0.012 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0018 | 0.0101 | 0.0101 |
Toxoplasma gondii | proliferation-associated protein 2G4, putative | 0.0101 | 0.0978 | 0.0956 |
Schistosoma mansoni | aminopeptidase P1 (M24 family) | 0.0101 | 0.0978 | 0.1169 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0123 | 0.0123 |
Giardia lamblia | Methionine aminopeptidase | 0.0101 | 0.0978 | 0.5 |
Plasmodium falciparum | methionine aminopeptidase 2 | 0.0101 | 0.0978 | 0.0923 |
Echinococcus granulosus | dnaJ subfamily B | 0.0416 | 0.4317 | 0.4317 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0018 | 0.0101 | 0.0101 |
Echinococcus granulosus | Proliferation associated protein 2G4 | 0.0101 | 0.0978 | 0.0978 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.0952 | 1 | 1 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.0798 | 0.8363 | 0.8353 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0101 | 0.0978 | 1 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.0952 | 1 | 1 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.0798 | 0.8363 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.0952 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0018 | 0.0101 | 0.012 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0798 | 0.8363 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0101 | 0.0978 | 0.0956 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0101 | 0.0978 | 0.0978 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0123 | 0.0123 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0014 | 0.006 | 0.0036 |
Echinococcus granulosus | muscleblind protein | 0.0152 | 0.152 | 0.152 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0101 | 0.0978 | 0.0956 |
Schistosoma mansoni | chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) | 0.0101 | 0.0978 | 0.1169 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.006 | 0.006 |
Toxoplasma gondii | methionine aminopeptidase | 0.0952 | 1 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0014 | 0.006 | 0.0043 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0006 | 0.0006 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0018 | 0.0101 | 0.0101 |
Echinococcus granulosus | xaa pro aminopeptidase | 0.0101 | 0.0978 | 0.0978 |
Leishmania major | transcription factor-like protein | 0.0101 | 0.0978 | 0.0956 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0101 | 0.0978 | 0.1169 |
Schistosoma mansoni | thyroid hormone receptor | 0.0018 | 0.0101 | 0.012 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0101 | 0.0978 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0011 | 0.0011 |
Echinococcus multilocularis | methionine aminopeptidase, type I | 0.0101 | 0.0978 | 0.0978 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0018 | 0.0101 | 0.012 |
Echinococcus multilocularis | xaa pro aminopeptidase | 0.0101 | 0.0978 | 0.0978 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0011 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0101 | 0.0101 |
Echinococcus granulosus | xaa Pro dipeptidase | 0.0101 | 0.0978 | 0.0978 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.0798 | 0.8363 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.007 | 0.0649 | 0.0649 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.0101 | 0.0101 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0798 | 0.8363 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0014 | 0.006 | 0.0043 |
Schistosoma mansoni | coup transcription factor | 0.0018 | 0.0101 | 0.012 |
Onchocerca volvulus | 0.0018 | 0.0101 | 0.103 | |
Brugia malayi | nuclear hormone receptor | 0.0018 | 0.0101 | 0.0101 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0101 | 0.0978 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.012 | 0.1181 | 0.1181 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0018 | 0.0101 | 0.0101 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0123 | 0.0123 |
Mycobacterium leprae | Probable cytoplasmic peptidase PepQ | 0.0101 | 0.0978 | 0.1143 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0014 | 0.006 | 0.0043 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0018 | 0.0101 | 0.103 |
Chlamydia trachomatis | aminopeptidase P | 0.0101 | 0.0978 | 0.1105 |
Mycobacterium ulcerans | dehydrogenase | 0.0014 | 0.006 | 0.0043 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0018 | 0.0101 | 0.0101 |
Brugia malayi | initiation factor 2-associated protein. | 0.0101 | 0.0978 | 0.0978 |
Echinococcus multilocularis | xaa Pro dipeptidase | 0.0101 | 0.0978 | 0.0978 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0054 | 0.048 | 0.048 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0101 | 0.0978 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0018 | 0.0101 | 0.0101 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0054 | 0.048 | 0.048 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0101 | 0.0978 | 1 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0952 | 1 | 1 |
Trypanosoma cruzi | aminopeptidase P1, putative | 0.0101 | 0.0978 | 0.0956 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0308 | 0.0284 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.0101 | 0.0101 |
