Detailed information for compound 283161

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 580.697 | Formula: C33H32N4O4S
  • H donors: 1 H acceptors: 4 LogP: 5.35 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccccc1)N(C)C
  • InChi: 1S/C33H32N4O4S/c1-4-10-31-34-29-20-19-26(36(2)3)21-28(29)33(39)37(31)22-23-15-17-24(18-16-23)27-13-8-9-14-30(27)42(40,41)35-32(38)25-11-6-5-7-12-25/h5-9,11-21H,4,10,22H2,1-3H3,(H,35,38)
  • InChiKey: WKLCKDWRZDOIQX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Angiotensin II type 2 (AT-2) receptor Starlite/ChEMBL No references
Oryctolagus cuniculus Angiotensin II type 1a (AT-1a) receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 305 aa 21.6 %
Brugia malayi ORL1-like opioid receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 333 aa 21.3 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 341 aa 23.2 %
Brugia malayi GnHR receptor homolog Angiotensin II type 1a (AT-1a) receptor   359 aa 364 aa 20.3 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 296 aa 23.0 %
Echinococcus multilocularis G-protein coupled receptor, putative Angiotensin II type 1a (AT-1a) receptor   359 aa 307 aa 22.5 %
Echinococcus granulosus growth hormone secretagogue receptor type 1 Angiotensin II type 1a (AT-1a) receptor   359 aa 342 aa 22.2 %
Echinococcus granulosus allatostatin A receptor Angiotensin II type 2 (AT-2) receptor   363 aa 340 aa 24.1 %
Echinococcus granulosus tm gpcr rhodopsin Angiotensin II type 1a (AT-1a) receptor   359 aa 306 aa 21.9 %
Brugia malayi putative neuropeptide receptor NPR1 Angiotensin II type 1a (AT-1a) receptor   359 aa 295 aa 27.1 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Angiotensin II type 2 (AT-2) receptor   363 aa 310 aa 23.5 %
Echinococcus multilocularis allatostatin A receptor Angiotensin II type 2 (AT-2) receptor   363 aa 342 aa 24.6 %
Schistosoma mansoni opsin-like receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 299 aa 25.1 %
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 398 aa 18.1 %
Schistosoma mansoni peptide (allatostatin)-like receptor Angiotensin II type 2 (AT-2) receptor   363 aa 364 aa 20.9 %
Echinococcus multilocularis neuropeptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 21.4 %
Loa Loa (eye worm) hypothetical protein Angiotensin II type 1a (AT-1a) receptor   359 aa 308 aa 27.3 %
Loa Loa (eye worm) hypothetical protein Angiotensin II type 1a (AT-1a) receptor   359 aa 335 aa 23.0 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 306 aa 22.5 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Angiotensin II type 1a (AT-1a) receptor   359 aa 325 aa 20.9 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 346 aa 18.2 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 398 aa 18.3 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Angiotensin II type 1a (AT-1a) receptor   359 aa 328 aa 20.7 %
Loa Loa (eye worm) neuropeptide F receptor Angiotensin II type 2 (AT-2) receptor   363 aa 356 aa 23.3 %
Schistosoma japonicum Rhodopsin, putative Angiotensin II type 2 (AT-2) receptor   363 aa 341 aa 22.0 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 21.8 %
Echinococcus granulosus thyrotropin releasing hormone receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 22.1 %
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Angiotensin II type 1a (AT-1a) receptor   359 aa 306 aa 21.9 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 399 aa 25.3 %
Echinococcus granulosus neuropeptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 306 aa 22.2 %
Schistosoma mansoni adenoreceptor Angiotensin II type 2 (AT-2) receptor   363 aa 328 aa 22.0 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 364 aa 23.1 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 311 aa 23.8 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 313 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0141 0.0379
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0091 0.0088
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0118 0.07 0.0806
Loa Loa (eye worm) hypothetical protein 0.0118 0.07 0.0707
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0253 0.0256
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0326 0.033
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.1118 0.1116
Plasmodium falciparum cGMP-specific phosphodiesterase 0.018 0.1118 0.2756
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.018 0.1118 0.1116
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0141 0.0139
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.018 0.1118 0.113
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0162 0.0444
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0445 0.2907 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0098 0.0099
Mycobacterium ulcerans hypothetical protein 0.0118 0.07 0.2398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.013 0.0342
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1481 0.9895 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0118 0.07 0.0697
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.1118 0.1116
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0003 0.0003
Trypanosoma brucei hypothetical protein, conserved 0.0118 0.07 0.0697
Brugia malayi hypothetical protein 0.0015 0.0005 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0091 0.0223
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0098 0.0113
Schistosoma mansoni hypothetical protein 0.0019 0.0029 0.003
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0052 0.0052
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0052 0.0049
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0098 0.0099
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0118 0.07 0.0707
Schistosoma mansoni lipoxygenase 0.0113 0.0666 0.0673
Loa Loa (eye worm) hypothetical protein 0.0032 0.0115 0.0117
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0162 0.016
Brugia malayi MH2 domain containing protein 0.0106 0.062 0.0714
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0262 0.0259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0091 0.0222
