Detailed information for compound 283627

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 666.786 | Formula: C37H38N4O6S
  • H donors: 1 H acceptors: 5 LogP: 6.32 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccccc1)N(C(=O)OCC(C)C)C
  • InChi: 1S/C37H38N4O6S/c1-5-11-34-38-32-21-20-29(40(4)37(44)47-24-25(2)3)22-31(32)36(43)41(34)23-26-16-18-27(19-17-26)30-14-9-10-15-33(30)48(45,46)39-35(42)28-12-7-6-8-13-28/h6-10,12-22,25H,5,11,23-24H2,1-4H3,(H,39,42)
  • InChiKey: ABDGWYREVLSZCO-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Angiotensin II type 2 (AT-2) receptor Starlite/ChEMBL No references
Oryctolagus cuniculus Angiotensin II type 1a (AT-1a) receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 398 aa 18.1 %
Schistosoma mansoni opsin-like receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 299 aa 25.1 %
Brugia malayi putative neuropeptide receptor NPR1 Angiotensin II type 1a (AT-1a) receptor   359 aa 295 aa 27.1 %
Echinococcus granulosus allatostatin A receptor Angiotensin II type 2 (AT-2) receptor   363 aa 340 aa 24.1 %
Echinococcus granulosus tm gpcr rhodopsin Angiotensin II type 1a (AT-1a) receptor   359 aa 306 aa 21.9 %
Echinococcus granulosus growth hormone secretagogue receptor type 1 Angiotensin II type 1a (AT-1a) receptor   359 aa 342 aa 22.2 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Angiotensin II type 2 (AT-2) receptor   363 aa 310 aa 23.5 %
Echinococcus multilocularis allatostatin A receptor Angiotensin II type 2 (AT-2) receptor   363 aa 342 aa 24.6 %
Echinococcus multilocularis G-protein coupled receptor, putative Angiotensin II type 1a (AT-1a) receptor   359 aa 307 aa 22.5 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 341 aa 23.2 %
Brugia malayi GnHR receptor homolog Angiotensin II type 1a (AT-1a) receptor   359 aa 364 aa 20.3 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 296 aa 23.0 %
Brugia malayi ORL1-like opioid receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 333 aa 21.3 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 305 aa 21.6 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Angiotensin II type 1a (AT-1a) receptor   359 aa 325 aa 20.9 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 346 aa 18.2 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 306 aa 22.5 %
Loa Loa (eye worm) hypothetical protein Angiotensin II type 1a (AT-1a) receptor   359 aa 335 aa 23.0 %
Loa Loa (eye worm) hypothetical protein Angiotensin II type 1a (AT-1a) receptor   359 aa 308 aa 27.3 %
Echinococcus multilocularis neuropeptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 21.4 %
Schistosoma mansoni peptide (allatostatin)-like receptor Angiotensin II type 2 (AT-2) receptor   363 aa 364 aa 20.9 %
Echinococcus granulosus thyrotropin releasing hormone receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 22.1 %
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Angiotensin II type 1a (AT-1a) receptor   359 aa 306 aa 21.9 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 21.8 %
Schistosoma japonicum Rhodopsin, putative Angiotensin II type 2 (AT-2) receptor   363 aa 341 aa 22.0 %
Loa Loa (eye worm) neuropeptide F receptor Angiotensin II type 2 (AT-2) receptor   363 aa 356 aa 23.3 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Angiotensin II type 1a (AT-1a) receptor   359 aa 328 aa 20.7 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 398 aa 18.3 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 313 aa 25.6 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 311 aa 23.8 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 364 aa 23.1 %
Schistosoma mansoni adenoreceptor Angiotensin II type 2 (AT-2) receptor   363 aa 328 aa 22.0 %
Echinococcus granulosus neuropeptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 306 aa 22.2 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 399 aa 25.3 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0198 0.0389
Brugia malayi Inositol-1 0.0036 0.0175 0.0429
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0104 0.0699 0.1835
Echinococcus granulosus GPCR family 2 0.0031 0.0135 0.0262
Schistosoma mansoni hypothetical protein 0.0014 0.0011 0.0012
Entamoeba histolytica disulphide oxidoreductase, putative 0.0104 0.0699 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0102 0.0236
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0041 0.0027
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0104 0.0699 0.1748
Echinococcus multilocularis serotonin receptor 0.0014 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.027
Schistosoma mansoni glutaminase 0.0265 0.1925 0.3484
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0107 0.0207
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0011 0.0014
Echinococcus granulosus orexin receptor type 2 0.0014 0.0011 0.0014
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0014 0.0011 0.0016
Echinococcus multilocularis 0.0021 0.0062 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0126 0.0301
Brugia malayi Dopamine receptor 0.0014 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0034 0.0162 0.0408
Schistosoma mansoni hypothetical protein 0.0019 0.0048 0.0078
Leishmania major NADH dehydrogenase, putative 0.0104 0.0699 0.0686
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0107 0.0259
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.012
Echinococcus granulosus g protein coupled receptor 0.0014 0.0011 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0064 0.039 0.0981
Trypanosoma brucei hypothetical protein, conserved 0.0104 0.0699 0.0686
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus granulosus thioredoxin glutathione reductase 0.0533 0.3979 0.794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.01 0.023
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0048 0.0087
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.1116 0.844 0.8437
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0175 0.0431
Plasmodium falciparum ferrodoxin reductase-like protein 0.0104 0.0699 0.1657
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0393 0.2907 0.7273
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0011 0.0012
Schistosoma mansoni biogenic amine receptor 0.0014 0.0011 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0011 0.0012
