Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0472 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0472 | 1 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0095 | 0.0398 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 1 | 1 |
Loa Loa (eye worm) | fucosyl transferase | 0.0095 | 0.0398 | 0.0398 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0095 | 0.0398 | 0.0398 |
Onchocerca volvulus | 0.008 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.008 | 0 | 0.5 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0095 | 0.0398 | 0.0398 |
Onchocerca volvulus | 0.008 | 0 | 0.5 | |
Onchocerca volvulus | 0.008 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.008 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0472 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0472 | 1 | 1 |
Brugia malayi | alpha1,3-fucosyltransferase homologue | 0.0095 | 0.0398 | 0.0398 |
Onchocerca volvulus | 0.008 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0398 | 0.0398 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0095 | 0.0398 | 0.0398 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.008 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0472 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0472 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0472 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0472 | 1 | 1 |
Brugia malayi | Fucosyl transferase family protein | 0.0095 | 0.0398 | 0.0398 |
Brugia malayi | Carboxylesterase family protein | 0.0472 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.008 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.008 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0472 | 1 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0095 | 0.0398 | 0.0398 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.008 | 0 | 0.5 |
Onchocerca volvulus | 0.008 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Conversion (functional) | = 2.65 % | Cyclic AMP accumulation in Rat brain cerebral cortical slices by the compound, activity expressed as % conversion | ChEMBL. | 3001304 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.