TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 982.179 | Formula: C47H75N13O10
H donors: 11 H acceptors: 10 LogP: -0.8 Rotable bonds: 36
Rule of 5 violations (Lipinski): 3
SMILES: CNCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(CC)C)C(=O)O)Cc1c[nH]cn1)C(CC)C)Cc1ccc(cc1)OC)C(C)C)CCCN=C(N)N
InChi: 1S/C47H75N13O10/c1-9-27(5)38(44(66)56-34(22-30-23-51-25-53-30)45(67)60-20-12-14-35(60)42(64)59-39(46(68)69)28(6)10-2)58-41(63)33(21-29-15-17-31(70-8)18-16-29)55-43(65)37(26(3)4)57-40(62)32(54-36(61)24-50-7)13-11-19-52-47(48)49/h15-18,23,25-28,32-35,37-39,50H,9-14,19-22,24H2,1-8H3,(H,51,53)(H,54,61)(H,55,65)(H,56,66)(H,57,62)(H,58,63)(H,59,64)(H,68,69)(H4,48,49,52)
InChiKey: CJJRANANVDTGEN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tensin	0.0055	0.0072	0.0057
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0061	0.0088	0.0088
Brugia malayi	Variant SH3 domain containing protein	0.0055	0.0072	0.2238
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0129	0.0269	0.0255
Echinococcus granulosus	epidermal growth factor receptor	0.0074	0.0123	0.0108
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Echinococcus granulosus	kinase suppressor of Ras 1	0.0074	0.0123	0.0108
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.0269	1
Echinococcus granulosus	integrin linked protein kinase	0.0074	0.0123	0.0108
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0076	0.0127	0.0127
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Loa Loa (eye worm)	TK/CSK protein kinase	0.0074	0.0123	0.4244
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Loa Loa (eye worm)	TK/ALK protein kinase	0.0074	0.0123	0.4244
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0074	0.0123	0.0123
Loa Loa (eye worm)	SH2 domain-containing protein	0.0055	0.0072	0.2238
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.3784	1	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0123	0.4244
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0055	0.0072	0.0057
Echinococcus granulosus	tensin	0.0055	0.0072	0.0057
Entamoeba histolytica	protein kinase domain containing protein	0.0123	0.0253	0.0229
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0129	0.0269	0.0255
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.3784	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0055	0.0072	0.0057
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Echinococcus granulosus	tyrosine protein kinase HCK	0.0074	0.0123	0.0108
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0000010674	0.0000010674
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Leishmania major	protein kinase, putative	0.0123	0.0253	0.0229
Schistosoma mansoni	tyrosine kinase	0.0129	0.0269	0.0255
Loa Loa (eye worm)	TK/EPH protein kinase	0.0074	0.0123	0.4244
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0037	0.0024	0.0372
Loa Loa (eye worm)	TK protein kinase	0.0074	0.0123	0.4244
Brugia malayi	Furin-like cysteine rich region family protein	0.0074	0.0123	0.4244
Loa Loa (eye worm)	TK/ROR protein kinase	0.0074	0.0123	0.4244
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0074	0.0123	0.0108
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0074	0.0123	0.0099
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0055	0.0072	0.0057
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0074	0.0123	0.0099
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0074	0.0123	0.0108
Giardia lamblia	Rrm3p helicase	0.3784	1	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0108	0.0212	0.7762
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0076	0.0127	0.45
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Echinococcus multilocularis	protein tyrosine kinase	0.0074	0.0123	0.0108
Onchocerca volvulus		0.0074	0.0123	0.2584
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0074	0.0123	0.432
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0129	0.0269	0.0255
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Onchocerca volvulus		0.0129	0.0269	1
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0074	0.0123	0.0108
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0055	0.0072	0.0057
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0129	0.0269	0.0255
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0074	0.0123	0.0108
Echinococcus granulosus	SH2 domain containing protein 7	0.0055	0.0072	0.0057
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0055	0.0072	0.0057
Toxoplasma gondii	aurora kinase	0.0123	0.0253	1
Onchocerca volvulus		0.0129	0.0269	1
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0074	0.0123	0.4244
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Echinococcus multilocularis	tyrosine protein kinase csk	0.0074	0.0123	0.0108
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0074	0.0123	0.0099
Brugia malayi	C-terminal src kinase protein 1	0.0074	0.0123	0.4244
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.2238
Schistosoma mansoni	protein kinase	0.0074	0.0123	0.0108
Schistosoma mansoni	tensin	0.0055	0.0072	0.0057
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0074	0.0123	0.0108
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.0269	1
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Schistosoma mansoni	protein kinase	0.0074	0.0123	0.0108
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0000010674	0.0000010674
