Detailed information for compound 286023

Basic information

Technical information
  • TDR Targets ID: 286023
  • Name: 2-(4-aminophenyl)-6-hydroxychromen-4-one
  • MW: 253.253 | Formula: C15H11NO3
  • H donors: 2 H acceptors: 2 LogP: 2.14 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(cc1)c1cc(=O)c2c(o1)ccc(c2)O
  • InChi: 1S/C15H11NO3/c16-10-3-1-9(2-4-10)15-8-13(18)12-7-11(17)5-6-14(12)19-15/h1-8,17H,16H2
  • InChiKey: YBQRUOMICVULNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-aminophenyl)-6-hydroxy-chromen-4-one
  • 2-(4-aminophenyl)-6-hydroxy-1-benzopyran-4-one
  • 2-(4-aminophenyl)-6-hydroxy-chromone
  • 4'-amino-6-hydroxyflavone
  • 2-(4-aminophenyl)-6-hydroxy-4-chromenone
  • 132018-32-7
  • 4′-Amino-6-hydroxyflavone
  • Aminogenistein
  • HSCI1_000192
  • 4H-1-Benzopyran-4-one, 2-(4-aminophenyl)-6-hydroxy-
  • ZINC00004898

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0047 0.1656 0.1656
Giardia lamblia Cathepsin B precursor 0.0047 0.1656 0.5
Echinococcus granulosus growth factor receptor bound protein 2 0.0009 0.0126 0.0126
Entamoeba histolytica cysteine protease, putative 0.0132 0.5039 0.5039
Entamoeba histolytica cysteine protease, putative 0.0132 0.5039 0.5039
Schistosoma mansoni cathepsin F (C01 family) 0.0256 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0132 0.5039 0.4054
Brugia malayi Cathepsin L-like precursor 0.0256 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.1656 0.1656
Echinococcus granulosus tyrosine protein kinase Lyn 0.001 0.0177 0.0177
Entamoeba histolytica cysteine proteinase, putative 0.0132 0.5039 0.5039
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0256 1 1
Giardia lamblia Hypothetical protein 0.0047 0.1656 0.5
Giardia lamblia Cathepsin L precursor 0.0047 0.1656 0.5
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0256 1 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.001 0.0177 0.0177
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.1656 0.1656
Entamoeba histolytica cysteine proteinase, putative 0.0132 0.5039 0.5039
Plasmodium vivax unspecified product 0.0132 0.5039 0.4054
Echinococcus granulosus cathepsin L 0.0132 0.5039 0.5039
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.001 0.0177 0.0177
Entamoeba histolytica cysteine protease, putative 0.0132 0.5039 0.5039
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0047 0.1656 0.1656
Entamoeba histolytica cysteine protease, putative 0.0256 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0177 0.0177
Entamoeba histolytica cysteine protease, putative 0.0047 0.1656 0.1656
Brugia malayi cathepsin Z-like cysteine proteinase 0.0047 0.1656 0.1656
Echinococcus multilocularis cathepsin b 0.0047 0.1656 0.1656
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0256 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0177 0.0177
Brugia malayi Papain family cysteine protease containing protein 0.0132 0.5039 0.5039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0132 0.5039 0.5039
Echinococcus granulosus c src tyrosine kinase 0.001 0.0177 0.0177
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0047 0.1656 0.1656
Echinococcus granulosus NCK adaptor protein 0.0009 0.0126 0.0126
Entamoeba histolytica cysteine protease, putative 0.0132 0.5039 0.5039
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0256 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0177 0.0177
Plasmodium falciparum cysteine proteinase falcipain 3 0.0256 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 1 1
Entamoeba histolytica cysteine protease, putative 0.0132 0.5039 0.5039
Entamoeba histolytica cysteine protease, putative 0.0132 0.5039 0.5039
Entamoeba histolytica cysteine proteinase, putative 0.0132 0.5039 0.5039
Echinococcus granulosus cathepsin l1 0.0256 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 1 1
Giardia lamblia Cathepsin L precursor 0.0047 0.1656 0.5
Echinococcus granulosus cathepsin b 0.0047 0.1656 0.1656
Entamoeba histolytica cysteine protease, putative 0.0132 0.5039 0.5039
Echinococcus multilocularis cysteine protease 0.0256 1 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0009 0.0126 0.0126
Schistosoma mansoni cathepsin F (C01 family) 0.0172 0.6617 0.6617
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0047 0.1656 0.1656
Brugia malayi cathepsin L-like cysteine proteinase 0.0047 0.1656 0.1656
Leishmania major cysteine peptidase A (CPA) 0.0256 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0047 0.1656 0.1656
Entamoeba histolytica cysteine protease, putative 0.0132 0.5039 0.5039
Plasmodium vivax vivapain-2 0.0256 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0047 0.1656 0.1656
