TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 434.122 | Formula: C7H17O15P3
H donors: 9 H acceptors: 12 LogP: -6.81 Rotable bonds: 6
Rule of 5 violations (Lipinski): 3
SMILES: O[C@@H]1[C@@H](O)[C@H](OP(=O)(O)O)[C@@]([C@@H]([C@@H]1O)OP(=O)(O)O)(C)OP(=O)(O)O
InChi: 1S/C7H17O15P3/c1-7(22-25(17,18)19)5(20-23(11,12)13)3(9)2(8)4(10)6(7)21-24(14,15)16/h2-6,8-10H,1H3,(H2,11,12,13)(H2,14,15,16)(H2,17,18,19)/t2-,3-,4-,5+,6-,7-/m1/s1
InChiKey: CSOHLFCWJIGHSY-HYBKHIPXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	inositol 1,4,5-trisphosphate receptor, type 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Inositol 1,4,5-trisphosphate receptor type 1, putative	Get druggable targets OG5_129492	All targets in OG5_129492
Brugia malayi	cation channel family protein	Get druggable targets OG5_129492	All targets in OG5_129492
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129492	All targets in OG5_129492
Schistosoma japonicum	ko:K04958 inositol 1,4,5-triphosphate receptor, type 1, putative	Get druggable targets OG5_129492	All targets in OG5_129492
Schistosoma japonicum	ko:K04959 inositol 1,4,5-triphosphate receptor, type 2, putative	Get druggable targets OG5_129492	All targets in OG5_129492
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129492	All targets in OG5_129492
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129492	All targets in OG5_129492
Schistosoma mansoni	inositol 145-trisphosphate receptor	Get druggable targets OG5_129492	All targets in OG5_129492
Schistosoma mansoni	inositol 145-trisphosphate receptor	Get druggable targets OG5_129492	All targets in OG5_129492

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	TAR-binding protein	0.007	0.0114	0.0114
Leishmania major	phospholipase c-like protein	0.0027	0.0004	0.0004
Brugia malayi	follicle stimulating hormone receptor	0.0248	0.0569	0.0569
Plasmodium vivax	glutathione reductase, putative	0.0052	0.0069	0.0069
Trypanosoma brucei	trypanothione reductase	0.0052	0.0069	0.0065
Mycobacterium tuberculosis	Probable dehydrogenase	0.0119	0.0239	0.0171
Trypanosoma cruzi	polyprenyl synthase, putative	0.1341	0.3355	0.3352
Echinococcus multilocularis	ryanodine receptor 44f	0.0094	0.0175	0.0164
Brugia malayi	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4	0.0059	0.0086	0.0086
Brugia malayi	CHE-14 protein	0.0116	0.0233	0.0233
Echinococcus granulosus	geranylgeranyl pyrophosphate synthase	0.1341	0.3355	0.3347
Echinococcus granulosus	histone acetyltransferase MYST2	0.006	0.0088	0.0077
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0053	0.007	0.3094
Schistosoma mansoni	sex comb on midleg homolog	0.0053	0.007	0.0058
Onchocerca volvulus		0.0053	0.007	0.3094
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0039	0.0035	0.0031
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0067	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0283	0.0657	0.0657
Schistosoma mansoni	geranylgeranyl pyrophosphate synthase	0.1341	0.3355	0.3347
Plasmodium vivax	geranylgeranyl pyrophosphate synthase	0.3947	1	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0052	0.0069	0.0057
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0012	0.0012
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0114	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0508	0.123	0.123
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.0106	0.0095
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.006	0.0088	0.0077
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0053	0.007	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0141	0.0141
Brugia malayi	glutathione reductase	0.0052	0.0069	0.0069
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0245	0.0561	0.0561
Echinococcus multilocularis	sterol regulatory element binding protein	0.0116	0.0233	0.0221
Schistosoma mansoni	hypothetical protein	0.0104	0.02	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0295	0.0295
Leishmania major	polyprenyl synthase, putative	0.1341	0.3355	0.3355
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0132	0.0273	0.0205
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0012	0.0012
Schistosoma mansoni	trans-prenyltransferase	0.1063	0.2647	0.2639
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0133	0.0274	0.024
Loa Loa (eye worm)	mbt repeat family protein	0.0053	0.007	0.007
Brugia malayi	mbt repeat family protein	0.0053	0.007	0.007
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	0.3947	1	1
Echinococcus granulosus	ryanodine receptor 44f	0.0094	0.0175	0.0164
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0245	0.0561	0.055
