Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | acetylcholinesterase | 0.0013 | 0.0128 | 0.0128 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0013 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0128 | 0.0128 |
Onchocerca volvulus | 0.0013 | 0.0128 | 1 | |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0034 | 0.0894 | 0.0894 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0128 | 0.0128 |
Mycobacterium ulcerans | glutaminase | 0.0267 | 0.9798 | 1 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0034 | 0.0894 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0128 | 0.0128 |
Echinococcus multilocularis | acetylcholinesterase | 0.0079 | 0.2646 | 0.2646 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0128 | 0.0128 |
Echinococcus multilocularis | neuroligin | 0.0013 | 0.0128 | 0.0128 |
Schistosoma mansoni | glutaminase | 0.0267 | 0.9798 | 0.9798 |
Trichomonas vaginalis | glutaminase, putative | 0.0267 | 0.9798 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0013 | 0.0128 | 0.0128 |
Echinococcus granulosus | neuroligin | 0.0013 | 0.0128 | 0.0128 |
Brugia malayi | Carboxylesterase family protein | 0.0013 | 0.0128 | 0.0131 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0013 | 0.0128 | 0.0128 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0272 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0079 | 0.2646 | 0.2646 |
Loa Loa (eye worm) | carboxylesterase | 0.0079 | 0.2646 | 0.2646 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0013 | 0.0128 | 0.0128 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0034 | 0.0894 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0013 | 0.0128 | 0.0128 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0013 | 0.0128 | 0.5 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0034 | 0.0894 | 0.5 |
Brugia malayi | Augmenter of liver regeneration | 0.0034 | 0.0894 | 0.0912 |
Brugia malayi | hypothetical protein | 0.0013 | 0.0128 | 0.0131 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0013 | 0.0128 | 0.0128 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0034 | 0.0894 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.4063 | 0.4063 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0034 | 0.0894 | 0.0894 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0013 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 1 | 1 |
Onchocerca volvulus | 0.0013 | 0.0128 | 1 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0013 | 0.0128 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0013 | 0.0128 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0128 | 0.0128 |
Onchocerca volvulus | 0.0013 | 0.0128 | 1 | |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.4063 | 0.4147 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2646 | 0.2646 |
Onchocerca volvulus | 0.0013 | 0.0128 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0013 | 0.0128 | 0.0131 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0034 | 0.0894 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | glutaminase 2 | 0.0267 | 0.9798 | 0.9798 |
Echinococcus granulosus | acetylcholinesterase | 0.0079 | 0.2646 | 0.2646 |
Brugia malayi | Carboxylesterase family protein | 0.0079 | 0.2646 | 0.27 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0034 | 0.0894 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.0128 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0013 | 0.0128 | 0.0128 |
Echinococcus multilocularis | serotonin receptor | 0.0272 | 1 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0267 | 0.9798 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0013 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0079 | 0.2646 | 0.2646 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0013 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | glutaminase | 0.0267 | 0.9798 | 0.9798 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0034 | 0.0894 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0013 | 0.0128 | 0.0128 |
Echinococcus multilocularis | serotonin receptor | 0.0272 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0013 | 0.0128 | 0.0131 |
Echinococcus multilocularis | acetylcholinesterase | 0.0079 | 0.2646 | 0.2646 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0034 | 0.0894 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0013 | 0.0128 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2646 | 0.2646 |
Echinococcus granulosus | acetylcholinesterase | 0.0079 | 0.2646 | 0.2646 |
Loa Loa (eye worm) | carboxylesterase | 0.0013 | 0.0128 | 0.0128 |
Schistosoma mansoni | gliotactin | 0.0013 | 0.0128 | 0.0128 |
Echinococcus granulosus | carboxylesterase 5A | 0.0079 | 0.2646 | 0.2646 |
Leishmania major | hypothetical protein, conserved | 0.0034 | 0.0894 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0079 | 0.2646 | 0.27 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0034 | 0.0894 | 0.0894 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0079 | 0.2646 | 0.2646 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0013 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.4063 | 0.4063 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 21 % | Percent inhibition of the leukotriene E4 (LTE4)-induced contraction of guinea pig tracheal spirals at 10 microM concentration | ChEMBL. | 2704027 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.