Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.0491 | 0.1003 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0778 | 0.8997 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0455 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0491 | 0.1003 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0778 | 0.8997 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | cytotoxicity of the compound in L1210 cell culture(cell proliferation inhibited by 50%) | ChEMBL. | 9057866 |
IC50 (functional) | > 100 uM | Antiviral activity was determined by the HCMV plaque assay using HFF cells | ChEMBL. | 9057866 |
IC50 (functional) | > 100 uM | Antiviral activity of the compound was estimated by HSV-1 ELISA method (data of single experiment) | ChEMBL. | 9057866 |
IC50 (functional) | > 100 uM | Cytotoxicity of the compound in HFF cells was estimated by the visual scoring of cells affected by virus infection in the plaque reduction assay. | ChEMBL. | 9057866 |
IC50 (functional) | > 100 uM | Cytotoxicity of the compound in KB cells. | ChEMBL. | 9057866 |
IC50 (functional) | > 100 uM | cytotoxicity of the compound in L1210 cell culture(cell proliferation inhibited by 50%) | ChEMBL. | 9057866 |
IC50 (functional) | > 100 uM | Antiviral activity was determined by the HCMV plaque assay using HFF cells | ChEMBL. | 9057866 |
IC50 (functional) | > 100 uM | Antiviral activity of the compound was estimated by HSV-1 ELISA method (data of single experiment) | ChEMBL. | 9057866 |
IC50 (functional) | > 100 uM | Cytotoxicity of the compound in HFF cells was estimated by the visual scoring of cells affected by virus infection in the plaque reduction assay. | ChEMBL. | 9057866 |
IC50 (functional) | > 100 uM | Cytotoxicity of the compound in KB cells. | ChEMBL. | 9057866 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.