Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.1693 | 0.623 |
Plasmodium falciparum | thioredoxin reductase | 0.0084 | 0.2653 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0191 | 0.6941 | 0.8837 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0212 | 0.7793 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0191 | 0.6941 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0191 | 0.6941 | 0.8837 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0191 | 0.6941 | 0.8837 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0029 | 0.0465 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1693 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0117 | 0.044 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0029 | 0.0465 | 0.5 |
Brugia malayi | hypothetical protein | 0.0035 | 0.072 | 0.2256 |
Brugia malayi | Thioredoxin reductase | 0.0084 | 0.2653 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.072 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0084 | 0.2672 | 1 |
Leishmania major | trypanothione reductase | 0.0084 | 0.2653 | 1 |
Treponema pallidum | NADH oxidase | 0.0029 | 0.0465 | 0.5 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0029 | 0.0465 | 0.1502 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0084 | 0.2653 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0192 | 0.0118 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0212 | 0.7793 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1693 | 0.163 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.072 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.1653 | 0.6076 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0084 | 0.2653 | 0.2985 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0192 | 0.0449 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0084 | 0.2653 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.1693 | 0.5614 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0029 | 0.0465 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0191 | 0.6941 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0982 | 0.3704 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.072 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.072 | 0.065 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.1693 | 0.5614 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0029 | 0.0465 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.072 | 0.2483 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0718 | 0.2477 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0212 | 0.7793 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0084 | 0.2672 | 1 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.0285 | 0.0512 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0084 | 0.2653 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.2255 | 0.8406 |
Toxoplasma gondii | thioredoxin reductase | 0.0084 | 0.2653 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0212 | 0.7793 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.1794 | 0.1732 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0191 | 0.6941 | 0.8837 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1693 | 0.163 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0811 | 0.2622 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0029 | 0.0465 | 0.0393 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0814 | 0.307 |
Brugia malayi | glutathione reductase | 0.0084 | 0.2653 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.072 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0029 | 0.0465 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.1693 | 0.1676 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0029 | 0.0465 | 0.1234 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.1693 | 0.623 |
Plasmodium falciparum | glutathione reductase | 0.0084 | 0.2653 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0192 | 0.0449 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0117 | 0.0042 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.072 | 0.2483 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0029 | 0.0465 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0084 | 0.2653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2087 | 0.7866 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.1653 | 0.6076 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0029 | 0.0465 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0907 | 0.3421 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.072 | 0.065 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1693 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0084 | 0.2653 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1693 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0084 | 0.2653 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0718 | 0.2477 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.0000000013 M | In vitro evaluation on guinea pig trachea. EC50 which is the molar concentration of the compound required to give 50% inhibition of the isoproterenol response(1x10E-6M) was determined. | ChEMBL. | 6145801 |
ED50 (functional) | = 0.023 mg kg-1 | Decrease in diastolic blood pressure in anesthetized guinea pigs induced with urethane. | ChEMBL. | 6145801 |
ED50 (functional) | = 0.51 mg kg-1 | Mean increase in the heart rate in anesthetized guinea pigs induced with urethane. | ChEMBL. | 6145801 |
Ratio (functional) | = 0.8 | Compound was determined for heart rate with respect to propanol | ChEMBL. | 6145801 |
Ratio (functional) | = 4.78 | Decrease in propanol | ChEMBL. | 6145801 |
Ratio (functional) | = 7.77 | Biological activity relative to propranolol. | ChEMBL. | 6145801 |
Ratio (functional) | = 22.2 | Selectivity ratio of the compound ED50(HR) / ED50(DBP) | ChEMBL. | 6145801 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.