Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1138 | 0.0501 | 0.0531 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.1138 | 0.0501 | 0.0531 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.1138 | 0.0501 | 0.0531 |
Loa Loa (eye worm) | hypothetical protein | 0.1138 | 0.0501 | 0.0531 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.1138 | 0.0501 | 0.0926 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.1138 | 0.0501 | 0.0926 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.1138 | 0.0501 | 0.0531 |
Loa Loa (eye worm) | hypothetical protein | 0.1138 | 0.0501 | 0.0531 |
Echinococcus granulosus | FTZ F1 alpha | 0.1138 | 0.0501 | 0.0839 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.1138 | 0.0501 | 0.0839 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1138 | 0.0501 | 0.0531 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1138 | 0.0501 | 0.0926 |
Schistosoma mansoni | coup transcription factor | 0.1138 | 0.0501 | 0.0839 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.1138 | 0.0501 | 0.0531 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.1138 | 0.0501 | 0.0926 |
Brugia malayi | ecdysteroid receptor | 0.1138 | 0.0501 | 0.0531 |
Brugia malayi | nuclear hormone receptor | 0.1138 | 0.0501 | 0.0531 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.1138 | 0.0501 | 0.0839 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1138 | 0.0501 | 0.0839 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1138 | 0.0501 | 0.0926 |
Brugia malayi | steroid hormone receptor | 0.1138 | 0.0501 | 0.0531 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.1138 | 0.0501 | 0.0839 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.1138 | 0.0501 | 0.0839 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.1138 | 0.0501 | 0.0839 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.1138 | 0.0501 | 0.0531 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.1138 | 0.0501 | 0.0926 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.1138 | 0.0501 | 0.0531 |
Loa Loa (eye worm) | hypothetical protein | 1.0173 | 0.8937 | 0.9469 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.1138 | 0.0501 | 0.0926 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.1138 | 0.0501 | 0.0531 |
Loa Loa (eye worm) | hypothetical protein | 0.1138 | 0.0501 | 0.0531 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1138 | 0.0501 | 0.0531 |
Schistosoma mansoni | thyroid hormone receptor | 0.1138 | 0.0501 | 0.0839 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.1138 | 0.0501 | 0.0531 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.7004 | 0.5978 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.1138 | 0.0501 | 0.0839 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.1138 | 0.0501 | 0.0531 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1138 | 0.0501 | 0.0531 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.1138 | 0.0501 | 0.0531 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.1138 | 0.0501 | 0.0839 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.1138 | 0.0501 | 0.0839 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1138 | 0.0501 | 0.0531 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.1138 | 0.0501 | 0.0531 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 1.071 | 0.9439 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.1138 | 0.0501 | 0.0839 |
Echinococcus multilocularis | FTZ F1 alpha | 0.1138 | 0.0501 | 0.0926 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.1138 | 0.0501 | 0.0926 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.1138 | 0.0501 | 0.0839 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.1138 | 0.0501 | 0.0531 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.1138 | 0.0501 | 0.0839 |
Schistosoma mansoni | thyroid hormone receptor | 0.1138 | 0.0501 | 0.0839 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.1138 | 0.0501 | 0.0839 |
Schistosoma mansoni | nuclear hormone receptor | 0.1138 | 0.0501 | 0.0839 |
Brugia malayi | nuclear hormone receptor | 1.071 | 0.9439 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1138 | 0.0501 | 0.0531 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1138 | 0.0501 | 0.0531 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.1138 | 0.0501 | 0.0531 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.1138 | 0.0501 | 0.0531 |
Loa Loa (eye worm) | hypothetical protein | 0.1138 | 0.0501 | 0.0531 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0949 | 0.0325 | 0.0543 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1138 | 0.0501 | 0.0531 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.1138 | 0.0501 | 0.0839 |
Brugia malayi | nuclear receptor NHR-88 | 0.1138 | 0.0501 | 0.0531 |
Loa Loa (eye worm) | hypothetical protein | 0.1138 | 0.0501 | 0.0531 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1138 | 0.0501 | 0.0839 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.1138 | 0.0501 | 0.0531 |
Loa Loa (eye worm) | steroid hormone receptor | 0.1138 | 0.0501 | 0.0531 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.7004 | 0.5978 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1138 | 0.0501 | 0.0531 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.6403 | 0.5417 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1138 | 0.0501 | 0.0531 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.1138 | 0.0501 | 0.0531 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 2.68 | Mutagenic activity of the compound was tested in an Ames test on S. typhimurium TA98; Activity is log of revertants/nmol | ChEMBL. | 1995902 |
logP (ADMET) | = 4.11 | Partition coefficient (logP) | ChEMBL. | 1995902 |
Potency (functional) | 1.2995 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.9953 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.