Detailed information for compound 284899

Basic information

Technical information
  • TDR Targets ID: 284899
  • Name: 1,8-dihydroxy-10-[2-(3-methoxyphenyl)acetyl]- 10H-anthracen-9-one
  • MW: 374.386 | Formula: C23H18O5
  • H donors: 2 H acceptors: 4 LogP: 4.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)CC(=O)C1c2cccc(c2C(=O)c2c1cccc2O)O
  • InChi: 1S/C23H18O5/c1-28-14-6-2-5-13(11-14)12-19(26)20-15-7-3-9-17(24)21(15)23(27)22-16(20)8-4-10-18(22)25/h2-11,20,24-25H,12H2,1H3
  • InChiKey: GVBUKLPKAAGWRW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,8-dihydroxy-10-[2-(3-methoxyphenyl)-1-oxoethyl]-10H-anthracen-9-one
  • 1,8-dihydroxy-10-[2-(3-methoxyphenyl)ethanoyl]-10H-anthracen-9-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0047 0.0047
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0056 0.0056
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0634 0.2515 0.2515
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0024 0.0054 0.0054
Trichomonas vaginalis heat shock protein, putative 0.002 0.0039 0.0112
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0039 0.0039
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0056 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0054
Brugia malayi hypothetical protein 0.0022 0.0047 0.0047
Trypanosoma brucei heat shock protein, putative 0.0025 0.0059 0.0059
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0046 0.0144 0.0144
Trypanosoma cruzi NADH dehydrogenase, putative 0.0229 0.0883 0.0883
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0047 0.0047
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0021 0.0043 0.0478
Brugia malayi hypothetical protein 0.0024 0.0056 0.0056
Echinococcus multilocularis cpg binding protein 0.0028 0.0073 0.0073
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0056 0.0056
Schistosoma mansoni amine GPCR 0.0024 0.0056 0.0056
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0229 0.0883 0.0883
Trichomonas vaginalis spcc417.12 protein, putative 0.0034 0.0097 0.0282
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0229 0.0883 0.0859
Trichomonas vaginalis apoptosis inducing factor, putative 0.0229 0.0883 0.2567
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0144 0.0144
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0033 0.0092 0.0092
Brugia malayi hypothetical protein 0.0019 0.0035 0.0035
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0229 0.0883 0.0883
Echinococcus multilocularis heat shock protein 90 0.0025 0.0059 0.0059
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0863 0.3439 0.3439
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0267
Brugia malayi hypothetical protein 0.0024 0.0057 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0046 0.0144 0.0144
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0202 0.0775 0.0775
Loa Loa (eye worm) carboxylesterase 0.0034 0.0097 0.0097
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0.0026 0.0026
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0229 0.0883 0.2511
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0149 0.0149
Echinococcus granulosus sex peptide receptor 0.0024 0.0056 0.0056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0057 0.0057
Loa Loa (eye worm) heat shock protein 90 0.0025 0.0059 0.0059
Onchocerca volvulus 0.0024 0.0056 0.0549
Trichomonas vaginalis glutamate synthase, putative 0.0229 0.0883 0.2567
Echinococcus multilocularis glutamate synthase 0.0229 0.0883 0.0883
Echinococcus multilocularis musashi 0.0049 0.0156 0.0156
Onchocerca volvulus 0.0024 0.0056 0.0549
Loa Loa (eye worm) PDE1B protein 0.0033 0.0092 0.0092
Trypanosoma brucei hypothetical protein, conserved 0.0229 0.0883 0.0883
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Loa Loa (eye worm) programmed cell death 8 0.0229 0.0883 0.0883
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0033 0.0092 0.0092
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0229 0.0883 0.0883
Echinococcus granulosus inositol monophosphatase 1 0.0021 0.0043 0.0043
Mycobacterium tuberculosis Probable oxidoreductase 0.0863 0.3439 0.3422
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0092 0.0267
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0056 0.0056
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Schistosoma mansoni endoplasmin 0.0025 0.0059 0.0059
Brugia malayi MH2 domain containing protein 0.0079 0.0277 0.0277
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0047 0.0047
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0056 0.0056
Schistosoma mansoni cpg binding protein 0.0028 0.0073 0.0073
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0229 0.0883 0.0883
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Trypanosoma brucei trypanothione reductase 0.2492 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0144 0.0144
Brugia malayi Steroid receptor seven-up type 2 0.0046 0.0144 0.0144
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0056 0.0056
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0194 0.074 0.074
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0047 0.0459
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0229 0.0883 0.0883
Brugia malayi CXXC zinc finger family protein 0.0027 0.0067 0.0067
Leishmania major hypothetical protein, conserved 0.0029 0.0077 0.0077
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0033 0.0092 0.0092
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0056 0.0056
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0229 0.0883 0.0859
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Echinococcus granulosus allatostatin A receptor 0.0024 0.0056 0.0056
Mycobacterium ulcerans ferredoxin reductase 0.0229 0.0883 0.2511
Echinococcus granulosus serotonin receptor 0.0024 0.0056 0.0056
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0046 0.0144 0.0144
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0056 0.0056
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0056 0.0056
Toxoplasma gondii selenide, water dikinase 0.0229 0.0883 0.0883
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0033 0.0092 0.0092
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0229 0.0883 0.0883
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0049 0.0156 0.0156
Echinococcus granulosus hypothetical protein 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0046 0.0144 0.0144
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0033 0.0093 0.0093
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0046 0.0144 0.0144
Loa Loa (eye worm) thioredoxin reductase 0.2492 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0149 0.0149
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0229 0.0883 0.2567
Echinococcus multilocularis neuropeptide s receptor 0.1077 0.4299 0.4299
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0056 0.0056
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0229 0.0883 0.2567
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0047 0.0047
Schistosoma mansoni Replicative DNA helicase 0.0216 0.0829 0.0829
Onchocerca volvulus 0.0034 0.0097 0.0961
Schistosoma mansoni hypothetical protein 0.0013 0.0012 0.0012
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0059 0.0059
Echinococcus multilocularis carboxylesterase 5A 0.0202 0.0775 0.0775
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.0006 0.0006
Trichomonas vaginalis heat shock protein, putative 0.002 0.0039 0.0112
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0229 0.0883 0.0883
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0093 0.0093
Brugia malayi AKH receptor 0.0024 0.0056 0.0056
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0056 0.0056
Trypanosoma brucei heat shock protein, putative 0.0025 0.0059 0.0059
Mycobacterium ulcerans carboxylesterase, LipT 0.0034 0.0097 0.0209
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Echinococcus multilocularis sex peptide receptor 0.0024 0.0056 0.0056
