Detailed information for compound 28489

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 362.379 | Formula: C21H18N2O4
  • H donors: 1 H acceptors: 2 LogP: 3.98 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c([nH]c2c1cc(c1ocnc1)c(c2)OC)c1ccccc1
  • InChi: 1S/C21H18N2O4/c1-3-26-21(24)19-14-9-15(18-11-22-12-27-18)17(25-2)10-16(14)23-20(19)13-7-5-4-6-8-13/h4-12,23H,3H2,1-2H3
  • InChiKey: MZXHOWYGVFTMTL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens IMP (inosine 5'-monophosphate) dehydrogenase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma mansoni inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Neospora caninum hypothetical protein Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium parvum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Toxoplasma gondii IMP dehydrogenas Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Loa Loa (eye worm) IMP dehydrogenase 1 Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium yoelii inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium knowlesi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Babesia bovis inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma japonicum ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative Get druggable targets OG5_126887 All targets in OG5_126887
Theileria parva Inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium berghei inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium hominis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma congolense GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus GPCR family 2 0.0031 0.0068 0.0102
Schistosoma mansoni thymidylate kinase 0.0141 0.1513 0.2497
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0366 0.036
Schistosoma mansoni hypothetical protein 0.0047 0.0277 0.0449
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0155 0.0557
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.0906 0.1289
Trichomonas vaginalis thymidylate kinase, putative 0.0141 0.1513 0.2287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0254 0.041
Toxoplasma gondii exonuclease III APE 0.0038 0.0155 0.0241
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0121 0.0191
Entamoeba histolytica Thymidylate kinase, putative 0.0141 0.1513 0.2287
Trypanosoma cruzi GMP reductase 0.0095 0.0906 0.1289
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0605 0.0795
Echinococcus multilocularis thyroid hormone receptor alpha 0.0139 0.149 0.1485
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0055 0.0389 0.0439
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0068 0.0061
Schistosoma mansoni hypothetical protein 0.0031 0.0068 0.0102
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0095 0.0906 0.5638
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0486 0.604 1
Leishmania major inosine-5-monophosphate dehydrogenase 0.0095 0.0906 0.1289
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0072 0.0605 0.3477
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0095 0.0906 0.5638
Loa Loa (eye worm) IMP dehydrogenase 1 0.0095 0.0906 0.3384
Schistosoma mansoni thyroid hormone receptor 0.0139 0.149 0.2459
Loa Loa (eye worm) hypothetical protein 0.0098 0.0943 0.3521
Schistosoma mansoni survival motor neuron protein 0.0047 0.0277 0.0449
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0306 0.1111
Brugia malayi Inositol-1 0.0072 0.0605 0.2242
Schistosoma mansoni hypothetical protein 0.0129 0.1354 0.2234
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0306 0.0303
Giardia lamblia CDC8 0.0141 0.1513 0.2244
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0072 0.0605 0.0796
Loa Loa (eye worm) hypothetical protein 0.023 0.2677 1
Loa Loa (eye worm) inositol-1 0.0072 0.0605 0.2261
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0045 0.0253 0.0946
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0039 0.0179 0.0647
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0605 0.0795
Brugia malayi thymidylate kinase 0.0141 0.1513 0.564
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.1354 0.2234
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0254 0.041
Echinococcus multilocularis GPCR, family 2 0.0031 0.0068 0.0061
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0121 0.0115
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0121 0.0191
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0095 0.0906 0.09
Plasmodium falciparum thymidylate kinase 0.0141 0.1513 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0155 0.0055
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0277 0.1015
Brugia malayi hypothetical protein 0.0032 0.0078 0.0268
Onchocerca volvulus Putative GMP reductase 0.0039 0.0179 0.1148
Trypanosoma brucei thymidine kinase 0.0499 0.6205 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0155 0.0246
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0121 0.0191
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0023
Schistosoma mansoni inositol monophosphatase 0.0072 0.0605 0.0993
