Detailed information for compound 284419

Basic information

Technical information
  • TDR Targets ID: 284419
  • Name: disodium [(2R)-6-methyl-2-[(3R,4S,10S,11R,12S ,13S,17R)-4,11,12-trihydroxy-10,13-dimethyl-3 -sulfonatooxy-2,3,4,5,6,7,8,9,11,12,14,15,16, 17-tetradecahydro-1H-cyclopenta[a]phenanthren -17-yl]heptyl] sulfate
  • MW: 658.773 | Formula: C27H48Na2O11S2
  • H donors: 3 H acceptors: 9 LogP: 3.55 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(CCC[C@H]([C@@H]1CCC2[C@@]1(C)[C@H](O)[C@H](O)C1C2CCC2[C@@]1(C)CC[C@H]([C@@H]2O)OS(=O)(=O)[O-])COS(=O)(=O)[O-])C.[NaH+].[NaH+]
  • InChi: 1S/C27H48O11S2.2Na/c1-15(2)6-5-7-16(14-37-39(31,32)33)18-10-11-19-17-8-9-20-23(28)21(38-40(34,35)36)12-13-26(20,3)22(17)24(29)25(30)27(18,19)4;;/h15-25,28-30H,5-14H2,1-4H3,(H,31,32,33)(H,34,35,36);;/q;2*+1/p-2/t16-,17?,18+,19?,20?,21+,22?,23-,24+,25+,26-,27+;;/m0../s1
  • InChiKey: PGYNHHCBOWWJDY-RATKTHMJSA-L  


Substructure search Similarity search

Network

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Synonyms

  • disodium [(2R)-6-methyl-2-[(3R,4S,10S,11R,12S,13S,17R)-4,11,12-trihydroxy-10,13-dimethyl-3-sulfato-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]heptyl] sulfate
  • disodium [(3R,4S,10S,11R,12S,13S,17R)-4,11,12-trihydroxy-10,13-dimethyl-17-[(2R)-6-methyl-1-sulfonatooxyheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] sulfate
  • disodium [(3R,4S,10S,11R,12S,13S,17R)-4,11,12-trihydroxy-10,13-dimethyl-17-[(1R)-5-methyl-1-(sulfonatooxymethyl)hexyl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] sulfate
  • disodium [(3R,4S,10S,11R,12S,13S,17R)-4,11,12-trihydroxy-10,13-dimethyl-17-[(1R)-5-methyl-1-(sulfatomethyl)hexyl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] sulfate
  • disodium [(3R,4S,10S,11R,12S,13S,17R)-4,11,12-trihydroxy-10,13-dimethyl-17-[(2R)-6-methyl-1-sulfonatooxy-heptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] sulfate
  • AIDS-005956
  • AIDS005956
  • Cholestane-3,4,21-triol, 3,21-bis(hydrogen sulfate), disodium salt, (3.alpha.4.alpha.)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0241 0.1116 0.1111
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.005 0.0044
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.031
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0035 0.1904
Echinococcus multilocularis pyruvate kinase 0.0017 0.0009 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0233 0.0233
Schistosoma mansoni opsin-like receptor 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0088 0.0088
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0071 0.0065
Schistosoma mansoni nAChR subunit 0.0029 0.0069 0.0063
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0035 0.0181
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0241 0.1116 0.1111
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0035 0.0035
Brugia malayi Serotonin receptor 0.0241 0.1116 0.1116
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0071 0.4358
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0062 0.0234 0.0234
Brugia malayi hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.2041 1 1
Echinococcus granulosus g-protein coupled receptor 0.0241 0.1116 0.1111
Brugia malayi putative neuropeptide receptor 0.0241 0.1116 0.1116
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0345 0.1629 0.1624
Echinococcus granulosus intermediate filament protein 0.0028 0.0064 0.0058
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0034 0.0092 0.0092
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0029 0.0069 0.0069
Loa Loa (eye worm) carboxylesterase 0.0345 0.1629 0.1629
Schistosoma mansoni adenoreceptor 0.0241 0.1116 0.1111
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.005 0.0044
Echinococcus granulosus neuropeptide s receptor 0.0241 0.1116 0.1111
Schistosoma mansoni amine GPCR 0.0241 0.1116 0.1111
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0178 1
Schistosoma mansoni amine GPCR 0.0241 0.1116 0.1111
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0506 0.3081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0405 0.0399
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0088 0.0505
Onchocerca volvulus 0.0029 0.0069 0.012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.1116 0.1111
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0035 0.0181
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0345 0.1629 0.1624
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.005 0.005
Schistosoma mansoni biogenic amine receptor 0.0241 0.1116 0.1111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0405 0.0399
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0088 0.0242
Mycobacterium ulcerans carboxylesterase, LipT 0.0345 0.1629 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0241 0.1116 0.1111
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0234 0.0229
Onchocerca volvulus 0.0241 0.1116 0.6754
Echinococcus granulosus neuropeptide Y receptor 0.0241 0.1116 0.1111
Echinococcus granulosus glycine receptor subunit alpha 1 0.0062 0.0234 0.0229
Loa Loa (eye worm) G-protein coupled receptor 0.0241 0.1116 0.1116
Brugia malayi hypothetical protein 0.0345 0.1629 0.1629
Onchocerca volvulus 0.0241 0.1116 0.6754
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0088 0.4884
Brugia malayi Serotonin receptor 0.0241 0.1116 0.1116
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0007 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0071 0.0065
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0029 0.0069 0.0063
Brugia malayi Pre-SET motif family protein 0.0204 0.0932 0.0932
