Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0085 | 0.0136 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0386 | 0.107 | 0.171 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0057 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0038 | 0.0061 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0057 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.2181 | 0.626 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.0435 | 0.1145 |
Brugia malayi | DnaJ domain containing protein | 0.006 | 0.0129 | 0.0206 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0435 | 0.0696 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0052 | 0.0083 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.0055 | 0.0088 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0055 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0097 | 0.0154 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0085 | 0.0136 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.0687 | 0.2086 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0027 | 0.0027 |
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0.0038 | 0.0038 |
Brugia malayi | thymidylate synthase | 0.2073 | 0.5946 | 0.9498 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0057 | 0.0091 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0038 | 0.0061 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0085 | 0.0136 |
Brugia malayi | N-terminal motif family protein | 0.0107 | 0.0265 | 0.0424 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3475 | 1 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0.0038 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2181 | 0.626 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2181 | 0.626 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2181 | 0.626 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.2181 | 0.626 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0755 | 0.2137 | 0.2137 |
Brugia malayi | hypothetical protein | 0.0986 | 0.2805 | 0.4481 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0097 | 0.0154 |
Echinococcus granulosus | peregrin | 0.0029 | 0.0038 | 0.0061 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.0038 | 0.0061 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0055 | 0.0088 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0029 | 0.0038 | 0.0061 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0057 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.0055 | 0.0088 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0052 | 0.0083 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0038 | 0.0038 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0085 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0097 | 0.0155 |
Echinococcus multilocularis | dnaJ subfamily C 6 | 0.006 | 0.0129 | 0.0206 |
Loa Loa (eye worm) | thymidylate synthase | 0.2073 | 0.5946 | 0.9498 |
Echinococcus multilocularis | peregrin | 0.0029 | 0.0038 | 0.0061 |
Echinococcus granulosus | dnaJ subfamily C 6 | 0.006 | 0.0129 | 0.0206 |
Echinococcus multilocularis | thymidylate synthase | 0.2073 | 0.5946 | 0.9498 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2073 | 0.5946 | 0.9498 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0027 | 0.0027 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0027 | 0.0027 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2073 | 0.5946 | 0.9498 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0435 | 0.0696 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0253 | 0.0687 | 0.1098 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0253 | 0.0687 | 0.1098 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.007 | 0.0112 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0085 | 0.0136 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3475 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2181 | 0.626 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0986 | 0.2805 | 0.4481 |
Echinococcus granulosus | dihydrofolate reductase | 0.2181 | 0.626 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0085 | 0.0136 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0027 | 0.0043 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0027 | 0.0027 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0085 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0027 | 0.0043 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.0126 | 0.0201 |
Echinococcus granulosus | thymidylate synthase | 0.2073 | 0.5946 | 0.9498 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.0435 | 0.1145 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0055 | 0.0088 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.0687 | 0.2086 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0038 | 0.0061 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.0435 | 0.1145 |
Brugia malayi | jmjC domain containing protein | 0.0094 | 0.0226 | 0.0361 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0052 | 0.0083 |
Schistosoma mansoni | dihydrofolate reductase | 0.2181 | 0.626 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3475 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0755 | 0.2137 | 0.2137 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.0055 | 0.0088 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0027 | 0.0027 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0166 | 0.0435 | 0.0673 |
Brugia malayi | Bromodomain containing protein | 0.0029 | 0.0038 | 0.0061 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0175 | 0.0461 | 0.1242 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.007 | 0.0112 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3475 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.0129 | 0.0206 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0057 | 0.0091 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3475 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.017 | 0.0272 |
Echinococcus granulosus | geminin | 0.0166 | 0.0435 | 0.0696 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0029 | 0.0038 | 0.0061 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0001 | 0.0002 |
Echinococcus multilocularis | geminin | 0.0166 | 0.0435 | 0.0696 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.0687 | 0.2086 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0265 | 0.0424 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0755 | 0.2137 | 0.3414 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.0687 | 0.2086 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2181 | 0.626 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0085 | 0.0136 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0175 | 0.0461 | 0.1242 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0057 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.0435 | 0.1145 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0986 | 0.2805 | 0.2805 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.0435 | 0.1145 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0027 | 0.0027 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0097 | 0.0154 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.0435 | 0.1145 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0057 | 0.0091 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0986 | 0.2805 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0097 | 0.0154 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0027 | 0.0027 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0057 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0755 | 0.2137 | 0.3414 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 0.0226 | 0.0361 |
Onchocerca volvulus | 0.2073 | 0.5946 | 1 | |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0107 | 0.0265 | 0.0385 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0166 | 0.0435 | 0.1145 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0085 | 0.0136 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.0687 | 0.2086 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0029 | 0.0038 | 0.0061 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0027 | 0.0027 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0057 | 0.0091 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.0687 | 0.2086 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0755 | 0.2137 | 0.2137 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 0.0226 | 0.0361 |
Loa Loa (eye worm) | DnaJ domain-containing protein | 0.006 | 0.0129 | 0.0206 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2181 | 0.626 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 33 % | Percent inhibition of the leukotriene D4 (LTD4)-induced contraction of guinea pig tracheal spirals at 4 microM concentration | ChEMBL. | 2704027 |
Inhibition (functional) | = 73 % | Inhibition of the leukotriene D4 (LTD4)-induced contraction of guinea pig tracheal spirals at 10 microM concentration | ChEMBL. | 2704027 |
KB (binding) | = 0.00000085 M | Dissociation constant (KB) versus leukotriene-4 was evaluated in vitro in isolated guinea pig tracheal strips | ChEMBL. | 2704027 |
Kb (binding) | = 0.00000085 M | Dissociation constant (KB) versus leukotriene-4 was evaluated in vitro in isolated guinea pig tracheal strips | ChEMBL. | 2704027 |
Protection (functional) | 0 % | Compound (50 mg/kg,intraperitoneally) was tested in spontaneously breathing, conscious guinea pigs challenged with aerosolized LTD4 (30-min preatreatment) ;nd is No Data. | ChEMBL. | 2704027 |
Protection (functional) | = 17 % | Compound (50 mg/kg,intraperitoneally) was tested in spontaneously breathing, conscious guinea pigs challenged with aerosolized LTD4 (60-min preatreatment) | ChEMBL. | 2704027 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.