Echinococcus granulosus	hypothetical protein	0.0055	0.0072	0.0057
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0055	0.0072	0.2238
Brugia malayi	Protein kinase domain containing protein	0.0129	0.0269	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.0269	1
Schistosoma mansoni	hypothetical protein	0.0074	0.0123	0.0108
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.0269	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0074	0.0123	0.0108
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0076	0.0127	0.0127
Echinococcus multilocularis	FL cytokine receptor	0.0074	0.0123	0.0108
Echinococcus granulosus	tyrosine protein kinase pr2	0.0074	0.0123	0.0108
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Loa Loa (eye worm)	TK protein kinase	0.0074	0.0123	0.4244
Entamoeba histolytica	hypothetical protein	0.0074	0.0123	0.0099
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0074	0.0123	0.0108
Entamoeba histolytica	hypothetical protein	0.0074	0.0123	0.0099
Loa Loa (eye worm)	TK/FER protein kinase	0.0074	0.0123	0.4244
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0129	0.0269	0.0255
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Echinococcus multilocularis	insulin receptor	0.0074	0.0123	0.0108
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0074	0.0123	0.4244
Entamoeba histolytica	hypothetical protein	0.0074	0.0123	0.0099
Schistosoma mansoni	protein kinase	0.0076	0.0127	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.2238
Echinococcus granulosus	SH2 motif	0.0055	0.0072	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0123	0.4244
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0074	0.0123	0.0108
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0074	0.0123	0.4244
Trichomonas vaginalis	AGC family protein kinase	0.0123	0.0253	0.0229
Schistosoma mansoni	growth factor receptor-bound protein	0.0055	0.0072	0.0057
Echinococcus granulosus	N chimaerin	0.0055	0.0072	0.0057
Echinococcus multilocularis	signal transduction protein lnk realted	0.0055	0.0072	0.0057
Schistosoma mansoni	serine/threonine protein kinase	0.0123	0.0253	0.0238
Echinococcus multilocularis	protein kinase	0.0074	0.0123	0.0108
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0074	0.0123	0.0108
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0074	0.0123	0.0108
Schistosoma mansoni	protein kinase	0.0074	0.0123	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0123	0.0108
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0055	0.0072	0.0057
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0000010674	0.0000010674
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Echinococcus multilocularis	protein kinase	0.0074	0.0123	0.0108
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0074	0.0123	0.0108
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0055	0.0072	0.0057
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Echinococcus granulosus	activin receptor type	0.0076	0.0127	0.0112
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0055	0.0072	0.2238
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0074	0.0123	0.0099
Brugia malayi	SH2 domain containing protein	0.0055	0.0072	0.2238
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0074	0.0123	0.0108
Entamoeba histolytica	serine/threonine kinase, putative	0.0074	0.0123	0.0099
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Onchocerca volvulus		0.0074	0.0123	0.2584
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0061	0.0088	0.0074
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0000010674	0.0000010674
Brugia malayi	hypothetical protein	0.0055	0.0072	0.2238
Schistosoma mansoni	ephrin receptor	0.0074	0.0123	0.0108
Echinococcus granulosus	tyrosine kinase	0.0074	0.0123	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Loa Loa (eye worm)	TK protein kinase	0.0074	0.0123	0.4244
Onchocerca volvulus		0.0129	0.0269	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0074	0.0123	0.0099
Entamoeba histolytica	hypothetical protein, conserved	0.0074	0.0123	0.0099
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0055	0.0072	0.2238
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Leishmania major	protein kinase, putative	0.0076	0.0127	0.0103
Brugia malayi	serine/threonine-protein kinase 6	0.0123	0.0253	0.9335
Schistosoma mansoni	protein tyrosine kinase	0.0074	0.0123	0.0108
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0123	0.0253	0.0238
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0123	0.0253	0.0238
Echinococcus multilocularis	aurora kinase A	0.0123	0.0253	0.0238
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0129	0.0269	0.0255
Schistosoma mansoni	serine/threonine protein kinase	0.0061	0.0088	0.0074
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.3784	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0123	0.0108
Echinococcus multilocularis	tyrosine protein kinase shark	0.0129	0.0269	0.0255
Loa Loa (eye worm)	cytochrome P450 family protein	0.0044	0.0043	0.1129
Loa Loa (eye worm)	serine/threonine protein kinase	0.0074	0.0123	0.4244
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0074	0.0123	0.4244
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0123	0.0253	1
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Loa Loa (eye worm)	AUR protein kinase	0.0123	0.0253	0.9335