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0029 0.0069 0.0063
Echinococcus granulosus sex peptide receptor 0.0241 0.1116 0.1111
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0035 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0035 0.1904
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0234 0.0229
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0064 0.0064
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0025 0.005 0.0044
Loa Loa (eye worm) acetylcholine receptor protein 0.0029 0.0069 0.0069
Onchocerca volvulus 0.0204 0.0934 0.5603
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0405 0.0399
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Onchocerca volvulus 0.0241 0.1116 0.6754
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0147 0.0651 0.0646
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0241 0.1116 0.1111
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0241 0.1116 0.6754
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0035 0.0029
Echinococcus multilocularis allatostatin A receptor 0.0241 0.1116 0.1111
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.005 0.0044
Onchocerca volvulus 0.0204 0.0934 0.5603
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0071 0.0065
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0006 0.0247
Brugia malayi putative neuropeptide receptor NPR1 0.0241 0.1116 0.1116
Brugia malayi ImpB/MucB/SamB family protein 0.0051 0.0178 0.0178
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0039 0.0686
Loa Loa (eye worm) hypothetical protein 0.0345 0.1629 0.1629
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.005 0.2937
Schistosoma mansoni hypothetical protein 0.0184 0.0835 0.0829
Echinococcus granulosus tachykinin peptides receptor 99D 0.0553 0.2656 0.2652
Brugia malayi Cation transporter family protein 0.0062 0.0234 0.0234
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.1116 0.1111
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.005 0.2937
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0155 0.092
Echinococcus granulosus nAChR subunit 0.0062 0.0234 0.0229
Echinococcus multilocularis neuropeptides capa receptor 0.0241 0.1116 0.1111
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0029 0.0069 0.0069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0071 0.0065
Schistosoma mansoni neuropeptide F-like receptor 0.0241 0.1116 0.1111
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0241 0.1116 0.1111
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.1116 0.1111
Brugia malayi Dopamine receptor 0.0241 0.1116 0.1116
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0241 0.1116 0.1111
Loa Loa (eye worm) norepinephrine transporter 0.0147 0.0651 0.0651
Onchocerca volvulus 0.0241 0.1116 0.6754
Schistosoma mansoni BC026374 protein (S09 family) 0.0345 0.1629 0.1624
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0034 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0147 0.0651 0.0651
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0062 0.0234 0.0229
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0241 0.1116 0.1111
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0006 0.0247
Onchocerca volvulus 0.0241 0.1116 0.6754
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.1116 0.1111
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0035 0.1699
Onchocerca volvulus 0.0029 0.0069 0.012
Echinococcus granulosus neuropeptide Y receptor 0.0241 0.1116 0.1111
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0107 0.0101
Echinococcus multilocularis g protein coupled receptor 0.0241 0.1116 0.1111
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0029 0.0069 0.0063
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Echinococcus multilocularis G protein coupled receptor 139 0.0241 0.1116 0.1111
Echinococcus multilocularis dna polymerase eta 0.0051 0.0178 0.0173
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0234 0.0234
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0088 0.0088
Brugia malayi glutathione reductase 0.0046 0.0155 0.0155
Onchocerca volvulus 0.0034 0.0092 0.0271
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0035 0.0181
Brugia malayi excitatory GABA receptor EXP-1A 0.0062 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0405 0.0399
Brugia malayi G-protein coupled receptor 0.0241 0.1116 0.1116
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0062 0.0234 0.0234
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Echinococcus multilocularis geminin 0.0184 0.0835 0.0829
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0241 0.1116 0.1111
Onchocerca volvulus 0.0029 0.0069 0.012
Onchocerca volvulus 0.0062 0.0234 0.117
Echinococcus granulosus neuropeptide receptor A26 0.0241 0.1116 0.1111
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.1116 0.1111
Echinococcus granulosus fmrfamide receptor 0.0241 0.1116 0.1111
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0062 0.0234 0.0234
Loa Loa (eye worm) GABA receptor subunit 0.0034 0.0092 0.0092
Onchocerca volvulus 0.0204 0.0934 0.5603
Echinococcus granulosus dna polymerase eta 0.0051 0.0178 0.0173
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.005 0.0044
Leishmania major pyruvate kinase 0.0033 0.0088 0.4755
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0448 0.2723
Loa Loa (eye worm) carboxylesterase 0.2041 1 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0241 0.1116 0.1111
Onchocerca volvulus 0.0147 0.0651 0.381
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.005 0.005
Loa Loa (eye worm) carboxylesterase 0.0345 0.1629 0.1629