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0346 0.2239 0.5032
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0141 0.0143
Schistosoma mansoni hypothetical protein 0.0032 0.0115 0.0117
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0141 0.0091
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.018 0.1118 0.113
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0098 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0112 0.0286
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.018 0.1118 0.1288
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0003 0.0003
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0445 0.2907 0.7285
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1265 0.844 0.8439
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0052 0.0049
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0029 0.003
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0604 0.398 0.8949
Trypanosoma brucei cAMP-specific phosphodiesterase 0.018 0.1118 0.1116
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0005 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0098 0.0113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0244 0.0247
Onchocerca volvulus Huntingtin homolog 0.0125 0.0747 0.2237
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0445 0.2907 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0118 0.07 0.2398
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0118 0.07 0.0806
Loa Loa (eye worm) hypothetical protein 0.0037 0.0151 0.0152
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.13 0.8679 0.8771
Mycobacterium tuberculosis Probable reductase 0.0346 0.2239 0.5032
Brugia malayi Cytochrome P450 family protein 0.0015 0.0003 0.0003
Plasmodium falciparum importin beta, putative 0.0028 0.0091 0.0156
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.111 0.7396 0.7395
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0118 0.07 0.2113
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0063 0.0064
Brugia malayi Inositol-1 0.0039 0.0162 0.0187
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0098 0.0099
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0118 0.07 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.3413
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0118 0.07 0.2113
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0098 0.0099
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.0185 0.0187
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0326 0.033
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.018 0.1118 0.1116
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0052 0.0052
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.1116
Loa Loa (eye worm) hypothetical protein 0.018 0.1118 0.113
Schistosoma mansoni rab6-interacting 0.0019 0.0029 0.003
Entamoeba histolytica disulphide oxidoreductase, putative 0.0118 0.07 1
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0209 0.0211
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0052 0.0049
Trypanosoma brucei NADH dehydrogenase 0.0118 0.07 0.0697
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0019 0.002
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0118 0.07 0.2113
Toxoplasma gondii selenide, water dikinase 0.0118 0.07 0.0701
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.018 0.1118 0.113
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.018 0.1118 0.113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0181 0.0502
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0091 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0098 0.0113
Echinococcus granulosus GPCR family 2 0.0032 0.0115 0.0117
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0052 0.0253 0.0256
Brugia malayi Pre-SET motif family protein 0.0063 0.0326 0.0376
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0346 0.2239 0.5032
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0098 0.0113
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0052 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0141 0.0379
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0118 0.07 0.1696
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.3413
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0118 0.07 0.1568
Echinococcus multilocularis cpg binding protein 0.0033 0.0123 0.0124
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0068 0.0065
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0141 0.0143
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0306 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0098 0.0113
Trypanosoma brucei unspecified product 0.0015 0.0005 0.0002
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.2756
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.018 0.1118 0.1288
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0162 0.1706
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0141 0.0139
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0019 0.002
Echinococcus multilocularis microtubule associated protein 2 0.0722 0.4773 0.4823
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1481 0.9895 1
Loa Loa (eye worm) hypothetical protein 0.018 0.1118 0.113
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.07 0.0697
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0005 0.0006
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0445 0.2907 0.7285
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.003
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.018 0.1118 0.113
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0262 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0112 0.0286
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.018 0.1118 0.113
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.3413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0109 0.028
Brugia malayi hypothetical protein 0.0019 0.0029 0.0034
Echinococcus granulosus microtubule associated protein 2 0.0722 0.4773 0.4823
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0098 0.0099
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.1922 0.1942
