Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0027 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.5 | 0.5 | |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0027 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 55 nM | Displacement of specific [3H]-SCH- 58261 binding at human Adenosine A2A receptor expressed in HEK-293 cells. | ChEMBL. | 11754583 |
Ki (binding) | = 55 nM | Displacement of specific [3H]-SCH- 58261 binding at human Adenosine A2A receptor expressed in HEK-293 cells. | ChEMBL. | 11754583 |
Ki (binding) | = 55 nM | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 19501513 |
Ki (binding) | = 75 nM | Displacement of specific [3H]-DPCPX binding at human Adenosine A1 receptor expressed in CHO cells. | ChEMBL. | 11754583 |
Ki (binding) | = 75 nM | Displacement of specific [3H]-DPCPX binding at human Adenosine A1 receptor expressed in CHO cells. | ChEMBL. | 11754583 |
Ki (binding) | > 10000 nM | Displacement of specific [3H]-DPCPX binding at human adenosine A2B receptor expressed in HEK-293 cells. | ChEMBL. | 11754583 |
Ki (binding) | > 10000 nM | Displacement of specific [3H]-MRE3008-F20 binding at human adenosine A3 receptor expressed in CHO cells. | ChEMBL. | 11754583 |
Ki (binding) | > 10000 nM | Displacement of specific [3H]-DPCPX binding at human adenosine A2B receptor expressed in HEK-293 cells. | ChEMBL. | 11754583 |
Ki (binding) | > 10000 nM | Displacement of specific [3H]-MRE3008-F20 binding at human adenosine A3 receptor expressed in CHO cells. | ChEMBL. | 11754583 |
Ki (binding) | > 10000 nM | Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 19501513 |
Ratio (binding) | > 181 | Selectivity ratio of human adenosine A2B receptor to human adenosine A2A receptor. | ChEMBL. | 11754583 |
Ratio (binding) | = 1.36 | Selectivity ratio of human adenosine A1 receptor to human adenosine A2A receptor. | ChEMBL. | 11754583 |
Ratio (binding) | > 181 | Selectivity ratio of human adenosine A2B receptor to human adenosine A2A receptor. | ChEMBL. | 11754583 |
Ratio (binding) | > 181 | Selectivity ratio of human adenosine A3 receptor to human adenosine A2A receptor. | ChEMBL. | 11754583 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.