Brugia malayi hypothetical protein 0.0241 0.1116 0.1116
Schistosoma mansoni opsin-like receptor 0.0241 0.1116 0.1111
Onchocerca volvulus 0.0241 0.1116 0.6754
Onchocerca volvulus 0.0241 0.1116 0.6754
Schistosoma mansoni neuropeptide receptor 0.0241 0.1116 0.1111
Schistosoma mansoni hypothetical protein 0.0241 0.1116 0.1111
Brugia malayi sulfakinin receptor protein 0.0241 0.1116 0.1116
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0345 0.1629 0.1624
Loa Loa (eye worm) LGC-31 protein 0.0062 0.0234 0.0234
Schistosoma mansoni hypothetical protein 0.0241 0.1116 0.1111
Echinococcus granulosus tm gpcr rhodopsin 0.0241 0.1116 0.1111
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0009 0.0238
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0062 0.0234 0.0229
Echinococcus granulosus tm gpcr rhodopsin 0.0241 0.1116 0.1111
Echinococcus granulosus glycine receptor subunit beta 0.0062 0.0234 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0035 0.1904
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0233 0.0227
Schistosoma mansoni hypothetical protein 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0506 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0007 0.0007
Schistosoma mansoni neuroligin 3 (S09 family) 0.0345 0.1629 0.1624
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.1116 0.1111
Echinococcus granulosus orexin receptor type 2 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.005 0.0044
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0029 0.0069 0.0063
Echinococcus multilocularis fmrfamide receptor 0.0241 0.1116 0.1111
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0241 0.1116 0.1111
Echinococcus multilocularis serotonin transporter 0.0147 0.0651 0.0646
Brugia malayi GnHR receptor homolog 0.0241 0.1116 0.1116
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0448 0.2723
Loa Loa (eye worm) hypothetical protein 0.0345 0.1629 0.1629
Echinococcus multilocularis neuropeptide FF receptor 2 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0345 0.1629 0.1629
Schistosoma mansoni biogenic amine receptor 0.0241 0.1116 0.1111
Onchocerca volvulus 0.0241 0.1116 0.6754
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0241 0.1116 0.1116
Echinococcus multilocularis neuropeptide receptor 0.0241 0.1116 0.1111
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0007 0.031
Schistosoma mansoni lamin 0.0028 0.0064 0.0058
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0062 0.0234 0.0234
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0234 0.0234
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Schistosoma mansoni biogenic amine (5HT) receptor 0.0241 0.1116 0.1111
Schistosoma mansoni hypothetical protein 0.0184 0.0835 0.0829
Echinococcus multilocularis neuropeptide s receptor 0.0241 0.1116 0.1111
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.1116 0.1111
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0006 0.5
Brugia malayi hypothetical protein 0.0241 0.1116 0.1116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0071 0.0065
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0204 0.0934 0.0929
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0204 0.0934 0.0934
Echinococcus granulosus neuropeptides capa receptor 0.0241 0.1116 0.1111
Echinococcus multilocularis para nitrobenzyl esterase 0.0345 0.1629 0.1624
Schistosoma mansoni intermediate filament proteins 0.0028 0.0064 0.0058
Schistosoma mansoni acetylcholine receptor-related 0.0029 0.0069 0.0063
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0241 0.1116 0.1116
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0062 0.0234 0.0229
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0009 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0035 0.1904
Brugia malayi Carboxylesterase family protein 0.0345 0.1629 0.1629
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.0064
Echinococcus multilocularis g-protein coupled receptor 0.0241 0.1116 0.1111
Onchocerca volvulus 0.0029 0.0071 0.0134
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0062 0.0234 0.0229
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0123 0.0118
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0233 0.0227
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Schistosoma mansoni nAChR subunit 0.0062 0.0234 0.0229
Brugia malayi AKH receptor 0.0241 0.1116 0.1116
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0006 0.0006
Brugia malayi larval opioid receptor 0.0241 0.1116 0.1116
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0234 0.0229
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0062 0.0234 0.0234
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0029 0.0069 0.0069
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0155 0.0149
Loa Loa (eye worm) ACC-1 protein 0.0062 0.0234 0.0234
Schistosoma mansoni lamin 0.0028 0.0064 0.0058
Loa Loa (eye worm) hypothetical protein 0.0025 0.005 0.005
Brugia malayi hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0345 0.1629 0.1629
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0001
Echinococcus multilocularis pyruvate kinase 0.0033 0.0088 0.0082
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0103 0.5663
Giardia lamblia DINP protein human, muc B family 0.0022 0.0035 0.3573
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0069 0.0069
Echinococcus granulosus peptide allatostatin:somatostatin 0.0241 0.1116 0.1111
Echinococcus multilocularis g protein coupled receptor 0.0241 0.1116 0.1111
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.1116 0.1111
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0006 0.5