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0145 0.039
Brugia malayi ecdysteroid receptor 0.0029 0.0098 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0005 0.0002
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.13 0.8679 0.8771
Schistosoma mansoni hypothetical protein 0.0159 0.0975 0.0986
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0141 0.0143
Schistosoma mansoni hypothetical protein 0.032 0.2059 0.2081
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0118 0.07 0.0707
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0052 0.0049
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1487 0.9935 1
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0118 0.07 0.1568
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0118 0.07 0.1568
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0118 0.07 0.1568
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0244 0.0281
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0063 0.0064
Echinococcus granulosus glutamate synthase 0.0118 0.07 0.0707
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.018 0.1118 0.1116
Plasmodium vivax thioredoxin reductase, putative 0.0604 0.398 1
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0118 0.07 1
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0118 0.07 0.1568
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0141 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.018 0.1118 0.3413
Echinococcus granulosus importin subunit beta 1 0.0028 0.0091 0.0092
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.3413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0253 0.0725
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.13 0.8679 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0118 0.07 0.0707
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1481 0.9895 1
Trichomonas vaginalis conserved hypothetical protein 0.018 0.1118 0.3413
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0098 0.0214
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0019 0.002
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.3413
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.3413
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.07 0.0697
Loa Loa (eye worm) glutaminase 2 0.0286 0.1831 0.1851
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0052 0.0049
Leishmania major DNA polymerase eta, putative 0.0022 0.0052 0.0049
Echinococcus granulosus RUN 0.0019 0.0029 0.003
Mycobacterium ulcerans glutaminase 0.0286 0.1831 0.6295
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0098 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0112 0.0286
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.018 0.1118 0.113
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0118 0.07 0.0701
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0098 0.0099
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0029 0.003
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.018 0.1118 0.1116
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0099
Loa Loa (eye worm) hypothetical protein 0.0125 0.0747 0.0755
Onchocerca volvulus 0.0029 0.0098 0.0214
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0118 0.07 0.0707
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0118 0.07 0.1957
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0162 0.0444
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0262 0.0259
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0005 0.0006
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0445 0.2907 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.018 0.1118 0.1116
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0098 0.0113
Brugia malayi glutathione reductase 0.0604 0.398 0.4586
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.13 0.8679 0.8771
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0052 0.0049
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0118 0.07 0.1568
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0118 0.07 0.0701
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.018 0.1118 0.113
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0118 0.07 0.0701
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0005 0.0002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0098 0.0099
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0141 0.1381
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0098 0.0099
Brugia malayi glutamate synthase 0.0118 0.07 0.0806
Brugia malayi Importin beta-1 subunit 0.0028 0.0091 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.111 0.7396 0.7395
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0118 0.07 0.2113
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.018 0.1118 0.113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0091 0.0223
Schistosoma mansoni glutaminase 0.0286 0.1831 0.1851
Loa Loa (eye worm) hypothetical protein 0.01 0.0577 0.0583
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0141 0.0143
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.2756
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0052 0.0253 0.025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0244 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0098 0.0113
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0098 0.0099
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0118 0.07 0.0707
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0434 0.2834 0.2864
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.018 0.1118 0.1116
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0162 0.016
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.018 0.1118 0.113
Leishmania major acetoin dehydrogenase e3 component-like protein 0.111 0.7396 0.7395
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0244 0.0247
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0019 0.0017
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0118 0.07 0.0697
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0052 0.0049
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.018 0.1118 0.1116
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0326 0.033