Trypanosoma cruzi	farnesyl pyrophosphate synthase	0.3947	1	1
Giardia lamblia	Farnesyl diphosphate synthase	0.3947	1	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0175	0.0382	0.0382
Loa Loa (eye worm)	MBCTL1	0.006	0.0088	0.0088
Onchocerca volvulus		0.0104	0.02	1
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0107	0.0208	0.0197
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0039	0.0035	0.0035
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.0097	0.0182	0.0171
Trypanosoma cruzi	farnesyl pyrophosphate synthase, putative	0.3947	1	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0104	0.02	0.02
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0039	0.0035	0.0023
Brugia malayi	mbt repeat family protein	0.0053	0.007	0.007
Mycobacterium tuberculosis	Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase)	0.1063	0.2647	0.2596
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0262	0.0262
Echinococcus multilocularis	ryanodine receptor 44f	0.0073	0.0122	0.011
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0245	0.0561	0.055
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0207	0.0464	0.0453
Echinococcus multilocularis	polycomb protein SCMH1	0.0053	0.007	0.0058
Schistosoma mansoni	hypothetical protein	0.0187	0.0412	0.0401
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.006	0.0088	0.0077
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.0106	0.0095
Plasmodium falciparum	glutathione reductase	0.0052	0.0069	0.0069
Trypanosoma cruzi	polyprenyl synthase, putative	0.1341	0.3355	0.3352
Echinococcus multilocularis	tar DNA binding protein	0.007	0.0114	0.0102
Loa Loa (eye worm)	RNA binding protein	0.007	0.0114	0.0114
Mycobacterium tuberculosis	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)	0.3947	1	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0119	0.0239	0.0171
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.0106	0.0103
Loa Loa (eye worm)	geranylgeranyl pyrophosphate synthetase	0.1341	0.3355	0.3355
Loa Loa (eye worm)	hypothetical protein	0.006	0.0088	0.0088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0245	0.0561	0.055
Toxoplasma gondii	polyprenyl synthetase superfamily protein	0.1063	0.2647	0.2644
Chlamydia trachomatis	geranylgeranyl pyrophosphate synthase	0.1063	0.2647	0.5
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.006	0.009	0.0078
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0114	0.0102
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0035	0.0031
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0175	0.0382	0.0382
Echinococcus multilocularis	farnesyl pyrophosphate synthase	0.3947	1	1
Toxoplasma gondii	thioredoxin reductase	0.0052	0.0069	0.0065
Entamoeba histolytica	bifunctional short chain isoprenyl diphosphate synthase, putative	0.1063	0.2647	1
Mycobacterium tuberculosis	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)	0.1063	0.2647	0.2596
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	0.3947	1	1
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0114	0.0102
Echinococcus granulosus	ryanodine receptor 44f	0.0073	0.0122	0.011
Loa Loa (eye worm)	glutathione reductase	0.0052	0.0069	0.0069
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	0.3947	1	1
Loa Loa (eye worm)	Plcb4 protein	0.0059	0.0086	0.0086
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0131	0.0271	0.0271
Wolbachia endosymbiont of Brugia malayi	geranylgeranyl pyrophosphate synthase	0.1063	0.2647	0.5
Onchocerca volvulus		0.0081	0.0141	0.6893
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0053	0.007	0.0058
Loa Loa (eye worm)	thioredoxin reductase	0.0052	0.0069	0.0069
Schistosoma mansoni	glutathione synthetase	0.1063	0.2647	0.2639
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0163	0.0352	0.0341
Echinococcus granulosus	prenyl decaprenyl diphosphate synthase	0.1063	0.2647	0.2639
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0233	0.0233
Leishmania major	trypanothione reductase	0.0052	0.0069	0.0069
Echinococcus multilocularis	histone acetyltransferase MYST2	0.006	0.0088	0.0077
Treponema pallidum	octaprenyl-diphosphate synthase	0.1341	0.3355	0.5
Schistosoma mansoni	ryanodine receptor related	0.0131	0.0271	0.0259
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0283	0.0657	0.0646
Mycobacterium ulcerans	polyprenyl diphosphate synthetase, GrcC1	0.1063	0.2647	0.2568
Echinococcus granulosus	Niemann Pick C1 protein	0.0116	0.0233	0.0221
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0245	0.0561	0.055
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0119	0.0239	0.0171