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0034 0.0092 0.0092
Chlamydia trachomatis pyruvate kinase 0.0033 0.0088 1
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0035 0.1904
Schistosoma mansoni nAChR subunit 0.0062 0.0234 0.0229
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0034 0.0092 0.0092
Onchocerca volvulus 0.0241 0.1116 0.6754
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0007 0.0001
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0062 0.0234 0.0234
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.1116 0.1111
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0062 0.0234 0.0229
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.1116 0.1111
Onchocerca volvulus 0.0232 0.1071 0.6468
Loa Loa (eye worm) hypothetical protein 0.0034 0.0092 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0035 0.1904
Echinococcus multilocularis carboxylesterase 5A 0.2041 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0241 0.1116 0.1111
Brugia malayi Cation transporter family protein 0.0062 0.0234 0.0234
Onchocerca volvulus Putative nachr subunit 0.0062 0.0234 0.117
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0103 0.6543
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0035 0.1904
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0007 0.0074
Brugia malayi ORL1-like opioid receptor 0.0241 0.1116 0.1116
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0448 0.8609
Schistosoma mansoni neurotransmitter gated ion channel 0.0029 0.0069 0.0063
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0035 0.1699
Onchocerca volvulus 0.0345 0.1629 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0405 0.0399
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.0039
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0088 0.4884
Giardia lamblia Pyruvate kinase 0.0033 0.0088 1
Schistosoma mansoni histamine h1 receptor 0.0241 0.1116 0.1111
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0088 0.0242
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0095 0.055
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0071 0.0065
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0241 0.1116 0.1116
Schistosoma mansoni nAChR subunit 0.0029 0.0069 0.0063
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0007 0.0074
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Plasmodium vivax hypothetical protein, conserved 0.0025 0.005 0.2937
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.005 0.005
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0066 0.006
Echinococcus granulosus hypothetical protein 0.0241 0.1116 0.1111
Onchocerca volvulus 0.0241 0.1116 0.6754
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0062 0.0234 0.0229
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0147 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0345 0.1629 0.1629
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0155 0.0155
Echinococcus multilocularis pyruvate kinase 0.0033 0.0088 0.0082
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0233 0.0227
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0123 0.0118
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Schistosoma mansoni amine GPCR 0.0241 0.1116 0.1111
Echinococcus multilocularis nAChR subunit 0.0034 0.0092 0.0087
Plasmodium falciparum glutathione reductase 0.0046 0.0155 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0062 0.0234 0.0229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.1116 0.1111
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0155 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0062 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0147 0.0651 0.0651
Schistosoma mansoni myosin xvIII 0.0241 0.1116 0.1111
Toxoplasma gondii hypothetical protein 0.0025 0.005 0.2937
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0034 0.0092 0.0087
Echinococcus granulosus BC026374 protein S09 family 0.0345 0.1629 0.1624
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0345 0.1629 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0233 0.0233
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0009 0.0238
Leishmania major DNA polymerase eta, putative 0.0051 0.0178 1
Echinococcus granulosus g protein coupled receptor 0.0241 0.1116 0.1111
Plasmodium falciparum thioredoxin reductase 0.0046 0.0155 1
Brugia malayi hypothetical protein 0.0025 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.005 0.005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0241 0.1116 0.1111
Echinococcus multilocularis sex peptide receptor 0.0241 0.1116 0.1111
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0241 0.1116 0.1111
Echinococcus granulosus pyruvate kinase 0.0017 0.0009 0.0004
Echinococcus granulosus nAChR subunit 0.0034 0.0092 0.0087
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0025 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Schistosoma mansoni pyruvate kinase 0.0033 0.0088 0.0082
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.005 0.0044
Echinococcus multilocularis pyruvate kinase 0.0026 0.0054 0.0048
Brugia malayi Dopamine receptor protein 1 0.0241 0.1116 0.1116
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0035 0.1699
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0035 0.1904
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0062 0.0234 0.0229
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0345 0.1629 0.1624
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0006 0.0247
Echinococcus multilocularis glycine receptor subunit beta 0.0062 0.0234 0.0229
Echinococcus granulosus neuroligin 0.0345 0.1629 0.1624