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0129	0.0269	0.0255
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0074	0.0123	0.0108
Entamoeba histolytica	cysteine surface protein, putative	0.0074	0.0123	0.0099
Trypanosoma brucei	ubiquitin-protein ligase, putative	0.0037	0.0024	0.0024
Schistosoma mansoni	protein kinase	0.0074	0.0123	0.0108
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0129	0.0269	0.0255
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Echinococcus granulosus	SH2 motif	0.0055	0.0072	0.0057
Echinococcus multilocularis	epidermal growth factor receptor	0.0074	0.0123	0.0108
Echinococcus multilocularis	tyrosine protein kinase csk	0.0074	0.0123	0.0108
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Schistosoma mansoni	tyrosine protein kinase	0.0074	0.0123	0.0108
Loa Loa (eye worm)	TK/FER protein kinase	0.0074	0.0123	0.4244
Entamoeba histolytica	ankyrin repeat protein	0.0074	0.0123	0.0099
Echinococcus multilocularis		0.0055	0.0072	0.0057
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0074	0.0123	0.432
Echinococcus multilocularis	epidermal growth factor receptor	0.0074	0.0123	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Entamoeba histolytica	hypothetical protein	0.0074	0.0123	0.0099
Loa Loa (eye worm)	TK protein kinase	0.0074	0.0123	0.4244
Echinococcus multilocularis	transfer RNA-Thr	0.0074	0.0123	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0074	0.0123	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0123	0.0099
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0129	0.0269	0.0255
Onchocerca volvulus		0.0129	0.0269	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.0269	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0074	0.0123	0.0099
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0074	0.0123	0.0108
Echinococcus granulosus	protein kinase	0.0074	0.0123	0.0108
Plasmodium vivax	protein kinase, putative	0.0074	0.0123	0.432
Onchocerca volvulus		0.0074	0.0123	0.2584
Giardia lamblia	Kinase, NEK	0.0074	0.0123	0.0035
Entamoeba histolytica	tyrosin kinase, putative	0.0074	0.0123	0.0099
Loa Loa (eye worm)	SH2 domain-containing protein	0.0055	0.0072	0.2238
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Loa Loa (eye worm)	AUR protein kinase	0.0123	0.0253	0.9335
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.2238
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Brugia malayi	Protein kinase domain containing protein	0.0129	0.0269	1
Entamoeba histolytica	hypothetical protein	0.0074	0.0123	0.0099
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Schistosoma mansoni	GTPase activating protein	0.0055	0.0072	0.0057
Echinococcus granulosus	expressed conserved protein	0.0055	0.0072	0.0057
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0074	0.0123	0.4244
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0123	0.4244
Onchocerca volvulus		0.0129	0.0269	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0129	0.0269	0.0255
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0129	0.0269	0.0255
Echinococcus granulosus	tyrosine protein kinase Blk	0.0129	0.0269	0.0255
Entamoeba histolytica	protein kinase domain containing protein	0.0076	0.0127	0.0103
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Giardia lamblia	Protein 21.1	0.0074	0.0123	0.0035
Onchocerca volvulus		0.0074	0.0123	0.2584
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0074	0.0123	0.0099
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.2238
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Brugia malayi	hypothetical protein	0.0129	0.0269	1
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Schistosoma mansoni	tensin-related	0.0055	0.0072	0.0057
Loa Loa (eye worm)	TK protein kinase	0.0074	0.0123	0.4244
Loa Loa (eye worm)	TK/FER protein kinase	0.0074	0.0123	0.4244
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.2238
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Brugia malayi	serine/threonine protein kinase 6	0.0123	0.0253	0.9335
Brugia malayi	Receptor family ligand binding region containing protein	0.0074	0.0123	0.4244
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0074	0.0123	0.4244
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0129	0.0269	0.0255
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0074	0.0123	0.4244
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Schistosoma mansoni	shc transforming protein	0.0055	0.0072	0.0057
Entamoeba histolytica	receptor protein kinase, putative	0.0074	0.0123	0.0099
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0061	0.0088	0.0088
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0055	0.0072	0.0057
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.0269	1
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Loa Loa (eye worm)	TK/RYK protein kinase	0.0074	0.0123	0.4244
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Brugia malayi	Ubiquitin conjugating enzyme protein 13	0.0037	0.0024	0.0372
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0055	0.0072	0.0057
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0074	0.0123	0.4244
Echinococcus multilocularis	SH2 motif	0.0055	0.0072	0.0057
Echinococcus multilocularis	tyrosine kinase	0.0129	0.0269	0.0255
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0076	0.0127	0.0112
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0074	0.0123	0.432
