Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0147 | 0.0897 | 0.1034 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0147 | 0.0897 | 0.0862 |
Brugia malayi | initiation factor 2-associated protein. | 0.0147 | 0.0897 | 0.0897 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0897 | 0.0897 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0147 | 0.0897 | 0.0897 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0116 | 0.0093 |
Schistosoma mansoni | peptidase | 0.0147 | 0.0897 | 0.1034 |
Plasmodium vivax | FACT complex subunit SPT16, putative | 0.0147 | 0.0897 | 0.0862 |
Plasmodium vivax | proliferation-associated protein 2g4, putative | 0.0147 | 0.0897 | 0.0862 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0276 | 0.0286 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.05 | 0.0555 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0097 | 0.0534 | 0.0505 |
Entamoeba histolytica | peptidase, putative | 0.0147 | 0.0897 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0227 | 0.1482 | 0.0642 |
Echinococcus granulosus | expressed conserved protein | 0.0091 | 0.0491 | 0.0461 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0147 | 0.0897 | 0.5414 |
Echinococcus multilocularis | methionine aminopeptidase, type I | 0.0147 | 0.0897 | 0.0862 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0139 | 0.084 | 0.0804 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.1389 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0182 | 0.0182 |
Echinococcus multilocularis | Proliferation associated protein 2G4 | 0.0147 | 0.0897 | 0.0862 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0116 | 0.0093 |
Treponema pallidum | methionine aminopeptidase (map) | 0.1162 | 0.8339 | 1 |
Mycobacterium ulcerans | dipeptidase PepE | 0.0147 | 0.0897 | 0.1076 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.1162 | 0.8339 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0147 | 0.0897 | 0.5414 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0147 | 0.0897 | 0.5414 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0093 | 0.05 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0897 | 0.0897 |
Schistosoma mansoni | proliferation-associated protein 2G4 38kDa (M24 family) | 0.0147 | 0.0897 | 0.1034 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0093 | 0.05 | 0.05 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0147 | 0.0897 | 0.0897 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0127 | 0.0106 |
Plasmodium falciparum | HP12 protein homolog, putative | 0.0227 | 0.1482 | 0.0642 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.05 | 0.047 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0147 | 0.0897 | 0.0897 |
Leishmania major | hypothetical protein, conserved | 0.0147 | 0.0897 | 0.0897 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0127 | 0.0096 |
Echinococcus granulosus | xaa Pro dipeptidase | 0.0147 | 0.0897 | 0.0869 |
Leishmania major | aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 | 0.0147 | 0.0897 | 0.0897 |
Toxoplasma gondii | methionine aminopeptidase | 0.1389 | 1 | 1 |
Toxoplasma gondii | proliferation-associated protein 2G4, putative | 0.0147 | 0.0897 | 0.0862 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0182 | 0.0182 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0227 | 0.1482 | 0.0642 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0127 | 0.0127 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0276 | 0.0286 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0012 | 0.0012 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.05 | 0.0555 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.1162 | 0.8339 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0196 | 0.0196 |
Leishmania major | transcription factor-like protein | 0.0147 | 0.0897 | 0.0897 |
Toxoplasma gondii | hypothetical protein | 0.0227 | 0.1482 | 0.1448 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.05 | 0.0463 |
Plasmodium vivax | hypothetical protein, conserved | 0.0227 | 0.1482 | 0.1448 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.05 | 0.0555 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0127 | 0.0096 |
Echinococcus granulosus | FACT complex subunit SPT16 | 0.0147 | 0.0897 | 0.0869 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0097 | 0.0534 | 0.0497 |
Schistosoma mansoni | chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) | 0.0147 | 0.0897 | 0.1034 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | metallopeptidase family M24 containing protein | 0.0147 | 0.0897 | 0.0897 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0099 | 0.0545 | 0.061 |
Echinococcus granulosus | xaa Pro dipeptidase | 0.0147 | 0.0897 | 0.0869 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.05 | 0.047 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.1162 | 0.8339 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0147 | 0.0897 | 0.0897 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.1162 | 0.8339 | 1 |
