Detailed information for compound 28485

Basic information

Technical information
  • TDR Targets ID: 28485
  • Name: 4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl-pro p-2-ynylamino]benzoic acid
  • MW: 350.331 | Formula: C17H14N6O3
  • H donors: 3 H acceptors: 7 LogP: 0.75 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C#CCN(c1ccc(cc1)C(=O)O)Cc1cnc2c(n1)c(O)nc(n2)N
  • InChi: 1S/C17H14N6O3/c1-2-7-23(12-5-3-10(4-6-12)16(25)26)9-11-8-19-14-13(20-11)15(24)22-17(18)21-14/h1,3-6,8H,7,9H2,(H,25,26)(H3,18,19,21,22,24)
  • InChiKey: HKTKOVQHDBPQRZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl-prop-2-ynyl-amino]benzoic acid
  • 4-[(2-azanyl-4-oxo-1H-pteridin-6-yl)methyl-prop-2-ynyl-amino]benzoic acid
  • 4-[(2-amino-4-keto-1H-pteridin-6-yl)methyl-propargyl-amino]benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.4647 0.4647
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.0014 0.1827 0.1827
Onchocerca volvulus 0.003 0.4647 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.1827 0.1827
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.1827 0.1827
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.1827 0.1827
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.0014 0.1827 0.1827
Brugia malayi ABC transporter transmembrane region family protein 0.0017 0.2289 0.2289
Loa Loa (eye worm) hypothetical protein 0.0017 0.2289 0.2289
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.4647 0.4647
Plasmodium vivax ABC transporter B family member 3, putative 0.0004 0 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.4647 0.4647
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.1827 0.1827
Brugia malayi ecdysone receptor 0.0014 0.1827 0.1827
Brugia malayi ecdysteroid receptor 0.003 0.4647 0.4647
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.4647 0.4647
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0017 0.2289 0.2289
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.4647 0.4647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.4647 0.4647
Schistosoma mansoni nuclear receptor 0.0014 0.1827 0.1827
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.0014 0.1827 0.1827
Echinococcus multilocularis FTZ F1 alpha 0.003 0.4647 0.4647
Loa Loa (eye worm) steroid hormone receptor 0.003 0.4647 0.4647
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.1827 0.1827
Plasmodium vivax ABC transporter B family member 4, putative 0.0004 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.1827 0.1827
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.1827 0.393
Brugia malayi Nuclear hormone receptor E75 0.0014 0.1827 0.1827
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.1827 0.1827
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 1 1
Brugia malayi hypothetical protein 0.0016 0.2129 0.2129
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.4647 0.4647
Giardia lamblia MRP-like ABC transporter 0.0017 0.2289 0.0031
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0004 0 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.2129 0.2129
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.1827 0.1827
Brugia malayi nuclear receptor RXR 0.0014 0.1827 0.1827
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.4647 0.4647
Trypanosoma brucei multidrug resistance protein E 0.0017 0.2289 0.2289
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.4647 0.4647
Trypanosoma brucei p-glycoprotein 0.0017 0.2289 0.2289
Brugia malayi hypothetical protein 0.0014 0.1827 0.1827
Schistosoma mansoni nuclear hormone receptor 0.003 0.4647 0.4647
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.2129 0.2129
Schistosoma mansoni coup transcription factor 0.003 0.4647 0.4647
Plasmodium vivax ABC transporter B family member 7, putative 0.0004 0 0.5
Schistosoma mansoni thyroid hormone receptor 0.003 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.003 0.4647 0.4647
Leishmania major p-glycoprotein e 0.0017 0.2289 0.2289
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.1827 0.393
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.4647 0.4647
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.4647 0.4647
Echinococcus granulosus multidrug resistance associated protein 1 0.0017 0.2289 0.2289
Leishmania major pentamidine resistance protein 1 0.0017 0.2289 0.2289
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.4647 0.4647
Brugia malayi nuclear hormone receptor 0.003 0.4647 0.4647
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.003 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.0014 0.1827 0.1827
Entamoeba histolytica multidrug resistance protein, putative 0.0017 0.2289 1
Brugia malayi nuclear hormone receptor 0.0014 0.1827 0.1827
Plasmodium falciparum multidrug resistance protein 1 0.0004 0 0.5
Plasmodium falciparum ABC transporter B family member 4, putative 0.0004 0 0.5
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0017 0.2289 0.2289
Echinococcus granulosus multidrug resistance associated protein 4 0.0013 0.1597 0.1597
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.4647 0.4647
Giardia lamblia ABC transporter, putative 0.0017 0.2289 0.0031
Brugia malayi hypothetical protein 0.0016 0.2129 0.2129
Schistosoma mansoni multidrug resistance protein 0.0017 0.2289 0.2289
Entamoeba histolytica ABC transporter, putative 0.0017 0.2289 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.2129 0.2129
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.0014 0.1827 0.1827