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0104 0.0699 0.1452
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0107 0.0207
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0104 0.0699 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0014 0.0011 0.0016
Loa Loa (eye worm) TYRA-2 protein 0.0014 0.0011 0.0027
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0104 0.0699 0.1389
Schistosoma mansoni opsin-like receptor 0.0014 0.0011 0.0012
Echinococcus multilocularis G-protein coupled receptor, putative 0.0014 0.0011 0.0014
Leishmania major trypanothione reductase 0.0533 0.3979 0.3971
Echinococcus granulosus glutamate synthase 0.0104 0.0699 0.1389
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0062 0.0049
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus granulosus microtubule associated protein 2 0.0668 0.5011 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.012
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0277 0.0582
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0198 0.0389
Brugia malayi MH2 domain containing protein 0.0116 0.0789 0.1974
Schistosoma mansoni biogenic amine receptor 0.0014 0.0011 0.0012
Brugia malayi glutamate synthase 0.0104 0.0699 0.1748
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0135 0.0329
Echinococcus multilocularis GPCR, family 2 0.0031 0.0135 0.0262
Schistosoma mansoni hypothetical protein 0.0031 0.0135 0.0237
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1116 0.844 0.8437
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0011 0.0014
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0176 0.0343
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0107 0.0259
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.064 0.16
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0175 0.0431
Schistosoma mansoni hypothetical protein 0.0533 0.3977 0.7204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0151 0.0367
Echinococcus granulosus G protein coupled receptor 139 0.0014 0.0011 0.0014
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0104 0.0699 0.0686
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0048 0.012
Schistosoma mansoni opsin-like receptor 0.0014 0.0011 0.0012
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.5011 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0107 0.0187
Loa Loa (eye worm) programmed cell death 8 0.0104 0.0699 0.1757
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0176 0.0343
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.098 0.7395 0.7392
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0011 0.0014
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0104 0.0699 0.2238
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0104 0.0699 0.0686
Trichomonas vaginalis apoptosis inducing factor, putative 0.0104 0.0699 0.1835
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0175 0.0161
Giardia lamblia Thioredoxin reductase 0.0104 0.0699 0.1916
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0011 0.0012
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0048 0.0087
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0104 0.0699 0.1757
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0135 0.034
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0237 0.0223
Leishmania major hypothetical protein, conserved 0.0104 0.0699 0.0686
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0107 0.0259
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0104 0.0699 0.0686
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.039 0.07
Schistosoma mansoni hypothetical protein 0.0101 0.0671 0.1209
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0107 0.0207
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0062 0.0049
Brugia malayi hypothetical protein 0.0014 0.0011 0.0016
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0104 0.0699 0.1389
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0104 0.0699 0.1835
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0393 0.2907 0.2897
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0062 0.0049
Loa Loa (eye worm) hypothetical protein 0.0028 0.0114 0.0286
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0014 0.0011 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1116 0.844 0.8437
Onchocerca volvulus 0.0019 0.0048 0.0098
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0176 0.0343
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0104 0.0699 0.1389
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.039 0.0772
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0026
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0237 0.0223
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus granulosus sex peptide receptor 0.0014 0.0011 0.0014
Echinococcus multilocularis neuropeptide FF receptor 2 0.0014 0.0011 0.0014
Brugia malayi putative neuropeptide receptor NPR1 0.0014 0.0011 0.0016
Trypanosoma cruzi NADH dehydrogenase, putative 0.0104 0.0699 0.0686
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0014 0.0011 0.0014
Echinococcus granulosus peptide allatostatin:somatostatin 0.0014 0.0011 0.0014
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0237 0.1186
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0114 0.0286
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.007 0.0131
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.001 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0119 0.0282
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0107 0.027
Schistosoma mansoni amine GPCR 0.0014 0.0011 0.0012
Brugia malayi glutaminase DH11.1 0.0265 0.1925 0.4833
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0062 0.0049
Brugia malayi Dopamine receptor protein 2 0.0014 0.0011 0.0016
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0014 0.0035
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0062 0.0049
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0011 0.0014
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0104 0.0699 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0368 0.0727
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0011
Leishmania major hypothetical protein, conserved 0.0104 0.0699 0.0686
Echinococcus granulosus hypothetical protein 0.0014 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Brugia malayi Pre-SET motif family protein 0.0442 0.3282 0.8246
