Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Lactobacillus casei | Thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0389 | 0.5 | 0.5 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 0.5 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0389 | 0.5 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 0.5 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 0.0001 M | Inhibitory activity against dihydrofolate reductase derived from Lactobacillus casei | ChEMBL. | 3100797 |
IC50 (binding) | > 0.0001 M | Inhibitory activity against dihydrofolate reductase derived from Lactobacillus casei | ChEMBL. | 3100797 |
IC50 (binding) | = 0.00039 M | Inhibitory activity against thymidylate synthase derived from Lactobacillus casei | ChEMBL. | 3100797 |
IC50 (binding) | = 0.00039 M | Inhibitory activity against thymidylate synthase derived from Lactobacillus casei | ChEMBL. | 3100797 |
IC50 (binding) | = 0.00075 M | Inhibitory activity against the thymidylate synthase in the Permeabilized L1210 cells | ChEMBL. | 3100797 |
IC50 (binding) | = 0.00075 M | Inhibitory activity against the thymidylate synthase in the Permeabilized L1210 cells | ChEMBL. | 3100797 |
IC50 (binding) | > 0.003 M | Inhibitory activity against thymidylate synthase in the intact L1210 cells | ChEMBL. | 3100797 |
IC50 (binding) | > 0.003 M | Inhibitory activity against thymidylate synthase in the intact L1210 cells | ChEMBL. | 3100797 |
IC50 (functional) | = 0.56 ng ml-1 | Inhibitory activity against Streptococcus faecium ATCC 8043 | ChEMBL. | 3100797 |
IC50 (functional) | > 2000 ng ml-1 | Inhibitory activity against Streptococcus faecium MTX-resistant | ChEMBL. | 3100797 |
IC50 (functional) | > 2000 ng ml-1 | Inhibitory activity against Lactobacillus casei ATCC 7469 | ChEMBL. | 3100797 |
IC50 (functional) | > 2000 ng ml-1 | Inhibitory activity against Lactobacillus casei MTX-resistant | ChEMBL. | 3100797 |
IC50 (binding) | = 3900 nM | The compound was tested for its inhibitory activity (IC50) against thymidylate synthase(TS) derived from L. casei | ChEMBL. | 1732551 |
IC50 (binding) | = 3900 nM | The compound was tested for its inhibitory activity (IC50) against thymidylate synthase(TS) derived from L. casei | ChEMBL. | 1732551 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.