Detailed information for compound 284730

Basic information

Technical information
  • TDR Targets ID: 284730
  • Name: 2-(2,4-dinitrophenyl)-1,3-dinitrobenzene
  • MW: 334.198 | Formula: C12H6N4O8
  • H donors: 0 H acceptors: 8 LogP: 2.86 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cc(ccc1c1c(cccc1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-]
  • InChi: 1S/C12H6N4O8/c17-13(18)7-4-5-8(11(6-7)16(23)24)12-9(14(19)20)2-1-3-10(12)15(21)22/h1-6H
  • InChiKey: SUGAJDLLCZMTPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,4-dinitrophenyl)-1,3-dinitro-benzene
  • 106323-82-4
  • 1,1'-BIPHENYL, 2,2',4,6'-TETRANITRO-
  • 2,4,2',6'-Tetranitrobiphenyl

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni opsin-like receptor 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0286 0.3182
Brugia malayi putative neuropeptide receptor 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Schistosoma mansoni amine GPCR 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0462 0.3675 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Onchocerca volvulus 0.1172 1 1
Echinococcus granulosus orexin receptor type 2 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Brugia malayi hypothetical protein 0.1172 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1172 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Echinococcus granulosus fmrfamide receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0119 0.006
Schistosoma mansoni neuropeptide receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0286 0.0286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0119 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0121 0.0643 1
Echinococcus granulosus biogenic amine 5HT receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni neuropeptide receptor 0.1172 1 1
Brugia malayi larval opioid receptor 0.1172 1 1
Echinococcus granulosus hypothetical protein 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Brugia malayi TAR-binding protein 0.0062 0.0118 0.0118
Schistosoma mansoni neuropeptide receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0286 0.3182
Brugia malayi putative neuropeptide receptor NPR1 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1172 1 1
Echinococcus multilocularis neuropeptide receptor 0.1172 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0118 0.0059
Echinococcus granulosus 7TM GPCR rhodopsin 0.1172 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0118 0.0059
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0121 0.0643 0.0531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Loa Loa (eye worm) G-protein coupled receptor 0.1172 1 1
Schistosoma mansoni hypothetical protein 0.1172 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Loa Loa (eye worm) TYRA-2 protein 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0121 0.0643 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0643 0.0643
Echinococcus multilocularis alpha 1A adrenergic receptor 0.1172 1 1
Echinococcus multilocularis neuropeptide receptor 0.1172 1 1
Schistosoma mansoni amine GPCR 0.1172 1 1
Brugia malayi G protein-coupled receptor 0.1172 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1172 1 1
Echinococcus granulosus cathepsin l1 0.0121 0.0643 0.0531
Brugia malayi hypothetical protein 0.1172 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.1172 1 1
Schistosoma mansoni amine GPCR 0.1172 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0121 0.0643 1
Onchocerca volvulus 0.1172 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0422 0.3318 0.8997
Trypanosoma cruzi major cysteine proteinase, putative 0.0363 0.2795 0.7525
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1172 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.1172 1 1
Echinococcus multilocularis fmrfamide receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis neuropeptide s receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.1172 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.1172 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0119 0.0119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0901 0.7583 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0462 0.3675 1
Schistosoma mansoni neuropeptide F-like receptor 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Schistosoma mansoni hypothetical protein 0.1172 1 1
Brugia malayi Dopamine receptor protein 1 0.1172 1 1
Echinococcus multilocularis cathepsin L 0.0062 0.0119 0.0001
Echinococcus granulosus neuropeptide FF receptor 2 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Echinococcus granulosus neuropeptide s receptor 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Leishmania major cathepsin L-like protease 0.0462 0.3675 1
Schistosoma mansoni hypothetical protein 0.1172 1 1
Echinococcus multilocularis somatostatin receptor 0.1172 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0118 0.0059
Onchocerca volvulus Cathepsin L homolog 0.0121 0.0643 0.0367
Brugia malayi Serotonin receptor 0.1172 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.1172 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.1172 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.1172 1 1
Loa Loa (eye worm) cysteine protease 0.0121 0.0643 0.0643
Echinococcus granulosus cathepsin l1 0.0081 0.0286 0.017