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0096 0.0347 0.0941
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0024 0.0054 0.0054
Echinococcus granulosus g protein coupled receptor 0.0024 0.0056 0.0056
Loa Loa (eye worm) MH2 domain-containing protein 0.0079 0.0277 0.0277
Echinococcus multilocularis serotonin receptor 0.0024 0.0056 0.0056
Schistosoma mansoni glutamate synthase 0.0229 0.0883 0.0883
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0097
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0863 0.3439 0.3439
Echinococcus multilocularis neuroligin 0.0034 0.0097 0.0097
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0229 0.0883 0.2567
Trichomonas vaginalis inositol monophosphatase, putative 0.0021 0.0043 0.0123
Brugia malayi neuropeptide F receptor 0.0024 0.0056 0.0056
Echinococcus granulosus FTZ F1 alpha 0.0046 0.0144 0.0144
Schistosoma mansoni amine GPCR 0.0024 0.0056 0.0056
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0047 0.0047
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0033 0.0093 0.0093
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0033 0.0092 0.0092
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0033 0.0092 0.0092
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0863 0.3439 0.3439
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0056 0.0056
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0056 0.0056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0061 0.0206 0.0206
Echinococcus granulosus intermediate filament protein 0.0049 0.0156 0.0156
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0033 0.0092 0.0092
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0229 0.0883 0.0859
Schistosoma mansoni histamine h1 receptor 0.0024 0.0056 0.0056
Giardia lamblia Glutamate synthase 0.0229 0.0883 0.2511
Echinococcus multilocularis dnaJ subfamily B 0.0379 0.1488 0.1488
Onchocerca volvulus 0.0034 0.0097 0.0961
Schistosoma mansoni RAR-like nuclear receptor 0.0046 0.0144 0.0144
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0149 0.0149
Brugia malayi ecdysone receptor 0.0022 0.0047 0.0047
Brugia malayi Serotonin receptor 0.0024 0.0056 0.0056
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0059 0.0059
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0012 0.0012
Entamoeba histolytica heat shock protein 90, putative 0.0025 0.0059 0.0667
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0096 0.0347 0.0347
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0056 0.0056
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0056 0.0056
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0092 0.0092
Echinococcus granulosus BC026374 protein S09 family 0.0034 0.0097 0.0097
Brugia malayi Thioredoxin reductase 0.2492 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.0097 0.0097
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0033 0.0092 0.0092
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0033 0.0092 0.0092
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0067 0.0067
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0229 0.0883 0.0883
Onchocerca volvulus 0.0024 0.0056 0.0549
Giardia lamblia Kinase, CMGC MAPK 0.0033 0.0093 0.0196
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0056 0.0056
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0056 0.0056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0056 0.0056
Brugia malayi Intermediate filament tail domain containing protein 0.0049 0.0156 0.0156
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0092 0.0092
Echinococcus granulosus ecdysone induced protein 78C 0.0046 0.0144 0.0144
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0012 0.0012
Echinococcus granulosus neuropeptide receptor 0.0024 0.0056 0.0056
Brugia malayi hypothetical protein 0.0024 0.0056 0.0056
Onchocerca volvulus 0.0024 0.0056 0.0549
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0073 0.0073
Brugia malayi nuclear receptor NHR-67 0.0022 0.0047 0.0047
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0863 0.3439 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0056 0.0056
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0229 0.0883 0.2511
Brugia malayi nuclear hormone receptor 0.0046 0.0144 0.0144
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0863 0.3439 0.3439
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0077 0.0077
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.0961 0.3832 0.3816
Echinococcus granulosus lamin dm0 0.0049 0.0156 0.0156
Leishmania major hypothetical protein, conserved 0.0229 0.0883 0.0883
Onchocerca volvulus 0.0024 0.0056 0.0549
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0056 0.0056
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0229 0.0883 1
Onchocerca volvulus 0.0034 0.0097 0.0961
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Loa Loa (eye worm) hypothetical protein 0.0149 0.0558 0.0558
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0097
Brugia malayi Serotonin receptor 0.0024 0.0056 0.0056
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0043 0.0043
Giardia lamblia Thioredoxin reductase 0.0229 0.0883 0.2511
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0229 0.0883 0.0883
Brugia malayi glutamate synthase 0.0229 0.0883 0.0883
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0059 0.0098
Loa Loa (eye worm) hypothetical protein 0.0202 0.0775 0.0775
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0046 0.0144 0.0144
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0056 0.0056
Schistosoma mansoni inositol monophosphatase 0.0021 0.0043 0.0043
Brugia malayi Carboxylesterase family protein 0.0034 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0033 0.0092 0.0092
Brugia malayi hypothetical protein 0.0024 0.0056 0.0056
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0229 0.0883 0.2494
Giardia lamblia NADH oxidase lateral transfer candidate 0.0863 0.3439 1
Schistosoma mansoni ap endonuclease 0.0016 0.0026 0.0026
Schistosoma mansoni BC026374 protein (S09 family) 0.0034 0.0097 0.0097
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0056 0.0056
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0057 0.0057
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0056 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0144 0.0144
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0229 0.0883 1
Echinococcus granulosus thioredoxin glutathione reductase 0.2492 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0079 0.0277 0.0277
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0033 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0229 0.0883 0.0883
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.002 0.0039 0.0013
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0229 0.0883 0.0883
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0033 0.0092 0.0092
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0863 0.3439 0.3439
Onchocerca volvulus 0.0022 0.0047 0.0459
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0863 0.3439 1
Onchocerca volvulus 0.022 0.0847 0.8395
Schistosoma mansoni hypothetical protein 0.0047 0.0149 0.0149
Schistosoma mansoni amine GPCR 0.0024 0.0056 0.0056
Giardia lamblia Grp94/Hsp90 0.002 0.0039 0.0038
Brugia malayi hypothetical protein 0.026 0.1009 0.1009
Echinococcus multilocularis acetylcholinesterase 0.0202 0.0775 0.0775
Leishmania major hypothetical protein, conserved 0.0033 0.0092 0.0092
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0229 0.0883 0.0883
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0118 0.0118
Echinococcus granulosus g protein coupled receptor 0.0024 0.0056 0.0056
Onchocerca volvulus 0.0027 0.0067 0.0659
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0216 0.0829 0.2353
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0149 0.0149
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0056 0.0056