Echinococcus multilocularis	activin receptor type	0.0076	0.0127	0.0112
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.0123	0.0099
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0074	0.0123	0.2584
Loa Loa (eye worm)	TK protein kinase	0.0074	0.0123	0.4244
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.3784	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Toxoplasma gondii	protein kinase	0.0074	0.0123	0.432
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0129	0.0269	0.0255
Onchocerca volvulus		0.0074	0.0123	0.2584
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0129	0.0269	0.0255
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0055	0.0072	0.2238
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0074	0.0123	0.0108
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0074	0.0123	0.4244
Entamoeba histolytica	tyrosin kinase, putative	0.0074	0.0123	0.0099
Schistosoma mansoni	protein kinase	0.0074	0.0123	0.0108
Echinococcus multilocularis	N chimaerin	0.0055	0.0072	0.0057
Entamoeba histolytica	protein kinase , putative	0.0123	0.0253	0.0229
Entamoeba histolytica	ankyrin repeat protein	0.0074	0.0123	0.0099
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0074	0.0123	0.0099
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0055	0.0072	0.0057
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0074	0.0123	0.4244
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0123	0.0253	0.0229
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Trichomonas vaginalis	TK family protein kinase	0.0074	0.0123	0.0099
Giardia lamblia	Aurora kinase	0.0123	0.0253	0.0166
Loa Loa (eye worm)	AUR protein kinase	0.0123	0.0253	0.9335
Schistosoma mansoni	suppressor of cytokine signaling	0.0055	0.0072	0.0057
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0000010674	0.0000010674
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0061	0.0088	0.2804
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Brugia malayi	Variant SH3 domain containing protein	0.0055	0.0072	0.2238
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0074	0.0123	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Echinococcus multilocularis	tensin	0.0055	0.0072	0.0057
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0074	0.0123	0.0108
Schistosoma mansoni	protein kinase	0.0076	0.0127	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Brugia malayi	Protein kinase domain containing protein	0.0129	0.0269	1
Trichomonas vaginalis	STE family protein kinase	0.0074	0.0123	0.0099
Brugia malayi	RhoGAP domain containing protein	0.0055	0.0072	0.2238
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0074	0.0123	0.0108
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0074	0.0123	0.0108
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Loa Loa (eye worm)	TK/FAK protein kinase	0.0074	0.0123	0.4244
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0123	0.0253	1
Schistosoma mansoni	nck2/grb4	0.0055	0.0072	0.0057
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0074	0.0123	0.0108
Echinococcus multilocularis	integrin linked protein kinase	0.0074	0.0123	0.0108
Schistosoma mansoni	protein kinase	0.0074	0.0123	0.0108
Trypanosoma cruzi	aurora B kinase, putative	0.0123	0.0253	0.0253
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Loa Loa (eye worm)	TK/ABL protein kinase	0.0129	0.0269	1
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0000010674	0.0000010674
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0074	0.0123	0.0108
Trichomonas vaginalis	AGC family protein kinase	0.0123	0.0253	0.0229
Echinococcus granulosus	growth factor receptor bound protein 2	0.0055	0.0072	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.2238
Entamoeba histolytica	receptor protein kinase, putative	0.0074	0.0123	0.0099
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0074	0.0123	0.4244
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0074	0.0123	0.0099
Trypanosoma brucei	Pseudokinase, putative	0.0074	0.0123	0.0123
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Schistosoma mansoni	tyrosine kinase	0.0129	0.0269	0.0255
Entamoeba histolytica	hypothetical protein	0.0074	0.0123	0.0099
Brugia malayi	SH2 domain containing protein	0.0055	0.0072	0.2238
Loa Loa (eye worm)	TK/INSR protein kinase	0.0074	0.0123	0.4244
Leishmania major	hypothetical protein, conserved	0.0074	0.0123	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0123	0.4244
Loa Loa (eye worm)	TK/FER protein kinase	0.0074	0.0123	0.4244
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0074	0.0123	0.0099
Brugia malayi	Variant SH3 domain containing protein	0.0055	0.0072	0.2238
Loa Loa (eye worm)	TK/FER protein kinase	0.0074	0.0123	0.4244
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0074	0.0123	0.0099
Schistosoma mansoni	signal transduction protein lnk-related	0.0055	0.0072	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0027	0.0476
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0074	0.0123	0.0108
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0000010674	0.0000010674
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0129	0.0269	0.0246
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0074	0.0123	0.0108
Plasmodium falciparum	tyrosine kinase-like protein	0.0074	0.0123	0.432
Onchocerca volvulus		0.0074	0.0123	0.2584