Schistosoma mansoni hypothetical protein 0.0165 0.1823 0.301
Trypanosoma cruzi thymidine kinase, putative 0.0499 0.6205 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.0906 0.1289
Schistosoma mansoni hypothetical protein 0.0031 0.0068 0.0102
Echinococcus granulosus thymidylate kinase 0.0141 0.1513 0.2497
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0089 0.0832 0.5107
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0306 0.0303
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0039 0.0179 0.0647
Toxoplasma gondii IMP dehydrogenas 0.0095 0.0906 0.5638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0254 0.041
Loa Loa (eye worm) beta-lactamase 0.0035 0.0121 0.0454
Loa Loa (eye worm) hypothetical protein 0.0035 0.0121 0.0454
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0155 0.0241
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0068 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0121 0.0454
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0366 0.0597
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0538 0.1989
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0121 0.019
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0155 0.0056
Trypanosoma brucei thymidylate kinase, putative 0.0141 0.1513 0.2422
Loa Loa (eye worm) hypothetical protein 0.0035 0.0121 0.0454
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0306 0.0473
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0155 0.0135
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0605 0.0957
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.005 0.0315 0.1393
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0064 0.0506 0.1556
Leishmania major hypothetical protein, conserved 0.0055 0.0389 0.0439
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0072 0.0605 0.3316
Mycobacterium ulcerans thymidylate kinase 0.0141 0.1513 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0254 0.0248
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0089 0.0832 0.5107
Toxoplasma gondii thymidylate kinase 0.0141 0.1513 1
Echinococcus granulosus geminin 0.0165 0.1823 0.301
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0095 0.0906 0.3171
Trichomonas vaginalis thymidine kinase, putative 0.0499 0.6205 1
Echinococcus multilocularis thymidine kinase 0.0486 0.604 0.6038
Brugia malayi beta-lactamase 0.0035 0.0121 0.0431
Plasmodium vivax thymidylate kinase, putative 0.0141 0.1513 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0605 0.0795
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0943 0.3506
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0045 0.0253 0.0946
Leishmania major thymidylate kinase-like protein 0.0141 0.1513 0.2287
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0068 0.0252
Echinococcus granulosus thymidine kinase 0.0486 0.604 1
Schistosoma mansoni hypothetical protein 0.0035 0.0121 0.019
Schistosoma mansoni hypothetical protein 0.0031 0.0068 0.0102
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0055 0.0389 0.0439
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0095 0.0906 0.5531
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0095 0.0906 0.1442
Brugia malayi beta-lactamase family protein 0.0035 0.0121 0.0431
Loa Loa (eye worm) hypothetical protein 0.0035 0.0121 0.0454
Trypanosoma cruzi thymidylate kinase, putative 0.0141 0.1513 0.2287
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0254 0.0949
Brugia malayi GMP reductase 0.0039 0.0179 0.0647
Loa Loa (eye worm) thymidylate kinase 0.0141 0.1513 0.5651
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0155 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0254 0.041
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2595 1
Trypanosoma cruzi thymidine kinase, putative 0.0499 0.6205 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0121 0.0454
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0306 0.1111
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0121 0.019
Loa Loa (eye worm) GMP reductase 0.0039 0.0179 0.0669
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0141 0.1513 1
Trichomonas vaginalis thymidine kinase, putative 0.0499 0.6205 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0072 0.0605 0.3477
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0006 0.0023
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0155 0.0241
Echinococcus granulosus thymidine kinase 0.0486 0.604 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0068 0.0061
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0155 0.0055
Trypanosoma brucei GMP reductase 0.0095 0.0906 0.1442
Entamoeba histolytica thymidine kinase, putative 0.0499 0.6205 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0155 0.0055
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0095 0.0906 0.1491
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0095 0.0906 0.3368
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0064 0.0506 0.2767
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0068 0.0102