Loa Loa (eye worm) steroid hormone receptor 0.0046 0.0144 0.0144
Schistosoma mansoni nuclear receptor 0.0022 0.0047 0.0047
Echinococcus granulosus acetylcholinesterase 0.0202 0.0775 0.0775
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0043 0.0043
Schistosoma mansoni intermediate filament proteins 0.0049 0.0156 0.0156
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Schistosoma mansoni ap endonuclease 0.0016 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0056 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0174 0.0505
Echinococcus multilocularis lamin 0.0049 0.0156 0.0156
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.0006 0.0006
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0229 0.0883 0.2511
Brugia malayi heat shock protein 90 0.0025 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Trypanosoma brucei heat shock protein, putative 0.0025 0.0059 0.0059
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0021 0.0043 0.0043
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0229 0.0883 0.0883
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0056 0.0056
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0033 0.0092 0.0092
Onchocerca volvulus 0.0024 0.0056 0.0549
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0061 0.0206 0.0206
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0033 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0033 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0056 0.0056
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0033 0.0092 0.0092
Brugia malayi Carboxylesterase family protein 0.0202 0.0775 0.0775
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0118 0.0118
Plasmodium falciparum thioredoxin reductase 0.2492 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0046 0.0144 0.0144
Onchocerca volvulus 0.0024 0.0056 0.0549
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0092
Plasmodium vivax heat shock protein 86, putative 0.0025 0.0059 0.0059
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0047 0.0149 0.0149
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.045 0.1771 0.1771
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0229 0.0883 0.0883
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0026 0.0026
Echinococcus multilocularis para nitrobenzyl esterase 0.0034 0.0097 0.0097
Brugia malayi hypothetical protein 0.0022 0.0047 0.0047
Schistosoma mansoni amine GPCR 0.0024 0.0056 0.0056
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0056 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0047 0.0047
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0056 0.0056
Schistosoma mansoni neuroligin 3 (S09 family) 0.0034 0.0097 0.0097
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0092
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0033 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0056 0.0056
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0267
Schistosoma mansoni hypothetical protein 0.045 0.1771 0.1771
Echinococcus granulosus acetylcholinesterase 0.0202 0.0775 0.0775
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0174 0.0505
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0073 0.0073
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0229 0.0883 0.2511
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0046 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0144 0.0144
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0059 0.0059
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0077 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0061 0.0206 0.0206
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0026 0.0026
Loa Loa (eye worm) carboxylesterase 0.0202 0.0775 0.0775
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0056 0.0056
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0033 0.0093 0.0093
Treponema pallidum oxidoreductase 0.0229 0.0883 0.2511
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0092 0.0092
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.002 0.0039 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0056 0.0056
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0.0026 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0144 0.0144
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0046 0.0144 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0046 0.0144 0.0144
Brugia malayi Dopamine receptor protein 2 0.0024 0.0056 0.0056
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0033 0.0092 0.0267
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0056 0.0056
Schistosoma mansoni heat shock protein 0.0025 0.0059 0.0059
Echinococcus granulosus carboxylesterase 5A 0.0202 0.0775 0.0775
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0021 0.0043 0.0123
Loa Loa (eye worm) hypothetical protein 0.026 0.1009 0.1009
Schistosoma mansoni hypothetical protein 0.0379 0.1488 0.1488
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0229 0.0883 0.0859
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0033 0.0092 0.0092
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0229 0.0883 0.0883
Echinococcus multilocularis heat shock protein 90 0.002 0.0039 0.0039
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0056 0.0056
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Echinococcus granulosus fmrfamide receptor 0.0024 0.0056 0.0056
Brugia malayi neuropeptide F receptor 0.0024 0.0056 0.0056
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0056 0.0056
Leishmania major hypothetical protein, conserved 0.0229 0.0883 0.0883
Brugia malayi MAP kinase sur-1 0.0033 0.0093 0.0093
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0229 0.0883 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0056 0.0056
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0038 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0174 0.0505
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0863 0.3439 0.3439
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0229 0.0883 0.2567
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0863 0.3439 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0229 0.0883 0.0883
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0863 0.3439 0.3439
Entamoeba histolytica thioredoxin reductase, putative 0.0229 0.0883 1
Mycobacterium ulcerans hypothetical protein 0.0229 0.0883 0.2511
Trypanosoma cruzi polo-like protein kinase, putative 0.0053 0.0174 0.0174
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0061 0.0206 0.0206
Trypanosoma brucei Heat shock protein 83, putative 0.0025 0.0059 0.0059
Brugia malayi Inositol-1 0.0021 0.0043 0.0043
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0863 0.3439 0.3439
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0102 0.0369 0.0369
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0863 0.3439 0.3439
Onchocerca volvulus 0.0024 0.0056 0.0549
Trichomonas vaginalis set domain proteins, putative 0.022 0.0847 0.2463
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0073 0.0073
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0229 0.0883 0.0883
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0056 0.0056
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0033 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Toxoplasma gondii histone lysine methyltransferase SET1 0.0051 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0033 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0024 0.0057 0.0057
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0056 0.0056
Schistosoma mansoni kinase 0.0027 0.0069 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0229 0.0883 0.0883
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0047 0.0047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0061 0.0206 0.0206
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0229 0.0883 1
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0229 0.0883 0.0859
