Detailed information for compound 283253

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 345.143 | Formula: C13H13BrO6
  • H donors: 3 H acceptors: 4 LogP: 1.56 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(C1OC(=C(C1=O)OCc1ccc(cc1)Br)O)O
  • InChi: 1S/C13H13BrO6/c14-8-3-1-7(2-4-8)6-19-12-10(17)11(9(16)5-15)20-13(12)18/h1-4,9,11,15-16,18H,5-6H2
  • InChiKey: DVRWAUJZRNXVJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis NMDA receptor 0.004 0.0091 0.0091
Echinococcus granulosus acetylcholinesterase 0.0067 0.0592 0.0592
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0095 0.114 0.1136
Schistosoma mansoni sodium/chloride dependent transporter 0.0095 0.114 0.1136
Loa Loa (eye worm) ShTK domain-containing protein 0.0096 0.1144 0.114
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.004 0.0091 0.0091
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0071 0.0672 0.5249
Loa Loa (eye worm) hypothetical protein 0.0095 0.114 0.1136
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0071 0.0672 0.2086
Echinococcus multilocularis acetylcholinesterase 0.0067 0.0592 0.0592
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0103 0.1281 0.1384
Toxoplasma gondii NADPH-glutathione reductase 0.0071 0.0672 0.2086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1124 0.112
Echinococcus granulosus acetylcholinesterase 0.0067 0.0592 0.0592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1124 0.112
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.2374 0.2374
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0071 0.0672 0.0597
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0071 0.0672 0.0672
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0071 0.0672 0.0668
Loa Loa (eye worm) pyridoxal-dependent decarboxylase 0.0046 0.0212 0.0207
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0095 0.114 0.1136
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0095 0.114 0.3548
Echinococcus granulosus carboxylesterase 5A 0.0067 0.0592 0.0592
Schistosoma mansoni alpha-glucosidase 0.0138 0.195 0.1946
Brugia malayi hypothetical protein 0.016 0.2371 0.2371
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0067 0.0592 0.0588
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0095 0.114 0.1136
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0095 0.114 0.1136
Echinococcus multilocularis carboxylesterase 5A 0.0067 0.0592 0.0592
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0071 0.0672 0.2086
Trypanosoma brucei trypanothione reductase 0.0204 0.3206 1
Onchocerca volvulus 0.0113 0.1473 0.1473
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0676 0.0672
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0095 0.114 0.114
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0061 0.0481 0.0481
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0005 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0676 0.5278
Brugia malayi PAS domain containing protein 0.0048 0.0236 0.0236
Onchocerca volvulus 0.0046 0.0212 0.0212
Brugia malayi beta-lactamase family protein 0.0071 0.0676 0.0676
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0353 0.0349
Echinococcus granulosus geminin 0.0183 0.2811 0.2811
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0071 0.0672 0.0597
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0672 0.2086
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0676 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0005 0.0005
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0676 0.0601
Leishmania major hypothetical protein, conserved 0.0071 0.0676 0.2097
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.2135 0.2131
Onchocerca volvulus 0.0562 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0672 0.2086
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0562 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0204 0.3206 0.3206
Loa Loa (eye worm) hypothetical protein 0.0095 0.114 0.1136
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0074 0.0726 0.021
Leishmania major ornithine decarboxylase, putative 0.0046 0.0212 0.0647
Loa Loa (eye worm) hypothetical protein 0.0113 0.1473 0.1469
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0091 0.0086
Mycobacterium ulcerans lipase LipD 0.0071 0.0676 0.5278
Brugia malayi glutathione reductase 0.0204 0.3206 0.3206
Schistosoma mansoni glutamate receptor kainate 0.004 0.0091 0.0086
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.2374 0.2374
Loa Loa (eye worm) tyrosinase 1 0.0096 0.1144 0.114
Echinococcus granulosus glutamate NMDA receptor subunit 0.004 0.0091 0.0091
Echinococcus multilocularis glutamate receptor 2 0.0061 0.0481 0.0481
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0071 0.0672 0.2086
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0113 0.1473 0.1469
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0095 0.114 0.1136
Trichomonas vaginalis mercuric reductase, putative 0.0071 0.0672 0.9946
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0061 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.0096 0.1144 0.114
Loa Loa (eye worm) beta-lactamase 0.0071 0.0676 0.0672
