Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | thioredoxin reductase | 0.015 | 0.9824 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.015 | 0.9824 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.015 | 0.9824 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.015 | 0.9824 | 1 |
Plasmodium falciparum | glutathione reductase | 0.015 | 0.9824 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0052 | 0.1212 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0052 | 0.1212 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.015 | 0.9824 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0052 | 0.1212 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0052 | 0.1212 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.015 | 0.9824 | 1 |
Treponema pallidum | NADH oxidase | 0.0052 | 0.1212 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.015 | 0.9824 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0052 | 0.1212 | 0.5 |
Leishmania major | trypanothione reductase | 0.015 | 0.9824 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0052 | 0.1212 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0052 | 0.1212 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.015 | 0.9824 | 0.5 |
Brugia malayi | glutathione reductase | 0.015 | 0.9824 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0152 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0052 | 0.1212 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0052 | 0.1212 | 0.1234 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.015 | 0.9824 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0052 | 0.1212 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0052 | 0.1212 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.015 | 0.9824 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.6 uM | Inhibitory activity towards group 2 metabotropic glutamate receptor by displacement of ACPD-sensitive [3H]- glutamate in rat forebrain membrane | ChEMBL. | 9871538 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.