Detailed information for compound 283217

Basic information

Technical information
  • TDR Targets ID: 283217
  • Name: 1-(2,4-dinitrophenyl)-2,4-dinitrobenzene
  • MW: 334.198 | Formula: C12H6N4O8
  • H donors: 0 H acceptors: 8 LogP: 2.86 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cc(ccc1c1ccc(cc1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-]
  • InChi: 1S/C12H6N4O8/c17-13(18)7-1-3-9(11(5-7)15(21)22)10-4-2-8(14(19)20)6-12(10)16(23)24/h1-6H
  • InChiKey: UDJCKALRMXKDIT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2,4-dinitrophenyl)-2,4-dinitro-benzene
  • 2,4,2',4'-tetranitrobiphenyl
  • 1820-59-3
  • 1,1'-BIPHENYL, 2,2',4,4'-TETRANITRO-
  • 2,2',4,4'-Tetranitrobiphenyl
  • 2,2',4,4'-Tetranitrobiphenyl, 2,2',4,4'-tetranitro-
  • 3-05-00-01772 (Beilstein Handbook Reference)
  • AI3-08861
  • BRN 2020774
  • Biphenyl, 2,2',4,4'-tetranitro- (8CI)
  • CCRIS 4119
  • NSC 97248
  • Biphenyl, 2,2',4,4'-tetranitro-
  • NSC97248

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.1172 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0462 0.3675 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Onchocerca volvulus 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Echinococcus granulosus orexin receptor type 2 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Brugia malayi putative neuropeptide receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0286 0.3182
Brugia malayi hypothetical protein 0.1172 1 1
Schistosoma mansoni amine GPCR 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Schistosoma mansoni opsin-like receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Onchocerca volvulus 0.1172 1 1
Brugia malayi TAR-binding protein 0.0062 0.0118 0.0118
Schistosoma mansoni neuropeptide receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0286 0.3182
Brugia malayi putative neuropeptide receptor NPR1 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1172 1 1
Echinococcus multilocularis neuropeptide receptor 0.1172 1 1
Schistosoma mansoni neuropeptide receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus hypothetical protein 0.1172 1 1
Brugia malayi larval opioid receptor 0.1172 1 1
Echinococcus granulosus fmrfamide receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni neuropeptide receptor 0.1172 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0119 0.006
Loa Loa (eye worm) hypothetical protein 0.0081 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0121 0.0643 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0119 0.006
Brugia malayi hypothetical protein 0.1172 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1172 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.1172 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.1172 1 1
Echinococcus multilocularis neuropeptide receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0643 0.0643
Schistosoma mansoni amine GPCR 0.1172 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Brugia malayi G protein-coupled receptor 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Schistosoma mansoni hypothetical protein 0.1172 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.1172 1 1
Loa Loa (eye worm) TYRA-2 protein 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0121 0.0643 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.1172 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0118 0.0059
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0121 0.0643 0.0531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0118 0.0059
Echinococcus granulosus 7TM GPCR rhodopsin 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis fmrfamide receptor 0.1172 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Echinococcus multilocularis neuropeptide s receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Onchocerca volvulus 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0422 0.3318 0.8997
Trypanosoma cruzi major cysteine proteinase, putative 0.0363 0.2795 0.7525
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1172 1 1
Schistosoma mansoni amine GPCR 0.1172 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0121 0.0643 1
Echinococcus granulosus cathepsin l1 0.0121 0.0643 0.0531
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.1172 1 1
Leishmania major cathepsin L-like protease 0.0462 0.3675 1
Schistosoma mansoni hypothetical protein 0.1172 1 1
Echinococcus multilocularis somatostatin receptor 0.1172 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Echinococcus granulosus neuropeptide s receptor 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Brugia malayi Dopamine receptor protein 1 0.1172 1 1
Schistosoma mansoni hypothetical protein 0.1172 1 1
Echinococcus multilocularis cathepsin L 0.0062 0.0119 0.0001
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0119 0.0119
Loa Loa (eye worm) G-protein coupled receptor 0.1172 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0462 0.3675 1
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0901 0.7583 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0081 0.0286 0.0228
Echinococcus granulosus alpha 1A adrenergic receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis allatostatin A receptor 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0425 0.0425
Onchocerca volvulus 0.0121 0.0643 0.0367