Trypanosoma brucei unspecified product 0.0022 0.0052 0.0049
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.018 0.1118 0.113
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0113 0.0666 0.0673
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0098 0.0099
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0118 0.07 0.0707
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0118 0.07 0.0707
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.1118 0.1116
Brugia malayi nuclear receptor RXR 0.0015 0.0005 0.0006
Plasmodium vivax ferrodoxin reductase, putative 0.0118 0.07 0.1696
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0052 0.0253 0.0256
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0253 0.0291
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0118 0.07 0.1568
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.1481 0.9895 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.3413
Mycobacterium ulcerans NADH dehydrogenase 0.0118 0.07 0.2398
Loa Loa (eye worm) hypothetical protein 0.0125 0.0747 0.0755
Schistosoma mansoni hypothetical protein 0.0032 0.0115 0.0117
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Schistosoma mansoni hypothetical protein 0.0015 0.0003 0.0003
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0048 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0326 0.033
Plasmodium vivax phosphodiesterase gamma, putative 0.018 0.1118 0.2756
Echinococcus granulosus thioredoxin glutathione reductase 0.0604 0.398 0.4022
Schistosoma mansoni hypothetical protein 0.0032 0.0115 0.0117
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0098 0.0214
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0098 0.0099
Brugia malayi Cytochrome P450 family protein 0.0015 0.0003 0.0003
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0445 0.2907 0.2938
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0673 0.4447 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0181 0.0502
Plasmodium vivax importin-beta 2, putative 0.0028 0.0091 0.0156
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0115 0.0133
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0141 0.0163
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0098 0.0113
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.018 0.1118 0.1288
Onchocerca volvulus 0.0063 0.0326 0.0925
Plasmodium vivax SET domain protein, putative 0.0063 0.0326 0.0751
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0115 0.0117
Schistosoma mansoni cpg binding protein 0.0033 0.0123 0.0124
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0141 0.0379
Schistosoma mansoni hypothetical protein 0.0118 0.07 0.0707
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0118 0.07 0.0697
Schistosoma mansoni cytochrome P450 0.0015 0.0003 0.0003
Brugia malayi CXXC zinc finger family protein 0.0031 0.0111 0.0128
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0118 0.07 0.1957
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0253 0.0725
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0118 0.07 0.2113
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0118 0.07 0.2113
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.3413
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0162 0.0164
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0244 0.0247
Schistosoma mansoni glutamate synthase 0.0118 0.07 0.0707
Loa Loa (eye worm) hypothetical protein 0.018 0.1118 0.113
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0052 0.0253 0.0256
Echinococcus multilocularis thioredoxin glutathione reductase 0.0604 0.398 0.4022
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0118 0.07 0.2398
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0052 0.0253 0.025
Echinococcus granulosus geminin 0.032 0.2059 0.2081
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0003 0.0003
Brugia malayi RNA, U transporter 1 0.008 0.044 0.0507
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0118 0.07 0.0707
Loa Loa (eye worm) PDE1B protein 0.018 0.1118 0.113
Toxoplasma gondii target of rapamycin (TOR), putative 0.0039 0.0163 0.0161
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0162 0.0444
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1496 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0052 0.0052
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.018 0.1118 0.3413
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0118 0.07 0.0806
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0098 0.0099
Giardia lamblia GTOR 0.0052 0.0253 0.0204
Schistosoma mansoni disulfide oxidoreductase 0.0118 0.07 0.0707
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.0181 0.0178
Loa Loa (eye worm) inositol-1 0.0039 0.0162 0.0164
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0118 0.07 0.0697
Loa Loa (eye worm) cytochrome P450 0.0015 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0137 0.0366
Trichomonas vaginalis glutamate synthase, putative 0.0118 0.07 0.2113
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0118 0.07 0.2113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0163 0.0446
Schistosoma mansoni glutamate synthase 0.0118 0.07 0.0707
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0118 0.07 0.0658
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0052 0.0101
Onchocerca volvulus 0.0031 0.0111 0.0254
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1496 1 1
Brugia malayi glutaminase DH11.1 0.0286 0.1831 0.211
Trichomonas vaginalis glutathione reductase, putative 0.0445 0.2907 0.8972
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0098 0.0113
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0091 0.0089
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0445 0.2907 0.7285
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.0185 0.0187
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0118 0.07 0.1568
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0118 0.07 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0098 0.0099
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0327 0.211 0.2431