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0074	0.0123	0.4244
Brugia malayi	Raf kinase	0.0074	0.0123	0.4244
Schistosoma mansoni	adapter molecule crk	0.0055	0.0072	0.0057
Loa Loa (eye worm)	TK protein kinase	0.0074	0.0123	0.4244
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0037	0.0024	0.0024
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0074	0.0123	0.0099
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0123	0.0253	0.0229
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0061	0.0088	0.0088
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0055	0.0072	0.0057
Echinococcus multilocularis	tyrosine protein kinase	0.0074	0.0123	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0123	0.4244
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Trypanosoma brucei	protein kinase, putative	0.0076	0.0127	0.0127
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0055	0.0072	0.0057
Brugia malayi	Tensin	0.0055	0.0072	0.2238
Entamoeba histolytica	tyrosin kinase, putative	0.0074	0.0123	0.0099
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Brugia malayi	Tyrosine-protein kinase PR2	0.0074	0.0123	0.4244
Echinococcus granulosus	activated cdc42 kinase 1	0.0074	0.0123	0.0108
Echinococcus multilocularis	tyrosine protein kinase csk	0.0074	0.0123	0.0108
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0074	0.0123	0.0108
Echinococcus granulosus	mitogen activated protein kinase	0.0061	0.0088	0.0074
Echinococcus multilocularis	NCK adaptor protein	0.0055	0.0072	0.0057
Echinococcus multilocularis	SH2 motif	0.0055	0.0072	0.0057
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0055	0.0072	0.0057
Echinococcus granulosus	ephrin type A receptor 4 A	0.0074	0.0123	0.0108
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.3784	1	1
Schistosoma mansoni	protein kinase	0.0074	0.0123	0.0108
Trypanosoma cruzi	protein kinase, putative	0.0074	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0123	0.4244
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0074	0.0123	0.0099
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Schistosoma mansoni	tyrosine kinase	0.0129	0.0269	0.0255
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0074	0.0123	0.0108
Onchocerca volvulus	Tyrosine kinase homolog	0.0074	0.0123	0.2584
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0074	0.0123	0.0099
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0074	0.0123	0.0108
Entamoeba histolytica	protein kinase, putative	0.0057	0.0076	0.0052
Entamoeba histolytica	hypothetical protein	0.0074	0.0123	0.0099
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0123	0.4244
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0074	0.0123	0.0099
Echinococcus multilocularis	ubiquitin conjugating enzyme E2 N	0.0037	0.0024	0.0009
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.0269	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0123	0.4244
Trichomonas vaginalis	AGC family protein kinase	0.0123	0.0253	0.0229
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0074	0.0123	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0123	0.4244
Loa Loa (eye worm)	STAT protein	0.0055	0.0072	0.2238
Entamoeba histolytica	hypothetical protein	0.0074	0.0123	0.0099
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0129	0.0269	0.0255
Onchocerca volvulus		0.0074	0.0123	0.2584
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0108	0.0212	0.7762
Plasmodium falciparum	protein kinase, putative	0.0076	0.0127	0.45
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0074	0.0123	0.4244
Loa Loa (eye worm)	TK protein kinase	0.0074	0.0123	0.4244
Echinococcus multilocularis	mitogen activated protein kinase	0.0061	0.0088	0.0074
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0055	0.0072	0.2238
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0061	0.0088	0.0088
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0076	0.0127	0.0112
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0074	0.0123	0.0099
Schistosoma mansoni	protein kinase	0.0074	0.0123	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0123	0.0099
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0055	0.0072	0.0057
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0074	0.0123	0.0108
Loa Loa (eye worm)	TK/DDR protein kinase	0.0074	0.0123	0.4244
Echinococcus granulosus	SHC transforming protein 3	0.0055	0.0072	0.0057
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0074	0.0123	0.0099
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0074	0.0123	0.0099
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0074	0.0123	0.4244
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0038	0.0027	0.0476
Schistosoma mansoni	tensin	0.0055	0.0072	0.0057
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0129	0.0269	0.0255
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Schistosoma mansoni	serine/threonine RGC	0.0074	0.0123	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.2238
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0057	0.0076	0.0052
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Entamoeba histolytica	serine/threonine kinase, putative	0.0074	0.0123	0.0099
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0074	0.0123	0.0099
Entamoeba histolytica	serine/threonine kinase, putative	0.0074	0.0123	0.0099