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus allatostatin A receptor 0.1172 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.1172 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0118 0.0118
Schistosoma mansoni opsin-like receptor 0.1172 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Echinococcus granulosus cathepsin L 0.0062 0.0119 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Echinococcus granulosus cathepsin l1 0.0081 0.0286 0.017
Loa Loa (eye worm) hypothetical protein 0.0081 0.0286 0.0286
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1172 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0118 0.0059
Onchocerca volvulus Cathepsin L homolog 0.0121 0.0643 0.0367
Brugia malayi Serotonin receptor 0.1172 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.1172 1 1
Loa Loa (eye worm) cysteine protease 0.0121 0.0643 0.0643
Schistosoma mansoni biogenic amine (5HT) receptor 0.1172 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.1172 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0121 0.0643 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.1172 1 1
Schistosoma mansoni neuropeptide receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Echinococcus granulosus dro:myosuppressin receptor 0.1172 1 1
Echinococcus granulosus somatostatin receptor 0.1172 1 1
Brugia malayi Dopamine receptor protein 2 0.1172 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.1172 1 1
Echinococcus granulosus g protein coupled receptor 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Echinococcus granulosus serotonin receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Loa Loa (eye worm) fucosyl transferase 0.0097 0.0425 0.0425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0121 0.0643 1
Echinococcus multilocularis neuropeptides capa receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Echinococcus multilocularis g-protein coupled receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.1172 1 1
Brugia malayi neuropeptide F receptor 0.1172 1 1
Schistosoma mansoni amine GPCR 0.1172 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0121 0.0643 0.0531
Echinococcus multilocularis neuropeptide Y receptor 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Leishmania major cathepsin L-like protease 0.0462 0.3675 1
Schistosoma mansoni opsin-like receptor 0.1172 1 1
Echinococcus multilocularis g protein coupled receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis g protein coupled receptor 0.1172 1 1
Schistosoma mansoni adenoreceptor 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Echinococcus granulosus neuropeptides capa receptor 0.1172 1 1
Echinococcus granulosus neuropeptide receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Echinococcus multilocularis orexin receptor type 2 0.1172 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1172 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.1172 1 1
Brugia malayi RE15519p 0.1172 1 1
Echinococcus multilocularis serotonin receptor 0.1172 1 1
Schistosoma mansoni myosin xvIII 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Echinococcus multilocularis cysteine protease 0.0121 0.0643 0.0531
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Schistosoma mansoni alpha(13)fucosyltransferase 0.0097 0.0425 0.0368
Plasmodium vivax vivapain-2 0.0121 0.0643 1
Echinococcus multilocularis cysteine protease 0.0121 0.0643 0.0531
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1172 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Plasmodium vivax vivapain-2 0.0121 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Brugia malayi ORL1-like opioid receptor 0.1172 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Brugia malayi GnHR receptor homolog 0.1172 1 1
Echinococcus granulosus g protein coupled receptor 0.1172 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0081 0.0286 0.0286
Onchocerca volvulus 0.0121 0.0643 0.0367
Onchocerca volvulus Cathepsin F homolog 0.0121 0.0643 0.0367
Echinococcus multilocularis g protein coupled receptor 0.1172 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0119 0.006
Echinococcus granulosus neuropeptide receptor 0.1172 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.1172 1 1
Echinococcus multilocularis sex peptide receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni alpha(13)fucosyltransferase 0.0097 0.0425 0.0368
Echinococcus multilocularis G protein coupled receptor 139 0.1172 1 1
Entamoeba histolytica cysteine protease, putative 0.0121 0.0643 1
Entamoeba histolytica cysteine proteinase, putative 0.0081 0.0286 0.3182
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Brugia malayi follicle stimulating hormone receptor 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1172 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.1172 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0081 0.0286 0.0286
Onchocerca volvulus 0.1172 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Onchocerca volvulus 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0121 0.0643 0.0587
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.0901 0.7583 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.1172 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0118 0.0059
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1172 1 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.0118 0.0118