Plasmodium vivax | hypothetical protein, conserved | 0.0155 | 0.1547 | 0.1496 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0018 | 0.0101 | 0.0101 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0018 | 0.0101 | 0.0101 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.022 | 0.022 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0014 | 0.006 | 0.0036 |
Brugia malayi | SWIRM domain containing protein | 0.0076 | 0.0712 | 0.0712 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0101 | 0.0978 | 0.0956 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0308 | 0.2537 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0018 | 0.0101 | 0.0101 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0101 | 0.0978 | 1 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0416 | 0.4317 | 0.4317 |
Leishmania major | protein kinase, putative | 0.0016 | 0.008 | 0.0056 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0016 | 0.008 | 0.0056 |
Echinococcus granulosus | FTZ F1 alpha | 0.0018 | 0.0101 | 0.0101 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0101 | 0.0978 | 0.0978 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0016 | 0.008 | 0.0056 |
Echinococcus multilocularis | xaa Pro dipeptidase | 0.0101 | 0.0978 | 0.0978 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0018 | 0.0101 | 0.0101 |
Trypanosoma brucei | Facilitates chromatin transcription complex subunit spt16 | 0.0101 | 0.0978 | 0.0956 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0011 | 0.0024 | 0.0024 |
Toxoplasma gondii | hypothetical protein | 0.0155 | 0.1547 | 0.1527 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.0016 | 0.008 | 0.0056 |
Schistosoma mansoni | amine oxidase | 0.0014 | 0.006 | 0.0072 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0011 | 0.0024 | 0.0024 |
Brugia malayi | Muscleblind-like protein | 0.0152 | 0.152 | 0.152 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0018 | 0.0101 | 0.0101 |
Leishmania major | aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 | 0.0101 | 0.0978 | 0.0956 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0018 | 0.0101 | 0.0101 |
Toxoplasma gondii | creatinase domain-containing protein | 0.0101 | 0.0978 | 0.0956 |
Brugia malayi | Cytochrome P450 family protein | 0.0011 | 0.0024 | 0.0024 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0016 | 0.008 | 0.0056 |
Plasmodium vivax | FACT complex subunit SPT16, putative | 0.0101 | 0.0978 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0477 | 0.0477 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.022 | 0.0263 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.012 | 0.1181 | 0.1181 |
Leishmania major | aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 | 0.0101 | 0.0978 | 0.0956 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0038 | 0.031 | 0.031 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.0952 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.0308 | 0.0284 |
Onchocerca volvulus | 0.0054 | 0.0477 | 0.4879 | |
Schistosoma mansoni | single-minded | 0.0016 | 0.008 | 0.0096 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0011 | 0.0013 |
Trypanosoma cruzi | aminopeptidase P, putative | 0.0101 | 0.0978 | 0.0956 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.001 | 0.0011 | 0.0011 |
Brugia malayi | Cytochrome P450 family protein | 0.0011 | 0.0024 | 0.0024 |
Schistosoma mansoni | nuclear hormone receptor | 0.0018 | 0.0101 | 0.012 |
Toxoplasma gondii | transcriptional elongation factor FACT140 | 0.0101 | 0.0978 | 0.0956 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0101 | 0.0978 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 9.4 | Antifighting activity was measured by the antagonism against foot-shock induced fighting | ChEMBL. | 7190614 |
Activity (functional) | = 25 | Spontaneous motor activity of mice was estimated after 60 minutes of oral adimistration. | ChEMBL. | 7190614 |
ED50 (functional) | = 1.98 mg kg-1 | Dose required to prevent convulsion and deathin 50% of mice during a 2 h observation was obtainedby graphical interpolation anti-pentylenetetrazole | ChEMBL. | 7190614 |
ED50 (functional) | = 1.98 mg kg-1 | Dose required to prevent convulsion and deathin 50% of mice during a 2 h observation was obtainedby graphical interpolation anti-pentylenetetrazole | ChEMBL. | 7190614 |
ED50 (functional) | = 50.8 mg kg-1 | Effective dose required for 50% reduction of the control response was obtained by graphical interpolation rotarod performance | ChEMBL. | 7190614 |
ED50 (functional) | = 50.8 mg kg-1 | Effective dose required for 50% reduction of the control response was obtained by graphical interpolation rotarod performance | ChEMBL. | 7190614 |
LD50 (ADMET) | > 1000 mg kg-1 | Lethal dose (LD50) required to inhibit the spontaneous motor activity. | ChEMBL. | 7190614 |
LD50 (ADMET) | > 1000 mg kg-1 | Lethal dose (LD50) required to inhibit the spontaneous motor activity. | ChEMBL. | 7190614 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.