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0286 0.0286
Echinococcus granulosus allatostatin A receptor 0.1172 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.1172 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.1172 1 1
Schistosoma mansoni opsin-like receptor 0.1172 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0118 0.0118
Echinococcus granulosus cathepsin L 0.0062 0.0119 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis allatostatin A receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0081 0.0286 0.0228
Brugia malayi hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Brugia malayi neuropeptide F receptor 0.1172 1 1
Schistosoma mansoni amine GPCR 0.1172 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.1172 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0121 0.0643 0.0531
Echinococcus multilocularis neuropeptides capa receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis g-protein coupled receptor 0.1172 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Echinococcus granulosus serotonin receptor 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Echinococcus granulosus g protein coupled receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Loa Loa (eye worm) fucosyl transferase 0.0097 0.0425 0.0425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0121 0.0643 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0121 0.0643 1
Schistosoma mansoni neuropeptide receptor 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.1172 1 1
Echinococcus granulosus somatostatin receptor 0.1172 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.1172 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.1172 1 1
Brugia malayi Dopamine receptor protein 2 0.1172 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1172 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.1172 1 1
Echinococcus multilocularis serotonin receptor 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Schistosoma mansoni myosin xvIII 0.1172 1 1
Brugia malayi RE15519p 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Echinococcus granulosus neuropeptide receptor 0.1172 1 1
Echinococcus granulosus neuropeptides capa receptor 0.1172 1 1
Echinococcus multilocularis orexin receptor type 2 0.1172 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis g protein coupled receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis g protein coupled receptor 0.1172 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1172 1 1
Schistosoma mansoni adenoreceptor 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Onchocerca volvulus 0.0121 0.0643 0.0367
Leishmania major cathepsin L-like protease 0.0462 0.3675 1
Schistosoma mansoni opsin-like receptor 0.1172 1 1
Brugia malayi ORL1-like opioid receptor 0.1172 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Plasmodium vivax vivapain-2 0.0121 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0081 0.0286 0.0286
Brugia malayi GnHR receptor homolog 0.1172 1 1
Echinococcus granulosus g protein coupled receptor 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1172 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Plasmodium vivax vivapain-2 0.0121 0.0643 1
Schistosoma mansoni alpha(13)fucosyltransferase 0.0097 0.0425 0.0368
Echinococcus multilocularis cysteine protease 0.0121 0.0643 0.0531
Echinococcus multilocularis cysteine protease 0.0121 0.0643 0.0531
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Onchocerca volvulus 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Entamoeba histolytica cysteine protease, putative 0.0121 0.0643 1
Echinococcus multilocularis G protein coupled receptor 139 0.1172 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0081 0.0286 0.3182
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Echinococcus granulosus neuropeptide receptor 0.1172 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.1172 1 1
Echinococcus multilocularis sex peptide receptor 0.1172 1 1
Schistosoma mansoni alpha(13)fucosyltransferase 0.0097 0.0425 0.0368
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis g protein coupled receptor 0.1172 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.1172 1 1
Onchocerca volvulus Cathepsin F homolog 0.0121 0.0643 0.0367
Onchocerca volvulus 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0119 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.1172 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0118 0.0059
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1172 1 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.0118 0.0118
Brugia malayi Papain family cysteine protease containing protein 0.0121 0.0643 0.0643
Brugia malayi G protein-coupled receptor F59B2.13 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.0901 0.7583 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Schistosoma mansoni cathepsin F (C01 family) 0.0121 0.0643 0.0587
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1172 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.1172 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0081 0.0286 0.0286
Brugia malayi hypothetical protein 0.1172 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Brugia malayi follicle stimulating hormone receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus g-protein coupled receptor 0.1172 1 1
