Detailed information for compound 286426

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 402.372 | Formula: C17H23FN2O8
  • H donors: 1 H acceptors: 4 LogP: -0.28 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1OC[C@H]([C@H]([C@@]1(F)CCn1cc(C)c(=O)[nH]c1=O)OC(=O)C)OC(=O)C
  • InChi: 1S/C17H23FN2O8/c1-9-7-20(16(24)19-14(9)23)6-5-17(18)13(28-11(3)22)12(27-10(2)21)8-26-15(17)25-4/h7,12-13,15H,5-6,8H2,1-4H3,(H,19,23,24)/t12-,13-,15?,17-/m1/s1
  • InChiKey: RLCXSDQLWKUZLN-BPBCKMDWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni notch 0.0062 0.0554 0.0625
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0079 0.0746 0.0843
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0079 0.0746 0.0746
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.3449 0.3449
Loa Loa (eye worm) hypothetical protein 0.0048 0.0404 0.0404
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0042 0.0329 0.0372
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0079 0.0746 0.159
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.2543 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.013 0.1324 0.1324
Brugia malayi nuclear receptor RXR 0.0042 0.0329 0.0329
Schistosoma mansoni hypothetical protein 0.0062 0.0554 0.0625
Loa Loa (eye worm) hypothetical protein 0.013 0.1324 0.1324
Onchocerca volvulus 0.0048 0.0404 0.0404
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0281 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0279
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0079 0.0746 0.159
Onchocerca volvulus 0.0037 0.0281 0.0281
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.133 0.1502
Brugia malayi RNA binding protein 0.0066 0.06 0.06
Loa Loa (eye worm) TAR-binding protein 0.0066 0.06 0.06
Schistosoma mansoni tar DNA-binding protein 0.0066 0.06 0.0678
Brugia malayi nuclear hormone receptor 0.0079 0.0746 0.0746
Toxoplasma gondii hypothetical protein 0.0048 0.0404 0.0642
Mycobacterium ulcerans beta-lactamase 0.0037 0.0281 0.1961
Brugia malayi PAN domain containing protein 0.0048 0.0404 0.0404
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0062 0.0554 0.0554
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0079 0.0746 0.159
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0281 0.1016
Schistosoma mansoni zinc finger protein 0.0037 0.0279 0.0315
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0355 0.3851 0.8203
Onchocerca volvulus 0.0062 0.0554 0.0554
Brugia malayi Calcium binding EGF domain containing protein 0.0062 0.0554 0.0554
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0079 0.0746 0.159
Loa Loa (eye worm) PAN domain-containing protein 0.0048 0.0404 0.0404
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0079 0.0746 0.0843
Echinococcus multilocularis transmembrane protease serine 3 0.013 0.133 0.2832
Echinococcus granulosus protein jagged 1 0.0062 0.0554 0.118
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0281 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0037 0.0279 0.0315
Brugia malayi EGF-like domain containing protein 0.0062 0.0554 0.0554
Brugia malayi Cadherin domain containing protein 0.0062 0.0554 0.0554
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0079 0.0746 0.0746
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0138 0.0862
Mycobacterium leprae Probable two component sensor kinase MprB 0.0015 0.0026 0.0342
Onchocerca volvulus 0.0062 0.0554 0.0554
Brugia malayi Kringle domain containing protein 0.043 0.4694 0.4694
Loa Loa (eye worm) hypothetical protein 0.0037 0.0281 0.0281
Brugia malayi nuclear hormone receptor family member nhr-6 0.0037 0.0279 0.0279
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0281 0.1961
Plasmodium vivax importin-beta 2, putative 0.003 0.0198 0.028
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0281 0.1961
Echinococcus multilocularis fat cadherin tumor suppressor 0.0062 0.0554 0.118
Echinococcus granulosus tissue type plasminogen activator 0.043 0.4694 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0746 0.0746
Mycobacterium leprae Probable lipase LipE 0.0037 0.0281 0.3729
Schistosoma mansoni steroid hormone receptor ad4bp 0.0079 0.0746 0.0843
Schistosoma mansoni nuclear receptor 0.0037 0.0279 0.0315
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0404 0.0404
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0138 0.0862
Schistosoma mansoni tar DNA-binding protein 0.0066 0.06 0.0678
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0279 0.0315
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0068
Entamoeba histolytica hypothetical protein 0.0024 0.0134 0.8684
Echinococcus granulosus transmembrane protease serine 3 0.013 0.133 0.2832
Brugia malayi PAN domain containing protein 0.0048 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0279