Echinococcus granulosus mitogen activated protein kinase 0.006 1 1
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0004 0 0.5
Plasmodium falciparum ABC transporter B family member 3, putative 0.0004 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.2129 0.2129
Plasmodium falciparum multidrug resistance protein 2 0.0004 0 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.4647 0.4647
Echinococcus granulosus multidrug resistance associated protein 7 0.0017 0.2289 0.2289
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.4647 1
Loa Loa (eye worm) hypothetical protein 0.003 0.4647 0.4647
Plasmodium falciparum multidrug resistance-associated protein 2 0.0004 0 0.5
Onchocerca volvulus 0.0014 0.1827 0.393
Entamoeba histolytica hypothetical protein 0.0017 0.2289 1
Loa Loa (eye worm) hypothetical protein 0.003 0.4647 0.4647
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.4647 0.4647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.4647 0.4647
Echinococcus multilocularis multidrug resistance associated protein 1 0.0017 0.2289 0.2289
Brugia malayi nuclear receptor NHR-88 0.003 0.4647 0.4647
Giardia lamblia Kinase, CMGC MAPK 0.006 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.4647 0.4647
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.1827 0.1827
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.2129 0.2129
Brugia malayi steroid hormone receptor 0.003 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.0014 0.1827 0.1827
Brugia malayi multidrug resistance related protein 1 0.0017 0.2289 0.2289
Echinococcus multilocularis mitogen activated protein kinase 0.006 1 1
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0004 0 0.5
Trichomonas vaginalis CMGC family protein kinase 0.006 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.2265 0.2265
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.4647 0.4647
Brugia malayi Nuclear hormone receptor E75 0.0014 0.1827 0.1827
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.0016 0.2129 0.2129
Schistosoma mansoni nuclear receptor 0.0014 0.1827 0.1827
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.4647 0.4647
Plasmodium falciparum ABC transporter B family member 7, putative 0.0004 0 0.5
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0004 0 0.5
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.006 1 1
Brugia malayi nuclear receptor NHR-88 0.0014 0.1827 0.1827
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0004 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.0017 0.2289 0.2289
Loa Loa (eye worm) hypothetical protein 0.003 0.4647 0.4647
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0017 0.2289 0.2289
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.0014 0.1827 0.1827
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.2289 1
Schistosoma mansoni nuclear hormone receptor 0.0014 0.1827 0.1827
Schistosoma mansoni thyroid hormone receptor 0.003 0.4647 0.4647
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.4647 1
Schistosoma mansoni multidrug resistance protein 0.0017 0.2289 0.2289
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.4647 0.4647
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0017 0.2289 0.2289
Onchocerca volvulus Bile acid receptor homolog 0.003 0.4647 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.2129 0.2129
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.1827 0.1827
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.1827 0.1827
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.1827 0.1827
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.4647 0.4647
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.0014 0.1827 0.1827
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0004 0 0.5
Brugia malayi hypothetical protein 0.0014 0.1827 0.1827
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0017 0.2289 0.2289
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.1827 0.1827
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.4647 0.4647
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0004 0 0.5
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.1827 0.1827
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.1827 0.1827
Onchocerca volvulus 0.0014 0.1827 0.393
Loa Loa (eye worm) DR-78 0.0014 0.1827 0.1827
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.4647 0.4647
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.2129 0.2129
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.4647 0.4647
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.003 0.4647 0.4647
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0004 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.4647 0.4647
Trichomonas vaginalis CMGC family protein kinase 0.006 1 1
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0004 0 0.5
Giardia lamblia Multidrug resistance-associated protein 1 0.0017 0.2289 0.0031
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0004 0 0.5
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.2289 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.4647 0.4647
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.1827 0.1827
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 1 1
Loa Loa (eye worm) multidrug resistance-associated protein 0.0013 0.1621 0.1621
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0004 0 0.5
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.1827 0.1827
