Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor alpha | 468 aa | 397 aa | 25.4 % |
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0162 | 0.0177 | 0.0174 |
Brugia malayi | thymidylate synthase | 0.7331 | 0.9648 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0696 | 0.0882 | 0.0826 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0696 | 0.0882 | 0.0905 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0162 | 0.0177 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7597 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0696 | 0.0882 | 0.0826 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0696 | 0.0882 | 0.0826 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.0099 | 0.0093 | 0.0086 |
Onchocerca volvulus | 0.7331 | 0.9648 | 1 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.7331 | 0.9648 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0696 | 0.0882 | 0.0905 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.7331 | 0.9648 | 1 |
Brugia malayi | hypothetical protein | 0.3487 | 0.457 | 0.4686 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0099 | 0.0093 | 0.0086 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0696 | 0.0882 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0427 | 0.0526 | 0.0454 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0696 | 0.0882 | 0.0826 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.7597 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0696 | 0.0882 | 0.0826 |
Mycobacterium ulcerans | thymidylate synthase | 0.7331 | 0.9648 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0696 | 0.0882 | 0.0905 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.3487 | 0.457 | 0.4519 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3487 | 0.457 | 1 |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.0099 | 0.0093 | 0.0096 |
Loa Loa (eye worm) | thymidylate synthase | 0.7331 | 0.9648 | 1 |
Onchocerca volvulus | 0.0036 | 0.001 | 0.001 | |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0099 | 0.0093 | 0.0086 |
Echinococcus multilocularis | thymidylate synthase | 0.7331 | 0.9648 | 1 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0099 | 0.0093 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0162 | 0.0177 | 0.0174 |
Schistosoma mansoni | dihydrofolate reductase | 0.0696 | 0.0882 | 0.0826 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.7597 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.7597 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.3487 | 0.457 | 0.4732 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7331 | 0.9648 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.7331 | 0.9648 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7597 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.49 uM | In vitro transactivation using receptor transactivation assay against hPPAR gamma | ChEMBL. | 11831892 |
EC50 (functional) | = 0.49 uM | In vitro transactivation using receptor transactivation assay against hPPAR gamma | ChEMBL. | 11831892 |
EC50 (functional) | = 11.7 uM | In vitro transactivation using receptor transactivation assay against hPPAR alpha | ChEMBL. | 11831892 |
EC50 (functional) | = 11.7 uM | In vitro transactivation using receptor transactivation assay against hPPAR alpha | ChEMBL. | 11831892 |
Max (functional) | = 84.7 % | Fold activation relative to maximum hPPAR alpha activation obtained with WY14643 | ChEMBL. | 11831892 |
Max (functional) | = 84.7 % | Fold activation relative to maximum hPPAR alpha activation obtained with WY14643 | ChEMBL. | 11831892 |
Max (functional) | = 127 % | Fold activation relative to maximum activation obtained with rosiglitazone | ChEMBL. | 11831892 |
Max (functional) | = 127 % | Fold activation relative to maximum activation obtained with rosiglitazone | ChEMBL. | 11831892 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.