Brugia malayi Carboxylesterase family protein 0.2041 1 1
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0088 0.5493
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Echinococcus granulosus lamin dm0 0.0028 0.0064 0.0058
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0035 0.0035
Entamoeba histolytica hypothetical protein 0.0034 0.0092 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0071 0.0065
Echinococcus granulosus 7tm_1 domain containing protein 0.0241 0.1116 0.1111
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0064 0.0064
Onchocerca volvulus Neuropeptide F receptor homolog 0.0241 0.1116 0.6754
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0241 0.1116 0.1111
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0034 0.0092 0.0087
Plasmodium vivax amine transporter, putative 0.0025 0.005 0.2937
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Plasmodium vivax SET domain protein, putative 0.0029 0.0071 0.4358
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0062 0.0234 0.0234
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0025 0.005 0.5346
Schistosoma mansoni acetylcholinesterase 0.0345 0.1629 0.1624
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0001
Schistosoma mansoni opsin-like receptor 0.0241 0.1116 0.1111
Brugia malayi hypothetical protein 0.0029 0.0069 0.0069
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0062 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0345 0.1629 0.1629
Schistosoma mansoni nAChR subunit 0.0062 0.0234 0.0229
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Echinococcus granulosus pyruvate kinase 0.0017 0.0009 0.0004
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0448 0.2723
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0062 0.0234 0.0229
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0088 0.4755
Brugia malayi Carboxylesterase family protein 0.0345 0.1629 0.1629
Echinococcus multilocularis acetylcholinesterase 0.2041 1 1
Brugia malayi hypothetical protein 0.0241 0.1116 0.1116
Brugia malayi hypothetical protein 0.0029 0.0069 0.0069
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0405 0.0399
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0088 0.5493
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.1116 0.1111
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0029 0.0069 0.0069
Brugia malayi hypothetical protein 0.0241 0.1116 0.1116
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0035 0.1904
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.005 0.005
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Brugia malayi Melatonin receptor type 1A 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0025 0.005 0.005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0448 0.2723
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0035 0.1904
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0007 0.0074
Schistosoma mansoni neuropeptide F-like receptor 0.0241 0.1116 0.1111
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0007 0.0064
Onchocerca volvulus 0.0241 0.1116 0.6754
Loa Loa (eye worm) hypothetical protein 0.0175 0.0792 0.0792
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.005 0.0044
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0062 0.0234 0.0229
Loa Loa (eye worm) hypothetical protein 0.0034 0.0092 0.0092
Mycobacterium tuberculosis Probable reductase 0.0106 0.0448 0.2723
Onchocerca volvulus 0.0345 0.1629 1
Echinococcus multilocularis neuropeptide Y receptor 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0147 0.0651 0.0651
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0062 0.0234 0.0234
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0035 0.0029
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0069 0.0069
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.1116 0.1111
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0155 0.0149
Loa Loa (eye worm) hypothetical protein 0.0034 0.0092 0.0092
Brugia malayi intermediate filament protein 0.0028 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0204 0.0934 0.0934
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.1116 0.1111
Schistosoma mansoni acetylcholine receptor subunit beta 0.0029 0.0069 0.0063
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0345 0.1629 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0241 0.1116 0.1111
Brugia malayi hypothetical protein 0.0029 0.0069 0.0069
Brugia malayi follicle stimulating hormone receptor 0.0241 0.1116 0.1116
Plasmodium falciparum transporter, putative 0.0025 0.005 0.2937
Schistosoma mansoni amine GPCR 0.0241 0.1116 0.1111
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0088 0.4755
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Onchocerca volvulus 0.0241 0.1116 0.6754
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0062 0.0234 0.0229
Brugia malayi RE15519p 0.0241 0.1116 0.1116
Echinococcus granulosus neuropeptide receptor 0.0241 0.1116 0.1111
Echinococcus granulosus rhodopsin orphan GPCR 0.0241 0.1116 0.1111
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0006 0.0247
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0095 0.055
Echinococcus multilocularis fmrfamide receptor 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0051 0.0178 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0035 0.1904
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0405 0.0405
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0034 0.0092 0.0092
Loa Loa (eye worm) solute carrier family 6 member 4 0.0147 0.0651 0.0651
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0241 0.1116 0.1111