Schistosoma mansoni | Xaa-Pro dipeptidase (M24 family) | 0.0147 | 0.0897 | 0.1034 |
Entamoeba histolytica | aminopeptidase, putative | 0.0147 | 0.0897 | 1 |
Giardia lamblia | Methionine aminopeptidase | 0.0147 | 0.0897 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0227 | 0.1482 | 0.0642 |
Echinococcus granulosus | geminin | 0.0177 | 0.1121 | 0.1093 |
Plasmodium vivax | methionine aminopeptidase 1c, putative | 0.0147 | 0.0897 | 0.0862 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0147 | 0.0897 | 0.5 |
Leishmania major | aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 | 0.0147 | 0.0897 | 0.0897 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.1162 | 0.8339 | 0.8176 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0097 | 0.0534 | 0.0534 |
Onchocerca volvulus | Dipeptidase C homolog | 0.0147 | 0.0897 | 0.579 |
Mycobacterium ulcerans | aminopeptidase | 0.0147 | 0.0897 | 0.1076 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0127 | 0.0088 |
Brugia malayi | DNA-binding protein, 42 kDa containing protein | 0.0147 | 0.0897 | 0.0897 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0039 | 0.0008 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1389 | 1 | 1 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0147 | 0.0897 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0147 | 0.0897 | 0.5414 |
Leishmania major | aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 | 0.0147 | 0.0897 | 0.0897 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0147 | 0.0897 | 0.0862 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0127 | 0.0127 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0116 | 0.0093 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0039 | 0.0039 |
Mycobacterium leprae | Probable cytoplasmic peptidase PepQ | 0.0147 | 0.0897 | 0.1076 |
Echinococcus multilocularis | xaa pro aminopeptidase | 0.0147 | 0.0897 | 0.0862 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0147 | 0.0897 | 0.5414 |
Onchocerca volvulus | 0.003 | 0.0039 | 0.0251 | |
Toxoplasma gondii | peptidase D, putative | 0.0147 | 0.0897 | 0.0862 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0012 | 0.0012 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0147 | 0.0897 | 0.5414 |
Onchocerca volvulus | 0.0236 | 0.155 | 1 | |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0097 | 0.0534 | 0.5952 |
Toxoplasma gondii | methionine aminopeptidase | 0.1162 | 0.8339 | 0.8333 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0182 | 0.0182 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.017 | 0.0132 |
Echinococcus multilocularis | FACT complex subunit SPT16 | 0.0147 | 0.0897 | 0.0862 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0147 | 0.0897 | 0.1034 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0207 | 0.134 | 0.134 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.1162 | 0.8339 | 0.8333 |
Leishmania major | methionine aminopeptidase 2, putative | 0.0147 | 0.0897 | 0.0897 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.05 | 0.0463 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0276 | 0.0276 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0147 | 0.0897 | 0.5414 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.0147 | 0.0897 | 0.0897 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.1162 | 0.8339 | 1 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.1389 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0039 | 0.0039 |
Onchocerca volvulus | FACT complex subunit SPT16 homolog | 0.0147 | 0.0897 | 0.579 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0276 | 0.0276 |
Giardia lamblia | Xaa-Pro dipeptidase | 0.0147 | 0.0897 | 0.5 |
Echinococcus multilocularis | Xaa Pro aminopeptidase 3 | 0.0147 | 0.0897 | 0.0862 |
Mycobacterium ulcerans | cytoplasmic peptidase PepQ | 0.0147 | 0.0897 | 0.1076 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0276 | 0.0246 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0116 | 0.0093 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0147 | 0.0897 | 0.5414 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0897 | 0.0897 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.1389 | 1 | 1 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.1389 | 1 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.1389 | 1 | 1 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.1389 | 1 | 1 |
Echinococcus granulosus | xaa pro aminopeptidase | 0.0147 | 0.0897 | 0.0869 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0534 | 0.0534 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.1162 | 0.8339 | 1 |
Toxoplasma gondii | transcriptional elongation factor FACT140 | 0.0147 | 0.0897 | 0.0862 |