Echinococcus multilocularis fibropellin Ia 0.0062 0.0554 0.118
Loa Loa (eye worm) hypothetical protein 0.0048 0.0404 0.0404
Leishmania major GTP-binding protein, putative 0.0022 0.0109 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0079 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0279
Onchocerca volvulus 0.0037 0.0279 0.0279
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.013 0.133 0.1502
Brugia malayi hypothetical protein 0.0042 0.0329 0.0329
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0079 0.0746 0.0746
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0109 0.0233
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0019 0.0074 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0329 0.0372
Schistosoma mansoni septate junction protein 0.0062 0.0554 0.0625
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0279
Schistosoma mansoni hypothetical protein 0.013 0.133 0.1502
Onchocerca volvulus 0.0669 0.7386 0.7386
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0138 0.0862
Mycobacterium tuberculosis Conserved protein 0.0037 0.0281 0.1016
Onchocerca volvulus 0.0048 0.0404 0.0404
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0134 0.4774
Brugia malayi Importin beta-1 subunit 0.003 0.0198 0.0198
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0138 1
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.133 0.1502
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0068
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0279 0.0595
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0138 1
Trypanosoma cruzi hypothetical protein, conserved 0.043 0.4694 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0079 0.0746 0.0746
Mycobacterium ulcerans lipase LipD 0.0037 0.0281 0.1961
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0109 0.0088
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0068 0.0169
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0079 0.0746 0.0843
Schistosoma mansoni tar DNA-binding protein 0.0066 0.06 0.0678
Loa Loa (eye worm) notch protein 0.0062 0.0554 0.0554
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0281 0.06
Echinococcus multilocularis importin subunit beta 1 0.003 0.0198 0.0422
Brugia malayi photoreceptor-specific nuclear receptor 0.0079 0.0746 0.0746
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0079 0.0746 0.0746
Schistosoma mansoni importin beta-1 0.003 0.0198 0.0224
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0279
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0079 0.0755 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0138 0.0138
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0079 0.0746 0.0843
Onchocerca volvulus Arrow homolog 0.013 0.1324 0.1324
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0138 0.1831
Brugia malayi PAN domain containing protein 0.0048 0.0404 0.0404
Brugia malayi beta-lactamase family protein 0.0037 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0025 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0279 0.0595
Toxoplasma gondii ABC1 family protein 0.0037 0.0281 0.0376
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0079 0.0746 0.0843
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Echinococcus granulosus enteropeptidase 0.013 0.133 0.2832
Echinococcus granulosus Tolloid protein 1 0.013 0.1324 0.2821
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0281 0.1016
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0019 0.0074 0.263
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0799 0.8854 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0109 0.0088
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0019 0.0074 0.263
Echinococcus granulosus snurportin 1 0.0319 0.3449 0.7348
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0281 0.1016
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.133 0.1502
Schistosoma mansoni cpg binding protein 0.0031 0.0216 0.0244
Schistosoma mansoni hypothetical protein 0.0062 0.0554 0.0625
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.133 0.1502
Schistosoma mansoni slit 0.0062 0.0554 0.0625
Loa Loa (eye worm) hypothetical protein 0.0079 0.0746 0.0746
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0138 0.0862
Leishmania major importin beta-1 subunit, putative 0.0024 0.0134 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0079 0.0746 0.0746
Brugia malayi Trypsin-like protease protein 5 0.013 0.133 0.133
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Brugia malayi Trypsin family protein 0.0799 0.8854 0.8854
Brugia malayi Cadherin domain containing protein 0.0062 0.0554 0.0554
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0279 0.0595
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0404 0.0642