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0088 0.0242
Schistosoma mansoni neuropeptide receptor 0.0241 0.1116 0.1111
Schistosoma mansoni nAChR subunit 0.0062 0.0234 0.0229
Schistosoma mansoni growth hormone secretagogue receptor 0.0241 0.1116 0.1111
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.1116 0.1111
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0241 0.1116 0.1111
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0039 0.0039
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0345 0.1629 0.1624
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0035 0.1699
Echinococcus granulosus biogenic amine 5HT receptor 0.0241 0.1116 0.1111
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Echinococcus multilocularis somatostatin receptor 0.0241 0.1116 0.1111
Onchocerca volvulus 0.0062 0.0234 0.117
Echinococcus multilocularis neuropeptides capa receptor 0.0241 0.1116 0.1111
Echinococcus granulosus dna polymerase kappa 0.0022 0.0035 0.0029
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0088 0.0505
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0062 0.0234 0.0229
Loa Loa (eye worm) hypothetical protein 0.0025 0.005 0.005
Schistosoma mansoni pyruvate kinase 0.0017 0.0009 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0405 0.0399
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Brugia malayi hypothetical protein 0.0029 0.0069 0.0069
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0001
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0032 0.0083 0.0083
Schistosoma mansoni sodium-dependent amino acid transporter 0.0025 0.005 0.0044
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0448 0.2723
Loa Loa (eye worm) TYRA-2 protein 0.0241 0.1116 0.1116
Onchocerca volvulus 0.0062 0.0234 0.117
Loa Loa (eye worm) hypothetical protein 0.0345 0.1629 0.1629
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0029 0.0069 0.0069
Plasmodium falciparum amino acid transporter, putative 0.0025 0.005 0.2937
Trichomonas vaginalis spcc417.12 protein, putative 0.0345 0.1629 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0241 0.1116 0.1116
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0241 0.1116 0.1111
Trypanosoma brucei trypanothione reductase 0.0046 0.0155 0.8689
Echinococcus granulosus acetylcholinesterase 0.2041 1 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0062 0.0234 0.0229
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0233 0.0227
Giardia lamblia Pyruvate kinase 0.0017 0.0009 0.0434
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0062 0.0234 0.0229
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0062 0.0234 0.0234
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0088 0.0505
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0088 0.0505
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0062 0.0234 0.0234
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.005 0.0044
Onchocerca volvulus 0.0345 0.1629 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0034 0.0092 0.0092
Echinococcus granulosus dro:myosuppressin receptor 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Schistosoma mansoni neurotransmitter gated ion channel 0.0034 0.0092 0.0087
Loa Loa (eye worm) neuropeptide F receptor 0.0241 0.1116 0.1116
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0062 0.0234 0.0229
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0241 0.1116 0.1111
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0062 0.0234 0.0229
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.005 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.1116 0.1111
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0007 0.0074
Loa Loa (eye worm) G-protein coupled receptor 0.0241 0.1116 0.1116
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0035 0.0181
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Brugia malayi hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) melatonin receptor type 1A 0.0241 0.1116 0.1116
Echinococcus multilocularis lamin 0.0028 0.0064 0.0058
Brugia malayi neuropeptide F receptor 0.0241 0.1116 0.1116
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0029 0.0069 0.0063
Schistosoma mansoni hypothetical protein 0.0241 0.1116 0.1111
Echinococcus granulosus pyruvate kinase 0.0017 0.0009 0.0004
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Echinococcus granulosus 7TM GPCR rhodopsin 0.0241 0.1116 0.1111
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0025 0.005 0.0044
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0035 0.0181
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0234 0.0234
Echinococcus multilocularis neuropeptide receptor 0.0241 0.1116 0.1111
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0241 0.1116 0.1116
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0233 0.0227
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0025 0.005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0033 0.0088 0.0088
Echinococcus multilocularis acetylcholinesterase 0.2041 1 1
Echinococcus granulosus glycine receptor subunit beta 0.0062 0.0234 0.0229
Echinococcus multilocularis glycine receptor subunit beta 0.0062 0.0234 0.0229
Brugia malayi Pre-SET motif family protein 0.0029 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) ACC-1 protein 0.0062 0.0234 0.0234
Plasmodium vivax glutathione reductase, putative 0.0046 0.0155 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0107 0.0107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.1116 0.1111
Echinococcus granulosus serotonin transporter 0.0147 0.0651 0.0646
