Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4528 | 0.2993 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0394 | 0.4528 | 0.4528 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4528 | 0.2993 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.5114 | 0.3743 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0835 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0394 | 0.4528 | 0.4445 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0149 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.0394 | 0.4528 | 0.4445 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0394 | 0.4528 | 0.4445 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0835 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0402 | 0.4628 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0441 | 0.5114 | 0.3743 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0394 | 0.4528 | 0.4528 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0835 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0394 | 0.4528 | 0.4445 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0835 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0394 | 0.4528 | 0.4445 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0835 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4528 | 0.2993 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0835 | 1 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0394 | 0.4528 | 0.4445 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0394 | 0.4528 | 0.4445 |
Schistosoma mansoni | zinc finger protein | 0.0394 | 0.4528 | 0.4445 |
Brugia malayi | hypothetical protein | 0.0394 | 0.4528 | 0.4445 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0394 | 0.4528 | 0.4445 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0394 | 0.4528 | 0.4445 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0394 | 0.4528 | 0.2993 |
Loa Loa (eye worm) | hypothetical protein | 0.0835 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4528 | 0.2993 |
Brugia malayi | tailless protein | 0.0394 | 0.4528 | 0.4445 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0394 | 0.4528 | 0.4528 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0835 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0394 | 0.4528 | 0.4528 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0402 | 0.4628 | 0.4547 |
Loa Loa (eye worm) | hypothetical protein | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.5114 | 0.3743 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0835 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0835 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.5114 | 0.3743 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4528 | 0.2993 |
Schistosoma mansoni | nuclear hormone receptor | 0.0835 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0835 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0835 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0394 | 0.4528 | 0.4528 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0394 | 0.4528 | 0.4528 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4528 | 0.2993 |
Schistosoma mansoni | thyroid hormone receptor | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0835 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0835 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0835 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0394 | 0.4528 | 0.4445 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0441 | 0.5114 | 0.5114 |
Brugia malayi | nuclear receptor RXR | 0.0441 | 0.5114 | 0.504 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0835 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0835 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0149 | 0.5 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0394 | 0.4528 | 0.4445 |
Brugia malayi | ecdysone receptor | 0.0394 | 0.4528 | 0.4445 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4528 | 0.2993 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0835 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0394 | 0.4528 | 0.4445 |
Brugia malayi | nuclear hormone receptor | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0835 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0835 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0835 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0394 | 0.4528 | 0.4445 |
Brugia malayi | hypothetical protein | 0.0441 | 0.5114 | 0.504 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0149 | 0.0149 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0394 | 0.4528 | 0.2993 |
Schistosoma mansoni | thyroid hormone receptor | 0.0835 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0394 | 0.4528 | 0.4445 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0835 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0835 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0835 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0835 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0402 | 0.4628 | 0.5 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0441 | 0.5114 | 0.504 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.5114 | 0.3743 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4528 | 0.2993 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0394 | 0.4528 | 0.2993 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0835 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0835 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0441 | 0.5114 | 0.504 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4528 | 0.2993 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0835 | 1 | 1 |
Onchocerca volvulus | 0.0835 | 1 | 1 | |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0394 | 0.4528 | 0.4528 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0394 | 0.4528 | 0.4445 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0835 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0441 | 0.5114 | 0.504 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4528 | 0.2993 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0835 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0394 | 0.4528 | 0.4445 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 0.4628 | 0.3121 |
Brugia malayi | conserved hypotetical protein | 0.0394 | 0.4528 | 0.4445 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0394 | 0.4528 | 0.4528 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0149 | 0.0149 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0394 | 0.4528 | 0.4528 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0394 | 0.4528 | 0.4528 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0441 | 0.5114 | 0.5114 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0394 | 0.4528 | 0.2993 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0441 | 0.5114 | 0.504 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0835 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0835 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0394 | 0.4528 | 0.4528 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4528 | 0.2993 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0835 | 1 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0394 | 0.4528 | 0.4528 |
Brugia malayi | steroid hormone receptor | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0835 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0149 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0402 | 0.4628 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0835 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0835 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0835 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0835 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0835 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0835 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.5114 | 0.3743 |
Brugia malayi | nuclear receptor NHR-88 | 0.0394 | 0.4528 | 0.4445 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0441 | 0.5114 | 0.504 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4528 | 0.2993 |
Loa Loa (eye worm) | hypothetical protein | 0.0394 | 0.4528 | 0.2993 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0835 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0835 | 1 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0394 | 0.4528 | 0.4445 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0835 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0835 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0835 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 132 uM | Concentration required for 50% inhibition of human Inosine-5'-monophosphate dehydrogenase 2 using Spectrophotometric assay | ChEMBL. | 9016322 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.