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0074	0.0123	0.0108
Brugia malayi	SH2 domain containing protein	0.0055	0.0072	0.2238
Echinococcus multilocularis	SHC transforming protein 3	0.0055	0.0072	0.0057
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Entamoeba histolytica	hypothetical protein	0.0074	0.0123	0.0099
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0074	0.0123	0.0108
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0074	0.0123	0.0108
Echinococcus granulosus	tyrosine protein kinase Srms	0.0129	0.0269	0.0255
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0055	0.0072	0.2238
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0037	0.0024	0.0372
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0074	0.0123	0.0099
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0123	0.0253	0.0229
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0074	0.0123	0.0099
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Trypanosoma cruzi	trans-sialidase, putative	0.0028	0.0000010674	0.0000010674
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Brugia malayi	Protein kinase domain containing protein	0.0129	0.0269	1
Echinococcus granulosus	tyrosine protein kinase	0.0074	0.0123	0.0108
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0129	0.0269	0.0255
Echinococcus granulosus	tyrosine kinase	0.0129	0.0269	0.0255
Giardia lamblia	Kinase	0.0074	0.0123	0.0035
Echinococcus granulosus	raf serine:threonine protein kinase	0.0074	0.0123	0.0108
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0000010674	0.0000010674
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0074	0.0123	0.4244
Echinococcus granulosus	activated cdc42 kinase 1	0.0074	0.0123	0.0108
Brugia malayi	ubiquitin conjugating enzyme protein 13	0.0037	0.0024	0.0372
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0076	0.0127	0.0127
Schistosoma mansoni	tyrosine kinase	0.0129	0.0269	0.0255
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0074	0.0123	0.0108
Schistosoma mansoni	tyrosine kinase	0.0129	0.0269	0.0255
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0074	0.0123	0.0108
Loa Loa (eye worm)	TK/Met protein kinase	0.0074	0.0123	0.4244
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0129	0.0269	0.0255
Brugia malayi	Protein kinase domain containing protein	0.0129	0.0269	1
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0074	0.0123	0.0108
Echinococcus multilocularis	c src tyrosine kinase	0.0129	0.0269	0.0255
Trichomonas vaginalis	protein kinase atn1, putative	0.0074	0.0123	0.0099
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0129	0.0269	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.2238
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0074	0.0123	0.0108
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0055	0.0072	0.0057
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0055	0.0072	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.2238
Loa Loa (eye worm)	SH2 domain-containing protein	0.0055	0.0072	0.2238
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0123	0.0099
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0074	0.0123	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0123	0.0099
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0123	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0123	0.4244
Schistosoma mansoni	vav2	0.0055	0.0072	0.0057
Echinococcus granulosus	protein tyrosine kinase	0.0074	0.0123	0.0108
Echinococcus granulosus	natriuretic peptide receptor 1	0.0074	0.0123	0.0108
Brugia malayi	SH2 domain containing protein	0.0129	0.0269	1
Trichomonas vaginalis	CMGC family protein kinase	0.0061	0.0088	0.0064
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.2238
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0074	0.0123	0.0108
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0055	0.0072	0.2238
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Onchocerca volvulus		0.0074	0.0123	0.2584
Echinococcus granulosus	tyrosine protein kinase csk	0.0074	0.0123	0.0108
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Schistosoma mansoni	protein kinase	0.0076	0.0127	0.0112
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0131	0.0274	0.0259
Trypanosoma brucei	protein kinase, putative	0.0061	0.0088	0.0088
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Schistosoma mansoni	protein kinase	0.0123	0.0253	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.2238
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0055	0.0072	0.0057
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.3784	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0074	0.0123	0.432
Loa Loa (eye worm)	TK/FER protein kinase	0.0074	0.0123	0.4244
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0123	0.0099
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0123	0.4244
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Entamoeba histolytica	SH2 domain containing protein	0.0055	0.0072	0.0048
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Trypanosoma cruzi	protein kinase, putative	0.0074	0.0123	0.0123
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Loa Loa (eye worm)	TK/FER protein kinase	0.0074	0.0123	0.4244
Schistosoma mansoni	hypothetical protein	0.0055	0.0072	0.0057
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0123	0.0099
Echinococcus granulosus	epidermal growth factor receptor	0.0074	0.0123	0.0108