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0281 0.0281
Toxoplasma gondii calcium binding egf domain-containing protein 0.013 0.1324 0.265
Brugia malayi PAN domain containing protein 0.0048 0.0404 0.0404
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0062 0.0554 0.0625
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0057 0.0124
Echinococcus granulosus neurogenic locus notch protein 0.0062 0.0554 0.118
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0079 0.0746 0.159
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.013 0.133 0.1502
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0057 0.0124
Echinococcus multilocularis neurogenic locus notch protein 0.0062 0.0554 0.118
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0279 0.0315
Brugia malayi orphan nuclear receptor NR2E1 0.0037 0.0279 0.0279
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.4629 0.986
Brugia malayi EGF-like domain containing protein 0.0062 0.0554 0.0554
Loa Loa (eye worm) DR-78 0.0037 0.0279 0.0279
Brugia malayi RNA, U transporter 1 0.0085 0.0817 0.0817
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Onchocerca volvulus 0.0062 0.0554 0.0554
Schistosoma mansoni hypothetical protein 0.0319 0.3449 0.3896
Loa Loa (eye worm) hypothetical protein 0.0042 0.0329 0.0329
Schistosoma mansoni hypothetical protein 0.0062 0.0554 0.0625
Brugia malayi Nuclear hormone receptor-like 1 0.0079 0.0746 0.0746
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0198 0.515
Schistosoma mansoni hypothetical protein 0.0062 0.0554 0.0625
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0057 0.0124
Brugia malayi Steroid receptor seven-up type 2 0.0079 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0048 0.0404 0.0404
Echinococcus multilocularis ecdysone induced protein 78C 0.0079 0.0746 0.159
Echinococcus multilocularis notch 0.0062 0.0554 0.118
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Brugia malayi hypothetical protein 0.013 0.133 0.133
Echinococcus multilocularis FTZ F1 alpha 0.0079 0.0746 0.159
Loa Loa (eye worm) hypothetical protein 0.0037 0.0281 0.0281
Onchocerca volvulus 0.0048 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0048 0.0404 0.0404
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0404 0.0642
Echinococcus multilocularis protein jagged 2 0.0062 0.0554 0.118
Onchocerca volvulus 0.013 0.133 0.133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0079 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0079 0.0746 0.0746
Schistosoma mansoni nuclear receptor nhr-48 0.0037 0.0279 0.0315
Echinococcus multilocularis neurogenic locus protein delta 0.0062 0.0554 0.118
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0279
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0404 0.0642
Brugia malayi PAN domain containing protein 0.0048 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Loa Loa (eye worm) hypothetical protein 0.0079 0.0746 0.0746
Schistosoma mansoni notch 0.0062 0.0554 0.0625
Echinococcus granulosus protein jagged 1 0.0062 0.0554 0.118
Onchocerca volvulus 0.0037 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0042 0.0329 0.0329
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0138 0.0294
Schistosoma mansoni hypothetical protein 0.0424 0.4629 0.5228
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Onchocerca volvulus 0.0048 0.0404 0.0404
Echinococcus granulosus laminin 0.013 0.1324 0.2821
Loa Loa (eye worm) hypothetical protein 0.003 0.0198 0.0198
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0404 0.0642
Schistosoma mansoni nuclear hormone receptor 0.0079 0.0746 0.0843
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0404 0.0642
Loa Loa (eye worm) nuclear hormone receptor 0.0037 0.0279 0.0279
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0138 0.0446
Loa Loa (eye worm) hypothetical protein 0.0037 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0079 0.0746 0.0746
Echinococcus multilocularis tissue type plasminogen activator 0.043 0.4694 1
Schistosoma mansoni egf-like domain protein 0.013 0.1324 0.1496
Giardia lamblia High cysteine protein 0.0062 0.0554 1
Onchocerca volvulus 0.0037 0.0281 0.0281
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0198 0.515
Echinococcus multilocularis slit 2 protein 0.0062 0.0554 0.118
Toxoplasma gondii PAN/Apple domain-containing protein 0.0048 0.0404 0.0642
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0079 0.0755 0.5592
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0138 0.0138
Onchocerca volvulus Slit protein homolog 0.0062 0.0554 0.0554
Schistosoma mansoni tar DNA-binding protein 0.0066 0.06 0.0678
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0281 0.0281
Echinococcus granulosus thyroid hormone receptor alpha 0.0037 0.0279 0.0595
