Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | neuropeptide F receptor | 0.0017 | 0.8503 | 0.8503 |
Schistosoma mansoni | lamin | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | neuropeptide F receptor | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | Dopamine receptor protein 2 | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | sulfakinin receptor protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.9354 | 0.9354 |
Brugia malayi | Serotonin receptor | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | Dopamine receptor | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | G protein-coupled receptor | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | GnHR receptor homolog | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | ORL1-like opioid receptor | 0.0017 | 0.8503 | 0.8503 |
Echinococcus granulosus | intermediate filament protein | 0.0018 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | Dopamine receptor protein 1 | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | G-protein coupled receptor | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Onchocerca volvulus | 0.0018 | 1 | 1 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | RE15519p | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0017 | 0.8503 | 0.8503 |
Echinococcus granulosus | lamin | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Echinococcus granulosus | lamin dm0 | 0.0018 | 1 | 1 |
Brugia malayi | G-protein coupled receptor | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | AKH receptor | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Echinococcus multilocularis | lamin | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Echinococcus multilocularis | musashi | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | follicle stimulating hormone receptor | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Echinococcus multilocularis | lamin dm0 | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Schistosoma mansoni | lamin | 0.0018 | 1 | 1 |
Brugia malayi | Serotonin receptor | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | neuropeptide F receptor | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Schistosoma mansoni | intermediate filament proteins | 0.0018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.9606 | 0.9606 |
Brugia malayi | larval opioid receptor | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | putative neuropeptide receptor | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Brugia malayi | Melatonin receptor type 1A | 0.0017 | 0.8503 | 0.8503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.8503 | 0.8503 |
Onchocerca volvulus | 0.0018 | 1 | 1 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0018 | 0.9354 | 0.9354 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.000000035 M | Cytotoxicity against P388 cells is the dose of the compound giving 50% decrease in the formation of formazan dye | ChEMBL. | 10206538 |
IC50 (functional) | = 0.000000035 M | Cytotoxicity against P388 cells is the dose of the compound giving 50% decrease in the formation of formazan dye | ChEMBL. | 10206538 |
LD50 (functional) | = 0.000073 M | Dose of the compound giving a 50% decrease in the living cell number (P388 cells) | ChEMBL. | 10206538 |
LD50 (functional) | = 0.000073 M | Dose of the compound giving a 50% decrease in the living cell number (P388 cells) | ChEMBL. | 10206538 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 10206538 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.