Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0139 | 0.0266 | 0.0266 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0086 | 0.01 | 0.01 |
Brugia malayi | Cation transporter family protein | 0.0139 | 0.0266 | 0.0266 |
Echinococcus granulosus | nAChR subunit | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.01 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0139 | 0.0266 | 0.0266 |
Schistosoma mansoni | nAChR subunit | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0086 | 0.01 | 0.01 |
Echinococcus multilocularis | nAChR subunit | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | Dihydrofolate reductase | 0.3274 | 1 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0086 | 0.01 | 0.01 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0139 | 0.0266 | 0.0266 |
Echinococcus multilocularis | nAChR subunit | 0.0086 | 0.01 | 0.01 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0139 | 0.0266 | 0.0266 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0139 | 0.0266 | 0.0266 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0139 | 0.0266 | 0.0266 |
Schistosoma mansoni | nAChR subunit | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0139 | 0.0266 | 0.0266 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0139 | 0.0266 | 0.0266 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0139 | 0.0266 | 0.0266 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.139 | 0.4151 | 0.2789 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.139 | 0.4151 | 0.4151 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.01 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Schistosoma mansoni | nAChR subunit | 0.0139 | 0.0266 | 0.0266 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3274 | 1 | 1 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0086 | 0.01 | 0.01 |
Onchocerca volvulus | Putative nachr subunit | 0.0139 | 0.0266 | 0.0641 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.01 | 0.01 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0139 | 0.0266 | 0.0266 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0354 | 0.0354 |
Schistosoma mansoni | nAChR subunit | 0.0139 | 0.0266 | 0.0266 |
Onchocerca volvulus | 0.0139 | 0.0266 | 0.0641 | |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Schistosoma mansoni | nAChR subunit | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0139 | 0.0266 | 0.0266 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3274 | 1 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | Cation transporter family protein | 0.0139 | 0.0266 | 0.0266 |
Onchocerca volvulus | 0.0086 | 0.01 | 0.0242 | |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | ACC-1 protein | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.01 | 0.01 |
Loa Loa (eye worm) | ACC-1 protein | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0086 | 0.01 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0086 | 0.01 | 0.01 |
Entamoeba histolytica | hypothetical protein | 0.0086 | 0.01 | 0.5 |
Brugia malayi | hypothetical protein | 0.0661 | 0.1888 | 0.1888 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Onchocerca volvulus | 0.0139 | 0.0266 | 0.0641 | |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0139 | 0.0266 | 0.0266 |
Echinococcus multilocularis | geminin | 0.0167 | 0.0354 | 0.0354 |
Brugia malayi | Cation transporter family protein | 0.0139 | 0.0266 | 0.0266 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3076 | 0.9385 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.01 | 0.01 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0139 | 0.0266 | 0.0266 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0086 | 0.01 | 0.01 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0086 | 0.01 | 0.01 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0139 | 0.0266 | 0.0266 |
Onchocerca volvulus | 0.0139 | 0.0266 | 0.0641 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3076 | 0.9385 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0139 | 0.0266 | 0.0266 |
Echinococcus granulosus | thymidylate synthase | 0.139 | 0.4151 | 0.4151 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.01 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.01 | 0.01 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3274 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3274 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3274 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3274 | 1 | 1 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.01 | 0.01 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0661 | 0.1888 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0139 | 0.0266 | 0.0266 |
Echinococcus multilocularis | thymidylate synthase | 0.139 | 0.4151 | 0.4151 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.01 | 0.01 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0139 | 0.0266 | 0.0266 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0139 | 0.0266 | 0.0266 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | thymidylate synthase | 0.139 | 0.4151 | 0.4151 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0139 | 0.0266 | 0.0266 |
Onchocerca volvulus | 0.0086 | 0.01 | 0.0242 | |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | thymidylate synthase | 0.139 | 0.4151 | 0.4151 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3076 | 0.9385 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0139 | 0.0266 | 0.0266 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0139 | 0.0266 | 0.0266 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3076 | 0.9385 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3076 | 0.9385 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0139 | 0.0266 | 0.0266 |
Echinococcus granulosus | geminin | 0.0167 | 0.0354 | 0.0354 |
Schistosoma mansoni | dihydrofolate reductase | 0.3274 | 1 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0139 | 0.0266 | 0.0266 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0139 | 0.0266 | 0.0266 |
Onchocerca volvulus | 0.0139 | 0.0266 | 0.0641 | |
Echinococcus granulosus | dihydrofolate reductase | 0.3274 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Onchocerca volvulus | 0.0139 | 0.0266 | 0.0641 | |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0139 | 0.0266 | 0.0266 |
Echinococcus granulosus | nAChR subunit | 0.0086 | 0.01 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | LGC-31 protein | 0.0139 | 0.0266 | 0.0266 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3076 | 0.9385 | 0.5 |
Onchocerca volvulus | 0.0139 | 0.0266 | 0.0641 | |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0139 | 0.0266 | 0.0266 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0139 | 0.0266 | 0.0266 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0139 | 0.0266 | 0.0266 |
Onchocerca volvulus | 0.139 | 0.4151 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0266 | 0.0266 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0139 | 0.0266 | 0.0266 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0139 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0139 | 0.0266 | 0.0266 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0354 | 0.0354 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 29 % | Percent inhibition of the leukotriene D4 (LTD4)-induced contraction of guinea pig tracheal spirals at 1 microM concentration | ChEMBL. | 2704027 |
Inhibition (functional) | = 100 % | Percent inhibition of the leukotriene E4 (LTE4)-induced contraction of guinea pig tracheal spirals at 10 microM concentration | ChEMBL. | 2704027 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.