Detailed information for compound 286237

Basic information

Technical information
  • TDR Targets ID: 286237
  • Name: 2,4-dinitro-1-(2-nitrophenyl)benzene
  • MW: 289.2 | Formula: C12H7N3O6
  • H donors: 0 H acceptors: 6 LogP: 3.03 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cc(ccc1c1ccccc1[N+](=O)[O-])[N+](=O)[O-]
  • InChi: 1S/C12H7N3O6/c16-13(17)8-5-6-10(12(7-8)15(20)21)9-3-1-2-4-11(9)14(18)19/h1-7H
  • InChiKey: JTJBOKJQQFQURC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 36712-35-3
  • 1,1'-BIPHENYL, 2,2',4-TRINITRO-
  • 2,4,2'-Trinitrobiphenyl
  • BRN 2543725
  • Biphenyl, 2,2',4-trinitro-
  • CCRIS 4115
  • NSC 105611
  • NSC105611

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Papain family cysteine protease containing protein 0.0121 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) cysteine protease 0.0121 0.0643 0.0643
Onchocerca volvulus 0.1172 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1172 1 1
Echinococcus multilocularis serotonin receptor 0.1172 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0119 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Schistosoma mansoni amine GPCR 0.1172 1 1
Loa Loa (eye worm) TYRA-2 protein 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Echinococcus granulosus g protein coupled receptor 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Schistosoma mansoni amine GPCR 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1172 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Echinococcus granulosus neuropeptide s receptor 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0118 0.0059
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.1172 1 1
Echinococcus granulosus cathepsin l1 0.0121 0.0643 0.0531
Echinococcus granulosus alpha 1A adrenergic receptor 0.1172 1 1
Brugia malayi cathepsin L-like precursor 0.0081 0.0286 0.0286
Brugia malayi larval opioid receptor 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0121 0.0643 1
Schistosoma mansoni biogenic amine receptor 0.1172 1 1
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0901 0.7583 0.5
Echinococcus granulosus cathepsin L cysteine protease 0.0062 0.0119 0.0001
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni neuropeptide receptor 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni amine GPCR 0.1172 1 1
Schistosoma mansoni biogenic amine receptor 0.1172 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1172 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1172 1 1
Schistosoma mansoni biogenic amine receptor 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Echinococcus multilocularis serotonin receptor 0.1172 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0121 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni amine GPCR 0.1172 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.1172 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.1172 1 1
Schistosoma mansoni opsin-like receptor 0.1172 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0081 0.0286 0.0286
Brugia malayi hypothetical protein 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Echinococcus granulosus sex peptide receptor 0.1172 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.1172 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0462 0.3675 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0121 0.0643 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.1172 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.1172 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0422 0.3318 0.8997
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis allatostatin A receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Loa Loa (eye worm) neuropeptide F receptor 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.1172 1 1
Onchocerca volvulus Cathepsin F homolog 0.0121 0.0643 0.0367
Echinococcus multilocularis neuropeptides capa receptor 0.1172 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Brugia malayi G-protein coupled receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.1172 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.1172 1 1
Echinococcus granulosus neuropeptide receptor 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.1172 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1172 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.1172 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0119 0.006
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Schistosoma mansoni opsin-like receptor 0.1172 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.1172 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.1172 1 1
Brugia malayi neuropeptide F receptor 0.1172 1 1
Echinococcus multilocularis cysteine protease 0.0121 0.0643 0.0531
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0643 0.0643
Onchocerca volvulus 0.1172 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.1172 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.1172 1 1
Brugia malayi putative neuropeptide receptor 0.1172 1 1
Schistosoma mansoni hypothetical protein 0.1172 1 1
Schistosoma mansoni hypothetical protein 0.1172 1 1
Echinococcus granulosus somatostatin receptor 0.1172 1 1
Echinococcus multilocularis g protein coupled receptor 0.1172 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0118 0.0059
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0901 0.7583 0.5
Onchocerca volvulus 0.0121 0.0643 0.0367
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0118 0.0118
Schistosoma mansoni neuropeptide receptor 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Echinococcus granulosus G protein coupled receptor 139 0.1172 1 1
