Detailed information for compound 283591

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 461.511 | Formula: C29H23N3O3
  • H donors: 1 H acceptors: 2 LogP: 4.8 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCc2c(C1c1ccc3c(c1)CCO3)[nH]c1c2cccc1)c1ccc(o1)c1ccccn1
  • InChi: 1S/C29H23N3O3/c33-29(26-11-10-25(35-26)23-7-3-4-14-30-23)32-15-12-21-20-5-1-2-6-22(20)31-27(21)28(32)19-8-9-24-18(17-19)13-16-34-24/h1-11,14,17,28,31H,12-13,15-16H2
  • InChiKey: WOHTVFKCMZMJPD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 5A, cGMP-specific Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania donovani cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum expressed protein Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans methionine aminopeptidase 0.0873 0.8442 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0148 0.2402
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Echinococcus granulosus methionyl aminopeptidase 2 0.011 0.0616 0.0384
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.011 0.0616 0.0616
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.1024 1 1
Echinococcus multilocularis xaa Pro dipeptidase 0.011 0.0616 0.0384
Echinococcus multilocularis xaa Pro dipeptidase 0.011 0.0616 0.0384
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0873 0.8442 1
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0873 0.8442 1
Trypanosoma cruzi Metallopeptidase family M24, putative 0.011 0.0616 0.0616
Echinococcus granulosus xaa Pro dipeptidase 0.011 0.0616 0.0384
Toxoplasma gondii methionine aminopeptidase 0.1024 1 1
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0873 0.8442 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0148 0.2402
Toxoplasma gondii hypothetical protein 0.0152 0.1043 0.0908
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.011 0.0616 0.0384
Toxoplasma gondii transcriptional elongation factor FACT140 0.011 0.0616 0.0475
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.011 0.0616 0.0457
Onchocerca volvulus Dipeptidase C homolog 0.011 0.0616 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.011 0.0616 0.0384
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.011 0.0616 0.0384
Trypanosoma brucei methionine aminopeptidase 2, putative 0.011 0.0616 0.0384
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.1043 0.1043
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.0241 0.0241
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0241 0.3911
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.1024 1 1
Echinococcus granulosus methionine aminopeptidase type I 0.011 0.0616 0.0384
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Leishmania major hypothetical protein, conserved 0.0152 0.1043 0.0822
Giardia lamblia Xaa-Pro dipeptidase 0.011 0.0616 0.5
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0873 0.8442 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.1024 1 1
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.011 0.0616 0.0384
Leishmania major transcription factor-like protein 0.011 0.0616 0.0384
Echinococcus multilocularis methionyl aminopeptidase 2 0.011 0.0616 0.0384
Toxoplasma gondii peptidase D, putative 0.011 0.0616 0.0475
Echinococcus granulosus xaa Pro dipeptidase 0.011 0.0616 0.0384
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.011 0.0616 1
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.1024 1 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.011 0.0616 1
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.011 0.0616 0.0384
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0873 0.8442 1
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.011 0.0616 0.0384
Plasmodium vivax hypothetical protein, conserved 0.0152 0.1043 0.0455
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.011 0.0616 0.0616
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.011 0.0616 1
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.011 0.0616 0.0457
Treponema pallidum methionine aminopeptidase (map) 0.0873 0.8442 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0241 0.3911
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.011 0.0616 1
Onchocerca volvulus 0.011 0.0616 0.5
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.011 0.0616 0.5
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.011 0.0616 0.0384
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0241 0.3911
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.011 0.0616 0.0384
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.011 0.0616 0.0457
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.0241 0.0241
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.011 0.0616 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.0241 0.3911
Plasmodium falciparum HP12 protein homolog, putative 0.0152 0.1043 0.0455
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0873 0.8442 0.8418
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0241 0.3911
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0074 0.0241 0.3911
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.1024 1 1
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0873 0.8442 1
Entamoeba histolytica methionine aminopeptidase, putative 0.011 0.0616 0.5
Entamoeba histolytica aminopeptidase, putative 0.011 0.0616 0.5
Schistosoma mansoni peptidase 0.011 0.0616 0.0457
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.0241 0.3911
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0241 0.3911
Trypanosoma brucei Metallopeptidase family M24, putative 0.011 0.0616 0.0384
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.011 0.0616 0.5
Loa Loa (eye worm) methionine aminopeptidase type I 0.1024 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0148 0.2402