Loa Loa (eye worm) Notch2 0.0062 0.0554 0.0554
Brugia malayi beta-lactamase family protein 0.0037 0.0281 0.0281
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0037 0.0279 0.0595
Onchocerca volvulus 0.013 0.133 0.133
Onchocerca volvulus 0.0048 0.0404 0.0404
Echinococcus granulosus ecdysone induced protein 78C 0.0079 0.0746 0.159
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0109 0.0233
Schistosoma mansoni cpg binding protein 0.003 0.0197 0.0222
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0068
Brugia malayi tailless protein 0.0037 0.0279 0.0279
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.133 0.1502
Brugia malayi hypothetical protein 0.0037 0.0279 0.0279
Schistosoma mansoni hypothetical protein 0.0062 0.0554 0.0625
Echinococcus granulosus protein jagged 2 0.0062 0.0554 0.118
Loa Loa (eye worm) hypothetical protein 0.013 0.133 0.133
Brugia malayi nuclear receptor NHR-88 0.0037 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Loa Loa (eye worm) hypothetical protein 0.013 0.133 0.133
Echinococcus multilocularis glycoprotein Antigen 5 0.013 0.133 0.2832
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.013 0.1324 0.1324
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Brugia malayi ecdysone receptor 0.0037 0.0279 0.0279
Brugia malayi TAR-binding protein 0.0066 0.06 0.06
Loa Loa (eye worm) PAN domain-containing protein 0.0048 0.0404 0.0404
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0079 0.0755 0.5592
Brugia malayi PAN domain containing protein 0.0048 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0079 0.0746 0.0746
Echinococcus granulosus FTZ F1 alpha 0.0079 0.0746 0.159
Loa Loa (eye worm) hypothetical protein 0.0799 0.8854 0.8854
Loa Loa (eye worm) hypothetical protein 0.0042 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.013 0.133 0.133
Onchocerca volvulus 0.003 0.0197 0.0197
Loa Loa (eye worm) PAN domain-containing protein 0.0048 0.0404 0.0404
Schistosoma mansoni ran 0.0022 0.0109 0.0123
Loa Loa (eye worm) hypothetical protein 0.013 0.133 0.133
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.013 0.133 0.1502
Brugia malayi EGF-like domain containing protein 0.0062 0.0554 0.0554
Echinococcus multilocularis enteropeptidase 0.013 0.133 0.2832
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0079 0.0746 0.0746
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0281 0.3729
Brugia malayi notch-like transmembrane receptor 0.0062 0.0554 0.0554
Echinococcus multilocularis laminin 0.013 0.1324 0.2821
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0279 0.0279
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0079 0.0746 0.0746
Onchocerca volvulus 0.0799 0.8854 0.8854
Onchocerca volvulus 0.0048 0.0404 0.0404
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0138 0.0862
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0138 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0079 0.0746 0.0746
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0138 0.0446
Mycobacterium tuberculosis Conserved protein 0.0037 0.0281 0.1016
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0068 0.0326
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0496 0.0844
Loa Loa (eye worm) RNA binding protein 0.0066 0.06 0.06
Schistosoma mansoni tar DNA-binding protein 0.0066 0.06 0.0678
Toxoplasma gondii kringle domain-containing protein 0.043 0.4694 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.013 0.133 0.1502
Brugia malayi EGF-like domain containing protein 0.0062 0.0554 0.0554
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0799 0.8854 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.013 0.1324 0.265
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0138 0.0862
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0079 0.0746 0.0746
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0138 0.0138
Echinococcus granulosus dnaJ subfamily B 0.0424 0.4629 0.986
Loa Loa (eye worm) TK/ROR protein kinase 0.043 0.4694 0.4694
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0279
Brugia malayi Trypsin family protein 0.013 0.133 0.133
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0079 0.0746 0.0746
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0281 0.0318
Brugia malayi nuclear receptor NHR-88 0.0079 0.0746 0.0746
Onchocerca volvulus 0.013 0.133 0.133
Echinococcus granulosus nuclear receptor nhr 48 0.0037 0.0279 0.0595
Echinococcus multilocularis neurogenic locus notch protein 4 0.0062 0.0554 0.118
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0279
Brugia malayi CXXC zinc finger family protein 0.003 0.0197 0.0197
Echinococcus multilocularis snurportin 1 0.0319 0.3449 0.7348
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0079 0.0746 0.159
