Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0073 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.021 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.021 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.021 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0073 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.021 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.021 | 1 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.021 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0073 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.021 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0073 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0073 | 0 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0073 | 0 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0073 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0073 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0073 | 0 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.021 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0073 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.021 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.021 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.021 | 1 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.021 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.021 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0073 | 0 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.021 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 38 % | Compound was tested in vitro for inhibition of [125I]-RANTES binding to THP-1 cell membranes rich in C-C chemokine receptor type 1 | ChEMBL. | 9871539 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.