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0011 0.0014
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0393 0.2907 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0594 0.4447 1
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0277 0.0547
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0011 0.0027
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0107 0.0187
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0277 0.0582
Treponema pallidum NADH oxidase 0.0393 0.2907 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0237 0.0585
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.5011 0.9079
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0062 0.0049
Schistosoma mansoni cpg binding protein 0.0029 0.0126 0.0221
Brugia malayi putative neuropeptide receptor 0.0014 0.0011 0.0016
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0289 0.2109 0.5295
Schistosoma mansoni amine GPCR 0.0014 0.0011 0.0012
Brugia malayi hypothetical protein 0.0014 0.0011 0.0016
Plasmodium vivax thioredoxin reductase, putative 0.0533 0.3979 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0175 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0168 0.0413
Brugia malayi hypothetical protein 0.0014 0.0011 0.0016
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.006 0.0046
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0104 0.0699 0.0686
Leishmania major hypothetical protein, conserved 0.0104 0.0699 0.0686
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0011 0.0014
Schistosoma mansoni inositol monophosphatase 0.0036 0.0175 0.0309
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0104 0.0699 0.2238
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0107 0.0187
Brugia malayi ecdysteroid receptor 0.0027 0.0107 0.0259
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0104 0.0699 0.0686
Schistosoma mansoni growth hormone secretagogue receptor 0.0014 0.0011 0.0012
Brugia malayi AKH receptor 0.0014 0.0011 0.0016
Trypanosoma brucei NADH dehydrogenase 0.0104 0.0699 0.0686
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.039 0.07
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0168 0.0413
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0011 0.0012
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0107 0.0187
Loa Loa (eye worm) thioredoxin reductase 0.0533 0.3979 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0107 0.0187
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0011 0.0014
Leishmania major cytochrome p450-like protein 0.0021 0.0062 0.0049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0014 0.0024
Onchocerca volvulus 0.0064 0.039 0.1015
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0014 0.0011 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0107 0.0259
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.027
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0062 0.0049
Onchocerca volvulus 0.0028 0.0114 0.0276
Onchocerca volvulus 0.0019 0.0048 0.0098
Schistosoma mansoni rab6-interacting 0.0019 0.0048 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0151 0.0367
Brugia malayi Melatonin receptor type 1A 0.0014 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0107 0.0207
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0237 0.0466
Schistosoma mansoni inositol monophosphatase 0.0036 0.0175 0.0309
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0104 0.0699 0.0686
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0176 0.0311
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0104 0.0699 0.1389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0083 0.0184
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0107 0.0207
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0104 0.0699 0.0686
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0271 0.0483
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0107 0.0207
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0533 0.3979 0.8934
Giardia lamblia GTOR 0.0044 0.0237 0.0224
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0107 0.0259
Echinococcus multilocularis lamin 0.0028 0.0114 0.022
Brugia malayi nuclear receptor NHR-88 0.0027 0.0107 0.0259
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.0776 0.1543
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Brugia malayi G protein-coupled receptor F59B2.13 0.0014 0.0011 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0104 0.0699 0.0686
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0062 0.0117
Schistosoma mansoni cytochrome P450 0.0021 0.0062 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.132 1 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0104 0.0699 0.0686
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0104 0.0699 0.2238
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0104 0.0699 0.1916
Echinococcus granulosus tachykinin peptides receptor 99D 0.0014 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0146 0.0191
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0224 0.0397
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.027
Onchocerca volvulus 0.0027 0.0107 0.0259
Brugia malayi hypothetical protein 0.0032 0.0144 0.035
Schistosoma mansoni hypothetical protein 0.0022 0.007 0.0118
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0175 0.0341
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0176 0.0433
Echinococcus multilocularis RUN 0.0019 0.0048 0.0087
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0114 0.0286
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0062 0.0157
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0011 0.0014
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0175 0.0161
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0026
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.132 1 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0104 0.0699 0.1835
Brugia malayi RE15519p 0.0014 0.0011 0.0016
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0393 0.2907 1
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0011 0.0027
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0011 0.0014
Brugia malayi Serotonin receptor 0.0014 0.0011 0.0016
Echinococcus multilocularis tumor protein p63 0.033 0.2425 0.4835
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0107 0.0187
