Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.1848 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0038 | 0.0091 | 0.0074 |
Echinococcus multilocularis | expressed conserved protein | 0.0097 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0161 | 0.0161 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0312 | 0.1595 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0312 | 0.1595 | 0.1595 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0038 | 0.0091 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0356 | 0.1832 | 0.1832 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0104 | 0.0453 | 0.0453 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0502 | 0.2634 | 0.2634 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0104 | 0.0453 | 0.0453 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.005 | 0.0161 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.005 | 0.0161 | 0.0534 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.005 | 0.0161 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.005 | 0.0161 | 0.101 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0149 | 0.0149 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.005 | 0.0161 | 0.101 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0149 | 0.0149 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.0021 | 0.0000003231 | 0.0000020262 |
Echinococcus granulosus | replication factor c subunit 1 | 0.0021 | 0.0000003231 | 0.0000003231 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.005 | 0.0161 | 0.3559 |
Schistosoma mansoni | patched 1 | 0.0044 | 0.0129 | 0.0129 |
Brugia malayi | Carboxylesterase family protein | 0.1848 | 1 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0038 | 0.0091 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0312 | 0.1595 | 1 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0021 | 0.0000003231 | 0.0000020262 |
Echinococcus multilocularis | neuroligin | 0.0312 | 0.1595 | 0.1595 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.005 | 0.0161 | 0.101 |
Onchocerca volvulus | 0.005 | 0.0161 | 0.101 | |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.0021 | 0.0000003231 | 0.0000003231 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0312 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1595 | 0.1595 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.0021 | 0 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.005 | 0.0161 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0149 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1595 | 0.1595 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0149 | 0.0149 |
Onchocerca volvulus | 0.0023 | 0.0011 | 0.0071 | |
Brugia malayi | hypothetical protein | 0.0502 | 0.2634 | 0.2634 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0091 | 0.0091 |
Brugia malayi | Carboxylesterase family protein | 0.0312 | 0.1595 | 0.1595 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.005 | 0.0161 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0038 | 0.0091 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0044 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0091 | 0.0091 |
Brugia malayi | Carboxylesterase family protein | 0.0312 | 0.1595 | 0.1595 |
Onchocerca volvulus | 0.0312 | 0.1595 | 1 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0312 | 0.1595 | 0.1595 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.005 | 0.0161 | 0.101 |
Echinococcus multilocularis | protein patched | 0.0044 | 0.0129 | 0.0129 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0312 | 0.1595 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.012 | 0.012 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0312 | 0.1595 | 0.1595 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0021 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0312 | 0.1595 | 0.1595 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0021 | 0 | 0.5 |
Onchocerca volvulus | 0.0312 | 0.1595 | 1 | |
Echinococcus multilocularis | replication factor c subunit 1 | 0.0021 | 0.0000003231 | 0.0000003231 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1595 | 0.1595 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.012 | 0.012 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.005 | 0.0161 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0244 | 0.122 | 0.122 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1848 | 1 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.005 | 0.0161 | 0.101 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0453 | 0.0453 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.005 | 0.0161 | 0.0534 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0149 | 0.0149 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.005 | 0.0161 | 0.3559 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1595 | 0.1595 |
Brugia malayi | AMP-binding enzyme family protein | 0.005 | 0.0161 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1595 | 0.1595 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.0171 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0184 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0091 | 0.0091 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0312 | 0.1595 | 0.1595 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0312 | 0.1595 | 0.1595 |
Brugia malayi | CHE-14 protein | 0.0044 | 0.0129 | 0.0129 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0312 | 0.1595 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0129 | 0.0809 |
Schistosoma mansoni | acetylcholinesterase | 0.0312 | 0.1595 | 0.1595 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0149 | 0.0149 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0148 | 0.0696 | 0.0696 |
Giardia lamblia | Replication factor C, subunit 1 | 0.0021 | 0.0000003231 | 0.5 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0021 | 0.0000003231 | 0.0000020262 |
Brugia malayi | AMP-binding enzyme family protein | 0.005 | 0.0161 | 0.0161 |
Toxoplasma gondii | ATPase, AAA family protein | 0.0021 | 0.0000003231 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0149 | 0.0149 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0104 | 0.0453 | 0.0453 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0312 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | carboxylesterase | 0.0312 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1848 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1848 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1848 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1848 | 1 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0102 | 0.0446 | 0.0446 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0149 | 0.0149 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.005 | 0.0161 | 0.101 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0149 | 0.0149 |
Echinococcus granulosus | neuroligin | 0.0312 | 0.1595 | 0.1595 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.012 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0091 | 0.0091 |
Onchocerca volvulus | 0.0102 | 0.0446 | 0.2798 | |
Onchocerca volvulus | 0.0052 | 0.0171 | 0.1069 | |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.005 | 0.0161 | 0.3559 |
Treponema pallidum | DNA ligase (lig) | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0148 | 0.0696 | 0.0696 |
Loa Loa (eye worm) | hypothetical protein | 0.1848 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.005 | 0.0161 | 0.101 |
Echinococcus multilocularis | protein dispatched 1 | 0.0051 | 0.0163 | 0.0163 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0105 | 0.0462 | 0.0462 |
Onchocerca volvulus | 0.0312 | 0.1595 | 1 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0312 | 0.1595 | 0.1595 |
Echinococcus multilocularis | tumor protein p63 | 0.0356 | 0.1832 | 0.1832 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0312 | 0.1595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0171 | 0.0171 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0312 | 0.1595 | 0.1595 |
Schistosoma mansoni | survival motor neuron protein | 0.0102 | 0.0446 | 0.0446 |
Brugia malayi | AMP-binding enzyme family protein | 0.005 | 0.0161 | 0.0161 |
Onchocerca volvulus | 0.0312 | 0.1595 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.0446 | 0.0446 |
Brugia malayi | Carboxylesterase family protein | 0.0312 | 0.1595 | 0.1595 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.005 | 0.0161 | 0.101 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.0021 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0312 | 0.1595 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0038 | 0.0091 | 0.0574 |
Echinococcus granulosus | expressed conserved protein | 0.0097 | 0.0418 | 0.0418 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1722 | 0.931 | 0.931 |
Schistosoma mansoni | gliotactin | 0.0312 | 0.1595 | 0.1595 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0312 | 0.1595 | 0.1595 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0312 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.1848 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0312 | 0.1595 | 0.1595 |
Brugia malayi | hypothetical protein | 0.0312 | 0.1595 | 0.1595 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0044 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0161 | 0.0161 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.0021 | 0.0000003231 | 0.0000071361 |
Echinococcus granulosus | carboxylesterase 5A | 0.1848 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1848 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0244 | 0.122 | 0.122 |
Onchocerca volvulus | 0.0312 | 0.1595 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0161 | 0.0161 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0502 | 0.2634 | 0.2634 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.012 | 0.012 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0104 | 0.0453 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0044 | 0.0129 | 0.0129 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0044 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0502 | 0.2634 | 0.2634 |
Echinococcus multilocularis | acetylcholinesterase | 0.1848 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | = 34 % | Percent displacement determined by inhibition of [3H]-CPP binding against N-methyl-D-aspartate glutamate receptor in mice at 10 microM | ChEMBL. | 2539478 |
MED (functional) | > 160 mg kg-1 | Ability to protect against NMDA-induced lethality in mice after intraperitoneal administration | ChEMBL. | 2539478 |
MED (functional) | > 160 mg kg-1 | Ability to protect against NMDA-induced lethality in mice after intraperitoneal administration | ChEMBL. | 2539478 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.