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Toxoplasma gondii heat shock protein 90, putative 0.0025 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0046 0.0144 0.0144
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0033 0.0092 0.0092
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0634 0.2515 0.2515
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0056 0.0056
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0056 0.0549
Echinococcus multilocularis Protein lozenge 0.0033 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Plasmodium vivax SET domain protein, putative 0.0028 0.0073 0.0073
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0033 0.0092 0.0092
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0229 0.0883 0.0883
Loa Loa (eye worm) hypothetical protein 0.0046 0.0144 0.0144
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0056 0.0056
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0229 0.0883 0.0883
Echinococcus granulosus geminin 0.045 0.1771 0.1771
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0144 0.0144
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0073 0.0073
Mycobacterium ulcerans glutamate synthase subunit beta 0.0229 0.0883 0.2511
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.0558 0.0558
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0026 0.0074
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Onchocerca volvulus 0.026 0.1009 1
Onchocerca volvulus 0.0059 0.0199 0.1972
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0112 0.0112
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.026 0.1009 0.1009
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0229 0.0883 0.2511
Trichomonas vaginalis glutathione reductase, putative 0.0863 0.3439 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0077 0.0077
Brugia malayi Carboxylesterase family protein 0.0034 0.0097 0.0097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0056 0.0056
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0056 0.0056
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0369 0.0369
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0096 0.0347 0.0322
Trypanosoma cruzi heat shock protein 90, putative 0.0015 0.0018 0.0018
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0056 0.0056
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0033 0.0092 0.0092
Schistosoma mansoni opsin-like receptor 0.0024 0.0056 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0174 0.0505
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0229 0.0883 0.0883
Plasmodium falciparum phosphodiesterase gamma, putative 0.0033 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0097
Loa Loa (eye worm) carboxylesterase 0.0034 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0229 0.0883 0.0883
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.0558 0.0558
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0056 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0046 0.0144 0.0144
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0033 0.0093 0.0093
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0144 0.0144
Plasmodium falciparum thioredoxin reductase 0.0863 0.3439 0.3439
Treponema pallidum heat shock protein 90 0.002 0.0039 0.0038
Onchocerca volvulus 0.0024 0.0056 0.0549
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Brugia malayi Pre-SET motif family protein 0.0028 0.0073 0.0073
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0863 0.3439 0.3439
Entamoeba histolytica disulphide oxidoreductase, putative 0.0229 0.0883 1
Schistosoma mansoni retinoic acid receptor RXR 0.0046 0.0144 0.0144
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0056 0.0056
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0229 0.0883 0.0883
Brugia malayi intermediate filament protein 0.0049 0.0156 0.0156
Schistosoma mansoni sulfide quinone reductase 0.0229 0.0883 0.0883
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0056 0.0549
Brugia malayi G-protein coupled receptor 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0229 0.0883 0.0883
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0144 0.0144
Schistosoma mansoni inositol monophosphatase 0.0021 0.0043 0.0043
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0092 0.0267
Plasmodium vivax thioredoxin reductase, putative 0.2492 1 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0863 0.3439 0.3439
Loa Loa (eye worm) hypothetical protein 0.0046 0.0144 0.0144
Brugia malayi ecdysteroid receptor 0.0046 0.0144 0.0144
Onchocerca volvulus Bile acid receptor homolog 0.0046 0.0144 0.1428
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Echinococcus granulosus neuropeptide receptor 0.0024 0.0056 0.0056
Brugia malayi jmjC domain containing protein 0.0039 0.0118 0.0118
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0056 0.0056
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0229 0.0883 0.0883
Mycobacterium leprae Conserved hypothetical protein 0.0283 0.1099 0.3128
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0056 0.0056
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0047 0.0047
Giardia lamblia Heat shock protein HSP 90-alpha 0.002 0.0039 0.0038
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Loa Loa (eye worm) hypothetical protein 0.0046 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Onchocerca volvulus 0.0024 0.0056 0.0549
Schistosoma mansoni lamin 0.0049 0.0156 0.0156
Brugia malayi hypothetical protein 0.0024 0.0056 0.0056
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0056 0.0056
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0034 0.0097 0.0072
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0033 0.0092 0.0092
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0056 0.0056
Trypanosoma cruzi Heat shock protein 83, putative 0.0025 0.0059 0.0059
Trypanosoma brucei heat shock protein, putative 0.0025 0.0059 0.0059
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0073
Brugia malayi hypothetical protein 0.0024 0.0056 0.0056
Loa Loa (eye worm) acetylcholinesterase 1 0.0202 0.0775 0.0775
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0033 0.0092 0.0092
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0033 0.0093 0.0093
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0267
Echinococcus granulosus para nitrobenzyl esterase 0.0034 0.0097 0.0097
Schistosoma mansoni cpg binding protein 0.0027 0.0067 0.0067
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0056 0.0056
Trichomonas vaginalis heat shock protein, putative 0.002 0.0039 0.0112
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0267
Echinococcus granulosus survival motor neuron protein 1 0.0292 0.1135 0.1135
Brugia malayi nuclear receptor RXR 0.0022 0.0047 0.0047
Brugia malayi jmjC domain containing protein 0.0038 0.0112 0.0112
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0057 0.0057
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0863 0.3439 1
Schistosoma mansoni glutamate synthase 0.0229 0.0883 0.0883
Brugia malayi RE15519p 0.0024 0.0056 0.0056
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0863 0.3439 0.3439
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0092 0.0267
Trypanosoma brucei protein kinase, putative 0.0033 0.0093 0.0093
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0056 0.0056
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0047 0.0047
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0149 0.0149
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0033 0.0092 0.0092
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0093 0.0269
Echinococcus granulosus cpg binding protein 0.0028 0.0073 0.0073
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0053 0.0174 0.0174
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0229 0.0883 0.2511
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0056 0.0056
