Detailed information for compound 28596

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 434.122 | Formula: C7H17O15P3
  • H donors: 9 H acceptors: 12 LogP: -6.81 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 3
  • SMILES: O[C@@H]1[C@@H](O)[C@H](OP(=O)(O)O)[C@@]([C@@H]([C@@H]1O)OP(=O)(O)O)(C)OP(=O)(O)O
  • InChi: 1S/C7H17O15P3/c1-7(22-25(17,18)19)5(20-23(11,12)13)3(9)2(8)4(10)6(7)21-24(14,15)16/h2-6,8-10H,1H3,(H2,11,12,13)(H2,14,15,16)(H2,17,18,19)/t2-,3-,4-,5+,6-,7-/m1/s1
  • InChiKey: CSOHLFCWJIGHSY-HYBKHIPXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens inositol 1,4,5-trisphosphate receptor, type 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129492 All targets in OG5_129492
Schistosoma mansoni inositol 145-trisphosphate receptor Get druggable targets OG5_129492 All targets in OG5_129492
Schistosoma mansoni inositol 145-trisphosphate receptor Get druggable targets OG5_129492 All targets in OG5_129492
Schistosoma japonicum ko:K04959 inositol 1,4,5-triphosphate receptor, type 2, putative Get druggable targets OG5_129492 All targets in OG5_129492
Schistosoma japonicum ko:K04958 inositol 1,4,5-triphosphate receptor, type 1, putative Get druggable targets OG5_129492 All targets in OG5_129492
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129492 All targets in OG5_129492
Schistosoma japonicum Inositol 1,4,5-trisphosphate receptor type 1, putative Get druggable targets OG5_129492 All targets in OG5_129492
Brugia malayi cation channel family protein Get druggable targets OG5_129492 All targets in OG5_129492
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129492 All targets in OG5_129492
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Thioredoxin reductase 0.0052 0.0069 0.0069
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0283 0.0657 0.0646
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0069 0.0069
Schistosoma mansoni alpha-glucosidase 0.0151 0.032 0.0309
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0283 0.0657 0.0646
Brugia malayi phospholipase C homolog 0.0044 0.0048 0.0048
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0069 0.0069
Onchocerca volvulus 0.0101 0.0194 0.9687
Schistosoma mansoni tar DNA-binding protein 0.007 0.0114 0.0102
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.007 0.0058
Schistosoma mansoni hypothetical protein 0.0319 0.075 0.074
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.1063 0.2647 0.2596
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0106 0.0095
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.3947 1 1
Echinococcus multilocularis survival motor neuron protein 1 0.0508 0.123 0.122
Schistosoma mansoni ryanodine receptor related 0.0131 0.0271 0.0259
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0059 0.0086 0.0086
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.3947 1 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.007 0.007
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0088 0.0077
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0088 0.0088
Brugia malayi CHE-14 protein 0.0116 0.0233 0.0233
Echinococcus granulosus tar DNA binding protein 0.007 0.0114 0.0102
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.1063 0.2647 0.5
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0044 0.0048 0.0037
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.0273 0.0205
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0245 0.0561 0.055
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.1063 0.2647 0.2639
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.3947 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0035 0.0035
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0088 0.0077
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.1341 0.3355 0.3347
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0283 0.0657 0.0646
Loa Loa (eye worm) MBCTL1 0.006 0.0088 0.0088
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0133 0.0274 0.024
Loa Loa (eye worm) Plcb4 protein 0.0059 0.0086 0.0086
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.1063 0.2647 0.5
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.1063 0.2647 1
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.3947 1 1
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0111 0.0218 0.0214
Trypanosoma brucei trypanothione reductase 0.0052 0.0069 0.0065
Loa Loa (eye worm) polyprenyl synthetase 0.1063 0.2647 0.2647
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0106 0.0095
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.0239 0.0171
Echinococcus granulosus geminin 0.0187 0.0412 0.0401
Toxoplasma gondii thioredoxin reductase 0.0052 0.0069 0.0065
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.1063 0.2647 1
Echinococcus granulosus survival motor neuron protein 1 0.0508 0.123 0.122
Trypanosoma brucei farnesyl pyrophosphate synthase 0.3947 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0069 0.0065
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0114 0.0114
Loa Loa (eye worm) TAR-binding protein 0.007 0.0114 0.0114
Trypanosoma brucei glucosidase, putative 0.0039 0.0035 0.0031
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.1063 0.2647 1
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0035 0.0035
Onchocerca volvulus 0.006 0.009 0.4145
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.1063 0.2647 0.2639
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0283 0.0657 0.0653
Loa Loa (eye worm) hypothetical protein 0.0141 0.0295 0.0295
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0029 0.001 0.001
Plasmodium vivax glutathione reductase, putative 0.0052 0.0069 0.0069
Mycobacterium tuberculosis Probable reductase 0.0119 0.0239 0.0171
Onchocerca volvulus 0.006 0.009 0.4145