Schistosoma mansoni	SH2A	0.0055	0.0072	0.0057
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0074	0.0123	0.0108
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0074	0.0123	0.0123
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.0269	1
Onchocerca volvulus		0.0074	0.0123	0.2584
Echinococcus multilocularis	SH2 motif	0.0055	0.0072	0.0057
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0055	0.0072	0.2238
Entamoeba histolytica	hypothetical protein	0.0074	0.0123	0.0099
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0123	0.0099
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0129	0.0269	0.0255
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.3784	1	1
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0129	0.0269	0.0255
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Loa Loa (eye worm)	SRC-1	0.0129	0.0269	1
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.3784	1	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0129	0.0269	0.0255
Plasmodium falciparum	protein kinase, putative	0.0074	0.0123	0.432
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.0269	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0074	0.0123	0.4244
Loa Loa (eye worm)	TK/ACK protein kinase	0.0074	0.0123	0.4244
Brugia malayi	Variant SH3 domain containing protein	0.0055	0.0072	0.2238
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0055	0.0072	0.0057
Onchocerca volvulus		0.0129	0.0269	1
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0123	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.2238
Echinococcus multilocularis	activated cdc42 kinase 1	0.0074	0.0123	0.0108
Brugia malayi	Cytochrome P450 family protein	0.0044	0.0043	0.1129
Echinococcus granulosus	receptor type guanylyl cyclase	0.0074	0.0123	0.0108
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0129	0.0269	0.0255
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Trypanosoma cruzi	trans-sialidase, putative	0.0028	0.0000010674	0.0000010674
Entamoeba histolytica	DNA repair and recombination protein, putative	0.3784	1	1
Brugia malayi	Sex muscle abnormal protein 5	0.0055	0.0072	0.2238
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0074	0.0123	0.0108
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0000010674	0.0000010674
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0074	0.0123	0.0108
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0055	0.0072	0.0057
Echinococcus granulosus	mitogen activated protein kinase 3	0.0061	0.0088	0.0074
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.0269	1
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0061	0.0088	0.0064
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Brugia malayi	SH2 domain containing protein	0.0055	0.0072	0.2238
Trichomonas vaginalis	AGC family protein kinase	0.0123	0.0253	0.0229
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0074	0.0123	0.432
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0000010674	0.0000010674
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0074	0.0123	0.0108
Entamoeba histolytica	protein kinase, putative	0.0123	0.0253	0.0229
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Echinococcus granulosus	insulin receptor	0.0074	0.0123	0.0108
Trypanosoma cruzi	trans-sialidase, putative	0.0028	0.0000010674	0.0000010674
Brugia malayi	SH2 domain containing protein	0.0055	0.0072	0.2238
Entamoeba histolytica	hypothetical protein, conserved	0.3784	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.0061	0.0088	0.0064
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0061	0.0088	0.0088
Entamoeba histolytica	tyrosin kinase, putative	0.0074	0.0123	0.0099
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0074	0.0123	0.4244
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0129	0.0269	0.0255
Trichomonas vaginalis	CMGC family protein kinase	0.0061	0.0088	0.0064
Brugia malayi	Tyrosine-protein kinase abl-1	0.0129	0.0269	1
Echinococcus multilocularis	heat shock protein 70	0.0074	0.0123	0.0108
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Brugia malayi	Guanylyl cyclase protein 23	0.0074	0.0123	0.4244
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0074	0.0123	0.4244
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0129	0.0269	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.2238
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Echinococcus multilocularis	tensin	0.0055	0.0072	0.0057
Echinococcus granulosus	NCK adaptor protein	0.0055	0.0072	0.0057
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0055	0.0072	0.0057
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0129	0.0269	0.0255
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Brugia malayi	hypothetical protein	0.0074	0.0123	0.4244
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Entamoeba histolytica	hypothetical protein	0.0074	0.0123	0.0099
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0055	0.0072	0.2238
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Toxoplasma gondii	protein kinase domain-containing protein	0.0074	0.0123	0.432
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Brugia malayi	hypothetical protein	0.0074	0.0123	0.4244
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Toxoplasma gondii	STE kinase	0.0074	0.0123	0.432
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0074	0.0123	0.2584