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0168 0.0413
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0135 0.0262
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.1823 0.4582
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0104 0.0699 0.1452
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0104 0.0699 0.1452
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0011 0.0012
Brugia malayi G protein-coupled receptor 0.0014 0.0011 0.0016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0011 0.0012
Leishmania major hypothetical protein, conserved 0.0049 0.0277 0.0263
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0004 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0107 0.0259
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0062 0.0049
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1116 0.844 0.8437
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0104 0.0699 0.1657
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0237 0.0597
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0011 0.0014
Toxoplasma gondii selenide, water dikinase 0.0104 0.0699 0.1625
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0011 0.0014
Schistosoma mansoni glutamate synthase 0.0104 0.0699 0.126
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0014 0.0011 0.0014
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0104 0.0699 0.1452
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0135 0.0262
Brugia malayi sulfakinin receptor protein 0.0014 0.0011 0.0016
Onchocerca volvulus 0.0048 0.0271 0.0695
Schistosoma mansoni hypothetical protein 0.0066 0.0406 0.0729
Brugia malayi Serotonin receptor 0.0014 0.0011 0.0016
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0011 0.0014
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0104 0.0699 0.1657
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Brugia malayi nuclear receptor RXR 0.0014 0.001 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0151 0.0367
Echinococcus multilocularis serotonin receptor 0.0014 0.0011 0.0014
Brugia malayi nuclear hormone receptor 0.0027 0.0107 0.0259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0082 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0237 0.0597
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0104 0.0699 0.1452
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0026
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0393 0.2907 0.5798
Brugia malayi Pre-SET motif family protein 0.0064 0.039 0.0971
Echinococcus multilocularis somatostatin receptor 0.0014 0.0011 0.0014
Trypanosoma cruzi trypanothione reductase, putative 0.0533 0.3979 0.3971
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0594 0.4447 1
Schistosoma mansoni amine GPCR 0.0014 0.0011 0.0012
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0104 0.0699 0.2238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0151 0.0367
Schistosoma mansoni hypothetical protein 0.0031 0.0135 0.0237
Trichomonas vaginalis glutamate synthase, putative 0.0104 0.0699 0.1835
Echinococcus granulosus cpg binding protein 0.0029 0.0126 0.0244
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0048 0.0087
Brugia malayi hypothetical protein 0.0014 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0026
Toxoplasma gondii thioredoxin reductase 0.0533 0.3979 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0175 0.0161
Echinococcus multilocularis sex peptide receptor 0.0014 0.0011 0.0014
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0237 0.0223
Echinococcus granulosus g-protein coupled receptor 0.0014 0.0011 0.0014
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0104 0.0699 0.0686
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0004 0.0001
Schistosoma mansoni glutamate synthase 0.0104 0.0699 0.126
Echinococcus multilocularis musashi 0.0028 0.0114 0.022
Echinococcus granulosus 7TM GPCR rhodopsin 0.0014 0.0011 0.0014
Leishmania major cytochrome p450-like protein 0.0021 0.0062 0.0049
Plasmodium vivax SET domain protein, putative 0.0064 0.039 0.0871
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0107 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0107 0.027
Echinococcus multilocularis g-protein coupled receptor 0.0014 0.0011 0.0014
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0176 0.0162
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0014 0.0011 0.0016
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0306 0.2239 0.4964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0082 0.0183
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.039 0.07
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0014 0.0011 0.0027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0107 0.0207
Echinococcus granulosus geminin 0.0533 0.3977 0.7935
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0104 0.0699 0.2238
Loa Loa (eye worm) hypothetical protein 0.0036 0.0176 0.0441
Echinococcus granulosus serotonin receptor 0.0014 0.0011 0.0014
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0104 0.0699 0.1835
Plasmodium vivax ferrodoxin reductase, putative 0.0104 0.0699 0.1657
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0107 0.0259
Trichomonas vaginalis glutamate synthase, putative 0.0104 0.0699 0.1835
Schistosoma mansoni hypothetical protein 0.0014 0.0011 0.0012
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0104 0.0699 0.1835
Brugia malayi CXXC zinc finger family protein 0.0028 0.0114 0.0276
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0011 0.0014
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0176 0.0162
Schistosoma mansoni cpg binding protein 0.0029 0.0126 0.0221
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0066 0.0406 0.1021
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0011 0.0027
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0107 0.0187
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0011 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0151 0.0367
Brugia malayi hypothetical protein 0.0014 0.0011 0.0016
Brugia malayi neuropeptide F receptor 0.0014 0.0011 0.0016
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0107 0.0207
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0169 0.0155
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0104 0.0699 0.1657
Loa Loa (eye worm) hypothetical protein 0.0049 0.0277 0.0695