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0079 0.0746 0.159
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0404 0.0642
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0279
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0079 0.0746 0.0746
Echinococcus granulosus neurogenic locus notch protein 4 0.0062 0.0554 0.118
Onchocerca volvulus Bile acid receptor homolog 0.0901 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Onchocerca volvulus 0.0048 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Onchocerca volvulus 0.0048 0.0404 0.0404
Brugia malayi PAN domain containing protein 0.0048 0.0404 0.0404
Echinococcus multilocularis tar DNA binding protein 0.0066 0.06 0.1278
Loa Loa (eye worm) PAN domain-containing protein 0.0048 0.0404 0.0404
Brugia malayi GCC2 and GCC3 family protein 0.0062 0.0554 0.0554
Toxoplasma gondii microneme protein MIC17B 0.0048 0.0404 0.0642
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0079 0.0746 0.159
Schistosoma mansoni RAR-like nuclear receptor 0.0079 0.0746 0.0843
Brugia malayi steroid hormone receptor 0.0079 0.0746 0.0746
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0198 0.0194
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.013 0.133 0.2832
Schistosoma mansoni laminin gamma-3 chain 0.0062 0.0554 0.0625
Echinococcus multilocularis neurogenic locus protein delta 0.0062 0.0554 0.118
Brugia malayi Muscle positioning protein 4 0.0062 0.0554 0.0554
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0279 0.0279
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0396 0.4318 0.9198
Echinococcus granulosus importin subunit beta 1 0.003 0.0198 0.0422
Loa Loa (eye worm) hypothetical protein 0.0025 0.0138 0.0138
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.06 0.06
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0079 0.0746 0.0746
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.133 0.1502
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0281 0.1016
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0037 0.0279 0.0279
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0079 0.0746 0.159
Brugia malayi nuclear receptor NHR-67 0.0037 0.0279 0.0279
Echinococcus granulosus protein jagged 2 0.0062 0.0554 0.118
Echinococcus granulosus cpg binding protein 0.0031 0.0216 0.0459
Echinococcus granulosus delta-like protein 1 0.0062 0.0554 0.118
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.013 0.1324 0.1324
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0079 0.0746 0.159
Echinococcus granulosus slit 2 protein 0.0062 0.0554 0.118
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0042 0.0329 0.0329
Schistosoma mansoni retinoic acid receptor RXR 0.0396 0.4318 0.4877
Onchocerca volvulus 0.0062 0.0554 0.0554
Brugia malayi nuclear hormone receptor family member odr-7 0.0037 0.0279 0.0279
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0019 0.0074 0.263
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.133 0.1502
Echinococcus granulosus tar DNA binding protein 0.0066 0.06 0.1278
Brugia malayi PAN domain containing protein 0.0048 0.0404 0.0404
Onchocerca volvulus 0.013 0.133 0.133
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0079 0.0746 0.0746
Onchocerca volvulus Putative cubilin 0.0062 0.0554 0.0554
Schistosoma mansoni notch 0.0062 0.0554 0.0625
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0079 0.0746 0.0746
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0079 0.0746 0.159
Echinococcus granulosus Mastin 0.013 0.133 0.2832
Schistosoma mansoni notch 0.0062 0.0554 0.0625
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0279 0.0595
Loa Loa (eye worm) hypothetical protein 0.0799 0.8854 0.8854
Onchocerca volvulus 0.0062 0.0554 0.0554
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0062 0.0554 0.0554
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0281 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.013 0.133 0.133
Brugia malayi nuclear receptor RXR 0.0037 0.0279 0.0279
Brugia malayi beta-lactamase 0.0037 0.0281 0.0281
Onchocerca volvulus 0.0025 0.0138 0.0138
Loa Loa (eye worm) steroid hormone receptor 0.0079 0.0746 0.0746
Echinococcus multilocularis cpg binding protein 0.0031 0.0216 0.0459
Echinococcus multilocularis fibrillin 1 0.013 0.1324 0.2821
Plasmodium falciparum cysteine repeat modular protein 1 0.043 0.4694 1
Schistosoma mansoni hypothetical protein 0.0062 0.0554 0.0625
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0138 0.0294
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.013 0.133 0.2832
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0048 0.0404 0.0642
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.013 0.1324 0.1324
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0281 0.0318
