Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | adenosine deaminase, putative | 0.0264 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0264 | 1 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0264 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0264 | 1 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0264 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0264 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0264 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0264 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0264 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0264 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0264 | 1 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0264 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0264 | 1 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0264 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0264 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0248 | 0 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0264 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0264 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0264 | 1 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of AQP4 in wild type mouse brain gilial cells assessed as osmotic water permeability at 10 to 100 uM after 15 mins by calcein quenching assay | ChEMBL. | 18572411 | |
Activity (binding) | Inhibition of AQP4 in mouse erythrocytes assessed as inhibition of osmotic water permeability at 100 uM after 15 mins by stopped-flow light scattering method | ChEMBL. | 18572411 | |
Activity (binding) | Inhibition of AQP4 in wild type mouse brain gilial cells assessed as reduction of osmotic equilibrium rate at 10 to 100 uM after 15 mins by calcein quenching assay relative to water permeability | ChEMBL. | 18572411 | |
Inhibition (binding) | = 0 % | In vitro inhibitory activity against H1N9 strain of Influenza neuraminidase (membrane) at 7 mM concentration | ChEMBL. | 9406595 |
Inhibition (binding) | = 0 % | In vitro inhibitory activity against H1N9 strain of Influenza neuraminidase (membrane) at 7 mM concentration | ChEMBL. | 9406595 |
Inhibition (binding) | = 23 % | Inhibition of human AQP4b-mediated water transport in Xenopus oocytes at 20 uM | ChEMBL. | 17178220 |
Ki (binding) | = 49 nM | Inhibitiory activity against human Carbonic anhydrase XII (hCA XII) | ChEMBL. | 16168653 |
Ki (binding) | = 49 nM | Inhibitiory activity against human Carbonic anhydrase XII (hCA XII) | ChEMBL. | 16168653 |
Ki (binding) | = 135 nM | Inhibitiory activity against human Carbonic anhydrase IX (hCA IX) | ChEMBL. | 16168653 |
Ki (binding) | = 135 nM | Inhibitiory activity against human Carbonic anhydrase IX (hCA IX) | ChEMBL. | 16168653 |
Ki (binding) | = 212 nM | Inhibition of murine mitochondrial isozyme Carbonic anhydrase V at 20 degrees C | ChEMBL. | 14971907 |
Ki (binding) | = 246 nM | Inhibition of human cytosolic isozyme Carbonic anhydrase II at 20 degree C | ChEMBL. | 14971907 |
Ki (binding) | = 246 nM | Inhibitiory activity against human Carbonic anhydrase II (hCA II) | ChEMBL. | 16168653 |
Ki (binding) | = 246 nM | Inhibition of human cytosolic isozyme Carbonic anhydrase II at 20 degree C | ChEMBL. | 14971907 |
Ki (binding) | = 246 nM | Inhibitiory activity against human Carbonic anhydrase II (hCA II) | ChEMBL. | 16168653 |
Ki (binding) | = 2850 nM | Inhibition of bovine membrane bound isozyme carbonic anhydrase IV isolated from microsomes at 20 degree C | ChEMBL. | 14971907 |
Ki (binding) | = 2850 nM | Inhibition of bovine membrane bound isozyme carbonic anhydrase IV isolated from microsomes at 20 degree C | ChEMBL. | 14971907 |
Ki (binding) | = 21400 nM | Inhibition of cloned human cytosolic isozyme Carbonic anhydrase I | ChEMBL. | 14971907 |
Ki (binding) | = 21400 nM | Inhibitiory activity against human Carbonic anhydrase I (hCA I) | ChEMBL. | 16168653 |
Ki (binding) | = 21400 nM | Inhibition of cloned human cytosolic isozyme Carbonic anhydrase I | ChEMBL. | 14971907 |
Ki (binding) | = 21400 nM | Inhibitiory activity against human Carbonic anhydrase I (hCA I) | ChEMBL. | 16168653 |
Log II50 (binding) | = 1.48 | Inhibitory activity against bovine Carbonic anhydrase | ChEMBL. | 2709382 |
Log II50 (binding) | = 1.48 | Inhibitory activity against bovine Carbonic anhydrase | ChEMBL. | 2709382 |
permeability (binding) | = 0.0129 cm/s | Inhibition of AQP4 expressed in rat FRT cells assessed as osmotic water permeability at 100 uM after 15 mins by stopped-flow light scattering method | ChEMBL. | 18572411 |
Ratio (binding) | = 1.16 | Selectivity ratio of KI, human carbonic anhydrase II (hCA II), to that of KI, mouse carbonic anhydrase V (mCA V) | ChEMBL. | 14971907 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
6 literature references were collected for this gene.