Echinococcus multilocularis nmda type glutamate receptor 0.0143 0.2043 0.2043
Loa Loa (eye worm) ShTK domain-containing protein 0.0096 0.1144 0.114
Echinococcus granulosus sodium and chloride dependent glycine 0.0095 0.114 0.114
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0143 0.2043 0.2043
Echinococcus multilocularis serotonin transporter 0.0562 1 1
Trichomonas vaginalis pyridoxal-dependent decarboxylase, putative 0.0046 0.0212 0.3083
Brugia malayi Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein 0.0046 0.0212 0.0212
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0071 0.0672 0.2086
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0071 0.0672 0.5249
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0071 0.0672 0.5249
Schistosoma mansoni sodium/chloride dependent transporter 0.0562 1 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0095 0.114 0.1136
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0676 0.0601
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0091 0.0086
Schistosoma mansoni lipoxygenase 0.0081 0.0866 0.0861
Schistosoma mansoni hypothetical protein 0.004 0.0091 0.0086
Onchocerca volvulus 0.0071 0.0676 0.0676
Onchocerca volvulus 0.0095 0.114 0.114
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0676 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1124 0.1124
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0095 0.114 0.1136
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0676 0.0014
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0095 0.114 0.1136
Echinococcus multilocularis sodium and chloride dependent glycine 0.0095 0.114 0.114
Echinococcus granulosus glutamate receptor ionotropic kainate 0.004 0.0091 0.0091
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0061 0.0481 0.0481
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0095 0.114 0.3548
Echinococcus multilocularis glutamate receptor subunit protein glur 0.004 0.0091 0.0091
Brugia malayi Common central domain of tyrosinase family protein 0.0096 0.1144 0.1144
Onchocerca volvulus 0.0095 0.114 0.114
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0672 0.2086
Brugia malayi Cation transporter family protein 0.0113 0.1473 0.1473
Onchocerca volvulus 0.0113 0.1473 0.1473
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0095 0.114 0.114
Loa Loa (eye worm) hypothetical protein 0.0071 0.0676 0.0672
Loa Loa (eye worm) hypothetical protein 0.0113 0.1473 0.1469
Loa Loa (eye worm) norepinephrine transporter 0.0562 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0676 1
Mycobacterium tuberculosis Conserved protein 0.0071 0.0676 0.0601
Onchocerca volvulus 0.0093 0.109 0.109
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0676 0.0601
Loa Loa (eye worm) hypothetical protein 0.0097 0.117 0.1166
Schistosoma mansoni alpha-glucosidase 0.0138 0.195 0.1946
Onchocerca volvulus 0.0096 0.1144 0.1144
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0005 0.0005
Echinococcus multilocularis thioredoxin glutathione reductase 0.0204 0.3206 0.3206
Loa Loa (eye worm) acetylcholinesterase 1 0.0067 0.0592 0.0588
Leishmania major trypanothione reductase 0.0204 0.3206 1
Brugia malayi Carboxylesterase family protein 0.0067 0.0592 0.0592
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0676 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0676 0.0672
Entamoeba histolytica ornithine decarboxylase, putative 0.0046 0.0212 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0353 0.0349
Mycobacterium ulcerans hypothetical protein 0.0071 0.0676 0.5278
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1124 0.1124
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0453 0.7936 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0676 0.0676
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0095 0.114 0.114
Plasmodium vivax hypothetical protein, conserved 0.0095 0.114 0.1847
Schistosoma mansoni ATP-binding cassette transporter 0.004 0.0091 0.0086
Plasmodium falciparum glutathione reductase 0.0204 0.3206 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0029 0.0029
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.004 0.0091 0.0091
Schistosoma mansoni tyrosinase precursor 0.0096 0.1144 0.114
Loa Loa (eye worm) hypothetical protein 0.016 0.2371 0.2367
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0353 0.0353
Mycobacterium tuberculosis Conserved protein 0.0071 0.0676 0.0601
Plasmodium vivax thioredoxin reductase, putative 0.0204 0.3206 1
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0676 0.2097
Toxoplasma gondii diaminopimelate decarboxylase 0.0046 0.0212 0.0647
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0676 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0676 0.2097
Echinococcus multilocularis geminin 0.0183 0.2811 0.2811
Toxoplasma gondii hypothetical protein 0.0095 0.114 0.3548
Schistosoma mansoni hypothetical protein 0.0037 0.0029 0.0025
Loa Loa (eye worm) hypothetical protein 0.0071 0.0676 0.0672
Schistosoma mansoni glutamate receptor NMDA 0.0061 0.0481 0.0477
Loa Loa (eye worm) hypothetical protein 0.0095 0.114 0.1136
Loa Loa (eye worm) hypothetical protein 0.0096 0.1144 0.114