Schistosoma mansoni steroid hormone receptor ad4bp 0.0046 0.0144 0.0144
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0056 0.0056
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0267
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0026 0.0026
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0267
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Echinococcus multilocularis thyroid hormone receptor alpha 0.0046 0.0144 0.0144
Trichomonas vaginalis glutamate synthase, putative 0.0229 0.0883 0.2567
Echinococcus granulosus lamin 0.0049 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Trypanosoma cruzi trypanothione reductase, putative 0.2492 1 1
Schistosoma mansoni opsin-like receptor 0.0024 0.0056 0.0056
Echinococcus multilocularis serotonin receptor 0.0024 0.0056 0.0056
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0056 0.0056
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0056 0.0056
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0056 0.0056
Trypanosoma brucei heat shock protein, putative 0.0025 0.0059 0.0059
Schistosoma mansoni gliotactin 0.0034 0.0097 0.0097
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0229 0.0883 0.0883
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.002 0.0039 0.0039
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0033 0.0092 0.0092
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0229 0.0883 0.0883
Loa Loa (eye worm) hypothetical protein 0.0029 0.0077 0.0077
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0174 0.0505
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0056 0.0056
Loa Loa (eye worm) intermediate filament protein 0.0049 0.0156 0.0156
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0056 0.0056
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0267
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0033 0.0092 0.0092
Onchocerca volvulus 0.0046 0.0144 0.1428
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0056 0.0056
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0073 0.0073
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Schistosoma mansoni jumonji domain containing protein 0.0038 0.0112 0.0112
Brugia malayi nuclear hormone receptor 0.0022 0.0047 0.0047
Schistosoma mansoni coup transcription factor 0.0046 0.0144 0.0144
Brugia malayi Pre-SET motif family protein 0.0194 0.074 0.074
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0092 0.0092
Echinococcus granulosus GPCR family 2 0.0047 0.0149 0.0149
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0863 0.3439 0.3439
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0026 0.0026
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0056 0.0056
Echinococcus multilocularis thioredoxin glutathione reductase 0.2492 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0229 0.0883 0.0883
Brugia malayi hypothetical protein 0.0029 0.0077 0.0077
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0056 0.0056
Trichomonas vaginalis endoplasmin, putative 0.0015 0.0021 0.0059
Toxoplasma gondii thioredoxin reductase 0.2492 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0229 0.0883 0.0859
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Echinococcus granulosus mitogen activated protein kinase 0.0033 0.0093 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0056 0.0056
Onchocerca volvulus 0.0024 0.0056 0.0549
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0229 0.0883 0.0883
Brugia malayi hypothetical protein 0.0024 0.0056 0.0056
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0229 0.0883 0.0859
Giardia lamblia Kinase, PLK 0.0053 0.0174 0.0433
Loa Loa (eye worm) glutathione reductase 0.2492 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0047 0.0047
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0034 0.0097 0.0097
Schistosoma mansoni hypothetical protein 0.0047 0.0149 0.0149
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0046 0.0144 0.0144
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0056 0.0056
Brugia malayi sulfakinin receptor protein 0.0024 0.0056 0.0056
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0229 0.0883 0.2567
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0047 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0026 0.0066 0.0192
Trypanosoma cruzi heat shock protein 85, putative 0.002 0.0039 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0093 0.0269
Brugia malayi serine/threonine-protein kinase plk-2 0.0053 0.0174 0.0174
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0058 0.0191 0.0191
Brugia malayi Dopamine receptor 0.0024 0.0056 0.0056
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0056 0.0056
Entamoeba histolytica heat shock protein 90, putative 0.0025 0.0059 0.0667
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0033 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.002 0.0039 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0046 0.0144 0.0144
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0034 0.0097 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0046 0.0144 0.0144
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Echinococcus multilocularis mitogen activated protein kinase 0.0033 0.0093 0.0093
Onchocerca volvulus 0.0024 0.0056 0.0549
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Chlamydia trachomatis thioredoxin reductase 0.0229 0.0883 0.0206
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0034 0.0097 0.0097
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0056 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0174 0.0174
Echinococcus granulosus dnaJ subfamily B 0.0379 0.1488 0.1488
Treponema pallidum replicative DNA helicase (dnaB) 0.0216 0.0829 0.2353
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0046 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0202 0.0775 0.0775
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0047 0.0047
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0229 0.0883 0.2511
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0026 0.0074
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Leishmania major trypanothione reductase 0.2492 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0092 0.0092
Plasmodium falciparum ferrodoxin reductase-like protein 0.0229 0.0883 0.0883
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0056 0.0056
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0033 0.0092 0.0092
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0033 0.0092 0.0194
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0229 0.0883 0.0883
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0073 0.0073
Onchocerca volvulus Serine\/threonine kinase homolog 0.0053 0.0174 0.172
Schistosoma mansoni cpg binding protein 0.0028 0.0073 0.0073
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0056 0.0056
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0059 0.0059
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0049 0.0156 0.0156
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0267
Plasmodium falciparum phosphodiesterase delta, putative 0.0033 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Echinococcus granulosus endoplasmin 0.002 0.0039 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0229 0.0883 0.2567
Echinococcus granulosus heat shock protein 0.0025 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0047 0.0149 0.0149
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Schistosoma mansoni biogenic amine receptor 0.0024 0.0056 0.0056
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0229 0.0883 0.2567
Plasmodium falciparum glutathione reductase 0.0863 0.3439 0.3439
Loa Loa (eye worm) hypothetical protein 0.1212 0.4842 0.4842
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0863 0.3439 1
Trichomonas vaginalis CAMK family protein kinase 0.0026 0.0066 0.0192
Echinococcus granulosus mitogen activated protein kinase 3 0.0033 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.0102 0.0369 0.0369
