Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | microtubule-associated protein tau | 0.0694 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0034 | 0.0052 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0449 | 0.6129 | 0.6129 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.1105 | 0.1105 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.1105 | 0.1674 |
Schistosoma mansoni | lipoxygenase | 0.0249 | 0.2987 | 0.2987 |
Schistosoma mansoni | tyrosine kinase | 0.0205 | 0.2296 | 0.2296 |
Schistosoma mansoni | dihydrofolate reductase | 0.0468 | 0.6434 | 0.6434 |
Schistosoma mansoni | tyrosine kinase | 0.0199 | 0.2203 | 0.2203 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0468 | 0.6434 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0468 | 0.6434 | 0.6434 |
Schistosoma mansoni | lipoxygenase | 0.0356 | 0.4676 | 0.4676 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0205 | 0.2296 | 0.2296 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.1105 | 0.1105 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0394 | 0.5275 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0356 | 0.4676 | 0.4676 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0468 | 0.6434 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0205 | 0.2296 | 0.2296 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.4439 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0468 | 0.6434 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0396 | 0.5303 | 0.8243 |
Schistosoma mansoni | tyrosine kinase | 0.0449 | 0.6129 | 0.6129 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0341 | 0.4439 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.4439 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0468 | 0.6434 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0199 | 0.2203 | 0.2203 |
Brugia malayi | thymidylate synthase | 0.013 | 0.1105 | 0.1718 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0449 | 0.6129 | 0.9526 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.1105 | 0.1718 |
Schistosoma mansoni | tyrosine kinase | 0.0205 | 0.2296 | 0.2296 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.4439 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0205 | 0.2296 | 0.2296 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.4439 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0205 | 0.2296 | 0.2296 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.4439 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0468 | 0.6434 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0468 | 0.6434 | 0.6434 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.2894 | 0.4498 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0449 | 0.6129 | 0.6129 |
Echinococcus granulosus | insulin receptor | 0.0449 | 0.6129 | 0.6129 |
Onchocerca volvulus | 0.0382 | 0.5078 | 0.9626 | |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0356 | 0.4676 | 0.4676 |
Onchocerca volvulus | 0.013 | 0.1105 | 0.2095 | |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0694 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0205 | 0.2296 | 0.2296 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0468 | 0.6434 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0468 | 0.6434 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0034 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0205 | 0.2296 | 0.3569 |
Echinococcus multilocularis | insulin receptor | 0.0449 | 0.6129 | 0.6129 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1105 | 0.1105 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0205 | 0.2296 | 0.3569 |
Schistosoma mansoni | tyrosine kinase | 0.0199 | 0.2203 | 0.2203 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0396 | 0.5303 | 0.8243 |
Schistosoma mansoni | tyrosine kinase | 0.0205 | 0.2296 | 0.2296 |
Brugia malayi | Protein kinase domain containing protein | 0.0249 | 0.2988 | 0.4644 |
Brugia malayi | Protein kinase domain containing protein | 0.0449 | 0.6129 | 0.9526 |
Schistosoma mansoni | tyrosine kinase | 0.0449 | 0.6129 | 0.6129 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.21 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.21 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.47 uM | Inhibitory activity of the compound against rat liver dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.47 uM | Inhibitory activity of the compound against rat liver dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (functional) | = 1.6 uM | Inhibition of Toxoplasma gondii cell growth | ChEMBL. | 8632434 |
IC50 (functional) | = 1.6 uM | Inhibition of Toxoplasma gondii cell growth | ChEMBL. | 8632434 |
IC50 (binding) | = 3.9 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 3.9 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 8632434 |
Selectivity (binding) | = 0.1 | Ratio of IC50 rat liver DHFR vs IC50 of P. carinii DHFR | ChEMBL. | 8632434 |
Selectivity (binding) | = 2.2 | Ratio of IC50 rat liver DHFR vs IC50 of T. gondii DHFR | ChEMBL. | 8632434 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Toxoplasma gondii | ChEMBL23 | 8632434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.