Leishmania major acetoin dehydrogenase e3 component-like protein 0.098 0.7395 0.7392
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0104 0.0699 0.0686
Schistosoma mansoni cpg binding protein 0.0028 0.0114 0.0199
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0014 0.002
Schistosoma mansoni hypothetical protein 0.0014 0.0011 0.0012
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0104 0.0699 0.1625
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0104 0.0699 0.1389
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.027
Trichomonas vaginalis set domain proteins, putative 0.0503 0.3749 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0011 0.0014
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0014 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Mycobacterium ulcerans NADH dehydrogenase 0.0104 0.0699 0.2238
Plasmodium falciparum thioredoxin reductase 0.0393 0.2907 0.7273
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Schistosoma mansoni histamine h1 receptor 0.0014 0.0011 0.0012
Schistosoma mansoni hypothetical protein 0.0014 0.0011 0.0012
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0104 0.0699 0.1389
Brugia malayi G-protein coupled receptor 0.0014 0.0011 0.0016
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0237 0.0223
Brugia malayi glutathione reductase 0.0533 0.3979 1
Brugia malayi hypothetical protein 0.0019 0.0048 0.0109
Schistosoma mansoni adenoreceptor 0.0014 0.0011 0.0012
Schistosoma mansoni neuropeptide f receptor 76f 0.0014 0.0011 0.0012
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0789 0.1983
Leishmania major cytochrome p450-like protein 0.0021 0.0062 0.0049
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0015 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0011 0.0012
Mycobacterium ulcerans hypothetical protein 0.0104 0.0699 0.2238
Schistosoma mansoni neuropeptide receptor 0.0014 0.0011 0.0012
Brugia malayi Cytochrome P450 family protein 0.0021 0.0062 0.0146
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0277 0.0263
Echinococcus granulosus neuropeptide receptor A26 0.046 0.3417 0.6817
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0083 0.0184
Echinococcus granulosus g protein coupled receptor 0.0014 0.0011 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0151 0.0367
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.064 0.16
Schistosoma mansoni sulfide quinone reductase 0.0104 0.0699 0.126
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0176 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0277 0.0582
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0393 0.2907 0.7262
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0277 0.0263
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0011 0.0014
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0175 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.01 0.023
Schistosoma mansoni hypothetical protein 0.0533 0.3977 0.7204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0188 0.0466
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0048 0.0087
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0104 0.0699 0.1757
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0011 0.0012
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0393 0.2907 0.2897
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0114 0.0286
Brugia malayi steroid hormone receptor 0.0027 0.0107 0.0259
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0107 0.027
Brugia malayi Dopamine receptor protein 1 0.0014 0.0011 0.0016
Schistosoma mansoni lipoxygenase 0.008 0.0513 0.0922
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0011 0.0014
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0393 0.2907 0.5264
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0176 0.0343
Schistosoma mansoni coup transcription factor 0.0027 0.0107 0.0187
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.027
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0169 0.0155
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0062 0.0157
Schistosoma mansoni hypothetical protein 0.0396 0.293 0.5305
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0107 0.0187
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0104 0.0699 0.1919
Loa Loa (eye worm) melatonin receptor type 1A 0.0014 0.0011 0.0027
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0011 0.0014
Brugia malayi hypothetical protein 0.0014 0.0011 0.0016
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0393 0.2907 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0014 0.0011 0.0014
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0146 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0107 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0168 0.0413
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0107 0.0207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.132 1 1
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0048 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0107 0.0259
Loa Loa (eye worm) inositol-1 0.0036 0.0175 0.0439
Loa Loa (eye worm) cytochrome P450 0.0021 0.0062 0.0157
Brugia malayi Tachykinin-like peptides receptor 99D 0.0014 0.0011 0.0016
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0014 0.0011 0.0027
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0014 0.0011 0.0012
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0014 0.0011 0.0012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0107 0.0207
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0393 0.2907 0.2897
Echinococcus multilocularis cpg binding protein 0.0029 0.0126 0.0244
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0107 0.0259
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0104 0.0699 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0594 0.4447 1
Echinococcus granulosus fmrfamide receptor 0.0014 0.0011 0.0014
Brugia malayi hypothetical protein 0.0019 0.0048 0.0109
Schistosoma mansoni hypothetical protein 0.0031 0.0135 0.0237
Brugia malayi hypothetical protein 0.0014 0.001 0.0015
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0014 0.0011 0.0012
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0306 0.2239 0.4964
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.001 0.0011
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0406 0.1011