Loa Loa (eye worm) ctsf protein 0.0121 0.0643 0.0643
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Echinococcus granulosus cathepsin L cysteine protease 0.0062 0.0119 0.0001
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0081 0.0286 0.0286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Echinococcus granulosus biogenic amine 5HT receptor 0.1172 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0462 0.3675 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.1172 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0121 0.0643 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1172 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.1172 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.1172 1 1
Echinococcus multilocularis fmrfamide receptor 0.1172 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0119 0.0119
Onchocerca volvulus Cathepsin L homolog 0.0121 0.0643 0.0367
Brugia malayi Dopamine receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1172 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0121 0.0643 0.1472
Echinococcus granulosus neuropeptides capa receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Brugia malayi RNA binding protein 0.0062 0.0118 0.0118
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.1172 1 1
Echinococcus granulosus neuropeptide Y receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0462 0.3675 1
Loa Loa (eye worm) neuropeptide F receptor 0.1172 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Echinococcus granulosus sex peptide receptor 0.1172 1 1
Echinococcus granulosus cysteine protease 0.0062 0.0119 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Schistosoma mansoni amine GPCR 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Schistosoma mansoni alpha(13)fucosyltransferase 0.0097 0.0425 0.0368
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni alpha(13)fucosyltransferase 0.0097 0.0425 0.0368
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.1172 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.1172 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.1172 1 1
Brugia malayi Fucosyl transferase family protein 0.0097 0.0425 0.0425
Brugia malayi G-protein coupled receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Echinococcus granulosus neuropeptide receptor A26 0.1172 1 1
Schistosoma mansoni hypothetical protein 0.1172 1 1
Brugia malayi alpha1,3-fucosyltransferase homologue 0.0097 0.0425 0.0425
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Toxoplasma gondii cathepsin CPL 0.0121 0.0643 0.5
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Brugia malayi Serotonin receptor 0.1172 1 1
Echinococcus granulosus neuropeptide Y receptor 0.1172 1 1
Schistosoma mansoni biogenic amine receptor 0.1172 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.1172 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Brugia malayi G-protein coupled receptor 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Echinococcus granulosus g protein coupled receptor 0.1172 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Leishmania major cathepsin L-like protease 0.0462 0.3675 1
Schistosoma mansoni cathepsin F (C01 family) 0.0121 0.0643 0.0587
Loa Loa (eye worm) neuropeptide F receptor 0.1172 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0121 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0901 0.7583 0.5
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0121 0.0643 0.0531
Brugia malayi Melatonin receptor type 1A 0.1172 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0121 0.0643 0.0643
Schistosoma mansoni histamine h1 receptor 0.1172 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1172 1 1
Echinococcus granulosus G protein coupled receptor 139 0.1172 1 1
Brugia malayi cathepsin L-like precursor 0.0081 0.0286 0.0286
Loa Loa (eye worm) fibroinase 0.0121 0.0643 0.0643
Brugia malayi sulfakinin receptor protein 0.1172 1 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0118 0.0118
Onchocerca volvulus 0.1172 1 1
Brugia malayi neuropeptide F receptor 0.1172 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0121 0.0643 0.0531
Echinococcus multilocularis serotonin receptor 0.1172 1 1
Schistosoma mansoni biogenic amine receptor 0.1172 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0121 0.0643 0.0531
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0118 0.0059
Brugia malayi gonadotropin-releasing hormone receptor 2 0.1172 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0121 0.0643 1
Schistosoma mansoni alpha(13)fucosyltransferase 0.0097 0.0425 0.0368
Brugia malayi AKH receptor 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0286 0.0286
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0118 0.0118
Schistosoma mansoni biogenic amine receptor 0.1172 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0121 0.0643 0.0531
Onchocerca volvulus 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.1172 1 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = -0.07 Mutagenic activity of the compound was tested in an Ames test on S. typhimurium TA98; Activity is log of revertants/nmol ChEMBL. 1995902
logP (ADMET) = 3 Partition coefficient (logP) ChEMBL. 1995902

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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