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.018 0.1118 0.113
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0098 0.0099
Schistosoma mansoni polycystin 1-related 0.0019 0.0029 0.003
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0003 0.0003
Brugia malayi hypothetical protein 0.0019 0.0029 0.0034
Echinococcus multilocularis 0.0015 0.0003 0.0003
Echinococcus granulosus dna polymerase eta 0.0022 0.0052 0.0052
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.018 0.1118 0.1116
Schistosoma mansoni inositol monophosphatase 0.0039 0.0162 0.0164
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0052 0.0253 0.3103
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1481 0.9895 1
Mycobacterium ulcerans glutamate synthase subunit beta 0.0118 0.07 0.2398
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0098 0.0099
Echinococcus multilocularis tumor protein p63 0.0391 0.2542 0.2569
Echinococcus multilocularis RUN 0.0019 0.0029 0.003
Trypanosoma brucei cAMP-specific phosphodiesterase 0.018 0.1118 0.1116
Trichomonas vaginalis glutaminase, putative 0.0286 0.1831 0.5629
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Echinococcus multilocularis GPCR, family 2 0.0032 0.0115 0.0117
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0445 0.2907 1
Echinococcus granulosus snurportin 1 0.0299 0.1922 0.1942
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0052 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0098 0.0099
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0098 0.0099
Brugia malayi nuclear hormone receptor 0.0029 0.0098 0.0113
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.018 0.1118 0.1288
Echinococcus granulosus dnaJ subfamily B 0.0442 0.2883 0.2914
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0005 0.0006
Echinococcus multilocularis glutamate synthase 0.0118 0.07 0.0707
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0118 0.07 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0141 0.0139
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0005 0.0006
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0118 0.07 0.2398
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.1118 0.1116
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0052 0.0049
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0118 0.07 0.1696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0091 0.0223
Loa Loa (eye worm) transcription factor SMAD2 0.0106 0.062 0.0626
Echinococcus granulosus cpg binding protein 0.0033 0.0123 0.0124
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0162 0.0549
Leishmania major NADH dehydrogenase, putative 0.0118 0.07 0.0697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0163 0.0446
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.3413
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0118 0.07 0.1568
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0006
Mycobacterium ulcerans dehydrogenase 0.0118 0.07 0.2398
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0445 0.2907 1
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0098 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0098 0.0113
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0118 0.07 0.1568
Brugia malayi hypothetical protein 0.0015 0.0005 0.0006
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0055 0.0111
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.018 0.1118 0.1288
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.018 0.1118 0.113
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.111 0.7396 0.7395
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0135 0.0298
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.1116
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0145 0.039
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0673 0.4447 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Schistosoma mansoni hypothetical protein 0.0442 0.2883 0.2914
Trypanosoma cruzi NADH dehydrogenase, putative 0.0118 0.07 0.0697
Leishmania major hypothetical protein, conserved 0.0053 0.0262 0.0259
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0326 0.033
Loa Loa (eye worm) hypothetical protein 0.0063 0.0326 0.033
Mycobacterium ulcerans monoxygenase 0.0118 0.07 0.2398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0163 0.0446
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0052 0.0169
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0098 0.0099
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0244 0.0247
Trichomonas vaginalis apoptosis inducing factor, putative 0.0118 0.07 0.2113
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0118 0.07 0.1957
Toxoplasma gondii thioredoxin reductase 0.0604 0.398 0.4004
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.018 0.1118 0.113
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0162 0.016
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.2756
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0673 0.4447 1
Entamoeba histolytica thioredoxin reductase, putative 0.0118 0.07 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0098 0.0113
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Onchocerca volvulus 0.0057 0.0288 0.0806
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.3413
Plasmodium vivax glutathione reductase, putative 0.0604 0.398 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Trypanosoma cruzi trypanothione reductase, putative 0.0445 0.2907 0.2905
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0118 0.07 0.0707
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1265 0.844 0.8439
Brugia malayi hypothetical protein 0.0125 0.0747 0.0861
Plasmodium falciparum cGMP-specific phosphodiesterase 0.018 0.1118 0.2756
Echinococcus multilocularis neuropeptide s receptor 0.0495 0.3242 0.3276
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.018 0.1118 0.113
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0019 0.0017
Trypanosoma cruzi trypanothione reductase, putative 0.0604 0.398 0.3978
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.018 0.1118 0.113
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0052 0.0169