Plasmodium vivax	thioredoxin reductase, putative	0.0052	0.0069	0.0069
Trypanosoma brucei	glucosidase, putative	0.0039	0.0035	0.0031
Plasmodium falciparum	thioredoxin reductase	0.0052	0.0069	0.0069
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0119	0.0239	0.0171
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0111	0.0218	0.0214
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0283	0.0657	0.0646
Echinococcus granulosus	geminin	0.0187	0.0412	0.0401
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0114	0.0102
Schistosoma mansoni	patched 1	0.0116	0.0233	0.0221
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0245	0.0561	0.055
Loa Loa (eye worm)	hypothetical protein	0.0053	0.007	0.007
Trypanosoma cruzi	solanesyl-diphosphate synthase, putative	0.1063	0.2647	0.2644
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0052	0.0069	0.0057
Trichomonas vaginalis	geranylgeranyl diphosphate synthase, putative	0.3947	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0233	0.0199
Echinococcus multilocularis	geminin	0.0187	0.0412	0.0401
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0245	0.0561	0.0561
Schistosoma mansoni	myelin transcription factor 1 myt1	0.006	0.0088	0.0077
Echinococcus granulosus	survival motor neuron protein 1	0.0508	0.123	0.122
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.0283	0.0657	0.0556
Echinococcus multilocularis	protein patched	0.0116	0.0233	0.0221
Brugia malayi	intermediate filament protein	0.003	0.0012	0.0012
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0248	0.0569	0.0569
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0283	0.0657	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0029	0.001	0.001
Loa Loa (eye worm)	polyprenyl synthetase	0.3947	1	1
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0027	0.0004	0.0004
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1663	0.4177	0.417
Trypanosoma brucei	farnesyl pyrophosphate synthase	0.3947	1	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0067	0.0106	0.0038
Onchocerca volvulus		0.0101	0.0194	0.9687
Plasmodium falciparum	octaprenyl pyrophosphate synthase	0.1063	0.2647	0.2647
Plasmodium vivax	octaprenyl pyrophosphate synthase, putative	0.1063	0.2647	0.2647
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0039	0.0035	0.0035
Echinococcus granulosus	polycomb protein SCMH1	0.0053	0.007	0.0058
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0175	0.0382	0.0371
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0119	0.0239	0.0171
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0283	0.0657	0.0653
Echinococcus granulosus	sterol regulatory element binding protein	0.0116	0.0233	0.0221
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0132	0.0273	0.0205
Schistosoma mansoni	survival motor neuron protein	0.0104	0.02	0.0188
Brugia malayi	geranylgeranyl pyrophosphate synthetase	0.1341	0.3355	0.3355
Mycobacterium tuberculosis	Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate	0.1063	0.2647	0.2596
Schistosoma mansoni	ryanodine receptor 1 skeletal muscle	0.0035	0.0026	0.0015
Brugia malayi	cation channel family protein	0.0201	0.0448	0.0448
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.0283	0.0657	0.0657
Schistosoma mansoni	hypothetical protein	0.0319	0.075	0.074
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.0027	0.0004	0.0004
Trypanosoma cruzi	solanesyl-diphosphate synthase, putative	0.1063	0.2647	0.2644
Leishmania major	farnesyl pyrophosphate synthase	0.3947	1	1
Entamoeba histolytica	geranylgeranyl pyrophosphate synthase, putative	0.1063	0.2647	1
Schistosoma mansoni	phospholipase C beta	0.0059	0.0086	0.0074
Plasmodium falciparum	geranylgeranyl pyrophosphate synthase, putative	0.3947	1	1
Leishmania major	hypothetical protein, conserved	0.0075	0.0128	0.0128
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0283	0.0657	0.0646
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0012	0.0012
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0133	0.0274	0.024
Onchocerca volvulus		0.006	0.009	0.4145
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.006	0.0088	0.0088
Brugia malayi	RNA binding protein	0.007	0.0114	0.0114
Echinococcus granulosus	lysosomal alpha glucosidase	0.0175	0.0382	0.0371
Echinococcus granulosus	farnesyl pyrophosphate synthase	0.3947	1	1
Loa Loa (eye worm)	polyprenyl synthetase	0.1063	0.2647	0.2647
Brugia malayi	RNA recognition motif domain containing protein	0.007	0.0114	0.0114
Trypanosoma cruzi	trypanothione reductase, putative	0.0052	0.0069	0.0065