Giardia lamblia Glutamate synthase 0.0104 0.0699 0.1916
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0104 0.0699 0.1452
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.0776 0.1543
Toxoplasma gondii NADPH-glutathione reductase 0.0393 0.2907 0.7262
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0014 0.0017
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0011 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0011 0.0012
Brugia malayi ORL1-like opioid receptor 0.0014 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0151 0.0367
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0169 0.0155
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0104 0.0699 0.1748
Echinococcus granulosus alpha 1A adrenergic receptor 0.0014 0.0011 0.0014
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0306 0.2239 0.4964
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0062 0.0157
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0237 0.0422
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.039 0.0772
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0011 0.0012
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0156 0.0382
Schistosoma mansoni neuropeptide receptor 0.0014 0.0011 0.0012
Brugia malayi intermediate filament protein 0.0028 0.0114 0.0275
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0176 0.0431
Brugia malayi Cytochrome P450 family protein 0.0021 0.0062 0.0146
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0104 0.0699 0.1389
Schistosoma mansoni loxhd1 0.0019 0.0048 0.0078
Brugia malayi cytochrome P450 0.0021 0.0062 0.0146
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0104 0.0699 0.1389
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0156 0.0382
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Onchocerca volvulus 0.0028 0.0114 0.0276
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0014 0.0011 0.0014
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0393 0.2907 0.7273
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0014 0.0011 0.0014
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.001 0.0026
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0151 0.0226
Schistosoma mansoni glutamate synthase 0.0104 0.0699 0.126
Mycobacterium ulcerans glutamate synthase subunit beta 0.0104 0.0699 0.2238
Echinococcus granulosus somatostatin receptor 0.0014 0.0011 0.0014
Plasmodium vivax glutathione reductase, putative 0.0533 0.3979 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0104 0.0699 0.1389
Echinococcus multilocularis thioredoxin glutathione reductase 0.0533 0.3979 0.794
Schistosoma mansoni rab6-interacting 0.0019 0.0048 0.0078
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0322 0.0663
Echinococcus granulosus RUN 0.0019 0.0048 0.0087
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0104 0.0699 0.2238
Mycobacterium tuberculosis Probable dehydrogenase 0.0306 0.2239 0.4964
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0107 0.0259
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0175 0.0161
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0107 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0107 0.027
Echinococcus granulosus intermediate filament protein 0.0028 0.0114 0.022
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0062 0.0157
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.001 0.0013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0107 0.0259
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0011 0.0014
Brugia malayi hypothetical protein 0.0014 0.0011 0.0016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0442 0.3282 0.8248
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0176 0.0162
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0011 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0237 0.0597
Trypanosoma cruzi hypothetical protein, conserved 0.0104 0.0699 0.0686
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.007 0.0131
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0104 0.0699 0.1625
Loa Loa (eye worm) glutathione reductase 0.0533 0.3979 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0198 0.0488
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0011 0.0014
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0104 0.0699 0.1835
Brugia malayi hypothetical protein 0.0014 0.0011 0.0016
Mycobacterium ulcerans ferredoxin reductase 0.0104 0.0699 0.2238
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0107 0.0259
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0104 0.0699 0.1835
Onchocerca volvulus 0.0104 0.0699 0.1841
Plasmodium falciparum glutathione reductase 0.0533 0.3979 1
Plasmodium falciparum glutathione reductase 0.0393 0.2907 0.7273
Mycobacterium tuberculosis Probable oxidoreductase 0.0594 0.4447 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0271 0.068
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0237 0.0223
Echinococcus granulosus dnaJ subfamily B 0.0396 0.293 0.5844
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0104 0.0699 0.2238
Trypanosoma brucei trypanothione reductase 0.0533 0.3979 0.3971
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0104 0.0699 0.1835
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0011 0.0014
Mycobacterium ulcerans dehydrogenase 0.0104 0.0699 0.2238
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.001 0.0011
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0393 0.2907 0.2897
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Trichomonas vaginalis glutaminase, putative 0.0265 0.1925 0.5118
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0393 0.2907 0.7273
Brugia malayi G-protein coupled receptor 0.0014 0.0011 0.0016
Schistosoma mansoni neuropeptide receptor 0.0014 0.0011 0.0012
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0237 0.0596
Echinococcus granulosus dro:myosuppressin receptor 0.0014 0.0011 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0107 0.0259
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0104 0.0699 0.1919
Echinococcus granulosus neuropeptide FF receptor 2 0.0014 0.0011 0.0014
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0107 0.0207
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.039 0.0772
Loa Loa (eye worm) hypothetical protein 0.0097 0.064 0.1609