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0055 0.0111
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0445 0.2907 0.2905
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0346 0.2239 0.5032
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0005 0.0002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0111 0.0112
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0091 0.0092
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0029 0.003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0029 0.0098 0.0099
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0118 0.07 0.2113
Loa Loa (eye worm) glutathione reductase 0.0604 0.398 0.4022
Echinococcus multilocularis geminin 0.032 0.2059 0.2081
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0052 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0052 0.0049
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0115 0.0133
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0115 0.0117
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0162 0.016
Schistosoma mansoni loxhd1 0.0019 0.0029 0.003
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0052 0.006
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.018 0.1118 0.1116
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0141 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0163 0.0446
Brugia malayi steroid hormone receptor 0.0029 0.0098 0.0113
Leishmania major trypanothione reductase 0.0604 0.398 0.3978
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0098 0.0099
Leishmania major hypothetical protein, conserved 0.018 0.1118 0.1116
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0118 0.07 0.1696
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.018 0.1118 0.113
Leishmania major hypothetical protein, conserved 0.0118 0.07 0.0697
Onchocerca volvulus Huntingtin homolog 0.0125 0.0747 0.2237
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.1118 0.1116
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0445 0.2907 0.6536
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0052 0.0049
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0098 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0109 0.028
Giardia lamblia Thioredoxin reductase 0.0118 0.07 0.0658
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.0181 0.0178
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0118 0.07 0.0697
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1265 0.844 0.8439
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0115 0.0117
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0098 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.018 0.1118 0.3413
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0052 0.0049
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0262 0.0261
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0445 0.2907 1
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0118 0.07 0.2398
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0363 0.0418
Plasmodium falciparum phosphodiesterase delta, putative 0.018 0.1118 0.2756
Schistosoma mansoni coup transcription factor 0.0029 0.0098 0.0099
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0445 0.2907 0.2905
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0118 0.07 0.2113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0181 0.0502
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0262 0.0589
Loa Loa (eye worm) hypothetical protein 0.0036 0.0141 0.0143
Leishmania major hypothetical protein, conserved 0.0118 0.07 0.0697
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.0185 0.0187
Echinococcus granulosus neuropeptide receptor A26 0.0495 0.3242 0.3276
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.018 0.1118 0.113
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0099
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0019 0.0022
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0055 0.0052
Trichomonas vaginalis mercuric reductase, putative 0.0445 0.2907 0.8972
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0118 0.07 0.0707
Schistosoma mansoni lipoxygenase 0.0079 0.0436 0.0441
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0098 0.0099
Onchocerca volvulus 0.0118 0.07 0.2088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1496 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0361 0.0365
Schistosoma mansoni cpg binding protein 0.0033 0.0123 0.0124
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0326 0.033
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0141 0.0143
Leishmania major hypothetical protein, conserved 0.0118 0.07 0.0697
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0019 0.0017
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0052 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0052 0.0049
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0052 0.0253 0.025
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0118 0.07 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0445 0.2907 0.335
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.018 0.1118 0.113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0244 0.0247
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.1265 0.844 0.8439
Schistosoma mansoni hypothetical protein 0.0024 0.0063 0.0064
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0118 0.07 0.0707
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0115 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0052 0.0049
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0288 0.0291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0098 0.0099
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0099
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0118 0.07 0.2398
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0098 0.0099
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0445 0.2907 0.2938
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.018 0.1118 0.3413
Plasmodium falciparum glutathione reductase 0.0604 0.398 1
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0118 0.07 0.2398