Giardia lamblia Multidrug resistance-associated protein 1 0.0017 0.2289 0.0031
Echinococcus multilocularis multidrug resistance associated protein 4 0.0013 0.1597 0.1597
Loa Loa (eye worm) hypothetical protein 0.0014 0.1827 0.1827
Trypanosoma cruzi multidrug resistance protein E, putative 0.0017 0.2289 0.2289
Loa Loa (eye worm) hypothetical protein 0.0016 0.2129 0.2129
Echinococcus granulosus FTZ F1 alpha 0.003 0.4647 0.4647
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.2289 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.4647 0.4647
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.4647 0.4647
Trypanosoma brucei protein kinase, putative 0.006 1 1
Schistosoma mansoni serine/threonine protein kinase 0.006 1 1
Plasmodium vivax ABC transporter B family member 5, putative 0.0004 0 0.5
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0017 0.2289 0.2289
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.1827 0.1827
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.4647 0.4647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.0014 0.1827 0.1827
Plasmodium vivax ABC transporter B family member 6, putative 0.0004 0 0.5
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0017 0.2289 0.2289
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.2129 0.2129
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.4647 0.4647
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 1 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0017 0.2289 0.2289
Brugia malayi conserved hypotetical protein 0.0014 0.1827 0.1827
Schistosoma mansoni multidrug resistance protein 0.0017 0.2289 0.2289
Leishmania major ABC-thiol transporter 0.0017 0.2289 0.2289
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0004 0 0.5
Echinococcus multilocularis multidrug resistance associated protein 7 0.0017 0.2289 0.2289
Trichomonas vaginalis CMGC family protein kinase 0.006 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.1827 0.1827
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.4647 0.4647
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.2129 0.2129
Plasmodium falciparum ABC transporter B family member 6, putative 0.0004 0 0.5
Plasmodium falciparum ABC transporter B family member 5, putative 0.0004 0 0.5
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0017 0.2289 0.2289
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0004 0 0.5
Brugia malayi nuclear receptor RXR 0.0016 0.2129 0.2129
Brugia malayi tailless protein 0.0014 0.1827 0.1827
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0017 0.2289 0.2289
Loa Loa (eye worm) hypothetical protein 0.0014 0.1827 0.1827
Plasmodium vivax multidrug resistance protein 1, putative 0.0004 0 0.5
Schistosoma mansoni multidrug resistance protein 0.0017 0.2289 0.2289
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.1827 0.1827
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.4647 0.4647
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.4647 0.4647
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.2129 0.2129
Loa Loa (eye worm) hypothetical protein 0.003 0.4647 0.4647
Schistosoma mansoni nuclear hormone receptor 0.0014 0.1827 0.1827
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.4647 0.4647
Brugia malayi nuclear receptor NHR-67 0.0014 0.1827 0.1827
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.4647 0.4647
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.1827 0.1827
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.2289 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.1827 0.1827
Trichomonas vaginalis CMGC family protein kinase 0.006 1 1
Schistosoma mansoni zinc finger protein 0.0014 0.1827 0.1827
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.4647 0.4647
Brugia malayi Steroid receptor seven-up type 2 0.003 0.4647 0.4647
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.1827 0.1827
Plasmodium vivax multidrug resistance protein 2, putative 0.0004 0 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.4647 0.4647
Loa Loa (eye worm) hypothetical protein 0.0014 0.1827 0.1827
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0004 0 0.5
Trypanosoma cruzi hypothetical protein 0.0013 0.1597 0.1597
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0004 0 0.5
Plasmodium falciparum multidrug resistance-associated protein 1 0.0004 0 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 0.0001 M Inhibitory activity against dihydrofolate reductase derived from Lactobacillus casei ChEMBL. 3100797
IC50 (binding) > 0.0001 M Inhibitory activity against dihydrofolate reductase derived from Lactobacillus casei ChEMBL. 3100797
IC50 (binding) > 0.00029 M Inhibitory activity against thymidylate synthase derived from Lactobacillus casei ChEMBL. 3100797
IC50 (binding) > 0.00029 M Inhibitory activity against thymidylate synthase derived from Lactobacillus casei ChEMBL. 3100797
IC50 (functional) = 0.76 ng ml-1 Inhibitory activity against Streptococcus faecium ATCC 8043 ChEMBL. 3100797
IC50 (functional) > 2000 ng ml-1 Inhibitory activity against Streptococcus faecium MTX-resistant ChEMBL. 3100797
IC50 (functional) > 2000 ng ml-1 Inhibitory activity against Lactobacillus casei ATCC 7469 ChEMBL. 3100797
IC50 (functional) > 2000 ng ml-1 Inhibitory activity against Lactobacillus casei MTX-resistant ChEMBL. 3100797

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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