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.1656 0.1656
Echinococcus multilocularis growth factor receptor bound protein 2 0.0009 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0047 0.1656 0.1656
Brugia malayi cathepsin L precursor 0.0047 0.1656 0.1656
Echinococcus multilocularis cathepsin L cysteine protease 0.0256 1 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0047 0.1656 0.1656
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0132 0.5039 0.5039
Brugia malayi fibroinase precursor 0.0047 0.1656 0.1656
Echinococcus granulosus cathepsin b 0.0047 0.1656 0.1656
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0256 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0047 0.1656 0.5
Leishmania major cathepsin L-like protease 0.0256 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0256 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0047 0.1656 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0085 0.315 0.1791
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0256 1 1
Loa Loa (eye worm) cathepsin B 0.0047 0.1656 0.1656
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.1656 0.1656
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0256 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 1 1
Schistosoma mansoni tyrosine kinase 0.001 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0085 0.315 0.315
Brugia malayi cathepsin Z-like cysteine proteinase 0.0047 0.1656 0.1656
Trypanosoma cruzi cruzipain precursor, putative 0.0256 1 1
Entamoeba histolytica cysteine protease, putative 0.0132 0.5039 0.5039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.6617 0.5946
Schistosoma mansoni adapter molecule crk 0.0009 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0009 0.0126 0.0126
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0047 0.1656 0.1656
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0177 0.0177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0047 0.1656 0.1656
Schistosoma mansoni cathepsin C 0.0047 0.1656 0.1656
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0132 0.5039 0.4054
Onchocerca volvulus 0.0256 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0085 0.315 0.315
Loa Loa (eye worm) hypothetical protein 0.0172 0.6617 0.6617
Onchocerca volvulus 0.0256 1 1
Schistosoma mansoni tyrosine kinase 0.001 0.0177 0.0177
Giardia lamblia Hypothetical protein 0.0047 0.1656 0.5
Trypanosoma cruzi cysteine proteinase, putative 0.0132 0.5039 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 1 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.001 0.0177 0.0177
Echinococcus granulosus cathepsin l1 0.0172 0.6617 0.6617
Entamoeba histolytica cysteine protease, putative 0.0047 0.1656 0.1656
Echinococcus granulosus cathepsin l cysteine peptidase 0.0256 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 1 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1656 0.1656
Trypanosoma cruzi cysteine peptidase, putative 0.0256 1 1
Giardia lamblia Cysteine protease 0.0047 0.1656 0.5
Brugia malayi Cathepsin L-like precursor 0.0256 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.001 0.0177 0.0177
Brugia malayi SRC-1 0.001 0.0177 0.0177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0172 0.6617 0.5946
Leishmania major cathepsin L-like protease 0.0256 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0256 1 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.001 0.0177 0.0177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.5039 0.4054
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0126 0.0126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 1 1
Onchocerca volvulus Cathepsin F homolog 0.0256 1 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0047 0.1656 0.1656
Entamoeba histolytica cysteine protease, putative 0.0132 0.5039 0.5039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 1 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.001 0.0177 0.0177
Giardia lamblia Cathepsin L precursor 0.0047 0.1656 0.5
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0047 0.1656 0.1656
Echinococcus granulosus tyrosine protein kinase Src42A 0.001 0.0177 0.0177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0256 1 1
Leishmania major cathepsin L-like protease 0.0256 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0047 0.1656 0.1656
Loa Loa (eye worm) hypothetical protein 0.0047 0.1656 0.1656
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0256 1 1
Leishmania major cathepsin L-like protease 0.0256 1 1
Brugia malayi Cathepsin L-like precursor 0.0256 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0177 0.0177
Brugia malayi cathepsin F-like cysteine proteinase 0.0085 0.315 0.315