Echinococcus multilocularis fmrfamide receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0121 0.0643 1
Brugia malayi Cathepsin L-like precursor 0.0081 0.0286 0.0286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Echinococcus granulosus tm gpcr rhodopsin 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Echinococcus multilocularis orexin receptor type 2 0.1172 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.1172 1 1
Brugia malayi TAR-binding protein 0.0062 0.0118 0.0118
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Echinococcus multilocularis g protein coupled receptor 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1172 1 1
Echinococcus granulosus cathepsin L 0.0062 0.0119 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Brugia malayi G protein-coupled receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0121 0.0643 0.0587
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.1172 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.1172 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1172 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.1172 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.1172 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0118 0.0059
Echinococcus granulosus neuropeptides capa receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni hypothetical protein 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Leishmania major cathepsin L-like protease 0.0462 0.3675 1
Schistosoma mansoni alpha(13)fucosyltransferase 0.0097 0.0425 0.0368
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0286 0.3182
Brugia malayi Dopamine receptor 0.1172 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.1172 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Trypanosoma cruzi cysteine peptidase, putative 0.0462 0.3675 1
Onchocerca volvulus 0.1172 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.1172 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0118 0.0118
Schistosoma mansoni histamine h1 receptor 0.1172 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.1172 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0119 0.006
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis neuropeptide receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.1172 1 1
Brugia malayi sulfakinin receptor protein 0.1172 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.1172 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.1172 1 1
Leishmania major cathepsin L-like protease 0.0462 0.3675 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Leishmania major cathepsin L-like protease 0.0462 0.3675 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Brugia malayi ORL1-like opioid receptor 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0121 0.0643 1
Echinococcus granulosus serotonin receptor 0.1172 1 1
Echinococcus multilocularis g protein coupled receptor 0.1172 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.1172 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0118 0.0059
Onchocerca volvulus 0.1172 1 1
Toxoplasma gondii cathepsin CPL 0.0121 0.0643 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0121 0.0643 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni amine GPCR 0.1172 1 1
Plasmodium vivax vivapain-2 0.0121 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0286 0.0286
Echinococcus multilocularis fmrfamide receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni neuropeptide receptor 0.1172 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Schistosoma mansoni alpha(13)fucosyltransferase 0.0097 0.0425 0.0368
Echinococcus granulosus cysteine protease 0.0062 0.0119 0.0001
Echinococcus granulosus neuropeptides capa receptor 0.1172 1 1
Entamoeba histolytica cysteine protease, putative 0.0121 0.0643 1
Onchocerca volvulus 0.1172 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1172 1 1
Brugia malayi follicle stimulating hormone receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.0118 0.0118
Loa Loa (eye worm) G-protein coupled receptor 0.1172 1 1
Echinococcus granulosus allatostatin A receptor 0.1172 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1172 1 1
Echinococcus granulosus g protein coupled receptor 0.1172 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0121 0.0643 0.0531
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Loa Loa (eye worm) fibroinase 0.0121 0.0643 0.0643
Echinococcus multilocularis cathepsin L cysteine protease 0.0121 0.0643 0.0531
Onchocerca volvulus 0.1172 1 1
Echinococcus granulosus g-protein coupled receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Brugia malayi Fucosyl transferase family protein 0.0097 0.0425 0.0425
Schistosoma mansoni cathepsin F (C01 family) 0.0121 0.0643 0.0587
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.1172 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.1172 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0363 0.2795 0.7525
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0121 0.0643 1
Onchocerca volvulus 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0286 0.0286
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1172 1 1
Echinococcus granulosus hypothetical protein 0.1172 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1172 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.1172 1 1
Brugia malayi RE15519p 0.1172 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.1172 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.1172 1 1
Brugia malayi RNA binding protein 0.0062 0.0118 0.0118
