Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 19, subfamily A, polypeptide 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | cytochrome P450, family 19, subfamily A, polypeptide 1 | 503 aa | 425 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0456 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0456 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0456 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0456 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0456 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0456 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0456 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0456 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0456 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0456 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0456 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0456 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0456 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0456 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0456 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0456 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0456 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0456 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0456 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0456 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0456 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0456 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0456 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0456 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0456 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 7 % | In vivo reduction in serum estradiol in PMSG-primed rats after 2 hr at 5 mg/kg oral dose | ChEMBL. | 8576919 |
Control (functional) | = 7 % | In vivo reduction in serum estradiol in PMSG-primed rats after 2 hr at 5 mg/kg oral dose | ChEMBL. | 8576919 |
Control (functional) | = 23 % | In vivo reduction in serum estradiol in PMSG-primed rats after 6 hr at 5 mg/kg oral dose | ChEMBL. | 8576919 |
Control (functional) | = 23 % | In vivo reduction in serum estradiol in PMSG-primed rats after 6 hr at 5 mg/kg oral dose | ChEMBL. | 8576919 |
IC50 (binding) | > 0.000001 M | In vitro inhibition to cytochrome P450 19A1 assayed using human placental microsomes | ChEMBL. | 8576919 |
IC50 (binding) | > 0.000001 M | In vitro inhibition to cytochrome P450 19A1 assayed using human placental microsomes | ChEMBL. | 8576919 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.