Brugia malayi G protein-coupled receptor F59B2.13 0.1172 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0121 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.1172 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0462 0.3675 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.1172 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.1172 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1172 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0121 0.0643 1
Echinococcus multilocularis fmrfamide receptor 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0081 0.0286 0.0286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Echinococcus granulosus biogenic amine 5HT receptor 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Echinococcus granulosus cathepsin L cysteine protease 0.0062 0.0119 0.0001
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) ctsf protein 0.0121 0.0643 0.0643
Echinococcus granulosus g-protein coupled receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Brugia malayi RNA binding protein 0.0062 0.0118 0.0118
Echinococcus granulosus neuropeptide Y receptor 0.1172 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.1172 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0462 0.3675 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.1172 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1172 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.1172 1 1
Echinococcus granulosus neuropeptides capa receptor 0.1172 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0121 0.0643 0.1472
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0119 0.0119
Onchocerca volvulus Cathepsin L homolog 0.0121 0.0643 0.0367
Brugia malayi Dopamine receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Toxoplasma gondii cathepsin CPL 0.0121 0.0643 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni biogenic amine receptor 0.1172 1 1
Brugia malayi Serotonin receptor 0.1172 1 1
Echinococcus granulosus neuropeptide Y receptor 0.1172 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.1172 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.1172 1 1
Brugia malayi G-protein coupled receptor 0.1172 1 1
Brugia malayi Fucosyl transferase family protein 0.0097 0.0425 0.0425
Schistosoma mansoni alpha-1 adrenergic receptor 0.1172 1 1
Brugia malayi alpha1,3-fucosyltransferase homologue 0.0097 0.0425 0.0425
Echinococcus granulosus neuropeptide receptor A26 0.1172 1 1
Schistosoma mansoni hypothetical protein 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Schistosoma mansoni alpha(13)fucosyltransferase 0.0097 0.0425 0.0368
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.1172 1 1
Echinococcus granulosus sex peptide receptor 0.1172 1 1
Echinococcus granulosus cysteine protease 0.0062 0.0119 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Schistosoma mansoni alpha(13)fucosyltransferase 0.0097 0.0425 0.0368
Brugia malayi hypothetical protein 0.1172 1 1
Schistosoma mansoni amine GPCR 0.1172 1 1
Echinococcus granulosus G protein coupled receptor 139 0.1172 1 1
Brugia malayi cathepsin L-like precursor 0.0081 0.0286 0.0286
Brugia malayi sulfakinin receptor protein 0.1172 1 1
Loa Loa (eye worm) fibroinase 0.0121 0.0643 0.0643
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0121 0.0643 0.0531
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0901 0.7583 0.5
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0121 0.0643 0.0643
Brugia malayi Melatonin receptor type 1A 0.1172 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1172 1 1
Schistosoma mansoni histamine h1 receptor 0.1172 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1172 1 1
Echinococcus granulosus g protein coupled receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Leishmania major cathepsin L-like protease 0.0462 0.3675 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0121 0.0643 0.0643
Loa Loa (eye worm) neuropeptide F receptor 0.1172 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0121 0.0643 0.0587
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Brugia malayi G-protein coupled receptor 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Onchocerca volvulus 0.1172 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0121 0.0643 0.0531
Onchocerca volvulus 0.1172 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0286 0.0286
Brugia malayi AKH receptor 0.1172 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0118 0.0118
Schistosoma mansoni biogenic amine receptor 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0121 0.0643 0.0531
Echinococcus multilocularis serotonin receptor 0.1172 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0118 0.0059
Brugia malayi gonadotropin-releasing hormone receptor 2 0.1172 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0121 0.0643 0.0531
Schistosoma mansoni biogenic amine receptor 0.1172 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0121 0.0643 1
Schistosoma mansoni alpha(13)fucosyltransferase 0.0097 0.0425 0.0368
Onchocerca volvulus 0.1172 1 1
Brugia malayi neuropeptide F receptor 0.1172 1 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 2.66 Mutagenic activity of the compound was tested in an Ames test on S. typhimurium TA98; Activity is log of revertants/nmol ChEMBL. 1995902
logP (ADMET) = 3 Partition coefficient (logP) ChEMBL. 1995902

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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