Chlamydia trachomatis glutamine binding protein 0.0103 0.1281 1
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.004 0.0091 0.0091
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1124 0.1124
Loa Loa (eye worm) thioredoxin reductase 0.0204 0.3206 0.3203
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0071 0.0672 0.2086
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.004 0.0091 0.0091
Schistosoma mansoni hypothetical protein 0.0183 0.2811 0.2808
Plasmodium vivax amine transporter, putative 0.0095 0.114 0.1847
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0095 0.114 0.1136
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0095 0.114 0.114
Loa Loa (eye worm) glutamate receptor 1 0.004 0.0091 0.0086
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0071 0.0672 0.0672
Loa Loa (eye worm) carboxylesterase 0.0067 0.0592 0.0588
Echinococcus granulosus glutamate receptor 2 0.0061 0.0481 0.0481
Schistosoma mansoni glutamate receptor kainate 0.004 0.0091 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1124 0.112
Schistosoma mansoni glutamate receptor NMDA 0.004 0.0091 0.0086
Loa Loa (eye worm) hypothetical protein 0.0095 0.114 0.1136
Mycobacterium tuberculosis Probable oxidoreductase 0.0071 0.0672 0.0597
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0095 0.114 0.114
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0061 0.0481 0.0481
Trypanosoma cruzi trypanothione reductase, putative 0.0204 0.3206 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0562 1 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0061 0.0481 0.0481
Toxoplasma gondii hypothetical protein 0.0095 0.114 0.3548
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0676 0.0601
Loa Loa (eye worm) hypothetical protein 0.0067 0.0592 0.0588
Loa Loa (eye worm) solute carrier family 6 member 4 0.0562 1 1
Toxoplasma gondii thioredoxin reductase 0.0204 0.3206 1
Brugia malayi ShTK domain containing protein 0.0096 0.1144 0.1144
Loa Loa (eye worm) hypothetical protein 0.0071 0.0676 0.0672
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0676 0.0672
Mycobacterium leprae Probable lipase LipE 0.0071 0.0676 1
Loa Loa (eye worm) glutathione reductase 0.0204 0.3206 0.3203
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0676 0.2097
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0071 0.0672 0.0597
Schistosoma mansoni lipoxygenase 0.0116 0.1527 0.1523
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0071 0.0672 0.2086
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1124 0.112
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0676 0.0676
Loa Loa (eye worm) serotonin transporter b 0.0562 1 1
Onchocerca volvulus 0.0096 0.1144 0.1144
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0676 0.0601
Brugia malayi follicle stimulating hormone receptor 0.0261 0.4284 0.4284
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.004 0.0091 0.0091
Plasmodium falciparum amino acid transporter, putative 0.0095 0.114 0.1847
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0095 0.114 0.3548
Echinococcus granulosus sodium and chloride dependent glycine 0.0095 0.114 0.114
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0236 0.0231
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0672 0.2086
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0676 0.5278
Trypanosoma brucei ornithine decarboxylase 0.0046 0.0212 0.0647
Onchocerca volvulus 0.0096 0.1144 0.1144
Echinococcus multilocularis acetylcholinesterase 0.0067 0.0592 0.0592
Loa Loa (eye worm) hypothetical protein 0.0095 0.114 0.1136
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0676 1
Schistosoma mansoni hypothetical protein 0.0183 0.2811 0.2808
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0095 0.114 0.114
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.2374 0.2371
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0095 0.114 0.1136
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0095 0.114 0.7689
Loa Loa (eye worm) hypothetical protein 0.0037 0.0029 0.0025
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0204 0.3206 0.3877
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0096 0.1144 0.1144
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0103 0.1281 0.0652
Onchocerca volvulus 0.0096 0.1144 0.1144
Trichomonas vaginalis diaminopimelate decarboxylase, putative 0.0046 0.0212 0.3083
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0095 0.114 0.114
Schistosoma mansoni glutamate receptor kainate 0.004 0.0091 0.0086
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0071 0.0672 0.2086
Echinococcus granulosus glutamate receptor subunit protein glur 0.004 0.0091 0.0091
Trypanosoma cruzi trypanothione reductase, putative 0.0071 0.0672 0.2086
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0071 0.0672 0.2086
Onchocerca volvulus 0.0071 0.0676 0.0676
Loa Loa (eye worm) hypothetical protein 0.0095 0.114 0.1136
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0071 0.0672 0.5
Echinococcus granulosus serotonin transporter 0.0562 1 1
Brugia malayi beta-lactamase 0.0071 0.0676 0.0676
Onchocerca volvulus 0.0071 0.0676 0.0676