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0289 0.2109 0.5295
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0237 0.1186
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0011 0.0012
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0011 0.0012
Trypanosoma cruzi trypanothione reductase, putative 0.0393 0.2907 0.2897
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0014 0.0011 0.0012
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0014 0.0011 0.0014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0011 0.0014
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0104 0.0699 0.1919
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0306 0.2239 0.4964
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0104 0.0699 0.1625
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0107 0.0259
Trichomonas vaginalis mercuric reductase, putative 0.0393 0.2907 0.7746
Brugia malayi GnHR receptor homolog 0.0014 0.0011 0.0016
Brugia malayi follicle stimulating hormone receptor 0.0251 0.1823 0.4576
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.001 0.0013
Onchocerca volvulus 0.0028 0.0114 0.0276
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0789 0.1983
Schistosoma mansoni opsin-like receptor 0.0014 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus granulosus 7tm_1 domain containing protein 0.0014 0.0011 0.0014
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0004 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0102 0.0236
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0393 0.2907 0.6488
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus multilocularis orexin receptor type 2 0.0014 0.0011 0.0014
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0011 0.0014
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0393 0.2907 0.5798
Echinococcus multilocularis allatostatin A receptor 0.0014 0.0011 0.0014
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0104 0.0699 0.1452
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0104 0.0699 1
Echinococcus granulosus g protein coupled receptor 0.0014 0.0011 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0107 0.027
Trichomonas vaginalis glutathione reductase, putative 0.0393 0.2907 0.7746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0083 0.0184
Schistosoma mansoni lamin 0.0028 0.0114 0.0198
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0107 0.0187
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0107 0.0259
Schistosoma mansoni biogenic amine receptor 0.0014 0.0011 0.0012
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0014 0.0011 0.0027
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0135 0.0329
Echinococcus multilocularis lamin dm0 0.0028 0.0114 0.022
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0393 0.2907 1
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.293 0.5844
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0135 0.034
Schistosoma mansoni hypothetical protein 0.0021 0.0062 0.0105
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0393 0.2907 0.7273
Schistosoma mansoni neuropeptide receptor 0.0014 0.0011 0.0012
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0014 0.0011 0.0012
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0104 0.0699 0.0686
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0237 0.0223
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0107 0.0207
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0014 0.0011 0.0014
Brugia malayi hypothetical protein 0.0014 0.0011 0.0016
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0104 0.0699 0.1748
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0011 0.0012
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0014 0.002
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0104 0.0699 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0175 0.0287
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0014 0.0011 0.0012
Echinococcus multilocularis glutamate synthase 0.0104 0.0699 0.1389
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0198 0.0499
Schistosoma mansoni disulfide oxidoreductase 0.0104 0.0699 0.126
Echinococcus granulosus neuropeptide receptor 0.0014 0.0011 0.0014
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0104 0.0699 0.1625
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0107 0.0207
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0104 0.0699 0.1835
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0014 0.0011 0.0016
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0014 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Brugia malayi hypothetical protein 0.0049 0.0277 0.0685
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.037 0.0663
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0176 0.0162
Mycobacterium ulcerans glutaminase 0.0265 0.1925 0.6549
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0176 0.0433
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.027
Brugia malayi Doublecortin family protein 0.0019 0.0048 0.0109
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Schistosoma mansoni amine GPCR 0.0014 0.0011 0.0012
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.039 0.0837
Mycobacterium ulcerans monoxygenase 0.0104 0.0699 0.2238
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0014 0.0011 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0107 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0082 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0107 0.027
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0011 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0107 0.0259
Schistosoma mansoni lamin 0.0028 0.0114 0.0198
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0014 0.0011 0.0016
Echinococcus granulosus tumor protein p63 0.033 0.2425 0.4835
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0011 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0011 0.0014
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0104 0.0699 0.1389
Echinococcus granulosus neuropeptide s receptor 0.046 0.3417 0.6817
Schistosoma mansoni polycystin 1-related 0.0019 0.0048 0.0078
Echinococcus granulosus lamin 0.0028 0.0114 0.022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0011 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0011 0.0014
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0104 0.0699 0.1835