Schistosoma mansoni rab6-interacting 0.0019 0.0029 0.003
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0135 0.0298
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.018 0.1118 0.113
Brugia malayi hypothetical protein 0.0053 0.0262 0.0302
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0098 0.0099
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0003 0.0003
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0118 0.07 0.2113
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0113 0.0666 0.0673
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0052 0.0253 0.025
Schistosoma mansoni sulfide quinone reductase 0.0118 0.07 0.0707
Entamoeba histolytica hypothetical protein 0.0023 0.0055 0.005
Trypanosoma brucei unspecified product 0.0015 0.0005 0.0002
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0162 0.0164
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0052 0.0049
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0118 0.07 0.0697
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0029 0.003
Plasmodium falciparum ferrodoxin reductase-like protein 0.0118 0.07 0.1696
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0098 0.0099
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0098 0.0099
Echinococcus granulosus dna polymerase kappa 0.0022 0.0052 0.0052
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.2756
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.1481 0.9895 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0186 0.1158 0.1163
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0019 0.0017
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0098 0.0099
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0052 0.0049
Plasmodium falciparum thioredoxin reductase 0.0604 0.398 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0673 0.4447 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0052 0.0052
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0577 0.0583
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0118 0.07 0.2398
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0053 0.0262 0.0265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0326 0.033
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0019 0.0017
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0262 0.0589
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0052 0.0049
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0346 0.2239 0.5032
Echinococcus multilocularis dnaJ subfamily B 0.0442 0.2883 0.2914
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0244 0.0247
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.3413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0163 0.0446
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0098 0.0099
Brugia malayi nuclear receptor NHR-88 0.0029 0.0098 0.0113
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0099
Leishmania major hypothetical protein, conserved 0.018 0.1118 0.1116
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0019 0.0017
Trypanosoma cruzi NADH dehydrogenase, putative 0.0118 0.07 0.0697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0181 0.0502
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0141 0.0139
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Loa Loa (eye worm) hypothetical protein 0.1481 0.9895 1
Echinococcus multilocularis snurportin 1 0.0299 0.1922 0.1942
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0098 0.0113
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0118 0.07 0.0697
Leishmania major importin beta-1 subunit, putative 0.0023 0.0055 0.0052
Schistosoma mansoni sulfide quinone reductase 0.0118 0.07 0.0707
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0098 0.0099
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0098 0.0099
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0068 0.0363 0.0367
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0118 0.07 0.0697
Loa Loa (eye worm) thioredoxin reductase 0.0604 0.398 0.4022
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0118 0.07 0.1696
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0346 0.2239 0.5032
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0029 0.003
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0052 0.0253 0.025
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0098 0.0113
Echinococcus granulosus neuropeptide s receptor 0.0495 0.3242 0.3276
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.1118 0.1116
Schistosoma mansoni hypothetical protein 0.0032 0.0115 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0163 0.0446
Plasmodium falciparum thioredoxin reductase 0.0445 0.2907 0.7285
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0118 0.07 0.0697
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.3413
Schistosoma mansoni microtubule-associated protein tau 0.0722 0.4773 0.4823
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0052 0.0253 0.025
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0141 0.0143
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0098 0.0099
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0314 0.0313
Leishmania major DNA polymerase kappa, putative 0.0022 0.0052 0.0049
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0098 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0091 0.0222
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0445 0.2907 0.7285
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Brugia malayi Thioredoxin reductase 0.0604 0.398 0.4586
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.018 0.1118 0.113
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0445 0.2907 0.2905
Brugia malayi cytochrome P450 0.0015 0.0003 0.0003
Trypanosoma brucei hypothetical protein, conserved 0.018 0.1118 0.1116
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0118 0.07 0.0697
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.3413
Trypanosoma brucei trypanothione reductase 0.0604 0.398 0.3978
Treponema pallidum NADH oxidase 0.0445 0.2907 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0052 0.0049
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0445 0.2907 0.2905