Schistosoma mansoni tyrosinase precursor 0.0096 0.1144 0.114
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0095 0.114 0.114
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0103 0.1281 1
Brugia malayi hypoxia-induced factor 1 0.0148 0.2135 0.2135
Trichomonas vaginalis ornithine decarboxylase, putative 0.0046 0.0212 0.3083
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0095 0.114 0.114
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0095 0.114 0.114
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0052 0.0316 0.0316
Echinococcus multilocularis sodium and chloride dependent glycine 0.0095 0.114 0.114
Loa Loa (eye worm) hypothetical protein 0.0067 0.0592 0.0588
Loa Loa (eye worm) hypothetical protein 0.0562 1 1
Trichomonas vaginalis esterase, putative 0.0071 0.0676 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.1527 0.1527
Echinococcus multilocularis glutamate receptor 2 0.004 0.0091 0.0091
Brugia malayi Thioredoxin reductase 0.0204 0.3206 0.3206
Brugia malayi hypothetical protein 0.0095 0.114 0.114
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0052 0.0316 0.0316
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0096 0.1144 0.1144
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0074 0.0726 0.021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0672 0.2086
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0071 0.0672 0.5
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0103 0.1281 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0353 0.0353
Brugia malayi Glutamate receptor 2 precursor 0.004 0.0091 0.0091
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0676 0.0676
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0071 0.0672 0.2086
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.2374 0.2374
Plasmodium falciparum transporter, putative 0.0095 0.114 0.1847
Loa Loa (eye worm) glutamate receptor 2 0.004 0.0091 0.0086
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.2374 0.2374
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0061 0.0481 0.0481
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1124 0.1124
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0061 0.0481 0.0481
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0071 0.0672 0.2086
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0095 0.114 0.114
Schistosoma mansoni sodium/chloride dependent transporter 0.0095 0.114 0.1136
Mycobacterium ulcerans beta-lactamase 0.0071 0.0676 0.5278
Loa Loa (eye worm) hypothetical protein 0.0562 1 1
Plasmodium falciparum thioredoxin reductase 0.0204 0.3206 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0113 0.1473 0.1469
Trichomonas vaginalis ornithine decarboxylase, putative 0.0046 0.0212 0.3083
Brugia malayi Glutamate receptor 1 precursor 0.004 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0071 0.0676 0.0672
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0071 0.0672 0.2086
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.1527 0.1527
Trichomonas vaginalis glutathione reductase, putative 0.0071 0.0672 0.9946
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1124 0.1124
Mycobacterium tuberculosis Conserved protein 0.0071 0.0676 0.0601
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0261 0.4284 0.4281
Onchocerca volvulus 0.0095 0.114 0.114
Brugia malayi Carboxylesterase family protein 0.0067 0.0592 0.0592
Brugia malayi beta-lactamase family protein 0.0071 0.0676 0.0676
Trichomonas vaginalis diaminopimelate decarboxylase, putative 0.0046 0.0212 0.3083
Schistosoma mansoni sodium-dependent amino acid transporter 0.0095 0.114 0.1136
Loa Loa (eye worm) hypothetical protein 0.0071 0.0676 0.0672
Toxoplasma gondii ABC1 family protein 0.0071 0.0676 0.2097
Mycobacterium ulcerans diaminopimelate decarboxylase LysA 0.0046 0.0212 0.1652
Plasmodium vivax glutathione reductase, putative 0.0204 0.3206 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0071 0.0672 0.0672
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0676 0.0672
Loa Loa (eye worm) hypothetical protein 0.0095 0.114 0.1136
Echinococcus granulosus nmda type glutamate receptor 0.0143 0.2043 0.2043
Schistosoma mansoni single-minded 0.0048 0.0236 0.0231
Onchocerca volvulus 0.0113 0.1473 0.1473
Giardia lamblia NADH oxidase lateral transfer candidate 0.0071 0.0672 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0672 0.2086
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0061 0.0481 0.0481
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0096 0.1144 0.1144
Loa Loa (eye worm) hypothetical protein 0.0562 1 1
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0096 0.1144 0.1144
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0676 0.0601
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0676 0.0601
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0103 0.1281 0.0652

Activities

Activity type Activity value Assay description Source Reference
Antilipid peroxidation (functional) NT 0 % Antilipid peroxidation of the compound was determined; - denotes No effects ChEMBL. 3351858

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.