Brugia malayi GnHR receptor homolog 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Echinococcus granulosus neuropeptide Y receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Plasmodium vivax vivapain-2 0.0121 0.0643 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1172 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1172 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.1172 1 1
Brugia malayi alpha1,3-fucosyltransferase homologue 0.0097 0.0425 0.0425
Brugia malayi Serotonin receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0425 0.0425
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0121 0.0643 1
Echinococcus multilocularis cysteine protease 0.0121 0.0643 0.0531
Echinococcus multilocularis neuropeptide receptor 0.1172 1 1
Loa Loa (eye worm) fucosyl transferase 0.0097 0.0425 0.0425
Brugia malayi Dopamine receptor protein 1 0.1172 1 1
Echinococcus granulosus g protein coupled receptor 0.1172 1 1
Schistosoma mansoni alpha(13)fucosyltransferase 0.0097 0.0425 0.0368
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1172 1 1
Schistosoma mansoni opsin-like receptor 0.1172 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Onchocerca volvulus 0.0121 0.0643 0.0367
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Brugia malayi Serotonin receptor 0.1172 1 1
Echinococcus granulosus fmrfamide receptor 0.1172 1 1
Brugia malayi AKH receptor 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Echinococcus multilocularis cathepsin L 0.0062 0.0119 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Onchocerca volvulus 0.1172 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.1172 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1172 1 1
Schistosoma mansoni neuropeptide receptor 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Echinococcus multilocularis sex peptide receptor 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0286 0.3182
Onchocerca volvulus Cathepsin L homolog 0.0121 0.0643 0.0367
Echinococcus multilocularis alpha 1A adrenergic receptor 0.1172 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.1172 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0121 0.0643 0.0643
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0121 0.0643 0.0531
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.1172 1 1
Onchocerca volvulus Cathepsin L homolog 0.0121 0.0643 0.0367
Loa Loa (eye worm) ctsf protein 0.0121 0.0643 0.0643
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1172 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.1172 1 1
Schistosoma mansoni myosin xvIII 0.1172 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0121 0.0643 0.1472
Brugia malayi hypothetical protein 0.1172 1 1
Echinococcus granulosus neuropeptide receptor A26 0.1172 1 1
Echinococcus granulosus orexin receptor type 2 0.1172 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0081 0.0286 0.0228
Brugia malayi Cathepsin L-like precursor 0.0081 0.0286 0.0286
Echinococcus multilocularis neuropeptide receptor A26 0.1172 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.1172 1 1
Schistosoma mansoni hypothetical protein 0.1172 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0118 0.0059
Schistosoma mansoni adenoreceptor 0.1172 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0462 0.3675 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0462 0.3675 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.1172 1 1
Onchocerca volvulus 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus multilocularis neuropeptide s receptor 0.1172 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0121 0.0643 0.0531
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Brugia malayi neuropeptide F receptor 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Brugia malayi Cathepsin L-like precursor 0.0121 0.0643 0.0643
Echinococcus multilocularis cathepsin L cysteine protease 0.0121 0.0643 0.0531
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0643 1
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Schistosoma mansoni alpha(13)fucosyltransferase 0.0097 0.0425 0.0368
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1172 1 1
Echinococcus multilocularis somatostatin receptor 0.1172 1 1
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.0901 0.7583 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0462 0.3675 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0643 1
Brugia malayi Melatonin receptor type 1A 0.1172 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1172 1 1
Brugia malayi hypothetical protein 0.1172 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.1172 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.1172 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0119 0.0119
Echinococcus granulosus neuropeptide Y receptor 0.1172 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0081 0.0286 0.3182
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.1172 1 1
Schistosoma mansoni alpha(13)fucosyltransferase 0.0097 0.0425 0.0368
Echinococcus granulosus 7TM GPCR rhodopsin 0.1172 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0121 0.0643 0.0531
Loa Loa (eye worm) hypothetical protein 0.0081 0.0286 0.0286
Echinococcus granulosus cathepsin l1 0.0081 0.0286 0.017
Brugia malayi Dopamine receptor protein 2 0.1172 1 1
Loa Loa (eye worm) hypothetical protein 0.1172 1 1
Echinococcus granulosus neuropeptide receptor 0.1172 1 1
Brugia malayi G-protein coupled receptor 0.1172 1 1
Echinococcus multilocularis g-protein coupled receptor 0.1172 1 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = -0.19 Mutagenic activity of the compound was tested in an Ames test on S. typhimurium TA98; Activity is log of revertants/nmol ChEMBL. 1995902
logP (ADMET) = 3.26 Partition coefficient (logP) ChEMBL. 1995902

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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