Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0043 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0043 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0043 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0043 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0043 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0043 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0043 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0043 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0043 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0043 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0043 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0043 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0043 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0043 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0043 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0043 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0043 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0043 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0043 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0043 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0043 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0043 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0043 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0043 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0043 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0043 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0043 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0043 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0043 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0043 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0043 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0043 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0043 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0043 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0043 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0043 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0043 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0043 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0043 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0043 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0043 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0043 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0043 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0043 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0043 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0043 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0043 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0043 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0043 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0043 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0043 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0043 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0043 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0043 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0043 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0043 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0043 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0043 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.5 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0043 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0043 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0043 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | < -4 | Inhibition of binding of [3H]-glycine to N-methyl-D-aspartate glutamate receptor 1 from crude synaptic membranes prepared from adult rat cerebral cortex. | ChEMBL. | 9526557 |
Log Ki (binding) | < 4 | Inhibition of binding of [3H]-glycine to N-methyl-D-aspartate glutamate receptor 1 from crude synaptic membranes prepared from adult rat cerebral cortex. | ChEMBL. | 9526557 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.