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.027
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0011 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0176 0.0433
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0114 0.0275
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0237 0.0466
Loa Loa (eye worm) hypothetical protein 0.0027 0.011 0.0276
Echinococcus granulosus allatostatin A receptor 0.0014 0.0011 0.0014
Brugia malayi neuropeptide F receptor 0.0014 0.0011 0.0016
Brugia malayi Cytochrome P450 family protein 0.0021 0.0062 0.0146
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0176 0.0311
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0011 0.0012
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0014 0.0011 0.0012
Schistosoma mansoni hypothetical protein 0.0031 0.0135 0.0237
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.098 0.7395 0.7392
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0104 0.0699 0.1389
Echinococcus multilocularis G protein coupled receptor 139 0.0014 0.0011 0.0014
Schistosoma mansoni alpha-1 adrenergic receptor 0.0014 0.0011 0.0012
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0011 0.0014
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0104 0.0699 0.1625
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Entamoeba histolytica thioredoxin reductase, putative 0.0104 0.0699 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0011 0.0012
Echinococcus multilocularis neuropeptide s receptor 0.046 0.3417 0.6817
Echinococcus multilocularis geminin 0.0533 0.3977 0.7935
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0107 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0168 0.0413
Schistosoma mansoni amine GPCR 0.0014 0.0011 0.0012
Schistosoma mansoni intermediate filament proteins 0.0028 0.0114 0.0198
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0107 0.027
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0107 0.0259
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Loa Loa (eye worm) glutaminase 0.0265 0.1925 0.4839
Schistosoma mansoni myosin xvIII 0.0014 0.0011 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0107 0.0259
Mycobacterium tuberculosis Probable reductase 0.0306 0.2239 0.4964
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0107 0.0187
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0104 0.0699 0.1389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0102 0.0236
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0011 0.0014
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0011 0.0014
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0277 0.0263
Brugia malayi hypothetical protein 0.0014 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0176 0.0343
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0107 0.0187
Schistosoma mansoni hypothetical protein 0.0104 0.0699 0.126
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0104 0.0699 0.0686
Brugia malayi Cytochrome P450 family protein 0.0021 0.0062 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.098 0.7395 0.7392
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Schistosoma mansoni lipoxygenase 0.0114 0.0776 0.14
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0011 0.0014
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0176 0.0343
Echinococcus granulosus lamin dm0 0.0028 0.0114 0.022
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0011 0.0014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.027
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0135 0.0262
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0135 0.0262
Plasmodium falciparum thioredoxin reductase 0.0533 0.3979 1
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0107 0.0207
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0011 0.0014
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0393 0.2907 1
Brugia malayi larval opioid receptor 0.0014 0.0011 0.0016
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0014 0.0011 0.0012
Loa Loa (eye worm) glutaminase 2 0.0265 0.1925 0.4839
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.039 0.07
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0175 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0083 0.0184
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0393 0.2907 0.7302
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0015 0.0038
Schistosoma mansoni sulfide quinone reductase 0.0104 0.0699 0.126
Brugia malayi Thioredoxin reductase 0.0533 0.3979 1
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0107 0.0187
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0048 0.0087
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0004 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0107 0.0259
Brugia malayi hypothetical protein 0.0014 0.001 0.0015
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0014 0.0011 0.0014
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0306 0.2239 0.4964
Echinococcus granulosus neuropeptide receptor 0.0014 0.0011 0.0014
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0104 0.0699 0.1657
Echinococcus multilocularis neuropeptide receptor A26 0.046 0.3417 0.6817
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0104 0.0699 0.1452
Giardia lamblia NADH oxidase lateral transfer candidate 0.0393 0.2907 1
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0011 0.0027
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0104 0.0699 0.1452
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.064 0.1609
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0027
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0393 0.2907 1
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0224 0.0397
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0104 0.0699 0.1452
Onchocerca volvulus 0.0503 0.3749 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.5 nM In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane ChEMBL. No reference
IC50 (binding) = 0.5 nM In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane ChEMBL. No reference
IC50 (binding) = 43 nM In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain ChEMBL. No reference
IC50 (binding) = 43 nM In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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