Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cation transporter family protein | 0.028 | 0.5817 | 0.5817 |
Onchocerca volvulus | 0.028 | 0.5817 | 1 | |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.028 | 0.5817 | 0.5817 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.028 | 0.5817 | 0.5817 |
Echinococcus multilocularis | acetylcholinesterase | 0.0429 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0429 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.4872 | 0.4872 |
Loa Loa (eye worm) | carboxylesterase | 0.0429 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0429 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0429 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0429 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0429 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0429 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.5817 | 0.5817 |
Onchocerca volvulus | 0.028 | 0.5817 | 1 | |
Onchocerca volvulus | 0.028 | 0.5817 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0429 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.5817 | 0.5817 |
Brugia malayi | Carboxylesterase family protein | 0.0429 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0429 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0429 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | ug ear-1 dose-1 | Antiinflammatory activity of compound was measured in the phorbol-ester induced mouse chronic ear edema assay; No data | ChEMBL. | No reference |
ED50 (functional) | 0 ug ear-1 dose-1 | Antiinflammatory activity of compound was measured in the phorbol-ester induced mouse chronic ear edema assay; No data | ChEMBL. | No reference |
IC50 (binding) | uM | Compound was measured for the inhibition of human platelet PLA2 (HP-PLA2); No data | ChEMBL. | No reference |
IC50 (binding) | 0 uM | Compound was measured for the inhibition of human platelet PLA2 (HP-PLA2); No data | ChEMBL. | No reference |
Inhibition (binding) | = 40 % | Tested for the percentage inhibition of human platelet PLA2 (HP-PLA2) at concentration of at 10 microM | ChEMBL. | No reference |
Inhibition (binding) | = 40 % | Tested for the percentage inhibition of human platelet PLA2 (HP-PLA2) at concentration of at 10 microM | ChEMBL. | No reference |
Inhibition (binding) | = 97 % | Tested for the percentage inhibition of human platelet PLA2 (HP-PLA2) at concentration of 100 uM | ChEMBL. | No reference |
Inhibition (binding) | = 97 % | Tested for the percentage inhibition of human platelet PLA2 (HP-PLA2) at concentration of 100 uM | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.