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0107 0.0101
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) acetylcholinesterase 1 0.2041 1 1
Echinococcus granulosus lamin 0.0028 0.0064 0.0058
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0062 0.0234 0.0229
Schistosoma mansoni neuropeptide f receptor 76f 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Echinococcus multilocularis dro:myosuppressin receptor 0.0241 0.1116 0.1111
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0088 0.0088
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0062 0.0234 0.0234
Echinococcus granulosus biogenic amine 5HT receptor 0.0241 0.1116 0.1111
Trypanosoma brucei unspecified product 0.0022 0.0035 0.1904
Brugia malayi hypothetical protein 0.0241 0.1116 0.1116
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Echinococcus granulosus pyruvate kinase 0.0033 0.0088 0.0082
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.1116 0.1111
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0234 0.0234
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0064
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0025 0.005 0.005
Echinococcus granulosus glycine receptor subunit alpha 1 0.0062 0.0234 0.0229
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0035 0.0029
Schistosoma mansoni biogenic amine receptor 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0025 0.005 0.005
Schistosoma mansoni neuropeptide receptor 0.0241 0.1116 0.1111
Echinococcus granulosus acetylcholinesterase 0.2041 1 1
Brugia malayi Dopamine receptor protein 2 0.0241 0.1116 0.1116
Schistosoma mansoni gliotactin 0.0345 0.1629 0.1624
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0553 0.2656 0.2652
Echinococcus multilocularis pyruvate kinase 0.0017 0.0009 0.0004
Echinococcus granulosus neuropeptide receptor 0.0241 0.1116 0.1111
Echinococcus granulosus neuropeptides capa receptor 0.0241 0.1116 0.1111
Echinococcus multilocularis pyruvate kinase 0.0017 0.0009 0.0004
Schistosoma mansoni alpha-1 adrenergic receptor 0.0241 0.1116 0.1111
Leishmania major DNA polymerase kappa, putative 0.0022 0.0035 0.1699
Loa Loa (eye worm) hypothetical protein 0.2041 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0233 0.0227
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0241 0.1116 0.1111
Brugia malayi Carboxylesterase family protein 0.0345 0.1629 0.1629
Leishmania major DNA polymerase eta, putative 0.0036 0.0103 0.5663
Loa Loa (eye worm) glutathione reductase 0.0046 0.0155 0.0155
Schistosoma mansoni neurotransmitter gated ion channel 0.0029 0.0069 0.0063
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.0932 0.0932
Onchocerca volvulus 0.0241 0.1116 0.6754
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0069 0.0069
Treponema pallidum sodium- and chloride- dependent transporter 0.0147 0.0651 1
Onchocerca volvulus 0.0241 0.1116 0.6754
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2041 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0241 0.1116 0.1111
Brugia malayi hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Echinococcus granulosus alpha 1A adrenergic receptor 0.0241 0.1116 0.1111
Brugia malayi hypothetical protein 0.0241 0.1116 0.1116
Onchocerca volvulus 0.0241 0.1116 0.6754
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0035 0.0181
Brugia malayi Cation transporter family protein 0.0204 0.0934 0.0934
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0241 0.1116 0.1111
Brugia malayi isocitrate dehydrogenase 0.0016 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0035 0.1699
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0506 0.3081
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.005 0.0044
Onchocerca volvulus 0.0241 0.1116 0.6754
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0241 0.1116 0.1111
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0025 0.005 0.0044
Echinococcus granulosus allatostatin A receptor 0.0241 0.1116 0.1111
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0241 0.1116 0.1111
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0025 0.005 0.0044
Brugia malayi Carboxylesterase family protein 0.0345 0.1629 0.1629
Echinococcus granulosus tar DNA binding protein 0.0062 0.0233 0.0227
Toxoplasma gondii thioredoxin reductase 0.0046 0.0155 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0062 0.0234 0.0229
Echinococcus multilocularis nAChR subunit 0.0062 0.0234 0.0229
Loa Loa (eye worm) neuropeptide F receptor 0.0241 0.1116 0.1116
Toxoplasma gondii hypothetical protein 0.0025 0.005 0.2937
Echinococcus granulosus tm gpcr rhodopsin 0.0241 0.1116 0.1111
Brugia malayi TAR-binding protein 0.0062 0.0233 0.0233
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0029 0.0071 0.0071
Trypanosoma brucei DNA polymerase eta, putative 0.0051 0.0178 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0345 0.1629 1
Echinococcus granulosus serotonin receptor 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.005 0.2937
Leishmania major pyruvate kinase 0.0033 0.0088 0.4755
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0155 0.8656
Leishmania major trypanothione reductase 0.0046 0.0155 0.8656
Echinococcus multilocularis orexin receptor type 2 0.0241 0.1116 0.1111
Echinococcus multilocularis BC026374 protein (S09 family) 0.0345 0.1629 0.1624
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0062 0.0234 0.0234
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Echinococcus granulosus g protein coupled receptor 0.0241 0.1116 0.1111
Schistosoma mansoni pyruvate kinase 0.0033 0.0088 0.0082
Plasmodium falciparum pyruvate kinase 0.0033 0.0088 0.5493