Echinococcus granulosus farnesyl pyrophosphate synthase 0.3947 1 1
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.007 0.007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0106 0.0038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0245 0.0561 0.055
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0283 0.0657 0.0657
Echinococcus multilocularis ryanodine receptor 44f 0.0073 0.0122 0.011
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.006 0.009 0.0078
Schistosoma mansoni hypothetical protein 0.0104 0.02 0.0188
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.1063 0.2647 0.2644
Trypanosoma cruzi polyprenyl synthase, putative 0.1341 0.3355 0.3352
Echinococcus multilocularis ryanodine receptor 44f 0.0094 0.0175 0.0164
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.1063 0.2647 0.2596
Echinococcus multilocularis tar DNA binding protein 0.007 0.0114 0.0102
Trypanosoma cruzi solanesyl-diphosphate synthase 0.1063 0.2647 0.2644
Loa Loa (eye worm) polyprenyl synthetase 0.3947 1 1
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0133 0.0274 0.024
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0088 0.0077
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.3947 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0035 0.0031
Echinococcus multilocularis protein dispatched 1 0.0116 0.0233 0.0221
Echinococcus granulosus ryanodine receptor 44f 0.0073 0.0122 0.011
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.007 0.0058
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.3947 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0106 0.0095
Loa Loa (eye worm) glutathione reductase 0.0052 0.0069 0.0069
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0035 0.0026 0.0015
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0106 0.0106
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0069 0.0057
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0283 0.0657 0.0653
Brugia malayi follicle stimulating hormone receptor 0.0248 0.0569 0.0569
Leishmania major farnesyl pyrophosphate synthase 0.3947 1 1
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0114 0.0114
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0207 0.0464 0.0453
Loa Loa (eye worm) hypothetical protein 0.0128 0.0262 0.0262
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0245 0.0561 0.055
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.007 0.0058
Treponema pallidum octaprenyl-diphosphate synthase 0.1341 0.3355 0.5
Brugia malayi cation channel family protein 0.0201 0.0448 0.0448
Schistosoma mansoni survival motor neuron protein 0.0104 0.02 0.0188
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0175 0.0382 0.0382
Echinococcus granulosus ryanodine receptor 44f 0.0094 0.0175 0.0164
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.1341 0.3355 0.3355
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0233 0.0199
Loa Loa (eye worm) hypothetical protein 0.006 0.009 0.009
Echinococcus granulosus Niemann Pick C1 protein 0.0116 0.0233 0.0221
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0133 0.0274 0.024
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.1063 0.2647 0.2639
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.0382 0.0371
Leishmania major solanesyl-diphosphate synthase, putative 0.1063 0.2647 0.2647
Schistosoma mansoni farnesyl pyrophosphate synthase 0.3947 1 1
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.1063 0.2647 0.2644
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0116 0.0233 0.0233
Leishmania major phospholipase c-like protein 0.0027 0.0004 0.0004
Schistosoma mansoni patched 1 0.0116 0.0233 0.0221
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0283 0.0657 0.0653
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.1063 0.2647 0.2568
Echinococcus granulosus Protein patched homolog 1 0.0116 0.0233 0.0221
Giardia lamblia Farnesyl diphosphate synthase 0.3947 1 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1663 0.4177 0.417
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0106 0.0095
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.1341 0.3355 0.3355
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.1341 0.3355 0.3347
Brugia malayi glutathione reductase 0.0052 0.0069 0.0069
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.3947 1 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.007 0.3094
Leishmania major trypanothione reductase 0.0052 0.0069 0.0069
Loa Loa (eye worm) ryanodine receptor 0.0035 0.0026 0.0026
Echinococcus granulosus lysosomal alpha glucosidase 0.0175 0.0382 0.0371
Leishmania major polyprenyl synthase, putative 0.1341 0.3355 0.3355
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.3947 1 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.007 0.0058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0245 0.0561 0.055
Echinococcus multilocularis protein patched 0.0116 0.0233 0.0221
Leishmania major hypothetical protein, conserved 0.0075 0.0128 0.0128
Brugia malayi Polyprenyl synthetase family protein 0.1063 0.2647 0.2647
Schistosoma mansoni hypothetical protein 0.0187 0.0412 0.0401
Loa Loa (eye worm) hypothetical protein 0.0094 0.0175 0.0175
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0245 0.0561 0.0561
Onchocerca volvulus 0.0053 0.007 0.3094
Schistosoma mansoni tar DNA-binding protein 0.007 0.0114 0.0102
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.006 0.0088 0.0088
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0027 0.0004 0.0004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0012 0.0012
Schistosoma mansoni phospholipase C beta 0.0059 0.0086 0.0074
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.007 0.0058
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0012
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.0239 0.0171
