Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0037 | 0.7831 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5353 | 0.5353 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.7831 | 0.7831 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0037 | 0.7831 | 0.7831 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.19 | 0.19 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.118 | 0.118 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.118 | 0.118 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | musashi | 0.0027 | 0.5353 | 0.5353 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.5353 | 0.5353 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.2254 | 0.2254 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.7831 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.5353 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.118 | 0.118 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.7831 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.118 | 0.118 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0037 | 0.7831 | 0.7831 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0037 | 0.7831 | 0.7831 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.118 | 0.118 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0037 | 0.7831 | 0.7831 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.5353 | 0.5353 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.2254 | 0.2254 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.118 | 0.118 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.118 | 0.118 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.5353 | 0.5353 |
Onchocerca volvulus | 0.0027 | 0.5353 | 1 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.5353 | 0.5353 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.118 | 0.118 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.118 | 0.118 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.5353 | 0.5353 |
Schistosoma mansoni | lamin | 0.0027 | 0.5353 | 0.5353 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.5353 | 0.5353 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.118 | 0.118 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0037 | 0.7831 | 0.5 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.7831 | 0.7831 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0037 | 0.7831 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.118 | 0.118 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0037 | 0.7831 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.7831 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.5353 | 0.5353 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0037 | 0.7831 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0037 | 0.7831 | 0.7831 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0037 | 0.7831 | 0.7831 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.118 | 0.118 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.19 | 0.19 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.118 | 0.118 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.19 | 0.19 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0037 | 0.7831 | 0.7831 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.118 | 0.118 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.5353 | 0.5353 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.118 | 0.118 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.118 | 0.118 |
Schistosoma mansoni | lamin | 0.0027 | 0.5353 | 0.5353 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0037 | 0.7831 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1778 | 0.1778 |
Echinococcus multilocularis | lamin | 0.0027 | 0.5353 | 0.5353 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.7831 | 0.7831 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.5353 | 0.5353 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5231 | 0.5231 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.118 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1778 | 0.1778 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.118 | 0.118 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | > 250 ug ml-1 | Compound was tested in vitro for the antiviral activity against HSV-1(strain HFEM) in Vero cells | ChEMBL. | 3009815 |
ID50 (functional) | > 250 ug ml-1 | Compound was tested in vitro for the antiviral activity against HSV-2(strain 196) in Vero cells | ChEMBL. | 3009815 |
ID50 (functional) | = 420 ug ml-1 | Cytotoxicity of the compound was measured by determining the incorporation of [methyl-3H]-thymidine into DNA of Vero cells | ChEMBL. | 3009815 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.