Trypanosoma cruzi GMP reductase 0.0095 0.0906 0.1289
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0254 0.041
Trichomonas vaginalis inositol monophosphatase, putative 0.0072 0.0605 0.0795
Trypanosoma brucei RNA helicase, putative 0.0218 0.2518 0.4046
Echinococcus granulosus survival motor neuron protein 1 0.023 0.2677 0.4426
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0089 0.0832 0.4987
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0254 0.0248
Echinococcus granulosus inositol monophosphatase 1 0.0072 0.0605 0.0993
Loa Loa (eye worm) hypothetical protein 0.0049 0.0306 0.1142
Onchocerca volvulus 0.0035 0.0121 0.0765
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.005 0.0315 0.0784
Schistosoma mansoni thymidine kinase 0.0486 0.604 1
Trypanosoma brucei thymidylate kinase, putative 0.0141 0.1513 0.2422
Chlamydia trachomatis thymidylate kinase 0.0141 0.1513 0.5
Schistosoma mansoni inositol monophosphatase 0.0072 0.0605 0.0993
Onchocerca volvulus Putative thymidylate kinase 0.0141 0.1513 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0943 0.3521
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0306 0.1325
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0141 0.1513 1
Leishmania major hypothetical protein, conserved 0.0049 0.0306 0.0303
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0155 0.0055
Echinococcus multilocularis geminin 0.0165 0.1823 0.1818
Trichomonas vaginalis thymidine kinase, putative 0.0499 0.6205 1
Schistosoma mansoni hypothetical protein 0.0218 0.2518 0.4162
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0068 0.0229
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0306 0.1325
Echinococcus multilocularis thymidine kinase 0.0486 0.604 0.6038
Brugia malayi hypothetical protein 0.023 0.2677 1
Echinococcus multilocularis inositol monophosphatase 1 0.0072 0.0605 0.0599
Leishmania major guanosine monophosphate reductase 0.0095 0.0906 0.1289
Loa Loa (eye worm) hypothetical protein 0.0031 0.0068 0.0252
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0943 0.3506
Schistosoma mansoni hypothetical protein 0.0031 0.0068 0.0102
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0006 0.0023
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0254 0.0927
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0155 0.0055
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0121 0.0431
Schistosoma mansoni hypothetical protein 0.0103 0.1017 0.1675
Trichomonas vaginalis thymidylate kinase, putative 0.0141 0.1513 0.2287
Schistosoma mansoni thyroid hormone receptor 0.0139 0.149 0.2459
Loa Loa (eye worm) hypothetical protein 0.0067 0.0538 0.2008
Onchocerca volvulus 0.0035 0.0121 0.0765
Echinococcus multilocularis transfer RNA-Ile 0.0486 0.604 0.6038
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0121 0.0176
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0121 0.0454
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.2677 0.2672
Loa Loa (eye worm) hypothetical protein 0.0035 0.0121 0.0454
Schistosoma mansoni ap endonuclease 0.0038 0.0155 0.0246
Schistosoma mansoni hypothetical protein 0.0141 0.1513 0.2497
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0121 0.0115
Brugia malayi hypothetical protein 0.0049 0.0306 0.1122
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0095 0.0906 0.1491
Schistosoma mansoni hypothetical protein 0.0067 0.0538 0.088
Treponema pallidum thymidylate kinase (tmk) 0.0141 0.1513 1
Leishmania major thymidine kinase, putative 0.0499 0.6205 1
Schistosoma mansoni hypothetical protein 0.0165 0.1823 0.301
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.0906 0.1289
Onchocerca volvulus 0.0035 0.0121 0.0765
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0141 0.1513 0.5625
Brugia malayi hypothetical protein 0.0035 0.0121 0.043
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0605 0.0795
Brugia malayi beta-lactamase family protein 0.0035 0.0121 0.0431
Giardia lamblia Deoxynucleoside kinase 0.0385 0.472 0.7546
Schistosoma mansoni thymidylate kinase 0.0141 0.1513 0.2497
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0155 0.0579
Onchocerca volvulus 0.0047 0.0277 0.18
Trypanosoma cruzi thymidylate kinase, putative 0.0141 0.1513 0.2287
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0605 0.0795
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0068 0.0229
Schistosoma mansoni lipoxygenase 0.0054 0.0366 0.0597
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.1354 0.1349
Giardia lamblia Thymidine kinase 0.0499 0.6205 1
Echinococcus multilocularis thymidylate kinase 0.0141 0.1513 0.1507
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0155 0.023
Schistosoma mansoni ap endonuclease 0.0038 0.0155 0.0246

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 1 uM Inhibition of 5'-inosine monophosphate dehydrogenase type II (IMPDH II) ChEMBL. 12657262
IC50 (binding) > 1 uM Inhibition of 5'-inosine monophosphate dehydrogenase type II (IMPDH II) ChEMBL. 12657262

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.