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.011 0.0616 0.0616
Entamoeba histolytica peptidase, putative 0.011 0.0616 0.5
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.011 0.0616 0.0384
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.1024 1 1
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0873 0.8442 0.8339
Toxoplasma gondii methionine aminopeptidase 0.0873 0.8442 0.8418
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.011 0.0616 0.0616
Leishmania major methionine aminopeptidase 2, putative 0.011 0.0616 0.0384
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.011 0.0616 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Entamoeba histolytica hypothetical protein, conserved 0.011 0.0616 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0074 0.0241 0.0241
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.011 0.0616 0.0457
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0873 0.8442 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Echinococcus multilocularis FACT complex subunit SPT16 0.011 0.0616 0.0384
Giardia lamblia Xaa-Pro dipeptidase 0.011 0.0616 0.5
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0873 0.8442 0.8403
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0873 0.8442 0.8339
Echinococcus multilocularis xaa pro aminopeptidase 0.011 0.0616 0.0384
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.011 0.0616 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.011 0.0616 1
Trypanosoma brucei methionine aminopeptidase, putative 0.1024 1 1
Trypanosoma cruzi Metallopeptidase family M24, putative 0.011 0.0616 0.0616
Toxoplasma gondii methionine aminopeptidase 2, putative 0.011 0.0616 0.0475
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0873 0.8442 1
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.011 0.0616 0.0457
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Chlamydia trachomatis methionine aminopeptidase 0.0873 0.8442 1
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.1024 1 1
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.011 0.0616 0.0457
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.1024 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.011 0.0616 0.0616
Trypanosoma cruzi aminopeptidase P, putative 0.011 0.0616 0.0616
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.011 0.0616 0.0384
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.011 0.0616 0.0457
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.011 0.0616 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.011 0.0616 1
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.011 0.0616 0.0475
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.011 0.0616 1
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.011 0.0616 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.0241 0.3911
Plasmodium vivax methionine aminopeptidase 1b, putative 0.1024 1 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.011 0.0616 0.0616
Trypanosoma brucei hypothetical protein, conserved 0.0152 0.1043 0.0822
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0074 0.0241 0.3911
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.011 0.0616 1
Toxoplasma gondii creatinase domain-containing protein 0.011 0.0616 0.0475
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.011 0.0616 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.011 0.0616 0.0616
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Echinococcus granulosus FACT complex subunit SPT16 0.011 0.0616 0.0384
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0074 0.0241 0.3911
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0074 0.0241 0.3911
Echinococcus granulosus Proliferation associated protein 2G4 0.011 0.0616 0.0384
Leishmania major hypothetical protein, conserved 0.011 0.0616 0.0384
Trypanosoma cruzi aminopeptidase P1, putative 0.011 0.0616 0.0616
Echinococcus granulosus xaa pro aminopeptidase 0.011 0.0616 0.0384
Echinococcus multilocularis Proliferation associated protein 2G4 0.011 0.0616 0.0384
Echinococcus multilocularis methionine aminopeptidase, type I 0.011 0.0616 0.0384
Giardia lamblia Methionine aminopeptidase 0.011 0.0616 0.5
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0074 0.0241 0.3911
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.011 0.0616 0.0384
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.011 0.0616 0.0384
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.1043 0.1043

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 32.3 nM Inhibitory activity against PDE5 from human corpus cavernosum ChEMBL. 12639576
Ki (binding) = 32.3 nM Inhibitory activity against PDE5 from human corpus cavernosum ChEMBL. 12639576
Selectivity (binding) > 3000 Relative inhibition of PDE1 (Phosphodiesterase) from human heart and PDE5 from human corpus cavernosum ChEMBL. 12639576
Selectivity (binding) = 32 Relative inhibition of PDE6 from human retinal cone and PDE5 from human corpus cavernosum ChEMBL. 12639576
Selectivity (binding) = 180 Relative inhibition of PDE4 from human skeletal muscle and PDE5 from human corpus cavernosum ChEMBL. 12639576
Selectivity (binding) = 308 Relative inhibition of PDE2 and PDE5 from human corpus cavernosum ChEMBL. 12639576
Selectivity (binding) > 3000 Relative inhibition of PDE1 (Phosphodiesterase) from human heart and PDE5 from human corpus cavernosum ChEMBL. 12639576
Selectivity (binding) > 3000 Relative inhibition of PDE3 from human platelets and PDE5 from human corpus cavernosum ChEMBL. 12639576

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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