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0056 0.0056
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0056 0.0056
Trypanosoma brucei polo-like protein kinase 0.0053 0.0174 0.0174
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0863 0.3439 0.3422
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0047 0.0047
Schistosoma mansoni nuclear receptor 0.0022 0.0047 0.0047
Echinococcus granulosus g protein coupled receptor 0.0024 0.0056 0.0056
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0033 0.0092 0.0092
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0047 0.0047
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0229 0.0883 0.2567
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0174 0.0505
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0056 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0061 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0024 0.0056 0.0056
Mycobacterium tuberculosis Probable reductase 0.0229 0.0883 0.0859
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0046 0.0144 0.0144
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0061 0.0206 0.0206
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0034 0.0097 0.0282
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0033 0.0092 0.0092
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.2492 1 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0229 0.0883 0.2567
Toxoplasma gondii exonuclease III APE 0.0016 0.0026 0.0026
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Echinococcus multilocularis acetylcholinesterase 0.0202 0.0775 0.0775
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0033 0.0092 0.0092
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0077 0.0077
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0033 0.0092 0.0092
Plasmodium vivax phosphodiesterase gamma, putative 0.0033 0.0092 0.0092
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0046 0.0144 0.0144
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0033 0.0092 0.0092
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0046 0.0144 0.0144
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0026 0.0026
Brugia malayi nuclear receptor NHR-88 0.0022 0.0047 0.0047
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0144 0.0144
Schistosoma mansoni acetylcholinesterase 0.0034 0.0097 0.0097
Brugia malayi GnHR receptor homolog 0.0024 0.0056 0.0056
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0229 0.0883 0.0883
Giardia lamblia Hypothetical protein 0.0033 0.0092 0.0194
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0047 0.0459
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0022 0.0047 0.0047
Brugia malayi hypothetical protein 0.0024 0.0056 0.0056
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0056 0.0056
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0033 0.0092 0.0092
Schistosoma mansoni heat shock protein 0.0025 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0056 0.0056
Schistosoma mansoni survival motor neuron protein 0.0059 0.0199 0.0199
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0229 0.0883 0.2494
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0229 0.0883 0.2511
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0053 0.0174 0.0174
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0056 0.0056
Brugia malayi steroid hormone receptor 0.0046 0.0144 0.0144
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0056 0.0056
Mycobacterium ulcerans NADH dehydrogenase 0.0229 0.0883 0.2511
Treponema pallidum thioredoxin reductase (trxB) 0.0229 0.0883 0.2511
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0144 0.0144
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0056 0.0056
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0053 0.0174 0.0174
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0047 0.0047
Plasmodium falciparum glutathione reductase 0.2492 1 1
Echinococcus granulosus somatostatin receptor 0.0024 0.0056 0.0056
Trypanosoma brucei NADH dehydrogenase 0.0229 0.0883 0.0883
Echinococcus multilocularis lamin dm0 0.0049 0.0156 0.0156
Brugia malayi cytoplasmic intermediate filament protein 0.0026 0.0065 0.0065
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0033 0.0092 0.0092
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0267
Schistosoma mansoni myosin xvIII 0.0024 0.0056 0.0056
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0229 0.0883 0.0883
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0056 0.0056
Schistosoma mansoni thyroid hormone receptor 0.0046 0.0144 0.0144
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1245 0.4975 0.4975
Brugia malayi follicle stimulating hormone receptor 0.0024 0.0056 0.0056
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0033 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0059 0.0199 0.0199
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0046 0.0144 0.0144
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0033 0.0092 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0056 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0046 0.0144 0.0144
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0033 0.0092 0.0092
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0056 0.0056
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0047 0.0047
Schistosoma mansoni neuropeptide receptor 0.0024 0.0056 0.0056
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0021 0.0043 0.0123
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0033 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Loa Loa (eye worm) DR-78 0.0022 0.0047 0.0047
Onchocerca volvulus 0.0028 0.0073 0.0724
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0056 0.0056
Echinococcus granulosus heat shock protein 90 0.0025 0.0059 0.0059
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0033 0.0092 0.0092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0061 0.0206 0.0206
Echinococcus multilocularis mitogen activated protein kinase 3 0.0033 0.0093 0.0093
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0056 0.0056
Brugia malayi photoreceptor-specific nuclear receptor 0.0046 0.0144 0.0144
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0056 0.0056
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0059 0.0199 0.0199
Leishmania major hypothetical protein, conserved 0.0033 0.0092 0.0092
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.0558 0.0558
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0056 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0056 0.0056
Echinococcus granulosus neuroligin 0.0034 0.0097 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0046 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0024 0.0057 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0024 0.0056 0.0056
Onchocerca volvulus Protein ultraspiracle homolog 0.0046 0.0144 0.1428
Brugia malayi hypothetical protein 0.0024 0.0056 0.0056
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0229 0.0883 0.2494
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0057 0.0057
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0229 0.0883 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0056 0.0056
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0863 0.3439 0.3439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0056 0.0056
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0097
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0033 0.0092 0.0267
Onchocerca volvulus 0.0049 0.0156 0.1541
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0229 0.0883 0.2511
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0229 0.0883 0.2511
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Onchocerca volvulus 0.0024 0.0056 0.0549
Brugia malayi nuclear receptor RXR 0.0024 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0024 0.0057 0.0057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Trypanosoma cruzi NADH dehydrogenase, putative 0.0229 0.0883 0.0883