Giardia lamblia Cathepsin B precursor 0.0047 0.1656 0.5
Loa Loa (eye worm) hypothetical protein 0.0085 0.315 0.315
Echinococcus multilocularis cysteine protease 0.0256 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0009 0.0126 0.0126
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0047 0.1656 0.1656
Echinococcus multilocularis tyrosine protein kinase Fgr 0.001 0.0177 0.0177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0256 1 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0047 0.1656 0.1656
Giardia lamblia Cathepsin B precursor 0.0047 0.1656 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0126 0.0126
Onchocerca volvulus 0.0256 1 1
Echinococcus granulosus cysteine protease 0.0132 0.5039 0.5039
Giardia lamblia Cysteine protease 0.0047 0.1656 0.5
Loa Loa (eye worm) ctsf protein 0.0256 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.1656 0.1656
Loa Loa (eye worm) hypothetical protein 0.0172 0.6617 0.6617
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0132 0.5039 0.5039
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0177 0.0177
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0047 0.1656 0.5
Echinococcus multilocularis cathepsin L 0.0047 0.1656 0.1656
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0256 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0085 0.315 0.315
Echinococcus multilocularis cathepsin L 0.0132 0.5039 0.5039
Giardia lamblia Cathepsin L-like protease 0.0047 0.1656 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0256 1 1
Giardia lamblia Cysteine protease 0.0047 0.1656 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0256 1 1
Entamoeba histolytica cysteine protease, putative 0.0132 0.5039 0.5039
Entamoeba histolytica cysteine proteinase 2 0.0132 0.5039 0.5039
Onchocerca volvulus Cathepsin L homolog 0.0256 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0256 1 1
Giardia lamblia Cathepsin L-like protease 0.0047 0.1656 0.5
Brugia malayi Cathepsin L-like precursor 0.0172 0.6617 0.6617
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0047 0.1656 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0132 0.5039 0.5039
Plasmodium vivax vivapain-3 0.0132 0.5039 0.4054
Giardia lamblia Cathepsin B precursor 0.0047 0.1656 0.5
Leishmania major cathepsin L-like protease 0.0256 1 1
Giardia lamblia Cathepsin L precursor 0.0047 0.1656 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.1656 0.1656
Trypanosoma cruzi cysteine peptidase, putative 0.0132 0.5039 0.4054
Entamoeba histolytica cysteine protease, putative 0.0132 0.5039 0.5039
Echinococcus multilocularis tyrosine protein kinase Src42A 0.001 0.0177 0.0177
Onchocerca volvulus Cathepsin L homolog 0.0256 1 1
Trypanosoma cruzi cysteine protease, putative 0.0132 0.5039 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.5039 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0256 1 1
Echinococcus multilocularis cathepsin b 0.0047 0.1656 0.1656
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0047 0.1656 0.1656
Brugia malayi Cathepsin L-like precursor 0.0256 1 1
Plasmodium vivax vivapain-2 0.0256 1 1
Loa Loa (eye worm) hypothetical protein 0.0256 1 1
Giardia lamblia Cathepsin B precursor 0.0047 0.1656 0.5
Echinococcus granulosus cathepsin L 0.0047 0.1656 0.1656
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 1 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.6617 0.6617
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.001 0.0177 0.0177
Brugia malayi Cathepsin L-like precursor 0.0085 0.315 0.315
Leishmania major cathepsin L-like protease 0.0256 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 1 1
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0126 0.0126
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0126 0.0126
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0047 0.1656 0.1656
Brugia malayi Cathepsin L-like precursor 0.0256 1 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.315 0.315
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0177 0.0177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 1 1
Onchocerca volvulus 0.0256 1 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1656 0.1656
Loa Loa (eye worm) hypothetical protein 0.0047 0.1656 0.1656
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0256 1 1
Schistosoma mansoni cathepsin B (C01 family) 0.0047 0.1656 0.1656
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0172 0.6617 0.5946
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0047 0.1656 0.1656
Onchocerca volvulus Cathepsin L homolog 0.0047 0.1656 0.1656
Entamoeba histolytica cysteine proteinase, putative 0.0256 1 1
Schistosoma mansoni tyrosine kinase 0.001 0.0177 0.0177
