Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | 0 M | In vitro inhibitory activity against growth of L1210 mouse leukemia cells at 10E-4 M concentration; IA means Inactive | ChEMBL. | 7108897 |
ILS (functional) | > 25 % | In vivo percent increase in life span (%ILS) of mice bearing L1210 leukemia at a dose of 400 mg/kg | ChEMBL. | 7108897 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.