Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | < 10 % | Displacement of specific [125I]-AB-MECA binding from human Adenosine A3 receptor expressed in HEK-293 cells | ChEMBL. | 8576921 |
Displacement (binding) | < 10 % | Displacement of specific [125I]-AB-MECA binding from human Adenosine A3 receptor expressed in HEK-293 cells | ChEMBL. | 8576921 |
Ki (binding) | = 7.1 uM | Displacement of specific [3H]-PIA binding from adenosine A1 receptor in rat brain membranes. | ChEMBL. | 8576921 |
Ki (binding) | = 7.1 uM | Displacement of specific [3H]-PIA binding from adenosine A1 receptor in rat brain membranes. | ChEMBL. | 8576921 |
Ki (binding) | = 29.9 uM | Affinity at Adenosine A2A receptor in rat striatal membranes by [3H]- CGS 21680 displacement. | ChEMBL. | 8576921 |
Ki (binding) | = 29.9 uM | Affinity at Adenosine A2A receptor in rat striatal membranes by [3H]- CGS 21680 displacement. | ChEMBL. | 8576921 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.