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0131 0.0271 0.0271
Schistosoma mansoni tar DNA-binding protein 0.007 0.0114 0.0102
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.006 0.009 0.0078
Brugia malayi mbt repeat family protein 0.0053 0.007 0.007
Brugia malayi intermediate filament protein 0.003 0.0012 0.0012
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.1063 0.2647 0.5
Echinococcus granulosus sterol regulatory element binding protein 0.0116 0.0233 0.0221
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0035 0.0023
Schistosoma mansoni trans-prenyltransferase 0.1063 0.2647 0.2639
Onchocerca volvulus 0.0104 0.02 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0116 0.0233 0.0221
Schistosoma mansoni tar DNA-binding protein 0.007 0.0114 0.0102
Loa Loa (eye worm) hypothetical protein 0.0125 0.0256 0.0256
Schistosoma mansoni hypothetical protein 0.0187 0.0412 0.0401
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0163 0.0352 0.0341
Brugia malayi Variant SH3 domain containing protein 0.0027 0.0004 0.0004
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.0239 0.0171
Echinococcus multilocularis geminin 0.0187 0.0412 0.0401
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0035 0.0031
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1063 0.2647 0.2644
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.3947 1 1
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.3947 1 1
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.1341 0.3355 0.3347
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0245 0.0561 0.055
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.0239 0.0171
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.1063 0.2647 0.2639
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.007 0.0058
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0111 0.0218 0.0214
Loa Loa (eye worm) RNA binding protein 0.007 0.0114 0.0114
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0027 0.0004 0.0004
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.1063 0.2647 0.2647
Loa Loa (eye worm) hypothetical protein 0.0107 0.0208 0.0208
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0106 0.0103
Schistosoma mansoni alpha glucosidase 0.0039 0.0035 0.0023
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0283 0.0657 0.0556
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0088 0.0077
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.1063 0.2647 0.2647
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.0273 0.0205
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.0239 0.0171
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.1063 0.2647 0.2568
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0245 0.0561 0.0561
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.3947 1 1
Loa Loa (eye worm) hypothetical protein 0.0283 0.0657 0.0657
Plasmodium falciparum thioredoxin reductase 0.0052 0.0069 0.0069
Plasmodium falciparum glutathione reductase 0.0052 0.0069 0.0069
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0245 0.0561 0.055
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0035 0.0023
Schistosoma mansoni alpha-glucosidase 0.0151 0.032 0.0309
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0245 0.0561 0.055
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0207 0.0464 0.0453
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.1063 0.2647 0.2644
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0107 0.0208 0.0197
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0283 0.0657 0.0657
Echinococcus multilocularis Niemann Pick C1 protein 0.0116 0.0233 0.0221
Brugia malayi hypothetical protein 0.0508 0.123 0.123
Loa Loa (eye worm) hypothetical protein 0.0116 0.0233 0.0233
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0035 0.0031
Brugia malayi Glycosyl hydrolases family 31 protein 0.0175 0.0382 0.0382
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0035 0.0035
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.0382 0.0371
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.1063 0.2647 0.2596
Onchocerca volvulus 0.0081 0.0141 0.6893
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.1063 0.2647 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.0273 0.014
Trypanosoma cruzi polyprenyl synthase, putative 0.1341 0.3355 0.3352
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.0273 0.0205
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0097 0.0182 0.0171
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0069 0.0057
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0088 0.0077
Loa Loa (eye worm) hypothetical protein 0.0508 0.123 0.123
Loa Loa (eye worm) hypothetical protein 0.0081 0.0141 0.0141
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0116 0.0233 0.0221
Brugia malayi mbt repeat family protein 0.0053 0.007 0.007
Schistosoma mansoni tar DNA-binding protein 0.007 0.0114 0.0102
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.007 0.0058
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.0569 0.0569
Schistosoma mansoni glutathione synthetase 0.1063 0.2647 0.2639
Brugia malayi RNA binding protein 0.007 0.0114 0.0114
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.3947 1 1
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0027 0.0004 0.0004
Brugia malayi TAR-binding protein 0.007 0.0114 0.0114
Loa Loa (eye worm) intermediate filament protein 0.003 0.0012 0.0012

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 44 nM Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membrane ChEMBL. 10197969
IC50 (binding) = 44 nM Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membrane ChEMBL. 10197969

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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