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0025 0.005 0.005
Loa Loa (eye worm) serotonin transporter b 0.0147 0.0651 0.0651
Echinococcus multilocularis neuropeptide receptor A26 0.0241 0.1116 0.1111
Echinococcus granulosus somatostatin receptor 0.0241 0.1116 0.1111
Onchocerca volvulus 0.0345 0.1629 1
Brugia malayi G-protein coupled receptor 0.0241 0.1116 0.1116
Schistosoma mansoni DNA polymerase eta 0.0051 0.0178 0.0173
Brugia malayi hypothetical protein 0.0029 0.0069 0.0069
Echinococcus multilocularis g protein coupled receptor 0.0241 0.1116 0.1111
Echinococcus multilocularis neuroligin 0.0345 0.1629 0.1624
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.005 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0035 0.1904
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0506 0.3081
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0035 0.0029
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0062 0.0234 0.0229
Schistosoma mansoni nAChR subunit 0.0062 0.0234 0.0229
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.1116 0.1116
Brugia malayi G protein-coupled receptor F59B2.13 0.0241 0.1116 0.1116
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0062 0.0234 0.0234
Mycobacterium tuberculosis Carboxylesterase LipT 0.0345 0.1629 1
Schistosoma mansoni neuropeptide receptor 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0025 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0061
Echinococcus granulosus G protein coupled receptor 139 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Brugia malayi Thioredoxin reductase 0.0046 0.0155 0.0155
Onchocerca volvulus 0.0345 0.1629 1
Echinococcus granulosus g protein coupled receptor 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Brugia malayi Tachykinin-like peptides receptor 99D 0.0241 0.1116 0.1116
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0241 0.1116 0.1111
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.005 0.0044
Echinococcus granulosus carboxylesterase 5A 0.2041 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0234 0.0234
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0241 0.1116 0.1111
Echinococcus multilocularis musashi 0.0028 0.0064 0.0058
Echinococcus multilocularis lamin dm0 0.0028 0.0064 0.0058
Brugia malayi neuropeptide F receptor 0.0241 0.1116 0.1116
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0241 0.1116 0.1111
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0241 0.1116 0.1111
Echinococcus multilocularis serotonin receptor 0.0241 0.1116 0.1111
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0241 0.1116 0.1111
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0034 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0034 0.0092 0.0092
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0007 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.1116 0.1111
Schistosoma mansoni nAChR subunit 0.0062 0.0234 0.0229
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0064 0.0064
Echinococcus granulosus geminin 0.0184 0.0835 0.0829
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0034 0.0092 0.0092
Brugia malayi G protein-coupled receptor 0.0241 0.1116 0.1116
Echinococcus granulosus pyruvate kinase 0.0033 0.0088 0.0082
Loa Loa (eye worm) RNA binding protein 0.0062 0.0233 0.0233
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.005 0.0044
Schistosoma mansoni amine GPCR 0.0241 0.1116 0.1111
Onchocerca volvulus 0.0034 0.0092 0.0271
Schistosoma mansoni nAChR subunit 0.0062 0.0234 0.0229
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Echinococcus multilocularis neuropeptide Y receptor 0.0241 0.1116 0.1111
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0204 0.0934 0.0929
Loa Loa (eye worm) hypothetical protein 0.0062 0.0234 0.0234
Schistosoma mansoni sodium/chloride dependent transporter 0.0147 0.0651 0.0646
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Onchocerca volvulus 0.0028 0.0064 0.0089
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Echinococcus multilocularis serotonin receptor 0.0241 0.1116 0.1111
Onchocerca volvulus 0.0028 0.0064 0.0089
Onchocerca volvulus 0.0241 0.1116 0.6754
Trichomonas vaginalis set domain proteins, putative 0.0232 0.1071 0.6564
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0062 0.0234 0.0234
Brugia malayi RNA binding protein 0.0062 0.0233 0.0233
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0241 0.1116 0.1111
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0241 0.1116 0.1111
Echinococcus granulosus para nitrobenzyl esterase 0.0345 0.1629 0.1624
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0062 0.0234 0.0229
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Echinococcus multilocularis rhodopsin orphan GPCR 0.0241 0.1116 0.1111
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0241 0.1116 0.1116
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0035 0.1904

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 107 uM Effective concentration was tested for cytoprotective effect against HIV-2 CBL 20 strain infection in CEM cells ChEMBL. 8145229
EC50 (functional) = 122 uM Effective concentration was tested for cytoprotective effect against HIV-1 infection in CEM cells ChEMBL. 8145229
IC50 (functional) > 152 uM Inhibition of HIV-1 mediated cytotoxicity in CEM (human leukaemia) cells. ChEMBL. 8145229
IC50 (functional) > 152 uM Inhibition of HIV-2 (ROD) nediated cytotoxicity in CEM (human leukaemia) cells. ChEMBL. 8145229

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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