Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | leukotriene B4 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuropeptide s receptor | 0.0535 | 0.1993 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0535 | 0.1993 | 1 |
Brugia malayi | Serotonin receptor | 0.0564 | 0.2277 | 0.3891 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0421 | 0.0862 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.1344 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1003 | 0.6624 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.1344 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 0.1756 | 0.2652 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0535 | 0.1993 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.1344 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.0862 | 0.1301 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0859 | 0.5195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 0.0418 | 0.0631 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0421 | 0.0862 | 0.0928 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0421 | 0.0862 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0376 | 0.0418 | 0.0631 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.1344 | 1 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0376 | 0.0418 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.1344 | 1 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0421 | 0.0862 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 0.1756 | 0.2652 |
Loa Loa (eye worm) | hypothetical protein | 0.0714 | 0.3764 | 0.5683 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.1344 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0859 | 0.5195 | 0.7843 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.1344 | 1 | 0.5 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0535 | 0.1993 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.1344 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.3 uM | Compound was tested for inhibition against binding of radioligand [3H]-LTB4 to Leukotriene B4 receptor in human neutrophil membranes | ChEMBL. | 10782692 |
IC50 (binding) | = 0.3 uM | Compound was tested for inhibition against binding of radioligand [3H]-LTB4 to Leukotriene B4 receptor in human neutrophil membranes | ChEMBL. | 10782692 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.