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0098 0.0099
Schistosoma mansoni hypothetical protein 0.0068 0.0363 0.0367
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0055 0.0111
Trichomonas vaginalis glutamate synthase, putative 0.0118 0.07 0.2113
Brugia malayi Doublecortin family protein 0.0019 0.0029 0.0034
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.0181 0.0178
Giardia lamblia Hypothetical protein 0.018 0.1118 0.1083
Schistosoma mansoni DNA polymerase eta 0.0022 0.0052 0.0052
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.018 0.1118 0.1288
Echinococcus granulosus tumor protein p63 0.0391 0.2542 0.2569
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.018 0.1118 0.1116
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0052 0.0049
Schistosoma mansoni glutamate synthase 0.0118 0.07 0.0707
Onchocerca volvulus 0.0494 0.3238 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0091 0.0223
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0052 0.011
Loa Loa (eye worm) hypothetical protein 0.0057 0.0288 0.0291
Giardia lamblia hypothetical protein 0.018 0.1118 0.1083
Brugia malayi Pre-SET motif family protein 0.0434 0.2834 0.3265
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Toxoplasma gondii NADPH-glutathione reductase 0.0445 0.2907 0.2924
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0327 0.211 0.2431
Brugia malayi Cytochrome P450 family protein 0.0015 0.0003 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0577 0.0664
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0098 0.0099
Schistosoma mansoni hypothetical protein 0.032 0.2059 0.2081
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0005 0.0006
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0052 0.0101
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0181 0.0502
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0445 0.2907 0.2924
Schistosoma mansoni cpg binding protein 0.0031 0.0111 0.0112
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0098 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0091 0.0222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0098 0.0099
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.018 0.1118 0.113
Giardia lamblia NADH oxidase lateral transfer candidate 0.0445 0.2907 0.2901
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.018 0.1118 0.113
Brugia malayi Cytochrome P450 family protein 0.0015 0.0003 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0577 0.0664
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0445 0.2907 0.2938
Loa Loa (eye worm) MH2 domain-containing protein 0.0106 0.062 0.0626
Schistosoma mansoni inositol monophosphatase 0.0039 0.0162 0.0164
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0244 0.0247
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0209 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0052 0.0049
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0118 0.07 0.0701
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0099
Mycobacterium ulcerans ferredoxin reductase 0.0118 0.07 0.2398
Plasmodium falciparum glutathione reductase 0.0445 0.2907 0.7285
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0029 0.003
Trichomonas vaginalis set domain proteins, putative 0.0494 0.3238 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.018 0.1118 0.3413
Echinococcus multilocularis dna polymerase eta 0.0022 0.0052 0.0052
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0162 0.0161
Echinococcus multilocularis neuropeptide receptor A26 0.0495 0.3242 0.3276
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0118 0.07 0.0701
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0202 0.0566
Schistosoma mansoni hypothetical protein 0.0299 0.1922 0.1942
Loa Loa (eye worm) programmed cell death 8 0.0118 0.07 0.0707
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0115 0.0117
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.0092
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.3413
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0052 0.006
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0118 0.07 0.0697
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.018 0.1118 0.1123
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0118 0.07 0.0707
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.018 0.1118 0.2756
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0262 0.0259
Loa Loa (eye worm) glutaminase 0.0286 0.1831 0.1851
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0005 0.0006
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0098 0.0099
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0118 0.07 0.0707
Leishmania major cAMP-specific phosphodiesterase, putative 0.018 0.1118 0.1116
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.018 0.1118 0.1116
Mycobacterium tuberculosis Probable dehydrogenase 0.0346 0.2239 0.5032
Giardia lamblia Glutamate synthase 0.0118 0.07 0.0658
Brugia malayi hypothetical protein 0.0034 0.0134 0.0155
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.0185 0.0213
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0099
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0029 0.003
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.018 0.1118 0.3413
Plasmodium falciparum phosphodiesterase gamma, putative 0.018 0.1118 0.2756
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0163 0.0446
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0253 0.0725
Schistosoma mansoni importin beta-1 0.0028 0.0091 0.0092
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0052 0.0253 0.3103

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.6 nM In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane ChEMBL. No reference
IC50 (binding) = 3.6 nM In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane ChEMBL. No reference
IC50 (binding) = 330 nM In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain ChEMBL. No reference
IC50 (binding) = 330 nM In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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