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0038	0.0027	0.0476
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0129	0.0269	0.0255
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0055	0.0072	0.0057
Schistosoma mansoni	tensin-related	0.0055	0.0072	0.0057
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0074	0.0123	0.0108
Brugia malayi	SRC-1	0.0129	0.0269	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.2238
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0055	0.0072	0.0057
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Brugia malayi	SH2 domain containing protein	0.0055	0.0072	0.2238
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Loa Loa (eye worm)	TK protein kinase	0.0129	0.0269	1
Echinococcus granulosus	c src tyrosine kinase	0.0129	0.0269	0.0255
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0061	0.0088	0.0064
Schistosoma mansoni	suppressor of cytokine signaling	0.0055	0.0072	0.0057
Echinococcus granulosus	aurora kinase A	0.0123	0.0253	0.0238
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0074	0.0123	0.0099
Entamoeba histolytica	tyrosine kinase, putative	0.0074	0.0123	0.0099
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0055	0.0072	0.0057
Trichomonas vaginalis	CMGC family protein kinase	0.0061	0.0088	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.2238
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0000010674	0.0000010674
Echinococcus granulosus	tyrosine kinase	0.0129	0.0269	0.0255
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0129	0.0269	0.0255
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0055	0.0072	0.0057
Schistosoma mansoni	hypothetical protein	0.3784	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.3784	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Entamoeba histolytica	protein kinase, putative	0.0074	0.0123	0.0099
Echinococcus multilocularis	SH2 domain containing protein 7	0.0055	0.0072	0.0057
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0074	0.0123	0.4244
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0123	0.0108
Echinococcus multilocularis	tyrosine kinase	0.0074	0.0123	0.0108
Plasmodium falciparum	protein kinase, putative	0.0074	0.0123	0.432
Schistosoma mansoni	ubiquitin conjugating enzyme 13	0.0037	0.0024	0.0009
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0061	0.0088	0.2886
Echinococcus granulosus	twitchin	0.0035	0.0019	0.0004
Brugia malayi	serine/threonine kinase 12	0.0123	0.0253	0.9335
Entamoeba histolytica	protein kinase, putative	0.0123	0.0253	0.0229
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0074	0.0123	0.4244
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0123	0.0099
Brugia malayi	MAP kinase sur-1	0.0061	0.0088	0.2886
Brugia malayi	SH2 domain containing protein	0.0055	0.0072	0.2238
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Schistosoma mansoni	ephrin receptor	0.0074	0.0123	0.0108
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0074	0.0123	0.4244
Echinococcus granulosus	tyrosine protein kinase csk	0.0074	0.0123	0.0108
Trypanosoma brucei	aurora B kinase	0.0123	0.0253	0.0252
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0074	0.0123	0.0108
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0055	0.0072	0.2238
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Echinococcus multilocularis	tyrosine protein kinase csk	0.0074	0.0123	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0123	0.4244
Trichomonas vaginalis	TKL family protein kinase	0.0074	0.0123	0.0099
Brugia malayi	ephrin receptor 1 precursor	0.0074	0.0123	0.4244
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0269	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0055	0.0072	0.0057
Leishmania major	protein kinase, putative	0.0074	0.0123	0.0099
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0123	0.4244
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0037	0.0024	0.0024
Brugia malayi	integrin-linked kinase	0.0074	0.0123	0.4244
Giardia lamblia	Kinase, NEK	0.0074	0.0123	0.0035
Echinococcus granulosus	signal transduction protein lnk realted	0.0055	0.0072	0.0057
Brugia malayi	SH2 domain containing protein	0.0129	0.0269	1
Echinococcus granulosus	ubiquitin conjugating enzyme E2 N	0.0037	0.0024	0.0009
Entamoeba histolytica	serine/threonine kinase, putative	0.0074	0.0123	0.0099
Schistosoma mansoni	tyrosine kinase	0.0074	0.0123	0.0108
Loa Loa (eye worm)	TK protein kinase	0.0074	0.0123	0.4244
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0129	0.0269	0.0255
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0074	0.0123	0.0099
Schistosoma mansoni	hypothetical protein	0.0055	0.0072	0.0057
Brugia malayi	protein-tyrosine kinase	0.0129	0.0269	1
Schistosoma mansoni	tyrosine kinase	0.0129	0.0269	0.0255

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	< 0.1 %	Compound was tested for agonist activity in rat isolated uterus assay	ChEMBL.	4009600
pA2 (functional)	= 7.2	Compound was tested for antagonist activity in rat isolated uterus assay; pA2 is the negative logarithm of the concentration of antagonist that reduces the response to an ED50 dose of angiotensin II to the response to half the ED50 dose	ChEMBL.	4009600

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 375363

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 283371