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0056 0.0056
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0067 0.0067
Loa Loa (eye worm) runx1 0.0033 0.0091 0.0091
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0033 0.0092 0.0092
Loa Loa (eye worm) twinkle helicase 0.0062 0.0208 0.0208
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0096 0.0347 0.0347
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.0745 0.2963 0.2944
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0047 0.0047
Echinococcus granulosus neuropeptide receptor A26 0.1077 0.4299 0.4299
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0092
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0033 0.0092 0.0267
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0033 0.0092 0.0092
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0056 0.0056
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0047 0.0047
Echinococcus multilocularis inositol monophosphatase 1 0.0021 0.0043 0.0043
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0033 0.0092 0.0092
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0077 0.0077
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0229 0.0883 0.0859
Plasmodium vivax endoplasmin, putative 0.0025 0.0059 0.0059
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0863 0.3439 0.3439
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0863 0.3439 0.3439
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0092
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0056 0.0056
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0033 0.0092 0.0092
Trypanosoma brucei heat shock protein, putative 0.0025 0.0059 0.0059
Onchocerca volvulus 0.0229 0.0883 0.8751
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0096 0.0347 0.0347
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0092 0.0092
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0056 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0046 0.0144 0.0144
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0056 0.0056
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0056 0.0056
Brugia malayi G-protein coupled receptor 0.0024 0.0056 0.0056
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0.0026 0.0026
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0024 0.0056 0.0056
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0016 0.0026 0.029
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0046 0.0144 0.0144
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0097
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0046 0.0144 0.0144
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0033 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.1245 0.4975 0.4975
Brugia malayi Melatonin receptor type 1A 0.0024 0.0056 0.0056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0144 0.0144
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0043 0.0043
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0046 0.0144 0.0144
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0453 0.1784 0.1784
Brugia malayi Carboxylesterase family protein 0.0034 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0057 0.0057
Echinococcus multilocularis GPCR, family 2 0.0047 0.0149 0.0149
Echinococcus multilocularis endoplasmin 0.002 0.0039 0.0039
Echinococcus multilocularis heat shock protein 0.0025 0.0059 0.0059
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0092
Toxoplasma gondii NADPH-glutathione reductase 0.0863 0.3439 0.3439
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0863 0.3439 0.3422
Echinococcus multilocularis ecdysone induced protein 78C 0.0046 0.0144 0.0144
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0033 0.0093 0.0093
Brugia malayi nuclear receptor NHR-88 0.0046 0.0144 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0046 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0048 0.0152 0.0152
Echinococcus multilocularis geminin 0.045 0.1771 0.1771
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0229 0.0883 0.0883
Brugia malayi hypothetical protein 0.0024 0.0056 0.0056
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0056 0.0056
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0229 0.0883 0.0883
Loa Loa (eye worm) inositol-1 0.0021 0.0043 0.0043
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0033 0.0092 0.0092
Giardia lamblia hypothetical protein 0.0033 0.0092 0.0194
Toxoplasma gondii heat shock protein HSP90 0.0025 0.0059 0.0059
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0021 0.0043 0.0049
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0056 0.0056
Brugia malayi Dopamine receptor protein 1 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0292 0.1135 0.1135
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0046 0.0144 0.0144
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0149 0.0149
Mycobacterium ulcerans dehydrogenase 0.0229 0.0883 0.2511
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0863 0.3439 0.3439
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0056 0.0056
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Brugia malayi tailless protein 0.0022 0.0047 0.0047
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0216 0.0829 0.2336
Brugia malayi ORL1-like opioid receptor 0.0024 0.0056 0.0056
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0056 0.0056
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0863 0.3439 0.3439
Echinococcus granulosus neuropeptide s receptor 0.1077 0.4299 0.4299
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0057 0.0057
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0229 0.0883 0.0859
Brugia malayi hypothetical protein 0.0024 0.0056 0.0056
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0073 0.0073
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0024 0.0056 0.0056
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0056 0.0056
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0229 0.0883 0.2511
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0229 0.0883 0.2567
Echinococcus multilocularis neuropeptide receptor A26 0.1077 0.4299 0.4299
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0046 0.0144 0.1428
Echinococcus multilocularis FTZ F1 alpha 0.0046 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0046 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0021 0.0043 0.0049
Echinococcus multilocularis survival motor neuron protein 1 0.0292 0.1135 0.1135
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.0097 0.0097
Echinococcus multilocularis BC026374 protein (S09 family) 0.0034 0.0097 0.0097
Schistosoma mansoni biogenic amine receptor 0.0024 0.0056 0.0056
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0033 0.0092 0.0092
Schistosoma mansoni lamin 0.0049 0.0156 0.0156
Schistosoma mansoni opsin-like receptor 0.0024 0.0056 0.0056
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0863 0.3439 1
Mycobacterium ulcerans heat shock protein 90 0.002 0.0039 0.0038
Brugia malayi putative neuropeptide receptor 0.0024 0.0056 0.0056
Echinococcus granulosus orexin receptor type 2 0.0024 0.0056 0.0056
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0047 0.0047
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0057 0.0057
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0229 0.0883 0.0859
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0093 0.0269
Schistosoma mansoni neuropeptide receptor 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0267
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0043 0.0043
Treponema pallidum NADH oxidase 0.0863 0.3439 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0267
Trypanosoma brucei heat shock protein 90, putative 0.0025 0.0059 0.0059
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0061 0.0206 0.0206