Onchocerca volvulus 0.0047 0.1656 0.1656
Loa Loa (eye worm) SRC-1 0.001 0.0177 0.0177
Schistosoma mansoni tyrosine kinase 0.001 0.0177 0.0177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.5039 0.4054
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0177 0.0177
Schistosoma mansoni nck2/grb4 0.0009 0.0126 0.0126
Trypanosoma cruzi cysteine peptidase, putative 0.0256 1 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0132 0.5039 0.5039
Brugia malayi Cathepsin L-like precursor 0.0172 0.6617 0.6617
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0047 0.1656 0.1656
Brugia malayi Papain family cysteine protease containing protein 0.0132 0.5039 0.5039
Entamoeba histolytica hypothetical protein 0.0047 0.1656 0.1656
Brugia malayi Cathepsin L-like cysteine proteinase 0.0172 0.6617 0.6617
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0047 0.1656 0.1656
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0132 0.5039 0.4054
Echinococcus multilocularis cathepsin L cysteine protease 0.0256 1 1
Echinococcus multilocularis NCK adaptor protein 0.0009 0.0126 0.0126
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0177 0.0177
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0009 0.0126 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0256 1 1
Onchocerca volvulus 0.0256 1 1
Brugia malayi cathepsin L-like precursor 0.0172 0.6617 0.6617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 1 1
Giardia lamblia Cathepsin B precursor 0.0047 0.1656 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0256 1 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0177 0.0177
Giardia lamblia Encystation-specific protease 0.0047 0.1656 0.5
Loa Loa (eye worm) hypothetical protein 0.0047 0.1656 0.1656
Brugia malayi Sex muscle abnormal protein 5 0.0009 0.0126 0.0126
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0047 0.1656 0.1656
Trypanosoma cruzi cysteine proteinase, putative 0.0132 0.5039 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0172 0.6617 0.6617
Plasmodium vivax unspecified product 0.0085 0.315 0.1791
Trypanosoma cruzi cysteine peptidase, putative 0.0085 0.315 0.1791
Giardia lamblia Cathepsin L precursor 0.0047 0.1656 0.5
Schistosoma mansoni cathepsin S (C01 family) 0.0047 0.1656 0.1656
Schistosoma mansoni cathepsin s 0.0085 0.315 0.315
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0177 0.0177
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0177 0.0177
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0047 0.1656 0.1656
Giardia lamblia Cathepsin B precursor 0.0047 0.1656 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0256 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 1 1
Leishmania major cathepsin L-like protease 0.0256 1 1
Entamoeba histolytica cysteine protease, putative 0.0132 0.5039 0.5039
Loa Loa (eye worm) cysteine protease 0.0256 1 1
Onchocerca volvulus 0.0172 0.6617 0.6617
Plasmodium vivax vivapain-1 0.0132 0.5039 0.4054
Echinococcus granulosus cathepsin L cysteine proteinase 0.0256 1 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1656 0.1656
Onchocerca volvulus 0.0256 1 1
Toxoplasma gondii cathepsin CPL 0.0256 1 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1656 0.1656
Giardia lamblia Cathepsin L precursor 0.0047 0.1656 0.5
Onchocerca volvulus 0.0256 1 1
Giardia lamblia Cathepsin B precursor 0.0047 0.1656 0.5
Loa Loa (eye worm) fibroinase 0.0256 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0256 1 1
Leishmania major cathepsin L-like protease 0.0256 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0256 1 1
Giardia lamblia Cysteine protease 0.0047 0.1656 0.5
Echinococcus granulosus cathepsin L cysteine protease 0.0132 0.5039 0.5039
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0047 0.1656 0.1656

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 2.03 ug ml-1 Cytotoxicity against human SK-MEL cells after 6 days by MTT assay ChEMBL. 1812215
ED50 (functional) = 2.65 ug ml-1 Cytotoxicity against human HT-29 cells after 6 days by MTT assay ChEMBL. 1812215
ED50 (functional) = 2.72 ug ml-1 Cytotoxicity against human A549 cells after 6 days by MTT assay ChEMBL. 1812215
ED50 (functional) > 25 ug ml-1 Cytotoxicity against human MCF7 cells after 6 days by MTT assay ChEMBL. 1812215
ED50 (functional) > 25 ug ml-1 Cytotoxicity against human MALME-3M cells after 6 days by MTT assay ChEMBL. 1812215
IC50 (binding) = 1 uM Inhibition of p56 lck ChEMBL. 1479375
IC50 (binding) = 1.2 uM Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro. ChEMBL. 1995903
IC50 (binding) = 1.2 uM Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro. ChEMBL. 1995903

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.