Plasmodium vivax | peptidase, putative | 0.0147 | 0.0897 | 0.0862 |
Toxoplasma gondii | creatinase domain-containing protein | 0.0147 | 0.0897 | 0.0862 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0147 | 0.0897 | 0.0862 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0127 | 0.0088 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0147 | 0.0897 | 0.5414 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0276 | 0.0286 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.1162 | 0.8339 | 0.8333 |
Mycobacterium tuberculosis | Probable cytoplasmic peptidase PepQ | 0.0147 | 0.0897 | 0.1076 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0139 | 0.084 | 0.0811 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0276 | 0.0276 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0276 | 0.0238 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.1121 | 0.1303 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0182 | 0.0182 |
Onchocerca volvulus | 0.0147 | 0.0897 | 0.579 | |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.1121 | 0.1303 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.1162 | 0.8339 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0147 | 0.0897 | 0.5414 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0276 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0127 | 0.0127 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0147 | 0.0897 | 0.579 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0147 | 0.0897 | 0.5414 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0068 | 0.0068 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0147 | 0.0897 | 0.5414 |
Echinococcus multilocularis | xaa Pro dipeptidase | 0.0147 | 0.0897 | 0.0862 |
Trichomonas vaginalis | set domain proteins, putative | 0.0236 | 0.155 | 1 |
Mycobacterium ulcerans | dipeptidase | 0.0147 | 0.0897 | 0.1076 |
Leishmania major | aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 | 0.0147 | 0.0897 | 0.0897 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0147 | 0.0897 | 1 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.1162 | 0.8339 | 0.8333 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0068 | 0.0035 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0147 | 0.0897 | 0.5414 |
Leishmania major | hypothetical protein, conserved | 0.0227 | 0.1482 | 0.1482 |
Entamoeba histolytica | Xaa-Pro dipeptidase, putative | 0.0147 | 0.0897 | 1 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.1389 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0276 | 0.0276 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.1389 | 1 | 1 |
Loa Loa (eye worm) | DNA-binding protein | 0.0147 | 0.0897 | 0.0897 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.1162 | 0.8339 | 1 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.1389 | 1 | 1 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.1162 | 0.8339 | 1 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0147 | 0.0897 | 0.1034 |
Echinococcus granulosus | Proliferation associated protein 2G4 | 0.0147 | 0.0897 | 0.0869 |
Mycobacterium tuberculosis | Dipeptidase PepE | 0.0147 | 0.0897 | 0.1076 |
Echinococcus multilocularis | xaa Pro dipeptidase | 0.0147 | 0.0897 | 0.0862 |
Echinococcus multilocularis | expressed conserved protein | 0.0091 | 0.0491 | 0.0454 |
Chlamydia trachomatis | methionine aminopeptidase | 0.1162 | 0.8339 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0276 | 0.0286 |
Echinococcus granulosus | Xaa Pro aminopeptidase 3 | 0.0147 | 0.0897 | 0.0869 |
Brugia malayi | Pre-SET motif family protein | 0.0207 | 0.134 | 0.134 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.0147 | 0.0897 | 0.0869 |
Schistosoma mansoni | aminopeptidase P1 (M24 family) | 0.0147 | 0.0897 | 0.1034 |
Echinococcus granulosus | methionine aminopeptidase type I | 0.0147 | 0.0897 | 0.0869 |
Echinococcus multilocularis | geminin | 0.0177 | 0.1121 | 0.1086 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.1389 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cell viability (functional) | = 42.6 % | Percent viability of rat hippocampal neurons exposed to hydrogen peroxide (50 microM) in the presence of the test agent (5 microM) | ChEMBL. | 8487263 |
ED20 (functional) | 0 mg kg-1 | Hypotensive effect in anesthetized normotensive rat expressed as effective dose; No effect | ChEMBL. | 8487263 |
Inhibition (functional) | = 65.2 % | Percent inhibition of 2,2'-azobis(2-amidinopropane)dihydrochloride induced decay of (R)-phycoerythrin fluorescence emission | ChEMBL. | 8487263 |
MIC (functional) | = 100 uM | Inhibition of iron-dependent peroxidation of rabbit vesicular membrane lipids (minimum test concentration that gave greater than 50% inhibition). | ChEMBL. | 8487263 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.