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0033 0.0093 0.0093
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0026 0.0065 0.0065
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0059 0.0171
Brugia malayi Carboxylesterase family protein 0.0202 0.0775 0.0775
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.002 0.0039 0.0015
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0056 0.0056
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0229 0.0883 0.2494
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0863 0.3439 0.3439
Schistosoma mansoni amine GPCR 0.0024 0.0056 0.0056
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0047 0.0047
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0229 0.0883 0.2494
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0149 0.0149
Onchocerca volvulus 0.0024 0.0056 0.0549
Schistosoma mansoni neuropeptide receptor 0.0024 0.0056 0.0056
Leishmania major NADH dehydrogenase, putative 0.0229 0.0883 0.0883
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Leishmania major cAMP-specific phosphodiesterase, putative 0.0033 0.0092 0.0092
Brugia malayi G protein-coupled receptor 0.0024 0.0056 0.0056
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0077 0.0077
Trypanosoma brucei heat shock protein 90, putative 0.0025 0.0059 0.0059
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0026 0.0026
Schistosoma mansoni adenoreceptor 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0097
Onchocerca volvulus 0.0034 0.0097 0.0961
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0056 0.0056
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0863 0.3439 1
Onchocerca volvulus 0.0024 0.0056 0.0549
Onchocerca volvulus 0.0022 0.0047 0.0459
Schistosoma mansoni thyroid hormone receptor 0.0046 0.0144 0.0144
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0033 0.0092 0.0092
Schistosoma mansoni lozenge 0.0033 0.0091 0.0091
Plasmodium falciparum heat shock protein 90 0.0025 0.0059 0.0059
Trypanosoma brucei heat shock protein, putative 0.0025 0.0059 0.0059
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0863 0.3439 0.3439
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0092 0.0092
Onchocerca volvulus 0.0034 0.0097 0.0961
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0229 0.0883 0.0883
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0267
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0053 0.0174 0.0174
Leishmania major heat shock protein 83-1 0.0025 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0057 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0174 0.0505
Onchocerca volvulus 0.0024 0.0056 0.0549
Plasmodium vivax ferrodoxin reductase, putative 0.0229 0.0883 0.0883
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0056 0.0056
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0229 0.0883 0.0883
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0267
Schistosoma mansoni hypothetical protein 0.0229 0.0883 0.0883
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0056 0.0056
Brugia malayi Endoplasmin precursor 0.0025 0.0059 0.0059
Trichomonas vaginalis heat shock protein, putative 0.0015 0.0021 0.0059
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0863 0.3439 0.3439
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0056 0.0056
Brugia malayi hypothetical protein 0.0034 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Plasmodium falciparum endoplasmin, putative 0.0015 0.0021 0.0021
Brugia malayi Carboxylesterase family protein 0.0034 0.0097 0.0097
Mycobacterium tuberculosis Carboxylesterase LipT 0.0034 0.0097 0.0072
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0056 0.0056
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Brugia malayi hypothetical protein 0.0292 0.1135 0.1135
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0018 0.0034 0.0008
Schistosoma mansoni disulfide oxidoreductase 0.0229 0.0883 0.0883
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0056 0.0056
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0038 0.0112 0.0112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0863 0.3439 0.3439
Loa Loa (eye worm) hypothetical protein 0.0024 0.0057 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0046 0.0144 0.0144
Trypanosoma brucei heat shock protein, putative 0.0025 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0046 0.0144 0.0144
Leishmania major hypothetical protein, conserved 0.0229 0.0883 0.0883
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0033 0.0092 0.0267
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0056 0.0056
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0047 0.0149 0.0149
Trypanosoma cruzi polo-like protein kinase, putative 0.0053 0.0174 0.0174
Echinococcus granulosus heat shock protein 90 0.002 0.0039 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0229 0.0883 0.0883
Trichomonas vaginalis mercuric reductase, putative 0.0863 0.3439 1
Onchocerca volvulus 0.0049 0.0156 0.1541
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0033 0.0093 0.0093
Schistosoma mansoni biogenic amine receptor 0.0024 0.0056 0.0056
Echinococcus multilocularis somatostatin receptor 0.0024 0.0056 0.0056
Brugia malayi conserved hypotetical protein 0.0022 0.0047 0.0047
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0056 0.0056
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0863 0.3439 0.3422
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0033 0.0092 0.0092
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0216 0.0829 0.2353
Schistosoma mansoni glutamate synthase 0.0229 0.0883 0.0883
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0863 0.3439 0.3439
Mycobacterium ulcerans monoxygenase 0.0229 0.0883 0.2511
Entamoeba histolytica serine/threonine protein kinase, putative 0.0053 0.0174 0.1966
Brugia malayi larval opioid receptor 0.0024 0.0056 0.0056
Schistosoma mansoni sulfide quinone reductase 0.0229 0.0883 0.0883
Trypanosoma cruzi trypanothione reductase, putative 0.0863 0.3439 0.3439
Onchocerca volvulus 0.0024 0.0056 0.0549
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0093 0.0269
Echinococcus granulosus glutamate synthase 0.0229 0.0883 0.0883
Schistosoma mansoni neuropeptide receptor 0.0024 0.0056 0.0056
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0096 0.0347 0.0347
Brugia malayi hypothetical protein 0.0024 0.0057 0.0057
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0229 0.0883 0.0883
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0033 0.0092 0.0267
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0056 0.0056
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0046 0.0144 0.0144
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0092 0.0092
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0229 0.0883 0.0883
Plasmodium vivax glutathione reductase, putative 0.2492 1 1
Schistosoma mansoni zinc finger protein 0.0022 0.0047 0.0047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0863 0.3439 0.3439
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0229 0.0883 0.0859
Schistosoma mansoni endoplasmin 0.0025 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0097
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0863 0.3439 0.3439
Loa Loa (eye worm) endoplasmin 0.0025 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0046 0.0144 0.0144

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) < 0.3 Deoxyribose degradation activity was measured as hydroxyl radical formation ChEMBL. 11262091
IC50 (functional) = 2.7 uM Concentration required to inhibit 50% growth of HaCaT cells ChEMBL. 11262091
IC50 (functional) = 3 uM Inhibition of LTB4 biosynthesis in bovine polymorphonuclear leukocytes using nordihydroguaiaretic acid ChEMBL. 11262091
logP (ADMET) = 4.16 Partition coefficient (logP) ChEMBL. 11262091

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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