Entamoeba histolytica	geranylgeranyl pyrophosphate synthetase, putative	0.1063	0.2647	1
Echinococcus granulosus	decaprenyl diphosphate synthase subunit 1	0.1063	0.2647	0.2639
Mycobacterium leprae	PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE)	0.1063	0.2647	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0508	0.123	0.122
Loa Loa (eye worm)	TAR-binding protein	0.007	0.0114	0.0114
Brugia malayi	hypothetical protein	0.0508	0.123	0.123
Brugia malayi	phospholipase C homolog	0.0044	0.0048	0.0048
Schistosoma mansoni	alpha-glucosidase	0.0151	0.032	0.0309
Schistosoma mansoni	sex comb on midleg homolog	0.0053	0.007	0.0058
Brugia malayi	Thioredoxin reductase	0.0052	0.0069	0.0069
Trypanosoma brucei	solanesyl-diphosphate synthase, putative	0.1063	0.2647	0.2644
Schistosoma mansoni	farnesyl pyrophosphate synthase	0.3947	1	1
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	0.3947	1	1
Schistosoma mansoni	alpha glucosidase	0.0039	0.0035	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0256	0.0256
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0114	0.0102
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0245	0.0561	0.055
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.0106	0.0095
Loa Loa (eye worm)	ryanodine receptor	0.0035	0.0026	0.0026
Schistosoma mansoni	alpha-glucosidase	0.0151	0.032	0.0309
Echinococcus multilocularis	prenyl (decaprenyl) diphosphate synthase	0.1063	0.2647	0.2639
Echinococcus granulosus	neutral alpha glucosidase AB	0.0039	0.0035	0.0023
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0175	0.0382	0.0371
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0207	0.0464	0.0453
Toxoplasma gondii	polyprenyl synthetase superfamily protein	0.3947	1	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.0106	0.0095
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0133	0.0274	0.024
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0283	0.0657	0.0657
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0035	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0175	0.0175
Echinococcus multilocularis	Niemann Pick C1 protein	0.0116	0.0233	0.0221
Echinococcus granulosus	Protein patched homolog 1	0.0116	0.0233	0.0221
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0283	0.0657	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0208	0.0208
Trypanosoma cruzi	solanesyl-diphosphate synthase	0.1063	0.2647	0.2644
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.006	0.009	0.0078
Leishmania major	alpha glucosidase II subunit, putative	0.0039	0.0035	0.0035
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0027	0.0004	0.0004
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0116	0.0233	0.0233
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0116	0.0233	0.0221
Brugia malayi	Polyprenyl synthetase family protein	0.1063	0.2647	0.2647
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0245	0.0561	0.055
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.0044	0.0048	0.0037
Wolbachia endosymbiont of Brugia malayi	geranylgeranyl pyrophosphate synthase	0.1063	0.2647	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.0012	0.0012
Echinococcus granulosus	SAM and MBT domain containing protein	0.0053	0.007	0.0058
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.0004	0.0004
Echinococcus multilocularis	protein dispatched 1	0.0116	0.0233	0.0221
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0111	0.0218	0.0214
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.007	0.0114	0.0114
Onchocerca volvulus		0.006	0.009	0.4145
Echinococcus multilocularis	geranylgeranyl pyrophosphate synthase	0.1341	0.3355	0.3347
Mycobacterium tuberculosis	Probable reductase	0.0119	0.0239	0.0171
Loa Loa (eye worm)	hypothetical protein	0.006	0.009	0.009
Echinococcus granulosus	tar DNA binding protein	0.007	0.0114	0.0102
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0132	0.0273	0.014
Leishmania major	solanesyl-diphosphate synthase, putative	0.1063	0.2647	0.2647
Echinococcus multilocularis	decaprenyl diphosphate synthase subunit 1	0.1063	0.2647	0.2639
Mycobacterium tuberculosis	Probable oxidoreductase	0.0132	0.0273	0.0205
Schistosoma mansoni	hypothetical protein	0.0187	0.0412	0.0401
Mycobacterium ulcerans	polyprenyl synthetase IdsB	0.1063	0.2647	0.2568

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 44 nM	Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membrane	ChEMBL.	10197969
IC50 (binding)	= 44 nM	Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membrane	ChEMBL.	10197969

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 28596