Echinococcus multilocularis Mastin 0.013 0.133 0.2832
Loa Loa (eye worm) hypothetical protein 0.0079 0.0746 0.0746
Onchocerca volvulus Neurogenic locus notch homolog 0.0062 0.0554 0.0554
Brugia malayi nuclear hormone receptor 0.0037 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0134 0.4774
Toxoplasma gondii microneme protein MIC4 0.0048 0.0404 0.0642
Onchocerca volvulus 0.013 0.133 0.133
Mycobacterium ulcerans hypothetical protein 0.0025 0.0138 0.0862
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0037 0.0281 0.0281
Echinococcus multilocularis Tolloid protein 1 0.013 0.1324 0.2821
Loa Loa (eye worm) PAN domain-containing protein 0.0048 0.0404 0.0404
Echinococcus multilocularis protein jagged 1 0.0062 0.0554 0.118
Echinococcus granulosus fibropellin Ia 0.0062 0.0554 0.118
Loa Loa (eye worm) hypothetical protein 0.013 0.1324 0.1324
Schistosoma mansoni cell polarity protein 0.0062 0.0554 0.0625
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.133 0.1502
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0281 0.1016
Loa Loa (eye worm) hypothetical protein 0.013 0.1324 0.1324
Schistosoma mansoni notch 0.0062 0.0554 0.0625
Loa Loa (eye worm) hypothetical protein 0.013 0.133 0.133
Echinococcus granulosus notch 0.0062 0.0554 0.118
Trichomonas vaginalis esterase, putative 0.0037 0.0281 1
Trichomonas vaginalis ran, putative 0.0022 0.0109 0.388
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0079 0.0746 0.0746
Onchocerca volvulus 0.0037 0.0279 0.0279
Onchocerca volvulus 0.0048 0.0404 0.0404
Toxoplasma gondii microneme protein MIC17A 0.0048 0.0404 0.0642
Loa Loa (eye worm) beta-lactamase 0.0037 0.0281 0.0281
Schistosoma mansoni thyroid hormone receptor 0.0079 0.0746 0.0843
Loa Loa (eye worm) hypothetical protein 0.0037 0.0281 0.0281
Brugia malayi EGF-like domain containing protein 0.0062 0.0554 0.0554
Brugia malayi Protein kinase domain containing protein 0.043 0.4694 0.4694
Leishmania major hypothetical protein, conserved 0.043 0.4694 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0057 0.0124
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0279 0.0279
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0042 0.0329 0.0701
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0037 0.0279 0.0315
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0092 0.0893 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0134 0.0286
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.013 0.1324 0.1496
Brugia malayi Calcium binding EGF domain containing protein 0.0062 0.0554 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0079 0.0746 0.0746
Loa Loa (eye worm) bone morphogenetic protein 1b 0.013 0.1324 0.1324
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0281 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0079 0.0746 0.0746
Onchocerca volvulus 0.043 0.4694 0.4694
Loa Loa (eye worm) hypothetical protein 0.0048 0.0404 0.0404
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0042 0.0329 0.0701
Brugia malayi hypothetical protein 0.0037 0.0279 0.0279
Mycobacterium ulcerans hypothetical protein 0.013 0.133 1
Echinococcus multilocularis neurogenic locus notch protein 0.0062 0.0554 0.118
Onchocerca volvulus 0.0048 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0019 0.0074 0.263
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0281 0.1016
Echinococcus multilocularis neural cadherin 0.0062 0.0554 0.118
Brugia malayi EGF-like domain containing protein 0.0062 0.0554 0.0554
Toxoplasma gondii microneme protein, putative 0.0048 0.0404 0.0642
Plasmodium falciparum importin beta, putative 0.003 0.0198 0.028
Loa Loa (eye worm) hypothetical protein 0.0025 0.0138 0.0138
Brugia malayi Fibulin-1 precursor 0.013 0.1324 0.1324
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.06 0.06
Echinococcus multilocularis protein jagged 1 0.0062 0.0554 0.118
Loa Loa (eye worm) hypothetical protein 0.0048 0.0404 0.0404
Echinococcus granulosus glycoprotein Antigen 5 0.013 0.133 0.2832
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0329 0.0329
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0281 0.0461
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0138 0.0862
Onchocerca volvulus 0.0079 0.0746 0.0746
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0281 0.06
Toxoplasma gondii hypothetical protein 0.0048 0.0404 0.0642
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0042 0.0329 0.0329
Brugia malayi PAN domain containing protein 0.0048 0.0404 0.0404
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.013 0.133 0.2832
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0109 0.0233
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.013 0.133 0.1502
Onchocerca volvulus 0.0048 0.0404 0.0404
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0134 0.4774
