Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0478 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0478 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0478 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0478 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0478 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0478 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0478 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0478 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0478 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0478 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0478 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0478 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.7 uM | Cytotoxicity of the compound in KB cells. | ChEMBL. | 9057866 |
IC50 (functional) | = 9.2 uM | The in vitro cytotoxicity against L1210 cells was evaluated | ChEMBL. | 9057866 |
IC50 (functional) | = 10 uM | Cytotoxicity of the compound in HFF cells was estimated by the visual scoring of cells affected by virus infection in the plaque reduction assay. | ChEMBL. | 9057866 |
IC50 (functional) | = 15 uM | Antiviral activity of the compound was estimated by HSV-1 ELISA method. | ChEMBL. | 9057866 |
IC50 (functional) | = 19 uM | Antiviral activity was determined by the HCMV plaque assay using HFF cells | ChEMBL. | 9057866 |
IC90 (functional) | = 6.3 uM | Antiviral activity of the compound was estimated by the HCMV yield reduction experiments. | ChEMBL. | 9057866 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.