Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | corticotropin releasing hormone receptor 2 | Starlite/ChEMBL | References |
Rattus norvegicus | Corticotropin releasing factor receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | Corticotropin releasing factor receptor 1 | 415 aa | 394 aa | 27.7 % |
Onchocerca volvulus | Pseudouridine-5 prime-monophosphatase homolog | Corticotropin releasing factor receptor 1 | 415 aa | 401 aa | 27.2 % |
Loa Loa (eye worm) | hypothetical protein | Corticotropin releasing factor receptor 1 | 415 aa | 359 aa | 21.4 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 2 | 431 aa | 400 aa | 26.5 % |
Onchocerca volvulus | Corticotropin releasing factor receptor 1 | 415 aa | 401 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.0187 | 0.2556 | 0.2556 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0187 | 0.2556 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase | 0.0187 | 0.2556 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0408 | 0.7985 | 1 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.0187 | 0.2556 | 0.5 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0187 | 0.2556 | 0.5 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.017 | 0.214 | 1 |
Chlamydia trachomatis | methionine aminopeptidase | 0.017 | 0.214 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.017 | 0.214 | 0.5 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.017 | 0.214 | 1 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.0187 | 0.2556 | 0.5 |
Treponema pallidum | methionine aminopeptidase (map) | 0.017 | 0.214 | 1 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.017 | 0.214 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.017 | 0.214 | 0.5 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0187 | 0.2556 | 0.5 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.017 | 0.214 | 1 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.0187 | 0.2556 | 1 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.017 | 0.214 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0408 | 0.7985 | 1 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.0187 | 0.2556 | 0.1807 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.017 | 0.214 | 0.1179 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.017 | 0.214 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 1 | 1 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.0187 | 0.2556 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0187 | 0.2556 | 0.1807 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.0187 | 0.2556 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 0.0933 | 0.0933 |
Brugia malayi | Methionine aminopeptidase protein type I | 0.0187 | 0.2556 | 0.2556 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.017 | 0.214 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 10000 nM | Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 1 | ChEMBL. | 10201844 |
Ki (binding) | > 10000 nM | Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 beta | ChEMBL. | 10201844 |
Ki (binding) | > 10000 nM | Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 1 | ChEMBL. | 10201844 |
Ki (binding) | > 10000 nM | Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 beta | ChEMBL. | 10201844 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.