Schistosoma mansoni cpg binding protein 0.0031 0.0216 0.0244
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0279 0.0595
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0015 0.0026 0.0342
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.133 0.1502
Echinococcus granulosus neurogenic locus protein delta 0.0062 0.0554 0.118
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0109 0.0109
Schistosoma mansoni coup transcription factor 0.0079 0.0746 0.0843
Onchocerca volvulus Protein ultraspiracle homolog 0.0079 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0281 0.06
Trichomonas vaginalis receptor histidine kinase, putative 0.0019 0.0074 0.263
Loa Loa (eye worm) hypothetical protein 0.0062 0.0554 0.0554
Brugia malayi conserved hypotetical protein 0.0037 0.0279 0.0279
Brugia malayi PAN domain containing protein 0.0048 0.0404 0.0404
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0109 0.0233
Mycobacterium ulcerans hypothetical protein 0.0037 0.0281 0.1961
Brugia malayi hypothetical protein 0.0042 0.0329 0.0329
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.133 0.1502
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0279
Toxoplasma gondii microneme protein MIC17C 0.0048 0.0404 0.0642
Trichomonas vaginalis sensor histidine kinase, putative 0.0019 0.0074 0.263
Echinococcus multilocularis thyroid hormone receptor alpha 0.0079 0.0746 0.159
Schistosoma mansoni hypothetical protein 0.043 0.4694 0.5302
Brugia malayi Delta serrate ligand family protein 0.0062 0.0554 0.0554
Loa Loa (eye worm) hypothetical protein 0.0901 1 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0138 0.1831
Brugia malayi Trypsin family protein 0.013 0.133 0.133
Echinococcus granulosus neurogenic locus notch protein 0.0062 0.0554 0.118
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0068
Echinococcus multilocularis nuclear receptor nhr 48 0.0037 0.0279 0.0595
Trichomonas vaginalis receptor histidine kinase, putative 0.0019 0.0074 0.263
Loa Loa (eye worm) hypothetical protein 0.0037 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0037 0.0279 0.0279
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0281 0.06
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0279 0.0595
Loa Loa (eye worm) hypothetical protein 0.043 0.4694 0.4694
Schistosoma mansoni nuclear receptor 0.0037 0.0279 0.0315
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.013 0.133 0.2832
Loa Loa (eye worm) hypothetical protein 0.0042 0.0329 0.0329
Mycobacterium tuberculosis Conserved protein 0.0037 0.0281 0.1016
Schistosoma mansoni hypothetical protein 0.013 0.133 0.1502
Brugia malayi Trypsin family protein 0.013 0.133 0.133
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0079 0.0746 0.0843
Brugia malayi Calcium binding EGF domain containing protein 0.013 0.1324 0.1324
Schistosoma mansoni hypothetical protein 0.0062 0.0554 0.0625
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0037 0.0279 0.0595
Loa Loa (eye worm) hypothetical protein 0.013 0.1324 0.1324
Brugia malayi Calcium binding EGF domain containing protein 0.0062 0.0554 0.0554
Schistosoma mansoni thyroid hormone receptor 0.0079 0.0746 0.0843
Echinococcus granulosus neural cadherin 0.0062 0.0554 0.118
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0079 0.0755 0.2897
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.133 0.1502
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0281 1
Loa Loa (eye worm) trypsin family protein 0.013 0.133 0.133
Brugia malayi EGF-like domain containing protein 0.0062 0.0554 0.0554
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0109 0.0109
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0079 0.0746 0.159
Schistosoma mansoni ran 0.0022 0.0109 0.0123
Loa Loa (eye worm) nuclear receptor NHR-67 0.0037 0.0279 0.0279
Plasmodium vivax cysteine repeat modular protein 1, putative 0.043 0.4694 1
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0281 0.1016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.013 0.133 0.1502
Leishmania major hypothetical protein, conserved 0.0037 0.0281 0.06
Toxoplasma gondii subtilisin SUB12 0.0048 0.0404 0.0642
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0037 0.0279 0.0279
Schistosoma mansoni notch 0.0062 0.0554 0.0625
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0572 0.0646
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0281 1
Toxoplasma gondii EGF family domain-containing protein 0.0062 0.0554 0.0969

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 0.001 M In vitro inhibitory growth activity against L1210 leukemic cells by incubating 5 x 10E4 cells/mL for 48 hour in 2 mL of media. ChEMBL. 2704026

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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